| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Cell Differentiation Unit, Vrije Universiteit Brussel-Free University of Brussels, Brussels, Belgium
Beta-cell mass regulation represents a critical issue for understanding diabetes, a disease characterized by a near-absolute (type 1) or relative (type 2) deficiency in the number of pancreatic beta cells. The number of islet beta cells present at birth is mainly generated by the proliferation and differentiation of pancreatic progenitor cells, a process called neogenesis. Shortly after birth, beta-cell neogenesis stops and a small proportion of cycling beta cells can still expand the cell number to compensate for increased insulin demands, albeit at a slow rate. The low capacity for self-replication in the adult is too limited to result in a significant regeneration following extensive tissue injury. Likewise, chronically increased metabolic demands can lead to beta-cell failure to compensate. Neogenesis from progenitor cells inside or outside islets represents a more potent mechanism leading to robust expansion of the beta-cell mass, but it may require external stimuli. For therapeutic purposes, advantage could be taken from the surprising differentiation plasticity of adult pancreatic cells and possibly also from stem cells. Recent studies have demonstrated that it is feasible to regenerate and expand the beta-cell mass by the application of hormones and growth factors like glucagon-like peptide-1, gastrin, epidermal growth factor, and others. Treatment with these external stimuli can restore a functional beta-cell mass in diabetic animals, but further studies are required before it can be applied to humans.
This article has been cited by other articles:
|
|
 |
|
  S.-w. Peng, L.-y. Zhu, M. Chen, M. Zhang, D.-z. Li, Y.-c. Fu, S.-r. Chen, and C.-j. Wei Heterogeneity in Mitotic Activity and Telomere Length Implies an Important Role of Young Islets in the Maintenance of Islet Mass in the Adult Pancreas Endocrinology, July 1, 2009; 150(7): 3058 - 3066. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Z. Young and A. Bordey GABA's Control of Stem and Cancer Cell Proliferation in Adult Neural and Peripheral Niches Physiology, June 1, 2009; 24(3): 171 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Di Bella, M. Regoli, C. Nicoletti, L. Ermini, L. Fonzi, and E. Bertelli An Appraisal of Intermediate Filament Expression in Adult and Developing Pancreas: Vimentin Is Expressed in {alpha} Cells of Rat and Mouse Embryos J. Histochem. Cytochem., June 1, 2009; 57(6): 577 - 586. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-I. Tschen, S. Dhawan, T. Gurlo, and A. Bhushan Age-Dependent Decline in {beta}-Cell Proliferation Restricts the Capacity of {beta}-Cell Regeneration in Mice Diabetes, June 1, 2009; 58(6): 1312 - 1320. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Wang, J. R. Walker, X. Wang, M. S. Tremblay, J. W. Lee, X. Wu, and P. G. Schultz Identification of small-molecule inducers of pancreatic {beta}-cell expansion PNAS, February 3, 2009; 106(5): 1427 - 1432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Bottino, A. Criscimanna, A. Casu, J. He, D. J. Van der Windt, W. A. Rudert, C. Giordano, and M. Trucco Recovery of Endogenous {beta}-Cell Function in Nonhuman Primates After Chemical Diabetes Induction and Islet Transplantation Diabetes, February 1, 2009; 58(2): 442 - 447. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Padidela, M. Patterson, N. Sharief, M. Ghatei, and K. Hussain Elevated basal and post-feed glucagon-like peptide 1 (GLP-1) concentrations in the neonatal period Eur. J. Endocrinol., January 1, 2009; 160(1): 53 - 58. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zehetner, C. Danzer, S. Collins, K. Eckhardt, P. A. Gerber, P. Ballschmieter, J. Galvanovskis, K. Shimomura, F. M. Ashcroft, B. Thorens, et al. pVHL is a regulator of glucose metabolism and insulin secretion in pancreatic {beta} cells Genes & Dev., November 15, 2008; 22(22): 3135 - 3146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. B Lemke, A. B Rogers, P. R Nambiar, and J. G Fox Obesity and non-insulin-dependent diabetes mellitus in Swiss-Webster mice associated with late-onset hepatocellular carcinoma J. Endocrinol., October 1, 2008; 199(1): 21 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Mimeault and S K Batra Recent progress on normal and malignant pancreatic stem/progenitor cell research: therapeutic implications for the treatment of type 1 or 2 diabetes mellitus and aggressive pancreatic cancer Gut, October 1, 2008; 57(10): 1456 - 1468. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. E. Bates, A. Sirek, M. A. Kiraly, J. T. Y. Yue, M. C. Riddell, S. G. Matthews, and M. Vranic Adaptation to intermittent stress promotes maintenance of {beta}-cell compensation: comparison with food restriction Am J Physiol Endocrinol Metab, October 1, 2008; 295(4): E947 - E958. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Jiang, W. Nishimura, D. Devor-Henneman, D. Kusewitt, H. Wang, M. P. Holloway, T. Dohi, E. Sabo, M. L. Robinson, D. C. Altieri, et al. Postnatal Expansion of the Pancreatic {beta}-Cell Mass Is Dependent on Survivin Diabetes, October 1, 2008; 57(10): 2718 - 2727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bertolino, R. Holmberg, E. Reissmann, O. Andersson, P.-O. Berggren, and C. F. Ibanez Activin B receptor ALK7 is a negative regulator of pancreatic {beta}-cell function PNAS, May 20, 2008; 105(20): 7246 - 7251. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. D. Hardt, M. D. Brendel, H. U. Kloer, and R. G. Bretzel Is Pancreatic Diabetes (Type 3c Diabetes) Underdiagnosed and Misdiagnosed? Diabetes Care, February 1, 2008; 31(Supplement_2): S165 - S169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Mziaut, S. Kersting, K.-P. Knoch, W.-H. Fan, M. Trajkovski, K. Erdmann, H. Bergert, F. Ehehalt, H.-D. Saeger, and M. Solimena ICA512 signaling enhances pancreatic -cell proliferation by regulating cyclins D through STATs PNAS, January 15, 2008; 105(2): 674 - 679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Movassat and B. Portha Early administration of keratinocyte growth factor improves {beta}-cell regeneration in rat with streptozotocin-induced diabetes J. Endocrinol., November 1, 2007; 195(2): 333 - 340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chen, S. Turner, E. Tsang, J. Stark, H. Turner, A. Mahsut, K. Keifer, M. Goldfinger, and M. K. Hellerstein Measurement of pancreatic islet cell proliferation by heavy water labeling Am J Physiol Endocrinol Metab, November 1, 2007; 293(5): E1459 - E1464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Gleason, D. N. Gross, and M. J. Birnbaum When the usual insulin is just not enough PNAS, May 22, 2007; 104(21): 8681 - 8682. [Full Text] [PDF]
|
|
|
|
 |
|
 R. Mussmann, M. Geese, F. Harder, S. Kegel, U. Andag, A. Lomow, U. Burk, D. Onichtchouk, C. Dohrmann, and M. Austen Inhibition of GSK3 Promotes Replication and Survival of Pancreatic Beta Cells J. Biol. Chem., April 20, 2007; 282(16): 12030 - 12037. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Ahren Insulin Secretion and Insulin Sensitivity in Relation to Fasting Glucose in Healthy Subjects Diabetes Care, March 1, 2007; 30(3): 644 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Jiang, H. Zhu, X. Chen, Y. Peng, J. Wang, F. Liu, S. Shi, B. Fu, Y. Lu, Q. Hong, et al. TIMP-1 Transgenic Mice Recover From Diabetes Induced by Multiple Low-Dose Streptozotocin Diabetes, January 1, 2007; 56(1): 49 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. G. Moss and C. J. Rhodes {beta}-Cell Regeneration: Epithelial Mesenchymal Transition Pre-EMTpted by Lineage Tracing? Diabetes, January 1, 2007; 56(1): 281 - 282. [Full Text] [PDF]
|
|
|
|
|
|
P. J. Miettinen, J. Ustinov, P. Ormio, R. Gao, J. Palgi, E. Hakonen, L. Juntti-Berggren, P.-O. Berggren, and T. Otonkoski Downregulation of EGF Receptor Signaling in Pancreatic Islets Causes Diabetes Due to Impaired Postnatal {beta}-Cell Growth Diabetes, December 1, 2006; 55(12): 3299 - 3308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mimeault and S. K. Batra Concise Review: Recent Advances on the Significance of Stem Cells in Tissue Regeneration and Cancer Therapies Stem Cells, November 1, 2006; 24(11): 2319 - 2345. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
