Physiological Reviews

Ca2+-Operated Transcriptional Networks: Molecular Mechanisms and In Vivo Models

Britt Mellström, Magali Savignac, Rosa Gomez-Villafuertes, Jose R. Naranjo


Calcium is the most universal signal used by living organisms to convey information to many different cellular processes. In this review we present well-known and recently identified proteins that sense and decode the calcium signal and are key elements in the nucleus to regulate the activity of various transcriptional networks. When possible, the review also presents in vivo models in which the genes encoding these calcium sensors-transducers have been modified, to emphasize the critical role of these Ca2+-operated mechanisms in many physiological functions.

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