|
|
||||||||
Physiological Reviews, Vol 77, 759-803, Copyright © 1997 by American Physiological Society
JOURNAL ARTICLE |
S. Mukherjee, R. N. Ghosh and F. R. Maxfield
Department of Biochemistry, Cornell University Medical College, New York, New York, USA.
Mammalian cells take up extracellular material by a variety of different mechanisms that are collectively termed endocytosis. Endocytic mechanisms serve many important cellular functions including the uptake of extracellular nutrients, regulation of cell-surface receptor expression, maintenance of cell polarity, and antigen presentation. Endocytic pathways are also utilized by viruses, toxins, and symbiotic microorganisms to gain entry into cells. One of the best-characterized endocytic mechanisms is receptor-mediated endocytosis via clathrin-coated pits. This type of endocytosis constitutes the major emphasis of this review, with a brief discussion of other endocytic mechanisms and their comparison with the receptor-mediated pathway. This review describes and evaluates critically current understanding of the mechanisms of entry of plasma membrane components such as the receptor-ligand complexes and membrane lipids as well as the extracellular fluid into cells. The intracellular sorting and trafficking of these molecules upon internalization are also described. The roles of endocytosis in physiological and pathological processes are discussed. These include maintenance of cell polarization, antigen presentation, glucose transport, atherosclerosis, Alzheimer's disease, and the endocytosis of toxins and viruses.
This article has been cited by other articles:
![]() |
S. M. Stamatovic, R. F. Keep, M. M. Wang, I. Jankovic, and A. V. Andjelkovic Caveolae-mediated Internalization of Occludin and Claudin-5 during CCL2-induced Tight Junction Remodeling in Brain Endothelial Cells J. Biol. Chem., July 10, 2009; 284(28): 19053 - 19066. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. W. Zhang and N. A. Monteiro-Riviere Mechanisms of Quantum Dot Nanoparticle Cellular Uptake Toxicol. Sci., July 1, 2009; 110(1): 138 - 155. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Barriere, M. Bagdany, F. Bossard, T. Okiyoneda, G. Wojewodka, D. Gruenert, D. Radzioch, and G. L. Lukacs Revisiting the Role of Cystic Fibrosis Transmembrane Conductance Regulator and Counterion Permeability in the pH Regulation of Endocytic Organelles Mol. Biol. Cell, July 1, 2009; 20(13): 3125 - 3141. [Abstract] [Full Text] [PDF] |
||||
![]() |
X. He, X. Sun, J. Wang, X. Wang, Q. Zhang, S. Tzipori, and H. Feng Antibody-Enhanced, Fc Gamma Receptor-Mediated Endocytosis of Clostridium difficile Toxin A Infect. Immun., June 1, 2009; 77(6): 2294 - 2303. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. M. Haggie and A. S. Verkman Defective organellar acidification as a cause of cystic fibrosis lung disease: reexamination of a recurring hypothesis Am J Physiol Lung Cell Mol Physiol, June 1, 2009; 296(6): L859 - L867. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Olswang-Kutz, Y. Gertel, S. Benjamin, O. Sela, O. Pekar, E. Arama, H. Steller, M. Horowitz, and D. Segal Drosophila Past1 is involved in endocytosis and is required for germline development and survival of the adult fly J. Cell Sci., February 15, 2009; 122(4): 471 - 480. [Abstract] [Full Text] [PDF] |
||||
![]() |
O. C. Ikonomov, J. Fligger, D. Sbrissa, R. Dondapati, K. Mlak, R. Deeb, and A. Shisheva Kinesin Adapter JLP Links PIKfyve to Microtubule-based Endosome-to-Trans-Golgi Network Traffic of Furin J. Biol. Chem., February 6, 2009; 284(6): 3750 - 3761. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. B. Doving, K. Sandvig, and A. Kasumyan Ligand-specific induction of endocytosis in taste receptor cells J. Exp. Biol., January 1, 2009; 212(1): 42 - 49. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. D. Sutherland and T. R. Kozel Macrophage Uptake, Intracellular Localization, and Degradation of Poly-{gamma}-D-Glutamic Acid, the Capsular Antigen of Bacillus anthracis Infect. Immun., January 1, 2009; 77(1): 532 - 538. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. E. Hulse, W. G. Swenson, P. E. Kunkler, D. M. White, and R. P. Kraig Monomeric IgG Is Neuroprotective via Enhancing Microglial Recycling Endocytosis and TNF-{alpha} J. Neurosci., November 19, 2008; 28(47): 12199 - 12211. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. G. Endres and N. S. Wingreen Accuracy of direct gradient sensing by single cells PNAS, October 14, 2008; 105(41): 15749 - 15754. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Yin, X. Fan, S. Yu, C. Li, and M.-S. Sy Binding of Recombinant but Not Endogenous Prion Protein to DNA Causes DNA Internalization and Expression in Mammalian Cells J. Biol. Chem., September 12, 2008; 283(37): 25446 - 25454. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. H. Petersen, N. J. Faergeman, L. Yu, and D. Wustner Kinetic imaging of NPC1L1 and sterol trafficking between plasma membrane and recycling endosomes in hepatoma cells J. Lipid Res., September 1, 2008; 49(9): 2023 - 2037. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. T. Miedel, Y. Rbaibi, C. J. Guerriero, G. Colletti, K. M. Weixel, O. A. Weisz, and K. Kiselyov Membrane traffic and turnover in TRP-ML1-deficient cells: a revised model for mucolipidosis type IV pathogenesis J. Exp. Med., June 9, 2008; 205(6): 1477 - 1490. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Denis, Y. D. Landry, and X. Zha ATP-binding Cassette A1-mediated Lipidation of Apolipoprotein A-I Occurs at the Plasma Membrane and Not in the Endocytic Compartments J. Biol. Chem., June 6, 2008; 283(23): 16178 - 16186. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Lelouvier, G. Tamagno, A. M. Kaindl, A. Roland, V. Lelievre, V. Le Verche, C. Loudes, P. Gressens, A. Faivre-Baumann, Z. Lenkei, et al. Dynamics of Somatostatin Type 2A Receptor Cargoes in Living Hippocampal Neurons J. Neurosci., April 23, 2008; 28(17): 4336 - 4349. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Endo, A. Sugiyama, S.-A. Li, K. Ohmori, H. Ohata, Y. Yoshida, M. Shibuya, K. Takei, M. Enari, and Y. Taya Regulation of clathrin-mediated endocytosis by p53. Genes Cells, April 1, 2008; 13(4): 375 - 386. [Abstract] [Full Text] [PDF] |
||||
![]() |
Q. Lu, Y. Zhang, T. Hu, P. Guo, W. Li, and X. Wang C. elegans Rab GTPase 2 is required for the degradation of apoptotic cells Development, March 15, 2008; 135(6): 1069 - 1080. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. B. Walter, B. W. Raden, R. Zeng, P. Hausermann, I. D. Bernstein, and J. A. Cooper ITIM-dependent endocytosis of CD33-related Siglecs: role of intracellular domain, tyrosine phosphorylation, and the tyrosine phosphatases, Shp1 and Shp2 J. Leukoc. Biol., January 1, 2008; 83(1): 200 - 211. [Abstract] [Full Text] [PDF] |
||||
![]() |
K.G. S. Kumar, H. Barriere, C. J. Carbone, J. Liu, G. Swaminathan, P. Xu, Y. Li, D. P. Baker, J. Peng, G. L. Lukacs, et al. Site-specific ubiquitination exposes a linear motif to promote interferon-{alpha} receptor endocytosis J. Cell Biol., December 3, 2007; 179(5): 935 - 950. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Desigaux, M. Sainlos, O. Lambert, R. Chevre, E. Letrou-Bonneval, J.-P. Vigneron, P. Lehn, J.-M. Lehn, and B. Pitard Self-assembled lamellar complexes of siRNA with lipidic aminoglycoside derivatives promote efficient siRNA delivery and interference PNAS, October 16, 2007; 104(42): 16534 - 16539. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Muller, U. Mettbach, D. Menzel, and J. Samaj Molecular Dissection of Endosomal Compartments in Plants Plant Physiology, October 1, 2007; 145(2): 293 - 304. [Full Text] [PDF] |
||||
![]() |
