Phys. Rev. -- Table of Contents (April 2006, 86, (2))

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Contents: Volume 86, Issue 2; April, 2006. [Index by Author] [Editorial Board]

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Articles

Kensaku Mori, Yuji K. Takahashi, Kei M. Igarashi, and Masahiro Yamaguchi: Maps of Odorant Molecular Features in the Mammalian Olfactory Bulb
Physiol. Rev. 86: 409-433, 2006; doi:10.1152/physrev.00021.2005 [Abstract] [Full Text] [PDF]

J. Enrique Silva: Thermogenic Mechanisms and Their Hormonal Regulation
Physiol. Rev. 86: 435-464, 2006; doi:10.1152/physrev.00009.2005 [Abstract] [Full Text] [PDF]

Béatrice Desvergne, Liliane Michalik, and Walter Wahli: Transcriptional Regulation of Metabolism
Physiol. Rev. 86: 465-514, 2006; doi:10.1152/physrev.00025.2005 [Abstract] [Full Text] [PDF]

Alain Tedgui and Ziad Mallat: Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways
Physiol. Rev. 86: 515-581, 2006; doi:10.1152/physrev.00024.2005 [Abstract] [Full Text] [PDF]

Stefan W. Ryter, Jawed Alam, and Augustine M. K. Choi: Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications
Physiol. Rev. 86: 583-650, 2006; doi:10.1152/physrev.00011.2005 [Abstract] [Full Text] [PDF]

Susan B. Roberts and Irwin Rosenberg: Nutrition and Aging: Changes in the Regulation of Energy Metabolism With Aging
Physiol. Rev. 86: 651-667, 2006; doi:10.1152/physrev.00019.2005 [Abstract] [Full Text] [PDF]

Olivier Staub and Daniela Rotin: Role of Ubiquitylation in Cellular Membrane Transport
Physiol. Rev. 86: 669-707, 2006; doi:10.1152/physrev.00020.2005 [Abstract] [Full Text] [PDF]

Linda J. Mullins, Matthew A. Bailey, and John J. Mullins: Hypertension, Kidney, and Transgenics: A Fresh Perspective
Physiol. Rev. 86: 709-746, 2006; doi:10.1152/physrev.00016.2005 [Abstract] [Full Text] [PDF]

Cover

Cover: Pathogenic and regulatory immunity in atherosclerosis. Lymphoid organs (green on the left) are specialized in antigen presentation and may be the major site of pathogenic (Th1 and/or Th2) or regulatory T-cell (Treg) priming in atherosclerosis. Antigen presentation may also occur within the atherosclerotic plaque (yellow on the right), which is rich in antigen presenting cells (APC: macrophages and dendritic cells). Continuous trafficking of immune cells between the inflamed atherosclerotic artery and the lymphoid organs may be necessary to mount an adaptive immune response. Distinct APC, mature or tolerogenic, elicit pathogenic or Treg cells, respectively. CD28 engagement and IL-2 production by pathogenic T cells are required for Treg survival and maintenance in the periphery. Treg suppress the pathogenic response through IL-10, TGF-β, and/or cell-cell contact-dependent mechanisms. See Tedgui, Alain, and Ziad Mallat. Physiol Rev 86:515-581, 2006.