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Cover: Paracrine hormones, released from the vascular endothelium in response to shear stress, impact on the subintimal space and vascular smooth muscle cell function. Artwork by Paul Ricketts. See Green, Daniel J., Maria T. E. Hopman, Jaume Padilla, M. Harold Laughlin, and Dick H. J. Thijssen. Physiol Rev 97: 495–527, 2017.