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Cover
Cover: Ribbon diagram depicting the crystallographic structure of human m-calpain in the absence of calcium. The seven "domains" identified in this structure are shown in different colors, labeled dI, dIIa, dIIb, dIII, dIV, dV, and dVI. The active site of the protease is in the cleft at the top of the diagram between dIIa and dIIb, with the active site cysteine shown as C105, and the penta-EF hand domains, dIV and dVI, are at the bottom of the diagram. (Adapted from Reverter D, Sorimachi H, and Bode W. Trends Cardiovasc Med 11:222-229, 2001, with permission from Prof. W. Bode.) See Goll, Darrel E., Valery F. Thompson, Hongqi Li, Wei Wei, and Jinyang Cong. Physiol Rev 83:731-801, 2003.