| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Institut National de la Santé et de la Recherche Médicale U. 689, Cardiovascular Research Center Lariboisiere, and University Paris 7, Paris, France
Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive immunoinflammatory mechanisms are involved. Inflammation is central at all stages of atherosclerosis. It is implicated in the formation of early fatty streaks, when the endothelium is activated and expresses chemokines and adhesion molecules leading to monocyte/lymphocyte recruitment and infiltration into the subendothelium. It also acts at the onset of adverse clinical vascular events, when activated cells within the plaque secrete matrix proteases that degrade extracellular matrix proteins and weaken the fibrous cap, leading to rupture and thrombus formation. Cells involved in the atherosclerotic process secrete and are activated by soluble factors, known as cytokines. Important recent advances in the comprehension of the mechanisms of atherosclerosis provided evidence that the immunoinflammatory response in atherosclerosis is modulated by regulatory pathways, in which the two anti-inflammatory cytokines interleukin-10 and transforming growth factor-
play a critical role. The purpose of this review is to bring together the current information concerning the role of cytokines in the development, progression, and complications of atherosclerosis. Specific emphasis is placed on the contribution of pro- and anti-inflammatory cytokines to pathogenic (innate and adaptive) and regulatory immunity in the context of atherosclerosis. Based on our current knowledge of the role of cytokines in atherosclerosis, we propose some novel therapeutic strategies to combat this disease. In addition, we discuss the potential of circulating cytokine levels as biomarkers of coronary artery disease.
This article has been cited by other articles:
|
|
 |
|
  D. Zhang, Z. Bi, Y. Li, H. Zheng, L. Li, J. Ouyang, B. Wang, and Y. Bi Sodium Ferulate Modified Gene Expression Profile of Oxidized Low-Density Lipoprotein-Stimulated Human Umbilical Vein Endothelial Cells Journal of Cardiovascular Pharmacology and Therapeutics, December 1, 2009; 14(4): 302 - 313. [Abstract] [PDF]
|
|
|
|
 |
|
 K. E. Barnholt, R. S. Kota, H. H. Aung, and J. C. Rutledge Adenosine Blocks IFN-{gamma}-Induced Phosphorylation of STAT1 on Serine 727 to Reduce Macrophage Activation J. Immunol., November 15, 2009; 183(10): 6767 - 6777. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Taleb, M. Romain, B. Ramkhelawon, C. Uyttenhove, G. Pasterkamp, O. Herbin, B. Esposito, N. Perez, H. Yasukawa, J. Van Snick, et al. Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis J. Exp. Med., September 28, 2009; 206(10): 2067 - 2077. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Mascitelli, F. Pezzetta, and M. R Goldstein Letter to the Editor American Journal of Lifestyle Medicine, September 1, 2009; 3(5): 410 - 411. [PDF]
|
|
|
|
 |
|
 A. Chaouat, L. Savale, C. Chouaid, L. Tu, B. Sztrymf, M. Canuet, B. Maitre, B. Housset, C. Brandt, P. Le Corvoisier, et al. Role for Interleukin-6 in COPD-Related Pulmonary Hypertension Chest, September 1, 2009; 136(3): 678 - 687. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-N. Zhang, J. Vincelette, Y. Cheng, U. Mehra, D. Chen, S.-K. Anandan, R. Gless, H. K. Webb, and Y.-X. Wang Inhibition of Soluble Epoxide Hydrolase Attenuated Atherosclerosis, Abdominal Aortic Aneurysm Formation, and Dyslipidemia Arterioscler Thromb Vasc Biol, September 1, 2009; 29(9): 1265 - 1270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Oh, S. Weng, S. K. Felton, S. Bhandare, A. Riek, B. Butler, B. M. Proctor, M. Petty, Z. Chen, K. B. Schechtman, et al. 1,25(OH)2 Vitamin D Inhibits Foam Cell Formation and Suppresses Macrophage Cholesterol Uptake in Patients With Type 2 Diabetes Mellitus Circulation, August 25, 2009; 120(8): 687 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lehrke, A. Becker, M. Greif, R. Stark, R. P Laubender, F. von Ziegler, C. Lebherz, J. Tittus, M. Reiser, C. Becker, et al. Chemerin is associated with markers of inflammation and components of the metabolic syndrome but does not predict coronary atherosclerosis Eur. J. Endocrinol., August 1, 2009; 161(2): 339 - 344. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Pruski, R. Krysiak, and B. Okopien Pleiotropic Action of Short-Term Metformin and Fenofibrate Treatment, Combined With Lifestyle Intervention, in Type 2 Diabetic Patients With Mixed Dyslipidemia Diabetes Care, August 1, 2009; 32(8): 1421 - 1424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Ionita, A. Vink, I. E. Dijke, J. D. Laman, W. Peeters, P. H. van der Kraak, F. L. Moll, J.-P. P.M. de Vries, G. Pasterkamp, and D. P.V. de Kleijn High Levels of Myeloid-Related Protein 14 in Human Atherosclerotic Plaques Correlate With the Characteristics of Rupture-Prone Lesions Arterioscler Thromb Vasc Biol, August 1, 2009; 29(8): 1220 - 1227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Martin-Ventura, J. Madrigal-Matute, B. Munoz-Garcia, L. M. Blanco-Colio, M. Van Oostrom, G. Zalba, A. Fortuno, C. Gomez-Guerrero, L. Ortega, A. Ortiz, et al. Increased CD74 expression in human atherosclerotic plaques: contribution to inflammatory responses in vascular cells Cardiovasc Res, August 1, 2009; 83(3): 586 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Sipido, A. Tedgui, S. D. Kristensen, G. Pasterkamp, H. Schunkert, M. Wehling, P. G. Steg, W. Eisert, F. Rademakers, B. Casadei, et al. Identifying needs and opportunities for advancing translational research in cardiovascular disease Cardiovasc Res, August 1, 2009; 83(3): 425 - 435. [Full Text] [PDF]
|
|
|
|
|
|
T. Chen, Z. Huang, L. Wang, Y. Wang, F. Wu, S. Meng, and C. Wang MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages Cardiovasc Res, July 1, 2009; 83(1): 131 - 139. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Lei, Y. Xiong, J. Chen, J.-B. Yang, Y. Wang, X.-Y. Yang, C. C. Y. Chang, B.-L. Song, T.-Y. Chang, and B.-L. Li TNF-alpha stimulates the ACAT1 expression in differentiating monocytes to promote the CE-laden cell formation J. Lipid Res., June 1, 2009; 50(6): 1057 - 1067. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lacchini, A. S. Heimann, F. S. Evangelista, L. Cardoso, G. J. J. Silva, and J. E. Krieger Cuff-induced vascular intima thickening is influenced by titration of the Ace gene in mice Physiol Genomics, May 13, 2009; 37(3): 225 - 230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Gautier, T. Huby, F. Saint-Charles, B. Ouzilleau, J. Pirault, V. Deswaerte, F. Ginhoux, E. R. Miller, J. L. Witztum, M. J. Chapman, et al. Conventional Dendritic Cells at the Crossroads Between Immunity and Cholesterol Homeostasis in Atherosclerosis Circulation, May 5, 2009; 119(17): 2367 - 2375. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ros Nuts and novel biomarkers of cardiovascular disease Am. J. Clinical Nutrition, May 1, 2009; 89(5): 1649S - 1656S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wang, Y. Zhou, L. Meng, X. Lu, N. Ou, and X. Li Inflammatory Mediators in Chinese Patients With Congestive Heart Failure J. Clin. Pharmacol., May 1, 2009; 49(5): 591 - 599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. E. Hastings, R. E. Feaver, M. Y. Lee, B. R. Wamhoff, and B. R. Blackman Human IL-8 Regulates Smooth Muscle Cell VCAM-1 Expression in Response to Endothelial Cells Exposed to Atheroprone Flow Arterioscler Thromb Vasc Biol, May 1, 2009; 29(5): 725 - 731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Ortiz-Munoz, J. L. Martin-Ventura, P. Hernandez-Vargas, B. Mallavia, V. Lopez-Parra, O. Lopez-Franco, B. Munoz-Garcia, P. Fernandez-Vizarra, L. Ortega, J. Egido, et al. Suppressors of Cytokine Signaling Modulate JAK/STAT-Mediated Cell Responses During Atherosclerosis Arterioscler Thromb Vasc Biol, April 1, 2009; 29(4): 525 - 531. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Chen, A. Frister, S. Wang, A. Ludwig, H. Behr, S. Pippig, B. Li, A. Simm, B. Hofmann, C. Pilowski, et al. Interaction of vascular smooth muscle cells and monocytes by soluble factors synergistically enhances IL-6 and MCP-1 production Am J Physiol Heart Circ Physiol, April 1, 2009; 296(4): H987 - H996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Mallat, S. Taleb, H. Ait-Oufella, and A. Tedgui The role of adaptive T cell immunity in atherosclerosis J. Lipid Res., April 1, 2009; 50(Supplement): S364 - S369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. N'Guessan, F. Riediger, K. Vardarova, S. Scharf, J. Eitel, B. Opitz, H. Slevogt, W. Weichert, A. C. Hocke, B. Schmeck, et al. Statins Control Oxidized LDL-Mediated Histone Modifications and Gene Expression in Cultured Human Endothelial Cells Arterioscler Thromb Vasc Biol, March 1, 2009; 29(3): 380 - 386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. K. Chatterjee, L. L. Stoll, G. M. Denning, A. Harrelson, A. L. Blomkalns, G. Idelman, F. G. Rothenberg, B. Neltner, S. A. Romig-Martin, E. W. Dickson, et al. Proinflammatory Phenotype of Perivascular Adipocytes: Influence of High-Fat Feeding Circ. Res., February 27, 2009; 104(4): 541 - 549. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Devaraj, J.-M. Yun, C. Duncan-Staley, and I. Jialal C-reactive protein induces M-CSF release and macrophage proliferation J. Leukoc. Biol., February 1, 2009; 85(2): 262 - 267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Pacher Cannabinoid CB1 Receptor Antagonists for Atherosclerosis and Cardiometabolic Disorders: New Hopes, Old Concerns? Arterioscler Thromb Vasc Biol, January 1, 2009; 29(1): 7 - 9. [Full Text] [PDF]
|
|
|
|
|
|
N. Bulat, G. Waeber, and C. Widmann LDLs stimulate p38 MAPKs and wound healing through SR-BI independently of Ras and PI3 kinase J. Lipid Res., January 1, 2009; 50(1): 81 - 89. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Kohler, L Ayers, J C T Pepperell, K L Packwood, B Ferry, N Crosthwaite, S Craig, M M Siccoli, R J O Davies, and J R Stradling Effects of continuous positive airway pressure on systemic inflammation in patients with moderate to severe obstructive sleep apnoea: a randomised controlled trial Thorax, January 1, 2009; 64(1): 67 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Newby Metalloproteinase Expression in Monocytes and Macrophages and its Relationship to Atherosclerotic Plaque Instability Arterioscler Thromb Vasc Biol, December 1, 2008; 28(12): 2108 - 2114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ammirati, A.-C. Vermi, D. Cianflone, M. Banfi, C. Foglieni, C. Godino, F. Airoldi, L. A. Ferri, C. L. Gorman, A. A. Manfredi, et al. Expansion of T-Cell Receptor {zeta}dim Effector T Cells in Acute Coronary Syndromes Arterioscler Thromb Vasc Biol, December 1, 2008; 28(12): 2305 - 2311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Schober Chemokines in Vascular Dysfunction and Remodeling Arterioscler Thromb Vasc Biol, November 1, 2008; 28(11): 1950 - 1959. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sampi, O. Ukkola, M. Paivansalo, Y. A. Kesaniemi, C. J. Binder, and S. Horkko Plasma Interleukin-5 Levels Are Related to Antibodies Binding to Oxidized Low-Density Lipoprotein and to Decreased Subclinical Atherosclerosis J. Am. Coll. Cardiol., October 21, 2008; 52(17): 1370 - 1378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Johnson, G. B. Sala-Newby, Y. Ismail, C. M. Aguilera, and A. C. Newby Low Tissue Inhibitor of Metalloproteinases 3 and High Matrix Metalloproteinase 14 Levels Defines a Subpopulation of Highly Invasive Foam-Cell Macrophages Arterioscler Thromb Vasc Biol, September 1, 2008; 28(9): 1647 - 1653. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Wong, M. Freiberg, R. Tracy, and L. Kuller Epidemiology of Cytokines: The Women On the Move through Activity and Nutrition (WOMAN) Study Am. J. Epidemiol., August 15, 2008; 168(4): 443 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ohayon, G. Finet, A. M. Gharib, D. A. Herzka, P. Tracqui, J. Heroux, G. Rioufol, M. S. Kotys, A. Elagha, and R. I. Pettigrew Necrotic core thickness and positive arterial remodeling index: emergent biomechanical factors for evaluating the risk of plaque rupture Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H717 - H727. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Mansouri, E. Bauge, B. Staels, and P. Gervois Systemic and Distal Repercussions of Liver-Specific Peroxisome Proliferator-Activated Receptor-{alpha} Control of the Acute-Phase Response Endocrinology, June 1, 2008; 149(6): 3215 - 3223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Braunersreuther, S. Steffens, C. Arnaud, G. Pelli, F. Burger, A. Proudfoot, and F. Mach A Novel RANTES Antagonist Prevents Progression of Established Atherosclerotic Lesions in Mice Arterioscler Thromb Vasc Biol, June 1, 2008; 28(6): 1090 - 1096. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.-W. Lin, I.-C. Chang, A. Tseng, M.-L. Wu, C.-H. Chen, C. A. Patenaude, M. D. Layne, and S.-F. Yet Transforming Growth Factor {beta} Up-regulates Cysteine-rich Protein 2 in Vascular Smooth Muscle Cells via Activating Transcription Factor 2 J. Biol. Chem., May 30, 2008; 283(22): 15003 - 15014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Mallat and A. Tedgui HDL, PTX3, and Vascular Protection Arterioscler Thromb Vasc Biol, May 1, 2008; 28(5): 809 - 811. [Full Text] [PDF]
|
|
|
|
|
|
G. D. Norata, P. Marchesi, A. Pirillo, P. Uboldi, G. Chiesa, V. Maina, C. Garlanda, A. Mantovani, and A. L. Catapano Long Pentraxin 3, a Key Component of Innate Immunity, Is Modulated by High-Density Lipoproteins in Endothelial Cells Arterioscler Thromb Vasc Biol, May 1, 2008; 28(5): 925 - 931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. N.T.P. Bakker, H. L. Matlung, P. Bonta, C. J. de Vries, N. van Rooijen, and E. VanBavel Blood flow-dependent arterial remodelling is facilitated by inflammation but directed by vascular tone Cardiovasc Res, May 1, 2008; 78(2): 341 - 348. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Loppnow, K. Werdan, and M. Buerke Invited review: Vascular cells contribute to atherosclerosis by cytokine- and innate-immunity-related inflammatory mechanisms Innate Immunity, April 1, 2008; 14(2): 63 - 87. [Abstract] [PDF]
|
|
|
|
|
|
D. Siegel-Axel, K. Daub, P. Seizer, S. Lindemann, and M. Gawaz Platelet lipoprotein interplay: trigger of foam cell formation and driver of atherosclerosis Cardiovasc Res, April 1, 2008; 78(1): 8 - 17. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Marfella, C. Di Filippo, M. Portoghese, F. Ferraraccio, B. Crescenzi, M. Siniscalchi, M. Barbieri, C. Bologna, M. R. Rizzo, F. Rossi, et al. Proteasome Activity as a Target of Hormone Replacement Therapy-Dependent Plaque Stabilization in Postmenopausal Women Hypertension, April 1, 2008; 51(4): 1135 - 1141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Combadiere, S. Potteaux, M. Rodero, T. Simon, A. Pezard, B. Esposito, R. Merval, A. Proudfoot, A. Tedgui, and Z. Mallat Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6Chi and Ly6Clo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice Circulation, April 1, 2008; 117(13): 1649 - 1657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Zernecke, J. Bernhagen, and C. Weber Macrophage Migration Inhibitory Factor in Cardiovascular Disease Circulation, March 25, 2008; 117(12): 1594 - 1602. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Navarro, C. Mora, M. Gomez, M. Muros, C. Lopez-Aguilar, and J. Garcia Influence of renal involvement on peripheral blood mononuclear cell expression behaviour of tumour necrosis factor-{alpha} and interleukin-6 in type 2 diabetic patients Nephrol. Dial. Transplant., March 1, 2008; 23(3): 919 - 926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Miller, D. Xu, D. L. Asquith, L. Denby, Y. Li, N. Sattar, A. H. Baker, I. B. McInnes, and F. Y. Liew IL-33 reduces the development of atherosclerosis J. Exp. Med., February 18, 2008; 205(2): 339 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Petrovan, Y. Yuan, and L. K. Curtiss Expression of the Lystbeige mutation is atheroprotective in chow-fed apolipoprotein E-deficient mice J. Lipid Res., February 1, 2008; 49(2): 429 - 437. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. R. S. Packard and P. Libby Inflammation in Atherosclerosis: From Vascular Biology to Biomarker Discovery and Risk Prediction Clin. Chem., January 1, 2008; 54(1): 24 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Mohty, P. Pibarot, J.-P. Despres, C. Cote, B. Arsenault, A. Cartier, P. Cosnay, C. Couture, and P. Mathieu Association Between Plasma LDL Particle Size, Valvular Accumulation of Oxidized LDL, and Inflammation in Patients With Aortic Stenosis Arterioscler Thromb Vasc Biol, January 1, 2008; 28(1): 187 - 193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Taleb, O. Herbin, H. Ait-Oufella, W. Verreth, P. Gourdy, V. Barateau, R. Merval, B. Esposito, K. Clement, P. Holvoet, et al. Defective Leptin/Leptin Receptor Signaling Improves Regulatory T Cell Immune Response and Protects Mice From Atherosclerosis Arterioscler Thromb Vasc Biol, December 1, 2007; 27(12): 2691 - 2698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Woodfin, M.-B. Voisin, and S. Nourshargh PECAM-1: A Multi-Functional Molecule in Inflammation and Vascular Biology Arterioscler Thromb Vasc Biol, December 1, 2007; 27(12): 2514 - 2523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Jagavelu, U. J.F. Tietge, M. Gaestel, H. Drexler, B. Schieffer, and U. Bavendiek Systemic Deficiency of the MAP Kinase Activated Protein Kinase 2 Reduces Atherosclerosis in Hypercholesterolemic Mice Circ. Res., November 26, 2007; 101(11): 1104 - 1112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.R.S. Girn, N.M. Orsi, and S. Homer-Vanniasinkam An overview of cytokine interactions in atherosclerosis and implications for peripheral arterial disease Vascular Medicine, November 1, 2007; 12(4): 299 - 309. [Abstract] [PDF]
|
|
|
|
|
|
A. Strom, M. Wigren, A. Hultgardh-Nilsson, A. Saxena, M. F. Gomez, S. Cardell, G. N. Fredrikson, and J. Nilsson Involvement of the CD1d Natural Killer T Cell Pathway in Neointima Formation After Vascular Injury Circ. Res., October 12, 2007; 101(8): e83 - e89. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ait-Oufella, B. Horvat, Y. Kerdiles, O. Herbin, P. Gourdy, J. Khallou-Laschet, R. Merval;, B. Esposito;, A. Tedgui, and Z. Mallat Measles Virus Nucleoprotein Induces a Regulatory Immune Response and Reduces Atherosclerosis in Mice Circulation, October 9, 2007; 116(15): 1707 - 1713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Duchene, F. Lecomte, S. Ahmed, C. Cayla, J. Pesquero, M. Bader, M. Perretti, and A. Ahluwalia A Novel Inflammatory Pathway Involved in Leukocyte Recruitment: Role for the Kinin B1 Receptor and the Chemokine CXCL5 J. Immunol., October 1, 2007; 179(7): 4849 - 4856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Gourdy, A. Schambourg, C. Filipe, V. Douin-Echinard, B. Garmy-Susini, B. Calippe, F. Terce, F. Bayard, and J.