HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lillis, A. P. Articles by Strickland, D. K. Search for Related Content PubMed PubMed Citation Articles by Lillis, A. P. Articles by Strickland, D. K.

LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies

Center for Vascular and Inflammatory Diseases and Departments of Surgery and Physiology, University of Maryland School of Medicine, Baltimore, Maryland; Department of Pathology, Duke University Medical Center, Durham, North Carolina; and Department of Pathology, Medical Scientist Training Program, and The BioMatrix Engineering and Regenerative Medicine Center, University of Alabama at Birmingham, Birmingham, Alabama

The LDL receptor-related protein (originally called LRP, but now referred to as LRP1) is a large endocytic receptor that is widely expressed in several tissues. LRP1 is a member of the LDL receptor family that plays diverse roles in various biological processes including lipoprotein metabolism, degradation of proteases, activation of lysosomal enzymes, and cellular entry of bacterial toxins and viruses. Deletion of the LRP1 gene leads to lethality in mice, revealing a critical, but as of yet, undefined role in development. Tissue-specific gene deletion studies reveal an important contribution of LRP1 in the vasculature, central nervous system, macrophages, and adipocytes. Three important properties of LRP1 dictate its diverse role in physiology: 1) its ability to recognize more than 30 distinct ligands, 2) its ability to bind a large number of cytoplasmic adaptor proteins via determinants located on its cytoplasmic domain in a phosphorylation-specific manner, and 3) its ability to associate with and modulate the activity of other transmembrane receptors such as integrins and receptor tyrosine kinases.

This article has been cited by other articles:

				D. T. Woodley, J. Fan, C.-F. Cheng, Y. Li, M. Chen, G. Bu, and W. Li Participation of the lipoprotein receptor LRP1 in hypoxia-HSP90{alpha} autocrine signaling to promote keratinocyte migration J. Cell Sci., May 15, 2009; 122(10): 1495 - 1498. [Abstract] [Full Text] [PDF]

				A. Gaultier, X. Wu, N. Le Moan, S. Takimoto, G. Mukandala, K. Akassoglou, W. M. Campana, and S. L. Gonias Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis J. Cell Sci., April 15, 2009; 122(8): 1155 - 1162. [Abstract] [Full Text] [PDF]

				J. Herz, Y. Chen, I. Masiulis, and L. Zhou Expanding functions of lipoprotein receptors J. Lipid Res., April 1, 2009; 50(Supplement): S287 - S292. [Abstract] [Full Text] [PDF]

				C. Zhang, J. An, D. K. Strickland, and M. Yepes The Low-Density Lipoprotein Receptor-Related Protein 1 Mediates Tissue-Type Plasminogen Activator-Induced Microglial Activation in the Ischemic Brain Am. J. Pathol., February 1, 2009; 174(2): 586 - 594. [Abstract] [Full Text] [PDF]