H. Barriere, C. Nemes, K. Du, and G. L. Lukacs Plasticity of Polyubiquitin Recognition as Lysosomal Targeting Signals by the Endosomal Sorting Machinery Mol. Biol. Cell, October 1, 2007; 18(10): 3952 - 3965. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. K. Huynh and S. Grinstein Regulation of Vacuolar pH and Its Modulation by Some Microbial Species Microbiol. Mol. Biol. Rev., September 1, 2007; 71(3): 452 - 462. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Tateno, H. Li, M. J. Schur, N. Bovin, P. R. Crocker, W. W. Wakarchuk, and J. C. Paulson Distinct Endocytic Mechanisms of CD22 (Siglec-2) and Siglec-F Reflect Roles in Cell Signaling and Innate Immunity Mol. Cell. Biol., August 15, 2007; 27(16): 5699 - 5710. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Zeng, S. Vangveravong, J. Xu, K. C. Chang, R. S. Hotchkiss, K. T. Wheeler, D. Shen, Z.-P. Zhuang, H. F. Kung, and R. H. Mach Subcellular Localization of Sigma-2 Receptors in Breast Cancer Cells Using Two-Photon and Confocal Microscopy Cancer Res., July 15, 2007; 67(14): 6708 - 6716. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Nath, E. Bananis, S. Sarkar, R. J. Stockert, A. O. Sperry, J. W. Murray, and A. W. Wolkoff Kif5B and Kifc1 Interact and Are Required for Motility and Fission of Early Endocytic Vesicles in Mouse Liver Mol. Biol. Cell, May 1, 2007; 18(5): 1839 - 1849. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Zhang, Q. Deng, and J. T. Barbieri Intracellular Localization of Type III-delivered Pseudomonas ExoS with Endosome Vesicles J. Biol. Chem., April 27, 2007; 282(17): 13022 - 13032. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Carey, M. K. Staudt, D. Bonaminio, J. C. M. van der Loo, and B. C. Trapnell PU.1 Redirects Adenovirus to Lysosomes in Alveolar Macrophages, Uncoupling Internalization from Infection J. Immunol., February 15, 2007; 178(4): 2440 - 2447. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. K. Lam, C. L. Siu, S. Hillmer, S. Jang, G. An, D. G. Robinson, and L. Jiang Rice SCAMP1 Defines Clathrin-Coated, trans-Golgi-Located Tubular-Vesicular Structures as an Early Endosome in Tobacco BY-2 Cells PLANT CELL, January 1, 2007; 19(1): 296 - 319. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Trushina, R. D. Singh, R. B. Dyer, S. Cao, V. H. Shah, R. G. Parton, R. E. Pagano, and C. T. McMurray Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo Hum. Mol. Genet., December 15, 2006; 15(24): 3578 - 3591. [Abstract] [Full Text] [PDF] |
||||
![]() |
Z.-Y. Huang, D. R. Barreda, R. G. Worth, Z. K. Indik, M.-K. Kim, P. Chien, and A. D. Schreiber Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis J. Leukoc. Biol., December 1, 2006; 80(6): 1553 - 1562. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Zheng, T. Tang, N. Tang, K. Kudlicka, K. Ohtsubo, P. Ma, J. D. Marth, M. G. Farquhar, and E. Lehtonen Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics PNAS, November 7, 2006; 103(45): 16776 - 16781. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. L. Leopold, R. L. Wendland, T. Vincent, and R. G. Crystal Neutralized Adenovirus-Immune Complexes Can Mediate Effective Gene Transfer via an Fc Receptor-Dependent Infection Pathway. J. Virol., October 1, 2006; 80(20): 10237 - 10247. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y.-J. Sun, K. Nishikawa, H. Yuda, Y.-L. Wang, H. Osaka, N. Fukazawa, A. Naito, Y. Kudo, K. Wada, and S. Aoki Solo/Trio8, a membrane-associated short isoform of trio, modulates endosome dynamics and neurite elongation. Mol. Cell. Biol., September 1, 2006; 26(18): 6923 - 6935. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. L. Prigozhina and C. M. Waterman-Storer Decreased polarity and increased random motility in PtK1 epithelial cells correlate with inhibition of endosomal recycling. J. Cell Sci., September 1, 2006; 119(Pt 17): 3571 - 3582. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Idkowiak-Baldys, K. P. Becker, K. Kitatani, and Y. A. Hannun Dynamic Sequestration of the Recycling Compartment by Classical Protein Kinase C J. Biol. Chem., August 4, 2006; 281(31): 22321 - 22331. [Abstract] [Full Text] [PDF] |
||||
![]() |
X. C. Li, O. A. Carretero, L. G. Navar, and J. L. Zhuo AT1 receptor-mediated accumulation of extracellular angiotensin II in proximal tubule cells: role of cytoskeleton microtubules and tyrosine phosphatases Am J Physiol Renal Physiol, August 1, 2006; 291(2): F375 - F383. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Kalia, S. Kumari, R. Chadda, M. M. Hill, R. G. Parton, and S. Mayor Arf6-independent GPI-anchored Protein-enriched Early Endosomal Compartments Fuse with Sorting Endosomes via a Rab5/Phosphatidylinositol-3'-Kinase-dependent Machinery Mol. Biol. Cell, August 1, 2006; 17(8): 3689 - 3704. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Umemoto, T. Tanaka, H. Kanda, S. Jin, K. Tohya, K. Otani, T. Matsutani, M. Matsumoto, Y. Ebisuno, M. H. Jang, et al. Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow J. Exp. Med., June 12, 2006; 203(6): 1603 - 1614. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. G.J. Batista, C. F. Silva, R. A. Mota, L. C. Costa, M. N.L. Meirelles, M. Meuser-Batista, and M. N.C. Soeiro Trypanosoma cruzi Modulates the Expression of Rabs and Alters the Endocytosis in Mouse Cardiomyocytes In Vitro J. Histochem. Cytochem., June 1, 2006; 54(6): 605 - 614. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Muro, M. Mateescu, C. Gajewski, M. Robinson, V. R. Muzykantov, and M. Koval Control of intracellular trafficking of ICAM-1-targeted nanocarriers by endothelial Na+/H+ exchanger proteins Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L809 - L817. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. G. Almeida, R. H. Takahashi, and G. K. Gouras Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system. J. Neurosci., April 19, 2006; 26(16): 4277 - 4288. [Abstract] [Full Text] [PDF] |
||||
![]() |
B.-S. Ding, T. Dziubla, V. V. Shuvaev, S. Muro, and V. R. Muzykantov Advanced drug delivery systems that target the vascular endothelium. Mol. Interv., April 1, 2006; 6(2): 98 - 112. [Abstract] [Full Text] [PDF] |
||||
![]() |
O. Staub and D. Rotin Role of Ubiquitylation in Cellular Membrane Transport Physiol Rev, April 1, 2006; 86(2): 669 - 707. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Yu, S. Bharadwaj, J. M. Brown, Y. Ma, W. Du, M. A. Davis, P. Michaely, P. Liu, M. C. Willingham, and L. L. Rudel Cholesterol-regulated Translocation of NPC1L1 to the Cell Surface Facilitates Free Cholesterol Uptake J. Biol. Chem., March 10, 2006; 281(10): 6616 - 6624. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. C.-H. Chen, P. J. Schweinsberg, S. Vashist, D. P. Mareiniss, E. J. Lambie, and B. D. Grant RAB-10 Is Required for Endocytic Recycling in the Caenorhabditis elegans Intestine Mol. Biol. Cell, March 1, 2006; 17(3): 1286 - 1297. [Abstract] [Full Text] [PDF] |
||||
![]() |
X.-J. Liang, S. Mukherjee, D.-W. Shen, F. R. Maxfield, and M. M. Gottesman Endocytic Recycling Compartments Altered in Cisplatin-Resistant Cancer Cells Cancer Res., February 15, 2006; 66(4): 2346 - 2353. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Jain, C. Dodia, A. B. Fisher, and S. R. Bates Pathways for clearance of surfactant protein A from the lung Am J Physiol Lung Cell Mol Physiol, December 1, 2005; 289(6): L1011 - L1018. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. J Wong, N. J Tublitz, and C. T Minson Neurokinin-1 receptor desensitization to consecutive microdialysis infusions of substance P in human skin J. Physiol., November 1, 2005; 568(3): 1047 - 1056. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Tsacoumango, S. J. Kil, L. Ma, F. D. Sonnichsen, and C. Carlin A novel dileucine lysosomal-sorting-signal mediates intracellular EGF-receptor retention independently of protein ubiquitylation J. Cell Sci., September 1, 2005; 118(17): 3959 - 3971. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. W. Shi Kam, M. O'Connell, J. A. Wisdom, and H. Dai Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction PNAS, August 16, 2005; 102(33): 11600 - 11605. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Bao and X. R. Bao Shedding light on the dynamics of endocytosis and viral budding PNAS, July 19, 2005; 102(29): 9997 - 9998. [Full Text] [PDF] |
||||
![]() |