-F. Arnal Transforming Growth Factor Activity Is a Key Determinant for the Effect of Estradiol on Fatty Streak Deposit in Hypercholesterolemic Mice Arterioscler Thromb Vasc Biol, October 1, 2007; 27(10): 2214 - 2221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rajesh, P. Mukhopadhyay, S. Batkai, G. Hasko, L. Liaudet, J. W. Huffman, A. Csiszar, Z. Ungvari, K. Mackie, S. Chatterjee, et al. CB2-receptor stimulation attenuates TNF-{alpha}-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2210 - H2218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ohayon, O. Dubreuil, P. Tracqui, S. Le Floc'h, G. Rioufol, L. Chalabreysse, F. Thivolet, R. I. Pettigrew, and G. Finet Influence of residual stress/strain on the biomechanical stability of vulnerable coronary plaques: potential impact for evaluating the risk of plaque rupture Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1987 - H1996. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Muniyappa, M. Montagnani, K. K. Koh, and M. J. Quon Cardiovascular Actions of Insulin Endocr. Rev., August 1, 2007; 28(5): 463 - 491. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. M. Caplice, S. Wang, M. Tracz, A. J. Croatt, J. P. Grande, Z. S. Katusic, and K. A. Nath Neoangiogenesis and the presence of progenitor cells in the venous limb of an arteriovenous fistula in the rat Am J Physiol Renal Physiol, August 1, 2007; 293(2): F470 - F475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Barlic, Y. Zhang, and P. M. Murphy Atherogenic Lipids Induce Adhesion of Human Coronary Artery Smooth Muscle Cells to Macrophages by Up-regulating Chemokine CX3CL1 on Smooth Muscle Cells in a TNF{alpha}-NF{kappa}B-dependent Manner J. Biol. Chem., June 29, 2007; 282(26): 19167 - 19176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Li, Y. Laumonnier, T. Syrovets, and T. Simmet Plasmin Triggers Cytokine Induction in Human Monocyte-Derived Macrophages Arterioscler Thromb Vasc Biol, June 1, 2007; 27(6): 1383 - 1389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Dentelli, A. Rosso, A. Balsamo, S. Colmenares Benedetto, A. Zeoli, M. Pegoraro, G. Camussi, L. Pegoraro, and M. F. Brizzi C-KIT, by interacting with the membrane-bound ligand, recruits endothelial progenitor cells to inflamed endothelium Blood, May 15, 2007; 109(10): 4264 - 4271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Grainger TGF-{beta} and atherosclerosis in man Cardiovasc Res, May 1, 2007; 74(2): 213 - 222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ait-Oufella, K. Kinugawa, J. Zoll, T. Simon, J. Boddaert, S. Heeneman, O. Blanc-Brude, V. Barateau, S. Potteaux, R. Merval, et al. Lactadherin Deficiency Leads to Apoptotic Cell Accumulation and Accelerated Atherosclerosis in Mice Circulation, April 24, 2007; 115(16): 2168 - 2177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Wang, W. Jin, and D. J. Rader Upregulation of Macrophage Endothelial Lipase by Toll-Like Receptors 4 and 3 Modulates Macrophage Interleukin-10 and -12 Production Circ. Res., April 13, 2007; 100(7): 1008 - 1015. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Marfella, M. Siniscalchi, M. Portoghese, C. Di Filippo, F. Ferraraccio, C. Schiattarella, B. Crescenzi, P. Sangiuolo, G. Ferraro, S. Siciliano, et al. Morning Blood Pressure Surge as a Destabilizing Factor of Atherosclerotic Plaque: Role of Ubiquitin-Proteasome Activity Hypertension, April 1, 2007; 49(4): 784 - 791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Oda, N. Tanaka, T. Arai, J. Araki, Y. Song, L. Zhang, A. Kuchiba, T. Hosoi, T. Shirasawa, M. Muramatsu, et al. Polymorphisms in pro- and anti-inflammatory cytokine genes and susceptibility to atherosclerosis: a pathological study of 1503 consecutive autopsy cases Hum. Mol. Genet., March 15, 2007; 16(6): 592 - 599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. B. Dahl, A. Yndestad, M. Skjelland, E. Oie, A. Dahl, A. Michelsen, J. K. Damas, S. H. Tunheim, T. Ueland, C. Smith, et al. Increased Expression of Visfatin in Macrophages of Human Unstable Carotid and Coronary Atherosclerosis: Possible Role in Inflammation and Plaque Destabilization Circulation, February 27, 2007; 115(8): 972 - 980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Qiu, A. C. Ho, W. Yu, and J. S. Hill Suppression of endothelial or lipoprotein lipase in THP-1 macrophages attenuates proinflammatory cytokine secretion J. Lipid Res., February 1, 2007; 48(2): 385 - 394. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Braunersreuther, A. Zernecke, C. Arnaud, E. A. Liehn, S. Steffens, E. Shagdarsuren, K. Bidzhekov, F. Burger, G. Pelli, B. Luckow, et al. Ccr5 But Not Ccr1 Deficiency Reduces Development of Diet-Induced Atherosclerosis in Mice Arterioscler Thromb Vasc Biol, February 1, 2007; 27(2): 373 - 379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J.A van Wanrooij, G. H.M van Puijvelde, P. de Vos, H. Yagita, T. J.C. van Berkel, and J. Kuiper Interruption of the Tnfrsf4/Tnfsf4 (OX40/OX40L) Pathway Attenuates Atherogenesis in Low-Density Lipoprotein Receptor-Deficient Mice Arterioscler Thromb Vasc Biol, January 1, 2007; 27(1): 204 - 210. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. T. de Jongh, R. G. Ijzerman, E. H. Serne, J. J. Voordouw, J. S. Yudkin, H. A. D.-v. de Waal, C. D. A. Stehouwer, and M. M. van Weissenbruch Visceral and Truncal Subcutaneous Adipose Tissue Are Associated with Impaired Capillary Recruitment in Healthy Individuals J. Clin. Endocrinol. Metab., December 1, 2006; 91(12): 5100 - 5106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Mazzadi, X. Andre-Fouet, N. Costes, P. Croisille, D. Revel, and M. F. Janier Mechanisms leading to reversible mechanical dysfunction in severe CAD: alternatives to myocardial stunning Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2570 - H2582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Caligiuri and A. Nicoletti Lymphocyte responses in acute coronary syndromes: lack of regulation spawns deviant behaviour Eur. Heart J., November 1, 2006; 27(21): 2485 - 2486. [Full Text] [PDF]
|
|
|
|
|
|
A.-K. L. Robertson and G. K Hansson T Cells in Atherogenesis: For Better or For Worse? Arterioscler Thromb Vasc Biol, November 1, 2006; 26(11): 2421 - 2432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Goronzy and C. M. Weyand Immunosuppression in Atherosclerosis: Mobilizing the Opposition Within Circulation, October 31, 2006; 114(18): 1901 - 1904. [Full Text] [PDF]
|
|
|
|
|
|
S. Lehoux and B. I. Levy Collateral Artery Growth: Making the Most of What You Have Circ. Res., September 15, 2006; 99(6): 567 - 569. [Full Text] [PDF]
|
|
|
|
|
|
G. Caligiuri, S. V. Kaveri, and A. Nicoletti IL-20 and Atherosclerosis: Another Brick In the Wall. Arterioscler Thromb Vasc Biol, September 1, 2006; 26(9): 1929 - 1930. [Full Text] [PDF]
|
|
|
|
|
|
S. Potteaux, C. Combadiere, B. Esposito, C. Lecureuil, H. Ait-Oufella, R. Merval, P. Ardouin, A. Tedgui, and Z. Mallat Role of Bone Marrow-Derived CC-Chemokine Receptor 5 in the Development of Atherosclerosis of Low-Density Lipoprotein Receptor Knockout Mice Arterioscler Thromb Vasc Biol, August 1, 2006; 26(8): 1858 - 1863. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
