Physiol Rev Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Physiol. Rev. 87: 593-658, 2007; doi:10.1152/physrev.00035.2006
0031-9333/07 $18.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (76)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Foskett, J. K.
Right arrow Articles by Mak, D.-O. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Foskett, J. K.
Right arrow Articles by Mak, D.-O. D.

Inositol Trisphosphate Receptor Ca2+ Release Channels

J. Kevin Foskett, Carl White, King-Ho Cheung and Don-On Daniel Mak

Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania

The inositol 1,4,5-trisphosphate (InsP3) receptors (InsP3Rs) are a family of Ca2+ release channels localized predominately in the endoplasmic reticulum of all cell types. They function to release Ca2+ into the cytoplasm in response to InsP3 produced by diverse stimuli, generating complex local and global Ca2+ signals that regulate numerous cell physiological processes ranging from gene transcription to secretion to learning and memory. The InsP3R is a calcium-selective cation channel whose gating is regulated not only by InsP3, but by other ligands as well, in particular cytoplasmic Ca2+. Over the last decade, detailed quantitative studies of InsP3R channel function and its regulation by ligands and interacting proteins have provided new insights into a remarkable richness of channel regulation and of the structural aspects that underlie signal transduction and permeation. Here, we focus on these developments and review and synthesize the literature regarding the structure and single-channel properties of the InsP3R.




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
S. Manita and W. N. Ross
Synaptic Activation and Membrane Potential Changes Modulate the Frequency of Spontaneous Elementary Ca2+ Release Events in the Dendrites of Pyramidal Neurons
J. Neurosci., June 17, 2009; 29(24): 7833 - 7845.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. J. Betzenhauser, L. E. Wagner II, H. S. Park, and D. I. Yule
ATP Regulation of Type-1 Inositol 1,4,5-Trisphosphate Receptor Activity Does Not Require Walker A-type ATP-binding Motifs
J. Biol. Chem., June 12, 2009; 284(24): 16156 - 16163.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. C. Patel, P. Witkovsky, M. V. Avshalumov, and M. E. Rice
Mobilization of Calcium from Intracellular Stores Facilitates Somatodendritic Dopamine Release
J. Neurosci., May 20, 2009; 29(20): 6568 - 6579.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. M. P. Pearce, D. B. Wormer, S. Wilkens, and R. J. H. Wojcikiewicz
An Endoplasmic Reticulum (ER) Membrane Complex Composed of SPFH1 and SPFH2 Mediates the ER-associated Degradation of Inositol 1,4,5-Trisphosphate Receptors
J. Biol. Chem., April 17, 2009; 284(16): 10433 - 10445.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
I. F. Smith and I. Parker
Imaging the quantal substructure of single IP3R channel activity during Ca2+ puffs in intact mammalian cells
PNAS, April 14, 2009; 106(15): 6404 - 6409.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Anyatonwu and S. K. Joseph
Surface Accessibility and Conformational Changes in the N-terminal Domain of Type I Inositol Trisphosphate Receptors: STUDIES USING CYSTEINE SUBSTITUTION MUTAGENESIS
J. Biol. Chem., March 20, 2009; 284(12): 8093 - 8102.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Rosker, G. Meur, E. J. A. Taylor, and C. W. Taylor
Functional Ryanodine Receptors in the Plasma Membrane of RINm5F Pancreatic {beta}-Cells
J. Biol. Chem., February 20, 2009; 284(8): 5186 - 5194.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Li, J. Chan, F. Haeseleer, K. Mikoshiba, K. Palczewski, M. Ikura, and J. B. Ames
Structural Insights into Ca2+-dependent Regulation of Inositol 1,4,5-Trisphosphate Receptors by CaBP1
J. Biol. Chem., January 23, 2009; 284(4): 2472 - 2481.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. A. Sliter, K. Kubota, D. S. Kirkpatrick, K. J. Alzayady, S. P. Gygi, and R. J. H. Wojcikiewicz
Mass Spectrometric Analysis of Type 1 Inositol 1,4,5-Trisphosphate Receptor Ubiquitination
J. Biol. Chem., December 19, 2008; 283(51): 35319 - 35328.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
G. Zhao, A. Adebiyi, E. Blaskova, Q. Xi, and J. H. Jaggar
Type 1 inositol 1,4,5-trisphosphate receptors mediate UTP-induced cation currents, Ca2+ signals, and vasoconstriction in cerebral arteries
Am J Physiol Cell Physiol, November 1, 2008; 295(5): C1376 - C1384.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
O. Brandman and T. Meyer
Feedback Loops Shape Cellular Signals in Space and Time
Science, October 17, 2008; 322(5900): 390 - 395.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
H. Cheng and W. J. Lederer
Calcium Sparks
Physiol Rev, October 1, 2008; 88(4): 1491 - 1545.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. S. Park, M. J. Betzenhauser, J. H. Won, J. Chen, and D. I. Yule
The Type 2 Inositol (1,4,5)-Trisphosphate (InsP3) Receptor Determines the Sensitivity of InsP3-induced Ca2+ Release to ATP in Pancreatic Acinar Cells
J. Biol. Chem., September 19, 2008; 283(38): 26081 - 26088.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Kang, J. Kang, H. Kwon, D. Frueh, S. H. Yoo, G. Wagner, and S. Park
Effects of Redox Potential and Ca2+ on the Inositol 1,4,5-Trisphosphate Receptor L3-1 Loop Region: IMPLICATIONS FOR RECEPTOR REGULATION
J. Biol. Chem., September 12, 2008; 283(37): 25567 - 25575.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. J. Betzenhauser, L. E. Wagner II, M. Iwai, T. Michikawa, K. Mikoshiba, and D. I. Yule
ATP Modulation of Ca2+ Release by Type-2 and Type-3 Inositol (1, 4, 5)-Triphosphate Receptors: DIFFERING ATP SENSITIVITIES AND MOLECULAR DETERMINANTS OF ACTION
J. Biol. Chem., August 1, 2008; 283(31): 21579 - 21587.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
Q. Jiang, M. He, X. Wang, and A. O. L. Wong
Grass carp somatolactin: II. Pharmacological study on postreceptor signaling mechanisms for PACAP-induced somatolactin-{alpha} and -{beta} gene expression
Am J Physiol Endocrinol Metab, August 1, 2008; 295(2): E477 - E490.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
L. E. Wagner II, S. K. Joseph, and D. I. Yule
Regulation of single inositol 1,4,5-trisphosphate receptor channel activity by protein kinase A phosphorylation
J. Physiol., August 1, 2008; 586(15): 3577 - 3596.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. W. Putney and G. S. Bird
Cytoplasmic calcium oscillations and store-operated calcium influx
J. Physiol., July 1, 2008; 586(13): 3055 - 3059.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Petravicz, T. A. Fiacco, and K. D. McCarthy
Loss of IP3 Receptor-Dependent Ca2+ Increases in Hippocampal Astrocytes Does Not Affect Baseline CA1 Pyramidal Neuron Synaptic Activity
J. Neurosci., May 7, 2008; 28(19): 4967 - 4973.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
G. Liang, Q. Li, Y. Tang, K. Kokame, T. Kikuchi, G. Wu, and X.-Z. Chen
Polycystin-2 is regulated by endoplasmic reticulum-associated degradation
Hum. Mol. Genet., April 15, 2008; 17(8): 1109 - 1119.
[Abstract] [Full Text] [PDF]

Home page
 JGPHome page
J. Xing, X. Yan, A. Estevez, and K. Strange
Highly Ca2+-selective TRPM Channels Regulate IP3-dependent Oscillatory Ca2+ Signaling in the C. elegans Intestine
J. Gen. Physiol., February 25, 2008; 131(3): 245 - 255.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. T. Schug, P. C. A. da Fonseca, C. D. Bhanumathy, L. Wagner II, X. Zhang, B. Bailey, E. P. Morris, D. I. Yule, and S. K. Joseph
Molecular Characterization of the Inositol 1,4,5-Trisphosphate Receptor Pore-forming Segment
J. Biol. Chem., February 1, 2008; 283(5): 2939 - 2948.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
O. Dellis, A. M. Rossi, S. G. Dedos, and C. W. Taylor
Counting Functional Inositol 1,4,5-Trisphosphate Receptors into the Plasma Membrane
J. Biol. Chem., January 11, 2008; 283(2): 751 - 755.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
J. H. Won, W. J. Cottrell, T. H. Foster, and D. I. Yule
Ca2+ release dynamics in parotid and pancreatic exocrine acinar cells evoked by spatially limited flash photolysis
Am J Physiol Gastrointest Liver Physiol, December 1, 2007; 293(6): G1166 - G1177.
[Abstract] [Full Text] [PDF]

Home page
 JGPHome page
L. Ionescu, C. White, K.-H. Cheung, J. Shuai, I. Parker, J. E. Pearson, J. K. Foskett, and D.-O. D. Mak
Mode Switching Is the Major Mechanism of Ligand Regulation of InsP3 Receptor Calcium Release Channels
J. Gen. Physiol., November 26, 2007; 130(6): 631 - 645.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. T. Khan, C. D. Bhanumathy, Z. T. Schug, and S. K. Joseph
Role of Inositol 1,4,5-Trisphosphate Receptors in Apoptosis in DT40 Lymphocytes
J. Biol. Chem., November 9, 2007; 282(45): 32983 - 32990.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Li, X. Wang, H. Vais, C. B. Thompson, J. K. Foskett, and C. White
Apoptosis regulation by Bcl-xL modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating
PNAS, July 24, 2007; 104(30): 12565 - 12570.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2007 by the American Physiological Society.