|
|
||||||||
Institute of Pharmacology, University of Heidelberg, Heidelberg, Germany
Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple subforms of G proteins together with receptors, effectors, and various regulatory proteins represent the components of a highly versatile signal transduction system. G protein-mediated signaling is employed by virtually all cells in the mammalian organism and is centrally involved in diverse physiological functions such as perception of sensory information, modulation of synaptic transmission, hormone release and actions, regulation of cell contraction and migration, or cell growth and differentiation. In this review, some of the functions of heterotrimeric G proteins in defined cells and tissues are described.
This article has been cited by other articles:
![]() |
E. E. Icaza, X. Huang, Y. Fu, R. R. Neubig, H. A. Baghdoyan, and R. Lydic Isoflurane-Induced Changes in Righting Response and Breathing Are Modulated by RGS Proteins Anesth. Analg., November 1, 2009; 109(5): 1500 - 1505. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Albarran-Juarez, R. Gilsbach, R. P. Piekorz, K. Pexa, N. Beetz, J. Schneider, B. Nurnberg, and L. Hein Modulation of {alpha}2-Adrenoceptor Functions by Heterotrimeric G{alpha}i Protein Isoforms J. Pharmacol. Exp. Ther., October 1, 2009; 331(1): 35 - 44. [Abstract] [Full Text] [PDF] |
||||
![]() |
H.-J. Hippe, N. M. Wolf, I. Abu-Taha, R. Mehringer, S. Just, S. Lutz, F. Niroomand, E. H. Postel, H. A. Katus, W. Rottbauer, et al. The interaction of nucleoside diphosphate kinase B with G{beta}{gamma} dimers controls heterotrimeric G protein function PNAS, September 22, 2009; 106(38): 16269 - 16274. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. M. Pilowsky, M. S. Y. Lung, D. Spirovski, and S. McMullan Differential regulation of the central neural cardiorespiratory system by metabotropic neurotransmitters Phil Trans R Soc B, September 12, 2009; 364(1529): 2537 - 2552. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. L. Aistrup, R. Villuendas, J. Ng, A. Gilchrist, T. W. Lynch, D. Gordon, I. Cokic, S. Mottl, R. Zhou, D. A. Dean, et al. Targeted G-protein inhibition as a novel approach to decrease vagal atrial fibrillation by selective parasympathetic attenuation Cardiovasc Res, August 1, 2009; 83(3): 481 - 492. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. C. Howlett, A. J. Gray, J. M. Hunter, and B. M. Willardson Role of Molecular Chaperones in G Protein {beta}5/Regulator of G Protein Signaling Dimer Assembly and G Protein {beta}{gamma} Dimer Specificity J. Biol. Chem., June 12, 2009; 284(24): 16386 - 16399. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Wang, Z. Gu, B. Heid, R. M. Akers, and H. Jiang Identification and characterization of the bovine G protein-coupled receptor GPR41 and GPR43 genes J Dairy Sci, June 1, 2009; 92(6): 2696 - 2705. [Abstract] [Full Text] [PDF] |
||||
![]() |
J.-P. Vilardaga, M. Bunemann, T. N. Feinstein, N. Lambert, V. O. Nikolaev, S. Engelhardt, M. J. Lohse, and C. Hoffmann Minireview: GPCR and G Proteins: Drug Efficacy and Activation in Live Cells Mol. Endocrinol., May 1, 2009; 23(5): 590 - 599. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Y. Xu, J. Porte, A. J. Knox, P. H. Weinreb, T. M. Maher, S. M. Violette, R. J. McAnulty, D. Sheppard, and G. Jenkins Lysophosphatidic Acid Induces {alpha}v{beta}6 Integrin-Mediated TGF-{beta} Activation via the LPA2 Receptor and the Small G Protein G{alpha}q Am. J. Pathol., April 1, 2009; 174(4): 1264 - 1279. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Klumpp and J. Krieglstein Reversible Phosphorylation of Histidine Residues in Proteins from Vertebrates Sci. Signal., March 10, 2009; 2(61): pe13 - pe13. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Korhonen, B. Fisslthaler, A. Moers, A. Wirth, D. Habermehl, T. Wieland, G. Schutz, N. Wettschureck, I. Fleming, and S. Offermanns Anaphylactic shock depends on endothelial Gq/G11 J. Exp. Med., February 16, 2009; 206(2): 411 - 420. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Oka, L. R. Saraiva, Y. Y. Kwan, and S. I. Korsching The fifth class of G{alpha} proteins PNAS, February 3, 2009; 106(5): 1484 - 1489. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. S. Willard, Z. Zheng, J. Guo, G. J. Digby, A. J. Kimple, J. M. Conley, C. A. Johnston, D. Bosch, M. D. Willard, V. J. Watts, et al. A Point Mutation to G{alpha}i Selectively Blocks GoLoco Motif Binding: DIRECT EVIDENCE FOR G{alpha}{middle dot}GoLoco COMPLEXES IN MITOTIC SPINDLE DYNAMICS J. Biol. Chem., December 26, 2008; 283(52): 36698 - 36710. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Rosskopf and M. C. Michel Pharmacogenomics of G Protein-Coupled Receptor Ligands in Cardiovascular Medicine Pharmacol. Rev., December 1, 2008; 60(4): 513 - 535. [Abstract] [Full Text] [PDF] |
||||
![]() |
Z. Zuberi, L. Birnbaumer, and A. Tinker The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2008; 295(6): R1822 - R1830. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Weinmeister, R. Lukowski, S. Linder, C. Traidl-Hoffmann, L. Hengst, F. Hofmann, and R. Feil Cyclic Guanosine Monophosphate-dependent Protein Kinase I Promotes Adhesion of Primary Vascular Smooth Muscle Cells Mol. Biol. Cell, October 1, 2008; 19(10): 4434 - 4441. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Noubade, R. del Rio, B. McElvany, J. F. Zachary, J. M. Millward, D. D. Wagner, H. Offner, E. P. Blankenhorn, and C. Teuscher Von-Willebrand Factor Influences Blood Brain Barrier Permeability and Brain Inflammation in Experimental Allergic Encephalomyelitis Am. J. Pathol., September 1, 2008; 173(3): 892 - 900. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Krechowec and A. Plagge Physiological Dysfunctions Associated with Mutations of the Imprinted Gnas Locus Physiology, August 1, 2008; 23(4): 221 - 229. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Trusov, W. Zhang, S. M. Assmann, and J. R. Botella G{gamma}1 + G{gamma}2 != G{beta}: Heterotrimeric G Protein G{gamma}-Deficient Mutants Do Not Recapitulate All Phenotypes of G{beta}-Deficient Mutants Plant Physiology, June 1, 2008; 147(2): 636 - 649. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Tokudome, I. Kishimoto, T. Horio, Y. Arai, D. O. Schwenke, J. Hino, I. Okano, Y. Kawano, M. Kohno, M. Miyazato, et al. Regulator of G-Protein Signaling Subtype 4 Mediates Antihypertrophic Effect of Locally Secreted Natriuretic Peptides in the Heart Circulation, May 6, 2008; 117(18): 2329 - 2339. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Soundararajan, F. S. Willard, A. J. Kimple, A. P. Turnbull, L. J. Ball, G. A. Schoch, C. Gileadi, O. Y. Fedorov, E. F. Dowler, V. A. Higman, et al. Structural diversity in the RGS domain and its interaction with heterotrimeric G protein {alpha}-subunits PNAS, April 29, 2008; 105(17): 6457 - 6462. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. R. DeGeorge Jr, E. Gao, M. Boucher, L. E. Vinge, J. S. Martini, P. W. Raake, J. K. Chuprun, D. M. Harris, G. W. Kim, S. Soltys, et al. Targeted Inhibition of Cardiomyocyte Gi Signaling Enhances Susceptibility to Apoptotic Cell Death in Response to Ischemic Stress Circulation, March 18, 2008; 117(11): 1378 - 1387. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Zhu, A. A. Gach, G. Liu, X. Xu, C. C. Lim, J. X. Zhang, L. Mao, K. Chuprun, W. J. Koch, R. Liao, et al. Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G{alpha}o* protein Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1335 - H1347. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. R. Zurita and L. Birnbaumer The same mutation in Gs{alpha} and transducin {alpha} reveals behavioral differences between these highly homologous G protein {alpha}-subunits PNAS, February 19, 2008; 105(7): 2363 - 2368. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Koontz, M. Bralic, J. Tomac, E. Pernjak-Pugel, G. Bantug, S. Jonjic, and W. J. Britt Altered development of the brain after focal herpesvirus infection of the central nervous system J. Exp. Med., February 18, 2008; 205(2): 423 - 435. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Plagge, G. Kelsey, and E. L Germain-Lee Physiological functions of the imprinted Gnas locus and its protein variants G{alpha}s and XL{alpha}s in human and mouse J. Endocrinol., February 1, 2008; 196(2): 193 - 214. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. LaCroix, J. Freeling, A. Giles, J. Wess, and Y.-F. Li Deficiency of M2 muscarinic acetylcholine receptors increases susceptibility of ventricular function to chronic adrenergic stress Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H810 - H820. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Zarbock and K. Ley Mechanisms and Consequences of Neutrophil Interaction with the Endothelium Am. J. Pathol., January 1, 2008; 172(1): 1 - 7. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Zarbock, T. L. Deem, T. L. Burcin, and K. Ley G{alpha}i2 is required for chemokine-induced neutrophil arrest Blood, November 15, 2007; 110(10): 3773 - 3779. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. McMullan and S. J. Nurrish Rho deep in thought Genes & Dev., November 1, 2007; 21(21): 2677 - 2682. [Full Text] [PDF] |
