Physiological Reviews (PRV) contains invited critical reviews of physiological topics as well as reviews in biochemistry, nutrition, general physiology, biophysics, and neuroscience. Reviews are invited from leading scientists worldwide by an American Editorial Board and a European Editorial Committee.
Physiological Reviews has the highest impact factor (26.866) in the Thomson Reuters physiology category, ranking number 1 among all physiology journals.
Our prestigious peer-reviewed journals (with high impact factors) are read by research leaders (both MDs and PhDs) in all experimental physiology specialties.
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Breakdown of circulation by classification of readers: physiologists, circulatory physiologists, pulmonary physiologists, renal physiologists, respiratory physiologists, exercise physiologists, endocrinologists, gastroenterologists, environmental physiologists, biochemists, neurologists, neuroscientists, pharmacologists, nutritionists, immunologists, geneticists, research workers in biology/cell biology, universities, foundations, medical schools, hospitals, libraries, and industrial libraries.
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Cover: V-ATPases are ATP-dependent proton pumps that both acidify intracellular compartments and pump protons across the plasma membrane of eukaryotic cells. They have been implicated in the survival, drug resistance, signaling, and invasiveness of tumor cells, making them an attractive and novel target in the development of therapeutics to limit tumor growth and metastasis. Model adapted from Couoh-Cardel et al. (J Biol Chem 2015). See Stransky, Laura, Kristina Cotter, and Michael Forgac. Physiol Rev 96: 1071–1091, 2016.