Phys. Rev. -- Table of Contents (October 2006, 86, (4))

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Michael J. Page and Enrico Di Cera: Role of Na⁺ and K⁺ in Enzyme Function
Physiol. Rev. 86: 1049-1092, 2006; doi:10.1152/physrev.00008.2006 [Abstract] [Full Text] [PDF]

Antonio G. García, Antonio M. García-De-Diego, Luis Gandía, Ricardo Borges, and Javier García-Sancho: Calcium Signaling and Exocytosis in Adrenal Chromaffin Cells
Physiol. Rev. 86: 1093-1131, 2006; doi:10.1152/physrev.00039.2005 [Abstract] [Full Text] [PDF]

Stefan J. Marciniak and David Ron: Endoplasmic Reticulum Stress Signaling in Disease
Physiol. Rev. 86: 1133-1149, 2006; doi:10.1152/physrev.00015.2006 [Abstract] [Full Text] [PDF]

Florian Lang, Christoph Böhmer, Monica Palmada, Guiscard Seebohm, Nathalie Strutz-Seebohm, and Volker Vallon: (Patho)physiological Significance of the Serum- and Glucocorticoid-Inducible Kinase Isoforms
Physiol. Rev. 86: 1151-1178, 2006; doi:10.1152/physrev.00050.2005 [Abstract] [Full Text] [PDF]

Balázs Sarkadi, László Homolya, Gergely Szakács, and András Váradi: Human Multidrug Resistance ABCB and ABCG Transporters: Participation in a Chemoimmunity Defense System
Physiol. Rev. 86: 1179-1236, 2006; doi:10.1152/physrev.00037.2005 [Abstract] [Full Text] [PDF]

Elina Ikonen: Mechanisms for Cellular Cholesterol Transport: Defects and Human Disease
Physiol. Rev. 86: 1237-1261, 2006; doi:10.1152/physrev.00022.2005 [Abstract] [Full Text] [PDF]

Nico Westerhof, Christa Boer, Regis R. Lamberts, and Pieter Sipkema: Cross-Talk Between Cardiac Muscle and Coronary Vasculature
Physiol. Rev. 86: 1263-1308, 2006; doi:10.1152/physrev.00029.2005 [Abstract] [Full Text] [PDF]

Dirk Roosterman, Tobias Goerge, Stefan W. Schneider, Nigel W. Bunnett, and Martin Steinhoff: Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ
Physiol. Rev. 86: 1309-1379, 2006; doi:10.1152/physrev.00026.2005 [Abstract] [Full Text] [PDF]

Cover

Cover: The skin as a neuroimmunoendocrine organ. The skin is closely connected to the peripheral sensory nervous system (PNS), the autonomous nervous system (ANS), and the central nervous system (CNS). Various stressors activate the CNS leading to release of neuromediators. They may stimulate release of noradrenaline and cortisol from adrenal glands or directly stimulate blood leukocytes, thereby modulating immune responses during inflammation and immunity. Exogenous or endogenous trigger factors may also stimulate release of neuromediators from primary afferent neurons by this means, modulating cutaneous inflammation, pain, and pruritus via various mediators with pro- or anti-inflammatory effects or controlling receptor function and peptidases. Autonomic nerves, in the skin mainly sympathetic cholinergic and rarely parasympathetic cholinergic nerves, innervate blood vessels and modulate immune cell function, thus maintaining skin homeostasis and regulating inflammation and host defense. See Roosterman, Dirk, Tobias Goerge, Stefan W. Schneider, Nigel W. Bunnett, and Martin Steinhoff. Physiol Rev 86: 1309–1379, 2006.