Table 3.

Expression of oxytocin and oxytocin receptors in the peripheral system

TissueSpeciesOT GeneOT BindingOTR mRNAReference Nos.
Female reproductive system
 Myometrium* Hum bov she 3-213_ 3-213_ 44,191, 299, 482, 529, 531
RatND 3-213_ 3-213_ 7,120, 194, 323, 624
Rab gp 3-213_ 164,479, 531
Pig 3-213_ 3-213_ 63, 351
 Endometrium Hum 3-213_ 3-213_ 299
Rat 3-213_ 3-213_ ND 101, 323, 327, 624
Bov she 3-213_ 3-213_ 44, 480, 482, 529
Pig 3-213_ 3-213_ 63, 351, 387, 388
Rab 3-213_ 355
 AmnionHum 3-213_ 3-213_ 3-213_ 104
Rat 3-213_ ND 328
Bov 3-213_ ND 193, 272
Rab 3-213_ 234
 ChorionHum 3-213_ 3-213_ 3-213_ 49, 104, 547
Rat 3-213_ ND 328
 DeciduaHum 3-213_ 3-213_ 3-213_ 104, 190, 547
Rat gp rab 3-213_ 190, 196, 479, 547, 550
 OvaryHum mar 3-213_ 3-213_ 3-213_ 147, 187, 198, 269,299
Mou 3-213_ 3-213_ 199
Bov 3-213_ 3-213_ 268, 271, 187
Gp pos 3-213_ 46, 619
 Corpus luteum Hum pig mac 3-213_ 3-213_ 126, 150, 269, 291, 292, 454, 585
Bov 3-213_ 3-213_ ND 173, 187, 272, 584
She 3-213_ 3-213_ 513, 554, 583
Rat bab goa 3-213_ 197, 243, 269
Male reproductive system
 TestisHum rat 3-213_ 3-213_ 45, 180, 269, 414
Mar 3-213_ 3-213_ 145
Mac 3-213_ (3-213_) 182
Mou(3-213_) 16, 415
Bov she ban 3-213_ 16, 47, 207, 563
Pig 3-213_ 354
 EpididymisHum 3-213_ (3-213_) 182
Mar(3-213_)(3-213_) 145
Wal 3-213_ 3-213_ 437
Pig 3-213_ 354
Rat 3-213_ 226
 Prostate glandHum 3-213_ (3-213_) 58, 182
MarND(3-213_) 145
Mar mac(3-213_) 145, 182
Wal 3-213_ 3-213_ 437
BovND 502
Rat gp dog(3-213_) 58
 Mammary gland* Hum(3-213_) 3-213_ 293, 294
Rat mar bov pig 3-213_ 294, 351, 399, 531, 533, 620
 KidneyRat 3-213_ 3-213_ 33, 34, 67, 353, 427, 504,551
Rab(3-213_) 14, 255
Pos 3-213_ 46
 HeartRat 3-213_ 3-213_ 3-213_ 221, 274
 Vascular endotheliumHum 3-213_ 3-213_ 555
 ThymusHum 3-213_ 3-213_ 205, 206
Rat 3-213_ 153
Mou 3-213_ 203
 AdipocytesRat 3-213_ 36, 61, 62, 144
 PancreasHum(3-213_) 10
Rat(3-213_) 3-213_ 10, 535, 608
 Adrenal glandHum rat ham gp 3-213_ 17, 180, 231, 419,473
Bov 3-213_ 3-213_ 420, 550
 OsteoblastsHum 3-213_ 3-213_ 117
Cell lines
 Osteosarcoma Saos-2Hum 3-213_ 3-213_ 117
 Myometrial PHM1-41Hum 3-213_ 138
 Pancreatic RINm5FRat 3-213_ 279
 Gonadotrope-derived αT3-1Mou 3-213_ 161
 Mammary tumor Hs578THum 3-213_ 242
 Breast cancer lines (e.g., MCF7)Hum(3-213_) 3-213_ 40, 168, 263, 496,549
 Vascular endothelial ECV304Hum 3-213_ 555
 Vascular smooth muscle (HVSMC)Hum 3-213_ 607
 Sweat gland NCL-SG3Hum(3-213_) 481
 Immature thymic pre-T RL12-NPMou 3-213_ 360
 Kidney epithelial LLC-PK1 Pig 3-213_ 3-213_ 215
  • F3-213 , Detectable signal; (+), weak or unclear signal (e.g., based on poorly characterized antireceptor antibodies) and/or contradictory reports have been published (for details, see the references); ND, not detected. Indicated species are as follows: bab, baboon; ban, bandicoot; bov, bovine; goa, goat; gp, guinea pig; ham, hamster; hum, human; mac, macaque monkey; mar, marmoset monkey; mou, mouse; pos, brushtail possum; rab, rabbit; she, sheep; wal, wallaby. * Oxytocin (OT) receptors are present in myometrial and mammary myoepithelial cells of all mammalians. † OT receptors are probably present in endometrium of all ruminants. ‡ OT has been found to be synthesized in the luteal cells of all species so far studied.