| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, South Carolina
It is now becoming apparent that dynamic changes occur within the interstitium that directly contribute to adverse myocardial remodeling following myocardial infarction (MI), with hypertensive heart disease and with intrinsic myocardial disease such as cardiomyopathy. Furthermore, a family of matrix proteases, the matrix metalloproteinases (MMPs) and the tissue inhibitors of MMPs (TIMPs), has been recognized to play an important role in matrix remodeling in these cardiac disease states. The purpose of this review is fivefold: 1) to examine and redefine the myocardial matrix as a critical and dynamic entity with respect to the remodeling process encountered with MI, hypertension, or cardiomyopathic disease; 2) present the remarkable progress that has been made with respect to MMP/TIMP biology and how it relates to myocardial matrix remodeling; 3) to evaluate critical translational/clinical studies that have provided a cause-effect relationship between alterations in MMP/TIMP regulation and myocardial matrix remodeling; 4) to provide a critical review and analysis of current diagnostic, prognostic, and pharmacological approaches that utilized our basic understanding of MMP/TIMPs in the context of cardiac disease; and 5) most importantly, to dispel the historical belief that the myocardial matrix is a passive structure and supplant this belief that the regulation of matrix protease pathways such as the MMPs and TIMPs will likely yield a new avenue of diagnostic and therapeutic strategies for myocardial remodeling and the progression to heart failure.
This article has been cited by other articles:
|
|
 |
|
  M. Franz, A. Berndt, A. Altendorf-Hofmann, N. Fiedler, P. Richter, J. Schumm, M. Fritzenwanger, H. R. Figulla, and B. R. Brehm Serum levels of large tenascin-C variants, matrix metalloproteinase-9, and tissue inhibitors of matrix metalloproteinases in concentric versus eccentric left ventricular hypertrophy Eur J Heart Fail, November 1, 2009; 11(11): 1057 - 1062. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Kassiri, V. Defamie, M. Hariri, G. Y. Oudit, S. Anthwal, F. Dawood, P. Liu, and R. Khokha Simultaneous Transforming Growth Factor {beta}-Tumor Necrosis Factor Activation and Cross-talk Cause Aberrant Remodeling Response and Myocardial Fibrosis in Timp3-deficient Heart J. Biol. Chem., October 23, 2009; 284(43): 29893 - 29904. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Swinnen, D. Vanhoutte, G. C. Van Almen, N. Hamdani, M. W.M. Schellings, J. D'hooge, J. Van der Velden, M. S. Weaver, E. H. Sage, P. Bornstein, et al. Absence of Thrombospondin-2 Causes Age-Related Dilated Cardiomyopathy Circulation, October 20, 2009; 120(16): 1585 - 1597. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. W.-K. Yip, M. Frenneaux, and J. E Sanderson Heart failure with a normal ejection fraction: new developments Heart, October 1, 2009; 95(19): 1549 - 1552. [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Jones, C. Beck, J. R. Barbour, J. A. Zavadzkas, R. Mukherjee, F. G. Spinale, and J. S. Ikonomidis Alterations in Aortic Cellular Constituents during Thoracic Aortic Aneurysm Development: Myofibroblast-Mediated Vascular Remodeling Am. J. Pathol., October 1, 2009; 175(4): 1746 - 1756. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Kassiri, J. Zhong, D. Guo, R. Basu, X. Wang, P. P. Liu, J. W. Scholey, J. M. Penninger, and G. Y. Oudit Loss of Angiotensin-Converting Enzyme 2 Accelerates Maladaptive Left Ventricular Remodeling in Response to Myocardial Infarction Circ Heart Fail, September 1, 2009; 2(5): 446 - 455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Pretorius, X.-J. Du, E. A. Woodcock, H. Kiriazis, R. C.Y. Lin, S. Marasco, R. L. Medcalf, Z. Ming, G. A. Head, J. W. Tan, et al. Reduced Phosphoinositide 3-Kinase (p110{alpha}) Activation Increases the Susceptibility to Atrial Fibrillation Am. J. Pathol., September 1, 2009; 175(3): 998 - 1009. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Kandasamy and R. Schulz Glycogen synthase kinase-3{beta} is activated by matrix metalloproteinase-2 mediated proteolysis in cardiomyoblasts Cardiovasc Res, September 1, 2009; 83(4): 698 - 706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Kandasamy, A. K. Chow, M. A.M. Ali, and R. Schulz Matrix metalloproteinase-2 and myocardial oxidative stress injury: beyond the matrix Cardiovasc Res, August 20, 2009; (2009) cvp268v2. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. G. Spinale, G. P. Escobar, R. Mukherjee, J. A. Zavadzkas, S. M. Saunders, L. B. Jeffords, A. M. Leone, C. Beck, S. Bouges, and R. E. Stroud Cardiac-Restricted Overexpression of Membrane Type-1 Matrix Metalloproteinase in Mice: Effects on Myocardial Remodeling With Aging Circ Heart Fail, July 1, 2009; 2(4): 351 - 360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. W. Dorn II Apoptotic and non-apoptotic programmed cardiomyocyte death in ventricular remodelling Cardiovasc Res, February 15, 2009; 81(3): 465 - 473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. S. Dhalla, H. K. Saini-Chohan, D. Rodriguez-Leyva, V. Elimban, M. R. Dent, and P. S. Tappia Subcellular remodelling may induce cardiac dysfunction in congestive heart failure Cardiovasc Res, February 15, 2009; 81(3): 429 - 438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Diez and G. Ertl A translational approach to myocardial remodelling Cardiovasc Res, February 15, 2009; 81(3): 409 - 411. [Full Text] [PDF]
|
|
|
|
 |
|
 R. F. Duisters, A. J. Tijsen, B. Schroen, J. J. Leenders, V. Lentink, I. van der Made, V. Herias, R. E. van Leeuwen, M. W. Schellings, P. Barenbrug, et al. miR-133 and miR-30 Regulate Connective Tissue Growth Factor: Implications for a Role of MicroRNAs in Myocardial Matrix Remodeling Circ. Res., January 30, 2009; 104(2): 170 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Bradshaw, C. F. Baicu, T. J. Rentz, A. O. Van Laer, J. Boggs, J. M. Lacy, and M. R. Zile Pressure Overload-Induced Alterations in Fibrillar Collagen Content and Myocardial Diastolic Function: Role of Secreted Protein Acidic and Rich in Cysteine (SPARC) in Post-Synthetic Procollagen Processing Circulation, January 20, 2009; 119(2): 269 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zhang, S.-j. Zhu, D. Wang, Y.-j. Wei, and S.-S. Hu Intramyocardial injection of tannic acid attenuates postinfarction remodeling: A novel approach to stabilize the breaking extracellular matrix J. Thorac. Cardiovasc. Surg., January 1, 2009; 137(1): 216 - 222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. E. Lindley, D. W. Infanger, M. Rishniw, Y. Zhou, M. F. Doobay, R. V. Sharma, and R. L. Davisson Scavenging superoxide selectively in mouse forebrain is associated with improved cardiac function and survival following myocardial infarction Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2009; 296(1): R1 - R8. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Bjornstad, N. O. Neverdal, O. A. Vengen, C. W. Knudsen, T. Husebye, J. Pepper, M. Lie, G. Christensen, and T. Tonnessen Alterations in circulating activin A, GDF-15, TGF-{beta}3 and MMP-2, -3, and -9 during one year of left ventricular reverse remodelling in patients operated for severe aortic stenosis Eur J Heart Fail, December 1, 2008; 10(12): 1201 - 1207. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Perlini, F. Salinaro, and M. L. Fonte Direct Renin Inhibition: Another Weapon to Modulate the Renin-Angiotensin System in Postinfarction Remodeling? Hypertension, December 1, 2008; 52(6): 1019 - 1021. [Full Text] [PDF]
|
|
|
|
|
|
A. Biolo, S. Ramamurthy, L. H. Connors, C. J. O'Hara, H. K. Meier-Ewert, P. T. Soo Hoo, D. B. Sawyer, D. S. Seldin, and F. Sam Matrix Metalloproteinases and Their Tissue Inhibitors in Cardiac Amyloidosis: Relationship to Structural, Functional Myocardial Changes and to Light Chain Amyloid Deposition Circ Heart Fail, November 1, 2008; 1(4): 249 - 257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Zavadzkas, R. A. Plyler, S. Bouges, C. N. Koval, W. T. Rivers, C. U. Beck, E. I. Chang, R. E. Stroud, R. Mukherjee, and F. G. Spinale Cardiac-restricted overexpression of extracellular matrix metalloproteinase inducer causes myocardial remodeling and dysfunction in aging mice Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1394 - H1402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Levick and G. L. Brower Regulation of matrix metalloproteinases is at the heart of myocardial remodeling Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1375 - H1376. [Full Text] [PDF]
|
|
|
|
|
|
F. G. Spinale, C. N. Koval, A. M. Deschamps, R. E. Stroud, and J. S. Ikonomidis Dynamic Changes in Matrix Metalloprotienase Activity Within the Human Myocardial Interstitium During Myocardial Arrest and Reperfusion Circulation, September 30, 2008; 118(14_suppl_1): S16 - S23. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nakagawa, G. Takemura, H. Kanamori, K. Goto, R. Maruyama, A. Tsujimoto, T. Ohno, H. Okada, A. Ogino, M. Esaki, et al. Mechanisms by Which Late Coronary Reperfusion Mitigates Postinfarction Cardiac Remodeling Circ. Res., July 3, 2008; 103(1): 98 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Frantz, S. Stork, K. Michels, M. Eigenthaler, G. Ertl, J. Bauersachs, and C.E. Angermann Tissue inhibitor of metalloproteinases levels in patients with chronic heart failure: An independent predictor of mortality Eur J Heart Fail, April 1, 2008; 10(4): 388 - 395. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
