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Physiol. Rev. 86: 515-581, 2006; doi:10.1152/physrev.00024.2005
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Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways

Alain Tedgui and Ziad Mallat

Institut National de la Santé et de la Recherche Médicale U. 689, Cardiovascular Research Center Lariboisiere, and University Paris 7, Paris, France

Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive immunoinflammatory mechanisms are involved. Inflammation is central at all stages of atherosclerosis. It is implicated in the formation of early fatty streaks, when the endothelium is activated and expresses chemokines and adhesion molecules leading to monocyte/lymphocyte recruitment and infiltration into the subendothelium. It also acts at the onset of adverse clinical vascular events, when activated cells within the plaque secrete matrix proteases that degrade extracellular matrix proteins and weaken the fibrous cap, leading to rupture and thrombus formation. Cells involved in the atherosclerotic process secrete and are activated by soluble factors, known as cytokines. Important recent advances in the comprehension of the mechanisms of atherosclerosis provided evidence that the immunoinflammatory response in atherosclerosis is modulated by regulatory pathways, in which the two anti-inflammatory cytokines interleukin-10 and transforming growth factor-beta play a critical role. The purpose of this review is to bring together the current information concerning the role of cytokines in the development, progression, and complications of atherosclerosis. Specific emphasis is placed on the contribution of pro- and anti-inflammatory cytokines to pathogenic (innate and adaptive) and regulatory immunity in the context of atherosclerosis. Based on our current knowledge of the role of cytokines in atherosclerosis, we propose some novel therapeutic strategies to combat this disease. In addition, we discuss the potential of circulating cytokine levels as biomarkers of coronary artery disease.





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Home page
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[Abstract] [Full Text] [PDF]


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Home page
J. Exp. Med.Home page
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J. Exp. Med., February 18, 2008; 205(2): 339 - 346.
[Abstract] [Full Text] [PDF]


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[Abstract] [Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
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CB2-receptor stimulation attenuates TNF-{alpha}-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion
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[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
J. Ohayon, O. Dubreuil, P. Tracqui, S. Le Floc'h, G. Rioufol, L. Chalabreysse, F. Thivolet, R. I. Pettigrew, and G. Finet
Influence of residual stress/strain on the biomechanical stability of vulnerable coronary plaques: potential impact for evaluating the risk of plaque rupture
Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1987 - H1996.
[Abstract] [Full Text] [PDF]


Home page
Ann. N. Y. Acad. Sci.Home page
U. E. NYDEGGER
Immune Complex Pathophysiology
Ann. N.Y. Acad. Sci., August 1, 2007; 1109(1): 66 - 83.
[Abstract] [Full Text] [PDF]


Home page
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R. Muniyappa, M. Montagnani, K. K. Koh, and M. J. Quon
Cardiovascular Actions of Insulin
Endocr. Rev., August 1, 2007; 28(5): 463 - 491.
[Abstract] [Full Text] [PDF]


Home page
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Neoangiogenesis and the presence of progenitor cells in the venous limb of an arteriovenous fistula in the rat
Am J Physiol Renal Physiol, August 1, 2007; 293(2): F470 - F475.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
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J. Biol. Chem., June 29, 2007; 282(26): 19167 - 19176.
[Abstract] [Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
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Plasmin Triggers Cytokine Induction in Human Monocyte-Derived Macrophages
Arterioscler. Thromb. Vasc. Biol., June 1, 2007; 27(6): 1383 - 1389.
[Abstract] [Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


Home page
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D. J. Grainger
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[Abstract] [Full Text] [PDF]


Home page
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H. Ait-Oufella, K. Kinugawa, J. Zoll, T. Simon, J. Boddaert, S. Heeneman, O. Blanc-Brude, V. Barateau, S. Potteaux, R. Merval, et al.
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Circulation, April 24, 2007; 115(16): 2168 - 2177.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
X. Wang, W. Jin, and D. J. Rader
Upregulation of Macrophage Endothelial Lipase by Toll-Like Receptors 4 and 3 Modulates Macrophage Interleukin-10 and -12 Production
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[Abstract] [Full Text] [PDF]


Home page
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Morning Blood Pressure Surge as a Destabilizing Factor of Atherosclerotic Plaque: Role of Ubiquitin-Proteasome Activity
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[Abstract] [Full Text] [PDF]


Home page
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K. Oda, N. Tanaka, T. Arai, J. Araki, Y. Song, L. Zhang, A. Kuchiba, T. Hosoi, T. Shirasawa, M. Muramatsu, et al.
Polymorphisms in pro- and anti-inflammatory cytokine genes and susceptibility to atherosclerosis: a pathological study of 1503 consecutive autopsy cases
Hum. Mol. Genet., March 15, 2007; 16(6): 592 - 599.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
T. B. Dahl, A. Yndestad, M. Skjelland, E. Oie, A. Dahl, A. Michelsen, J. K. Damas, S. H. Tunheim, T. Ueland, C. Smith, et al.
Increased Expression of Visfatin in Macrophages of Human Unstable Carotid and Coronary Atherosclerosis: Possible Role in Inflammation and Plaque Destabilization
Circulation, February 27, 2007; 115(8): 972 - 980.
[Abstract] [Full Text] [PDF]


Home page
J. Lipid Res.Home page
G. Qiu, A. C. Ho, W. Yu, and J. S. Hill
Suppression of endothelial or lipoprotein lipase in THP-1 macrophages attenuates proinflammatory cytokine secretion
J. Lipid Res., February 1, 2007; 48(2): 385 - 394.
[Abstract] [Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
V. Braunersreuther, A. Zernecke, C. Arnaud, E. A. Liehn, S. Steffens, E. Shagdarsuren, K. Bidzhekov, F. Burger, G. Pelli, B. Luckow, et al.
Ccr5 But Not Ccr1 Deficiency Reduces Development of Diet-Induced Atherosclerosis in Mice
Arterioscler. Thromb. Vasc. Biol., February 1, 2007; 27(2): 373 - 379.
[Abstract] [Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
E. J.A van Wanrooij, G. H.M van Puijvelde, P. de Vos, H. Yagita, T. J.C. van Berkel, and J. Kuiper
Interruption of the Tnfrsf4/Tnfsf4 (OX40/OX40L) Pathway Attenuates Atherogenesis in Low-Density Lipoprotein Receptor-Deficient Mice
Arterioscler. Thromb. Vasc. Biol., January 1, 2007; 27(1): 204 - 210.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
R. T. de Jongh, R. G. Ijzerman, E. H. Serne, J. J. Voordouw, J. S. Yudkin, H. A. D.-v. de Waal, C. D. A. Stehouwer, and M. M. van Weissenbruch
Visceral and Truncal Subcutaneous Adipose Tissue Are Associated with Impaired Capillary Recruitment in Healthy Individuals
J. Clin. Endocrinol. Metab., December 1, 2006; 91(12): 5100 - 5106.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
A. N. Mazzadi, X. Andre-Fouet, N. Costes, P. Croisille, D. Revel, and M. F. Janier
Mechanisms leading to reversible mechanical dysfunction in severe CAD: alternatives to myocardial stunning
Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2570 - H2582.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart JHome page
G. Caligiuri and A. Nicoletti
Lymphocyte responses in acute coronary syndromes: lack of regulation spawns deviant behaviour
Eur. Heart J., November 1, 2006; 27(21): 2485 - 2486.
[Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
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T Cells in Atherogenesis: For Better or For Worse?
Arterioscler. Thromb. Vasc. Biol., November 1, 2006; 26(11): 2421 - 2432.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
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Immunosuppression in Atherosclerosis: Mobilizing the Opposition Within
Circulation, October 31, 2006; 114(18): 1901 - 1904.
[Full Text] [PDF]


Home page
Circ. Res.Home page
S. Lehoux and B. I. Levy
Collateral Artery Growth: Making the Most of What You Have
Circ. Res., September 15, 2006; 99(6): 567 - 569.
[Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
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IL-20 and Atherosclerosis: Another Brick In the Wall.
Arterioscler. Thromb. Vasc. Biol., September 1, 2006; 26(9): 1929 - 1930.
[Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
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Role of Bone Marrow-Derived CC-Chemokine Receptor 5 in the Development of Atherosclerosis of Low-Density Lipoprotein Receptor Knockout Mice
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