M. Bruewer, M. Utech, A. I. Ivanov, A. M. Hopkins, C. A. Parkos, and A. Nusrat Interferon-{gamma} induces internalization of epithelial tight junction proteins via a macropinocytosis-like process FASEB J, June 1, 2005; 19(8): 923 - 933. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Fatima, F. A. Yaghini, Z. Pavicevic, S. Kalyankrishna, N. Jafari, E. Luong, A. Estes, and K. U. Malik Intact Actin Filaments Are Required for Cytosolic Phospholipase A2 Translocation but Not for Its Activation by Norepinephrine in Vascular Smooth Muscle Cells J. Pharmacol. Exp. Ther., June 1, 2005; 313(3): 1017 - 1026. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Kaushansky On the molecular origins of the chronic myeloproliferative disorders: it all makes sense Blood, June 1, 2005; 105(11): 4187 - 4190. [Full Text] [PDF] |
||||
![]() |
F. Alpy, V. K. Latchumanan, V. Kedinger, A. Janoshazi, C. Thiele, C. Wendling, M.-C. Rio, and C. Tomasetto Functional Characterization of the MENTAL Domain J. Biol. Chem., May 6, 2005; 280(18): 17945 - 17952. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. K. Rajasekaran, G. Anilkumar, and J. J. Christiansen Is prostate-specific membrane antigen a multifunctional protein? Am J Physiol Cell Physiol, May 1, 2005; 288(5): C975 - C981. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. D. Paasche, T. Attramadal, K. Kristiansen, M. P. Oksvold, H. K. Johansen, H. S. Huitfeldt, S. G. Dahl, and H. Attramadal Subtype-Specific Sorting of the ETA Endothelin Receptor by a Novel Endocytic Recycling Signal for G Protein-Coupled Receptors Mol. Pharmacol., May 1, 2005; 67(5): 1581 - 1590. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Van Hoof, K. W. Rodenburg, and D. J. Van der Horst Intracellular fate of LDL receptor family members depends on the cooperation between their ligand-binding and EGF domains J. Cell Sci., March 15, 2005; 118(6): 1309 - 1320. [Abstract] [Full Text] [PDF] |
||||
![]() |
O. Meier, M. Gastaldelli, K. Boucke, S. Hemmi, and U. F. Greber Early Steps of Clathrin-Mediated Endocytosis Involved in Phagosomal Escape of Fc{gamma} Receptor-Targeted Adenovirus J. Virol., February 15, 2005; 79(4): 2604 - 2613. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. B. Walter, B. W. Raden, D. M. Kamikura, J. A. Cooper, and I. D. Bernstein Influence of CD33 expression levels and ITIM-dependent internalization on gemtuzumab ozogamicin-induced cytotoxicity Blood, February 1, 2005; 105(3): 1295 - 1302. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Hara-Chikuma, B. Yang, N. D. Sonawane, S. Sasaki, S. Uchida, and A. S. Verkman ClC-3 Chloride Channels Facilitate Endosomal Acidification and Chloride Accumulation J. Biol. Chem., January 14, 2005; 280(2): 1241 - 1247. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Kaushansky On the Molecular Origins of the Chronic Myeloproliferative Disorders: It All Makes Sense Hematology, January 1, 2005; 2005(1): 533 - 537. [Full Text] [PDF] |
||||
![]() |
A.-S. Zhang, A. D. Sheftel, and P. Ponka Intracellular kinetics of iron in reticulocytes: evidence for endosome involvement in iron targeting to mitochondria Blood, January 1, 2005; 105(1): 368 - 375. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. P. Foster, J. M. Melancon, T. L. Olivier, and K. G. Kousoulas Herpes Simplex Virus Type 1 Glycoprotein K and the UL20 Protein Are Interdependent for Intracellular Trafficking and trans-Golgi Network Localization J. Virol., December 1, 2004; 78(23): 13262 - 13277. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Monks and M. C Neville Albumin transcytosis across the epithelium of the lactating mouse mammary gland J. Physiol., October 1, 2004; 560(1): 267 - 280. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Gekle, K. Volker, S. Mildenberger, R. Freudinger, G. E. Shull, and M. Wiemann NHE3 Na+/H+ exchanger supports proximal tubular protein reabsorption in vivo Am J Physiol Renal Physiol, September 1, 2004; 287(3): F469 - F473. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. B. Scott, I. Michailidis, Y. Mu, D. Logothetis, and M. D. Ehlers Endocytosis and Degradative Sorting of NMDA Receptors by Conserved Membrane-Proximal Signals J. Neurosci., August 11, 2004; 24(32): 7096 - 7109. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Van Bambeke, S. Carryn, C. Seral, H. Chanteux, D. Tyteca, M.-P. Mingeot-Leclercq, and P. M. Tulkens Cellular Pharmacokinetics and Pharmacodynamics of the Glycopeptide Antibiotic Oritavancin (LY333328) in a Model of J774 Mouse Macrophages Antimicrob. Agents Chemother., August 1, 2004; 48(8): 2853 - 2860. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. X. Lin and F. R. Maxfield Fluorescence imaging in living animals. Focus on "Uptake and trafficking of fluorescent conjugates of folic acid in intact kidney determined using intravital two-photon microscopy" Am J Physiol Cell Physiol, August 1, 2004; 287(2): C257 - C259. [Full Text] [PDF] |
||||
![]() |
E. Bananis, S. Nath, K. Gordon, P. Satir, R. J. Stockert, J. W. Murray, and A. W. Wolkoff Microtubule-Dependent Movement of Late Endocytic Vesicles In Vitro: Requirements for Dynein and Kinesin Mol. Biol. Cell, August 1, 2004; 15(8): 3688 - 3697. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. B. Schapiro, T. T. Soe, W. G. Mallet, and F. R. Maxfield Role of Cytoplasmic Domain Serines in Intracellular Trafficking of Furin Mol. Biol. Cell, June 1, 2004; 15(6): 2884 - 2894. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Faundez and H. C. Hartzell Intracellular Chloride Channels: Determinants of Function in the Endosomal Pathway Sci. Signal., May 18, 2004; 2004(233): re8 - re8. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Lombry, D. A. Edwards, V. Preat, and R. Vanbever Alveolar macrophages are a primary barrier to pulmonary absorption of macromolecules Am J Physiol Lung Cell Mol Physiol, May 1, 2004; 286(5): L1002 - L1008. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Wadehra, L. Goodglick, and J. Braun The Tetraspan Protein EMP2 Modulates the Surface Expression of Caveolins and Glycosylphosphatidyl Inositol-linked Proteins Mol. Biol. Cell, May 1, 2004; 15(5): 2073 - 2083. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Aschenbrenner, S. N. Naccache, and T. Hasson Uncoated Endocytic Vesicles Require the Unconventional Myosin, Myo6, for Rapid Transport through Actin Barriers Mol. Biol. Cell, May 1, 2004; 15(5): 2253 - 2263. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Hayashi, K. Szaszi, N. Coady-Osberg, W. Furuya, A. P. Bretscher, J. Orlowski, and S. Grinstein Inhibition and Redistribution of NHE3, the Apical Na+/H+ Exchanger, by Clostridium difficile Toxin B J. Gen. Physiol., April 26, 2004; 123(5): 491 - 504. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Hao, S. Mukherjee, Y. Sun, and F. R. Maxfield Effects of Cholesterol Depletion and Increased Lipid Unsaturation on the Properties of Endocytic Membranes J. Biol. Chem., April 2, 2004; 279(14): 14171 - 14178. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. R. M. Eckhardt, L. Cai, B. Sun, N. R. Webb, and D. R. van der Westhuyzen High Density Lipoprotein Uptake by Scavenger Receptor SR-BII J. Biol. Chem., April 2, 2004; 279(14): 14372 - 14381. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Sharma, F. Pampinella, C. Nemes, M. Benharouga, J. So, K. Du, K. G. Bache, B. Papsin, N. Zerangue, H. Stenmark, et al. Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes J. Cell Biol., March 15, 2004; 164(6): 923 - 933. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Wustner, M. Mondal, A. Huang, and F. R. Maxfield Different transport routes for high density lipoprotein and its associated free sterol in polarized hepatic cells J. Lipid Res., March 1, 2004; 45(3): 427 - 437. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Engstler, L. Thilo, F. Weise, C. G. Grunfelder, H. Schwarz, M. Boshart, and P. Overath Kinetics of endocytosis and recycling of the GPI-anchored variant surface glycoprotein in Trypanosoma brucei J. Cell Sci., March 1, 2004; 117(7): 1105 - 1115. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Watabe, J. C. Valencia, K.-i. Yasumoto, T. Kushimoto, H. Ando, J. Muller, W. D. Vieira, M. Mizoguchi, E. Appella, and V. J. Hearing Regulation of Tyrosinase Processing and Trafficking by Organellar pH and by Proteasome Activity J. Biol. Chem., February 27, 2004; 279(9): 7971 - 7981. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. J. Johnson, A. Zecevic, and E. J. Kwon Protocadherin {alpha}3 Acts at Sites Distinct from Classic Cadherins in Rat Testis and Sperm Biol Reprod, February 1, 2004; 70(2): 303 - 312. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. X. Lin, W. G. Mallet, A. Y. Huang, and F. R. Maxfield Endocytosed Cation-Independent Mannose 6-Phosphate Receptor Traffics via the Endocytic Recycling Compartment en Route to the trans-Golgi Network and a Subpopulation of Late Endosomes Mol. Biol. Cell, February 1, 2004; 15(2): 721 - 733. [Abstract] [Full Text] [PDF] |
||||
![]() |
K.-W. Lee, B. Liu, L. Ma, H. Li, P. Bang, H. P. Koeffler, and P. Cohen Cellular Internalization of Insulin-like Growth Factor Binding Protein-3: DISTINCT ENDOCYTIC PATHWAYS FACILITATE RE-UPTAKE AND NUCLEAR LOCALIZATION J. Biol. Chem., January 2, 2004; 279(1): 469 - 476. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. P. Becker and Y. A. Hannun cPKC-dependent Sequestration of Membrane-recycling Components in a Subset of Recycling Endosomes J. Biol. Chem., December 26, 2003; 278(52): 52747 - 52754. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Klisic, J. Zhang, V. Nief, L. Reyes, O. W. Moe, and P. M. Ambuhl Albumin Regulates the Na+/H+ Exchanger 3 in OKP Cells J. Am. Soc. Nephrol., December 1, 2003; 14(12): 3008 - 3016. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. A. Rajasekaran, G. Anilkumar, E. Oshima, J. U. Bowie, H. Liu, W. Heston, N. H. Bander, and A. K. Rajasekaran A Novel Cytoplasmic Tail MXXXL Motif Mediates the Internalization of Prostate-specific Membrane Antigen Mol. Biol. Cell, December 1, 2003; 14(12): 4835 - 4845. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Krishnamurthy, H. Kishi, M. Shi, C. Galet, R. S. Bhaskaran, T. Hirakawa, and M. Ascoli Postendocytotic Trafficking of the Follicle-Stimulating Hormone (FSH)-FSH Receptor Complex Mol. Endocrinol., November 1, 2003; 17(11): 2162 - 2176. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. A. Picciano, N. Ameen, B. D. Grant, and N. A. Bradbury Rme-1 regulates the recycling of the cystic fibrosis transmembrane conductance regulator Am J Physiol Cell Physiol, November 1, 2003; 285(5): C1009 - C1018. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Muro, X. Cui, C. Gajewski, J.-C. Murciano, V. R. Muzykantov, and M. Koval Slow intracellular trafficking of catalase nanoparticles targeted to ICAM-1 protects endothelial cells from oxidative stress Am J Physiol Cell Physiol, November 1, 2003; 285(5): C1339 - C1347. [Abstract] [Full Text] [PDF] |
||||
![]() |
S.-J. Seo, H.-M. Cheon, J. Sun, T. W. Sappington, and A. S. Raikhel Tissue- and Stage-specific Expression of Two Lipophorin Receptor Variants with Seven and Eight Ligand-binding Repeats in the Adult Mosquito J. Biol. Chem., October 24, 2003; 278(43): 41954 - 41962. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Gekle, P. Knaus, R. Nielsen, S. Mildenberger, R. Freudinger, V. Wohlfarth, C. Sauvant, and E. I Christensen Transforming growth factor-{beta}1 reduces megalin- and cubilin-mediated endocytosis of albumin in proximal-tubule-derived opossum kidney cells J. Physiol., October 15, 2003; 552(2): 471 - 481. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. J. Provoda, E. M. Stier, and K.-D. Lee Tumor Cell Killing Enabled by Listeriolysin O-liposome-mediated Delivery of the Protein Toxin Gelonin J. Biol. Chem., September 12, 2003; 278(37): 35102 - 35108. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Wissel, C. Schulz, M. Rudiger, M. Krull, P. A. Stevens, and R. R. Wauer Chlamydia pneumoniae Affect Surfactant Trafficking and Secretion Due to Changes of Type II Cell Cytoskeleton Am. J. Respir. Cell Mol. Biol., September 1, 2003; 29(3): 303 - 313. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |