| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Laboratoire d'Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France
To migrate, a cell first extends protrusions such as lamellipodia and filopodia, forms adhesions, and finally retracts its tail. The actin cytoskeleton plays a major role in this process. The first part of this review (sect. II) describes the formation of the lamellipodial and filopodial actin networks. In lamellipodia, the WASP-Arp2/3 pathways generate a branched filament array. This polarized dendritic actin array is maintained in rapid treadmilling by the concerted action of ADF, profilin, and capping proteins. In filopodia, formins catalyze the processive assembly of nonbranched actin filaments. Cell matrix adhesions mechanically couple actin filaments to the substrate to convert the treadmilling into protrusion and the actomyosin contraction into traction of the cell body and retraction of the tail. The second part of this review (sect. III) focuses on the function and the regulation of major proteins (vinculin, talin, tensin, and 
-actinin) that control the nucleation, the binding, and the barbed-end growth of actin filaments in adhesions.
This article has been cited by other articles:
|
|
 |
|
  M. Roh-Johnson and B. Goldstein In vivo roles for Arp2/3 in cortical actin organization during C. elegans gastrulation J. Cell Sci., November 1, 2009; 122(21): 3983 - 3993. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. A. Kopera, L. Su, B. Bilinska, C. Y. Cheng, and D. D. Mruk An in Vivo Study on Adjudin and Blood-Testis Barrier Dynamics Endocrinology, October 1, 2009; 150(10): 4724 - 4733. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Has, C. Herz, E. Zimina, H.-Y. Qu, Y. He, Z.-G. Zhang, T.-T. Wen, Y. Gache, M. Aumailley, and L. Bruckner-Tuderman Kindlin-1 Is Required for RhoGTPase-Mediated Lamellipodia Formation in Keratinocytes Am. J. Pathol., October 1, 2009; 175(4): 1442 - 1452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Asperti, V. Astro, A. Totaro, S. Paris, and I. de Curtis Liprin-{alpha}1 promotes cell spreading on the extracellular matrix by affecting the distribution of activated integrins J. Cell Sci., September 15, 2009; 122(18): 3225 - 3232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Soll, D. Wessels, S. Kuhl, and D. F. Lusche How a Cell Crawls and the Role of Cortical Myosin II Eukaryot. Cell, September 1, 2009; 8(9): 1381 - 1396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. C. Chan, P. D. Arora, P. Bozavikov, and C. A. McCulloch FAK, PIP5KI{gamma} and gelsolin cooperatively mediate force-induced expression of {alpha}-smooth muscle actin J. Cell Sci., August 1, 2009; 122(15): 2769 - 2781. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-C. Liu, Y.-M. Jen, S. S. Jiang, J.-L. Chang, C. A. Hsiung, C.-H. Wang, and J.-L. Juang G{alpha}12-Mediated Pathway Promotes Invasiveness of Nasopharyngeal Carcinoma by Modulating Actin Cytoskeleton Reorganization Cancer Res., August 1, 2009; 69(15): 6122 - 6130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Oellerich, M. Gronborg, K. Neumann, H.-H. Hsiao, H. Urlaub, and J. Wienands SLP-65 Phosphorylation Dynamics Reveals a Functional Basis for Signal Integration by Receptor-proximal Adaptor Proteins Mol. Cell. Proteomics, July 1, 2009; 8(7): 1738 - 1750. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Munderloh, G. P. Solis, V. Bodrikov, F. A. Jaeger, M. Wiechers, E. Malaga-Trillo, and C. A. O. Stuermer Reggies/Flotillins Regulate Retinal Axon Regeneration in the Zebrafish Optic Nerve and Differentiation of Hippocampal and N2a Neurons J. Neurosci., May 20, 2009; 29(20): 6607 - 6615. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. D. Notarangelo and R. Badolato Leukocyte trafficking in primary immunodeficiencies J. Leukoc. Biol., March 1, 2009; 85(3): 335 - 343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Lewkowicz, F. Herit, C. Le Clainche, P. Bourdoncle, F. Perez, and F. Niedergang The microtubule-binding protein CLIP-170 coordinates mDia1 and actin reorganization during CR3-mediated phagocytosis J. Cell Biol., December 29, 2008; 183(7): 1287 - 1298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Gardel, B. Sabass, L. Ji, G. Danuser, U. S. Schwarz, and C. M. Waterman Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed J. Cell Biol., December 15, 2008; 183(6): 999 - 1005. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hammerschmidt and D. Wedlich Regulated adhesion as a driving force of gastrulation movements Development, November 15, 2008; 135(22): 3625 - 3641. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. W. Kahsai, J. Cui, H. U. Kaniskan, P. P. Garner, and G. Fenteany Analogs of Tetrahydroisoquinoline Natural Products That Inhibit Cell Migration and Target Galectin-3 Outside of Its Carbohydrate-binding Site J. Biol. Chem., September 5, 2008; 283(36): 24534 - 24545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Bretscher On the shape of migrating cells -- a `front-to-back' model J. Cell Sci., August 15, 2008; 121(16): 2625 - 2628. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Schwab, P. Hanley, A. Fabian, and C. Stock Potassium Channels Keep Mobile Cells on the Go Physiology, August 1, 2008; 23(4): 212 - 220. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