||||
![]() |
I. V. Ivanova, R. Schubert, D. B. Duridanova, T. B. Bolton, L. T. Lubomirov, and H. S. Gagov Heart/Cardiac Muscle: Cocaine- and amphetamine-regulated transcript (CART) peptide as an in vivo regulator of cardiac function in Rana ridibunda frog Exp Physiol, November 1, 2007; 92(6): 1037 - 1046. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Shi, S. Partida-Sanchez, R. S. Misra, M. Tighe, M. T. Borchers, J. J. Lee, M. I. Simon, and F. E. Lund Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes J. Exp. Med., October 29, 2007; 204(11): 2705 - 2718. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Willoughby and D. M. F. Cooper Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains Physiol Rev, July 1, 2007; 87(3): 965 - 1010. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Lattin, D. A. Zidar, K. Schroder, S. Kellie, D. A. Hume, and M. J. Sweet G-protein-coupled receptor expression, function, and signaling in macrophages J. Leukoc. Biol., July 1, 2007; 82(1): 16 - 32. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Thiele, R. Werner, W. Ahrens, U. Hoppe, C. Marschke, P. Staedt, and O. Hiort A Disruptive Mutation in Exon 3 of the GNAS Gene with Albright Hereditary Osteodystrophy, Normocalcemic Pseudohypoparathyroidism, and Selective Long Transcript Variant Gs{alpha}-L Deficiency J. Clin. Endocrinol. Metab., May 1, 2007; 92(5): 1764 - 1768. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Voss, J. N. McLaughlin, M. Holinstat, R. Zent, and H. E. Hamm PAR1, but Not PAR4, Activates Human Platelets through a Gi/o/Phosphoinositide-3 Kinase Signaling Axis Mol. Pharmacol., May 1, 2007; 71(5): 1399 - 1406. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Engelhardt and F. Rochais G Proteins: More Than Transducers of Receptor-Generated Signals? Circ. Res., April 27, 2007; 100(8): 1109 - 1111. [Full Text] [PDF] |
||||
![]() |
H.-J. Hippe, M. Luedde, S. Lutz, H. Koehler, T. Eschenhagen, N. Frey, H. A. Katus, T. Wieland, and F. Niroomand Regulation of Cardiac cAMP Synthesis and Contractility by Nucleoside Diphosphate Kinase B/G Protein {beta}{gamma} Dimer Complexes Circ. Res., April 27, 2007; 100(8): 1191 - 1199. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. Torrecilla, E. J. Spragg, B. Poulin, P. J. McWilliams, S. C. Mistry, A. Blaukat, and A. B. Tobin Phosphorylation and regulation of a G protein-coupled receptor by protein kinase CK2 J. Cell Biol., April 9, 2007; 177(1): 127 - 137. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. S. Pero, M. T. Borchers, K. Spicher, S. I. Ochkur, L. Sikora, S. P. Rao, H. Abdala-Valencia, K. R. O'Neill, H. Shen, M. P. McGarry, et al. G{alpha}i2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation PNAS, March 13, 2007; 104(11): 4371 - 4376. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. L. Matsumoto, K. Narzinski, G. V. Nikiforovich, and T. J. Baranski A Comprehensive Structure-Function Map of the Intracellular Surface of the Human C5a Receptor: II. ELUCIDATION OF G PROTEIN SPECIFICITY DETERMINANTS J. Biol. Chem., February 2, 2007; 282(5): 3122 - 3133. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Antl, M.-L. von Bruhl, C. Eiglsperger, M. Werner, I. Konrad, T. Kocher, M. Wilm, F. Hofmann, S. Massberg, and J. Schlossmann IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation Blood, January 15, 2007; 109(2): 552 - 559. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Ghil, J.-M. Choi, S.-S. Kim, Y.-D. Lee, Y. Liao, L. Birnbaumer, and H. Suh-Kim Compartmentalization of protein kinase A signaling by the heterotrimeric G protein Go PNAS, December 12, 2006; 103(50): 19158 - 19163. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Offermanns Activation of Platelet Function Through G Protein-Coupled Receptors Circ. Res., December 8, 2006; 99(12): 1293 - 1304. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. O. Nikolaev, C. Hoffmann, M. Bunemann, M. J. Lohse, and J.-P. Vilardaga Molecular Basis of Partial Agonism at the Neurotransmitter {alpha}2A-Adrenergic Receptor and Gi-protein Heterotrimer J. Biol. Chem., August 25, 2006; 281(34): 24506 - 24511. [Abstract] [Full Text] [PDF] |
||||
![]() |
C.-W. Lee, R. Rivera, S. Gardell, A. E. Dubin, and J. Chun GPR92 as a New G12/13- and Gq-coupled Lysophosphatidic Acid Receptor That Increases cAMP, LPA5 J. Biol. Chem., August 18, 2006; 281(33): 23589 - 23597. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |