| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio; Scuola Superiore Sant'Anna, Pisa, Italy; Department of Physiology, New York Medical College, Valhalla, New York; and Department of Pediatrics, University of Alberta, Edmonton, Canada
The alterations in myocardial energy substrate metabolism that occur in heart failure, and the causes and consequences of these abnormalities, are poorly understood. There is evidence to suggest that impaired substrate metabolism contributes to contractile dysfunction and to the progressive left ventricular remodeling that are characteristic of the heart failure state. The general concept that has recently emerged is that myocardial substrate selection is relatively normal during the early stages of heart failure; however, in the advanced stages there is a downregulation in fatty acid oxidation, increased glycolysis and glucose oxidation, reduced respiratory chain activity, and an impaired reserve for mitochondrial oxidative flux. This review discusses 1) the metabolic changes that occur in chronic heart failure, with emphasis on the mechanisms that regulate the changes in the expression of metabolic genes and the function of metabolic pathways; 2) the consequences of these metabolic changes on cardiac function; 3) the role of changes in myocardial substrate metabolism on ventricular remodeling and disease progression; and 4) the therapeutic potential of acute and long-term manipulation of cardiac substrate metabolism in heart failure.
This article has been cited by other articles:
|
|
 |
|
  S. Serpillon, B. C. Floyd, R. S. Gupte, S. George, M. Kozicky, V. Neito, F. Recchia, W. Stanley, M. S. Wolin, and S. A. Gupte Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH Am J Physiol Heart Circ Physiol, July 1, 2009; 297(1): H153 - H162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. L. Folmes, C. S. Wagg, M. Shen, A. S. Clanachan, R. Tian, and G. D. Lopaschuk Suppression of 5'-AMP-activated protein kinase activity does not impair recovery of contractile function during reperfusion of ischemic hearts Am J Physiol Heart Circ Physiol, July 1, 2009; 297(1): H313 - H321. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gladka, H. el Azzouzi, L. J. De Windt, and P. A. da Costa Martins Aquaporin 7: the glycerol aquaeductus in the heart Cardiovasc Res, July 1, 2009; 83(1): 3 - 4. [Full Text] [PDF]
|
|
|
|
|
|
M. K. Duda, K. M. O'Shea, and W. C. Stanley {omega}-3 polyunsaturated fatty acid supplementation for the treatment of heart failure: mechanisms and clinical potential Cardiovasc Res, June 20, 2009; (2009) cvp169v2. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Yan, M. E. Young, L. Cui, G. D. Lopaschuk, R. Liao, and R. Tian Increased Glucose Uptake and Oxidation in Mouse Hearts Prevent High Fatty Acid Oxidation but Cause Cardiac Dysfunction in Diet-Induced Obesity Circulation, June 2, 2009; 119(21): 2818 - 2828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Nagendran and E. D. Michelakis Mitochondrial NOS is upregulated in the hypoxic heart: implications for the function of the hypertrophied right ventricle Am J Physiol Heart Circ Physiol, June 1, 2009; 296(6): H1723 - H1726. [Full Text] [PDF]
|
|
|
|
 |
|
 B. C. Bergman, T. Tsvetkova, B. Lowes, and E. E. Wolfel Myocardial glucose and lactate metabolism during rest and atrial pacing in humans J. Physiol., May 1, 2009; 587(9): 2087 - 2099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Pellieux, C. Montessuit, I. Papageorgiou, and R. Lerch Angiotensin II downregulates the fatty acid oxidation pathway in adult rat cardiomyocytes via release of tumour necrosis factor-{alpha} Cardiovasc Res, May 1, 2009; 82(2): 341 - 350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ashrafian and S. Neubauer Metabolomic Profiling of Cardiac Substrate Utilization: Fanning the Flames of Systems Biology? Circulation, April 7, 2009; 119(13): 1700 - 1702. [Full Text] [PDF]
|
|
|
|
|
|
A. T. Turer, R. D. Stevens, J. R. Bain, M. J. Muehlbauer, J. van der Westhuizen, J. P. Mathew, D. A. Schwinn, D. D. Glower, C. B. Newgard, and M. V. Podgoreanu Metabolomic Profiling Reveals Distinct Patterns of Myocardial Substrate Use in Humans With Coronary Artery Disease or Left Ventricular Dysfunction During Surgical Ischemia/Reperfusion Circulation, April 7, 2009; 119(13): 1736 - 1746. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gnecchi, H. He, L. G. Melo, N. Noiseaux, F. Morello, R. A. de Boer, L. Zhang, R. E. Pratt, V. J. Dzau, and J. S. Ingwall Early Beneficial Effects of Bone Marrow-Derived Mesenchymal Stem Cells Overexpressing Akt on Cardiac Metabolism After Myocardial Infarction Stem Cells, April 1, 2009; 27(4): 971 - 979. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. van Bilsen, F. A. van Nieuwenhoven, and G. J. van der Vusse Metabolic remodelling of the failing heart: beneficial or detrimental? Cardiovasc Res, February 15, 2009; 81(3): 420 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Ingwall Energy metabolism in heart failure and remodelling Cardiovasc Res, February 15, 2009; 81(3): 412 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Akki and A.-M. L. Seymour Western diet impairs metabolic remodelling and contractile efficiency in cardiac hypertrophy Cardiovasc Res, February 15, 2009; 81(3): 610 - 617. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. C. Bergman, T. Tsvetkova, B. Lowes, and E. E. Wolfel Myocardial FFA metabolism during rest and atrial pacing in humans Am J Physiol Endocrinol Metab, February 1, 2009; 296(2): E358 - E366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Duda, K. M. O'Shea, A. Tintinu, W. Xu, R. J. Khairallah, B. R. Barrows, D. J. Chess, A. M. Azimzadeh, W. S. Harris, V. G. Sharov, et al. Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction Cardiovasc Res, February 1, 2009; 81(2): 319 - 327. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Wang, H. Liu, T. A. Salerno, B. Tomanek, R. Summers, R. Deslauriers, R. C. Arora, and G. Tian Alternate antegrade/retrograde perfusion: an effective technique to preserve hypertrophied hearts during valvular surgery Eur. J. Cardiothorac. Surg., January 1, 2009; 35(1): 69 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Yang, L. Yang, Z. Qu, and J. N. Weiss Glycolytic Oscillations in Isolated Rabbit Ventricular Myocytes J. Biol. Chem., December 26, 2008; 283(52): 36321 - 36327. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Palanivel, V. Vu, M. Park, X. Fang, and G. Sweeney Differential impact of adipokines derived from primary adipocytes of wild-type versus streptozotocin-induced diabetic rats on glucose and fatty acid metabolism in cardiomyocytes J. Endocrinol., December 1, 2008; 199(3): 389 - 397. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. D. Akavia and D. Benayahu Meta-analysis and profiling of cardiac expression modules Physiol Genomics, November 12, 2008; 35(3): 305 - 315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Qanud, M. Mamdani, M. Pepe, R. J. Khairallah, J. Gravel, B. Lei, S. A. Gupte, V. G. Sharov, H. N. Sabbah, W. C. Stanley, et al. Reverse changes in cardiac substrate oxidation in dogs recovering from heart failure Am J Physiol Heart Circ Physiol, November 1, 2008; 295(5): H2098 - H2105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Rosca, E. J. Vazquez, J. Kerner, W. Parland, M. P. Chandler, W. Stanley, H. N. Sabbah, and C. L. Hoppel Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation Cardiovasc Res, October 1, 2008; 80(1): 30 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sidhu, A. Gangasani, L. G. Korotchkina, G. Suzuki, J. A. Fallavollita, J. M. Canty Jr., and M. S. Patel Tissue-specific pyruvate dehydrogenase complex deficiency causes cardiac hypertrophy and sudden death of weaned male mice Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H946 - H952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Sugden PDC deletion: the way to a man's heart disease Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H917 - H919. [Full Text] [PDF]
|
|
|
|
|
|
L. Zhou, H. Huang, T. A. McElfresh, D. A. Prosdocimo, and W. C. Stanley Impact of anaerobic glycolysis and oxidative substrate selection on contractile function and mechanical efficiency during moderate severity ischemia Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H939 - H945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Wu, E. Y. Zhang, J. Zhang, R. J. Bache, and D. A. Beard Phosphate metabolite concentrations and ATP hydrolysis potential in normal and ischaemic hearts J. Physiol., September 1, 2008; 586(17): 4193 - 4208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Schroeder, L. E. Cochlin, L. C. Heather, K. Clarke, G. K. Radda, and D. J. Tyler In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance PNAS, August 19, 2008; 105(33): 12051 - 12056. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. F. Soto, P. Herrero, K. B. Schechtman, A. D. Waggoner, J. M. Baumstark, A. A. Ehsani, and R. J. Gropler Exercise training impacts the myocardial metabolism of older individuals in a gender-specific manner Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H842 - H850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Rennison, T. A. McElfresh, I. C. Okere, H. V. Patel, A. B. Foster, K. K. Patel, M. S. Stoll, P. E. Minkler, H. Fujioka, B. D. Hoit, et al. Enhanced acyl-CoA dehydrogenase activity is associated with improved mitochondrial and contractile function in heart failure Cardiovasc Res, July 15, 2008; 79(2): 331 - 340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Chess and W. C. Stanley Role of diet and fuel overabundance in the development and progression of heart failure Cardiovasc Res, July 15, 2008; 79(2): 269 - 278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Bertrand, S. Horman, C. Beauloye, and J.-L. Vanoverschelde Insulin signalling in the heart Cardiovasc Res, July 15, 2008; 79(2): 238 - 248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Schwenk, J. J.F.P. Luiken, A. Bonen, and J. F.C. Glatz Regulation of sarcolemmal glucose and fatty acid transporters in cardiac disease Cardiovasc Res, July 15, 2008; 79(2): 249 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Ussher and G. D. Lopaschuk The malonyl CoA axis as a potential target for treating ischaemic heart disease Cardiovasc Res, July 15, 2008; 79(2): 259 - 268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Lopaschuk and D. P. Kelly Signalling in cardiac metabolism Cardiovasc Res, July 15, 2008; 79(2): 205 - 207. [Full Text] [PDF]
|
|
|
|
 |
|
 J. Nagendran, V. Gurtu, D. Z. Fu, J. R.B. Dyck, A. Haromy, D. B. Ross, I. M. Rebeyka, and E. D. Michelakis A dynamic and chamber-specific mitochondrial remodeling in right ventricular hypertrophy can be therapeutically targeted J. Thorac. Cardiovasc. Surg., July 1, 2008; 136(1): 168 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tominaga, H. Katoh, K. Odagiri, Y. Takeuchi, H. Kawashima, M. Saotome, T. Urushida, H. Satoh, and H. Hayashi Different effects of palmitoyl-L-carnitine and palmitoyl-CoA on mitochondrial function in rat ventricular myocytes Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H105 - H112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Mazzatti, M. A. Smith, R. C. Oita, F.-L. Lim, A. J. White, and M. B. Reid Muscle unloading-induced metabolic remodeling is associated with acute alterations in PPAR{delta} and UCP-3 expression Physiol Genomics, July 1, 2008; 34(2): 149 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gandhi, B. A. Finegan, and A. S. Clanachan Role of glucose metabolism in the recovery of postischemic LV mechanical function: effects of insulin and other metabolic modulators Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2576 - H2586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Wang, R. V. Donthi, J. Wang, A. J. Lange, L. J. Watson, S. P. Jones, and P. N. Epstein Cardiac phosphatase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase increases glycolysis, hypertrophy, and myocyte resistance to hypoxia Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2889 - H2897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Khairallah, R. J. Khairallah, M. E. Young, B. G. Allen, M. A. Gillis, G. Danialou, C. F. Deschepper, B. J. Petrof, and C. Des Rosiers Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiency PNAS, May 13, 2008; 105(19): 7028 - 7033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Doenst, H. Bugger, M. Schwarzer, G. Faerber, M. A. Borger, and F. W. Mohr Three good reasons for heart surgeons to understand cardiac metabolism Eur. J. Cardiothorac. Surg., May 1, 2008; 33(5): 862 - 871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Gelinas, F. Labarthe, B. Bouchard, J. Mc Duff, G. Charron, M. E. Young, and C. Des Rosiers Alterations in carbohydrate metabolism and its regulation in PPAR{alpha} null mouse hearts Am J Physiol Heart Circ Physiol, April 1, 2008; 294(4): H1571 - H1580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Omar, H. Fraser, and A. S. Clanachan Ischemia-induced activation of AMPK does not increase glucose uptake in glycogen-replete isolated working rat hearts Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1266 - H1273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Dobrzyn, H. Sampath, A. Dobrzyn, M. Miyazaki, and J. M. Ntambi Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart Am J Physiol Endocrinol Metab, February 1, 2008; 294(2): E357 - E364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhou, H. Huang, C. L. Yuan, W. Keung, G. D. Lopaschuk, and W. C. Stanley Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H954 - H960. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Philip-Couderc, N. I. Tavares, A. Roatti, R. Lerch, C. Montessuit, and A. J. Baertschi Forkhead Transcription Factors Coordinate Expression of Myocardial KATP Channel Subunits and Energy Metabolism Circ. Res., February 1, 2008; 102(2): e20 - e35. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Sironi, A. Pingitore, S. Ghione, D. De Marchi, B. Scattini, V. Positano, E. Muscelli, D. Ciociaro, M. Lombardi, E. Ferrannini, et al. Early Hypertension Is Associated With Reduced Regional Cardiac Function, Insulin Resistance, Epicardial, and Visceral Fat Hypertension, February 1, 2008; 51(2): 282 - 288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. George Sarcoplasmic reticulum Ca2+ leak in heart failure: mere observation or functional relevance? Cardiovasc Res, January 15, 2008; 77(2): 302 - 314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Fliegner, D. Westermann, A. Riad, C. Schubert, E. Becher, J. Fielitz, C. Tschope, and V. Regitz-Zagrosek Up-regulation of PPAR{gamma} in myocardial infarction Eur J Heart Fail, January 1, 2008; 10(1): 30 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Herrero, C. S. Dence, A. R. Coggan, Z. Kisrieva-Ware, P. Eisenbeis, and R. J. Gropler L-3-11C-Lactate as a PET Tracer of Myocardial Lactate Metabolism: A Feasibility Study J. Nucl. Med., December 1, 2007; 48(12): 2046 - 2055. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. W. van der Meer, S. Hammer, J. W.A. Smit, M. Frolich, J. J. Bax, M. Diamant, L. J. Rijzewijk, A. de Roos, J. A. Romijn, and H. J. Lamb Short-Term Caloric Restriction Induces Accumulation of Myocardial Triglycerides and Decreases Left Ventricular Diastolic Function in Healthy Subjects Diabetes, December 1, 2007; 56(12): 2849 - 2853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Saito, D. Fujioka, K.-i. Kawabata, T. Kobayashi, T. Yano, T. Nakamura, Y. Kodama, H. Takano, Y. Kitta, J.-e. Obata, et al. Statin reverses reduction of adiponectin receptor expression in infarcted heart and in TNF-{alpha}-treated cardiomyocytes in association with improved glucose uptake Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3490 - H3497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Neglia, A. De Caterina, P. Marraccini, A. Natali, M. Ciardetti, C. Vecoli, A. Gastaldelli, D. Ciociaro, P. Pellegrini, R. Testa, et al. Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3270 - H3278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P.Y. Koonen, M. Febbraio, S. Bonnet, J. Nagendran, M. E. Young, E. D. Michelakis, and J. R.B. Dyck CD36 Expression Contributes to Age-Induced Cardiomyopathy in Mice Circulation, November 6, 2007; 116(19): 2139 - 2147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Pilz, H. Scharnagl, B. Tiran, B. Wellnitz, U. Seelhorst, B. O. Boehm, and W. Marz Elevated plasma free fatty acids predict sudden cardiac death: a 6.85-year follow-up of 3315 patients after coronary angiography Eur. Heart J., November 2, 2007; 28(22): 2763 - 2769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Mozaffarian Free fatty acids, cardiovascular mortality, and cardiometabolic stress Eur. Heart J., November 2, 2007; 28(22): 2699 - 2700. [Full Text] [PDF]
|
|
|
|
|
|
M. F. Essop Cardiac metabolic adaptations in response to chronic hypoxia J. Physiol., November 1, 2007; 584(3): 715 - 726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Lionetti, L. Guiducci, A. Simioniuc, G. D. Aquaro, C. Simi, D. De Marchi, S. Burchielli, L. Pratali, M. Piacenti, M. Lombardi, et al. Mismatch between uniform increase in cardiac glucose uptake and regional contractile dysfunction in pacing-induced heart failure Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2747 - H2756. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Duda, K. M. O'Shea, B. Lei, B. R. Barrows, A. M. Azimzadeh, T. E. McElfresh, B. D. Hoit, W. J. Kop, and W. C. Stanley Dietary supplementation with {omega}-3 PUFA increases adiponectin and attenuates ventricular remodeling and dysfunction with pressure overload Cardiovasc Res, November 1, 2007; 76(2): 303 - 310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Chen, C. De Diego, L.-H. Xie, J.-H. Yang, T. S Klitzner, and J. N Weiss Effects of metabolic inhibition on conduction, Ca transients, and arrhythmia vulnerability in embryonic mouse hearts Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2472 - H2478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. McGavock, I. Lingvay, I. Zib, T. Tillery, N. Salas, R. Unger, B. D. Levine, P. Raskin, R. G. Victor, and L. S. Szczepaniak Cardiac Steatosis in Diabetes Mellitus: A 1H-Magnetic Resonance Spectroscopy Study Circulation, September 4, 2007; 116(10): 1170 - 1175. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Lucchinetti, J. Aguirre, J. Feng, M. Zhu, M. Suter, D. R. Spahn, L. Harter, and M. Zaugg Molecular Evidence of Late Preconditioning After Sevoflurane Inhalation in Healthy Volunteers Anesth. Analg., September 1, 2007; 105(3): 629 - 640. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Chess, B. Lei, B. D. Hoit, A. M. Azimzadeh, and W. C. Stanley Deleterious effects of sugar and protective effects of starch on cardiac remodeling, contractile dysfunction, and mortality in response to pressure overload Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1853 - H1860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Takahashi, T. Asai, H. Murakami, R. Murakami, M. Tsuzuki, Y. Numaguchi, H. Matsui, T. Murohara, and K. Okumura Pressure Overload-Induced Cardiomyopathy in Heterozygous Carrier Mice of Carnitine Transporter Gene Mutation Hypertension, September 1, 2007; 50(3): 497 - 502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ashrafian, M. P. Frenneaux, and L. H. Opie Metabolic Mechanisms in Heart Failure Circulation, July 24, 2007; 116(4): 434 - 448. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. C. Sparagna, A. J. Chicco, R. C. Murphy, M. R. Bristow, C. A. Johnson, M. L. Rees, M. L. Maxey, S. A. McCune, and R. L. Moore Loss of cardiac tetralinoleoyl cardiolipin in human and experimental heart failure J. Lipid Res., July 1, 2007; 48(7): 1559 - 1570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. King, M. E. Young, J. Kerner, H. Huang, K. M. O'Shea, S. E. H. Alexson, C. L. Hoppel, and W. C. Stanley Diabetes or peroxisome proliferator-activated receptor {alpha} agonist increases mitochondrial thioesterase I activity in heart J. Lipid Res., July 1, 2007; 48(7): 1511 - 1517. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Palanivel, X. Fang, M. Park, M. Eguchi, S. Pallan, S. De Girolamo, Y. Liu, Y. Wang, A. Xu, and G. Sweeney Globular and full-length forms of adiponectin mediate specific changes in glucose and fatty acid uptake and metabolism in cardiomyocytes Cardiovasc Res, July 1, 2007; 75(1): 148 - 157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Wang, H. Liu, T. A. Salerno, B. Xiang, G. Li, M. Gruwel, M. Jackson, D. Manley, B. Tomanek, R. Deslauriers, et al. Does Normothermic Normokalemic Simultaneous Antegrade/Retrograde Perfusion Improve Myocardial Oxygenation and Energy Metabolism for Hypertrophied Hearts? Ann. Thorac. Surg., May 1, 2007; 83(5): 1751 - 1758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yang, N. Sambandam, X. Han, R. W. Gross, M. Courtois, A. Kovacs, M. Febbraio, B. N. Finck, and D. P. Kelly CD36 Deficiency Rescues Lipotoxic Cardiomyopathy Circ. Res., April 27, 2007; 100(8): 1208 - 1217. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Labinskyy, M. Bellomo, M. P. Chandler, M. E. Young, V. Lionetti, K. Qanud, F. Bigazzi, T. Sampietro, W. C. Stanley, and F. A. Recchia Chronic Activation of Peroxisome Proliferator-Activated Receptor-{alpha} with Fenofibrate Prevents Alterations in Cardiac Metabolic Phenotype without Changing the Onset of Decompensation in Pacing-Induced Heart Failure J. Pharmacol. Exp. Ther., April 1, 2007; 321(1): 165 - 171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Fauconnier, D. C. Andersson, S.-J. Zhang, J. T. Lanner, R. Wibom, A. Katz, J. D. Bruton, and H. Westerblad Effects of Palmitate on Ca2+ Handling in Adult Control and ob/ob Cardiomyocytes: Impact of Mitochondrial Reactive Oxygen Species Diabetes, April 1, 2007; 56(4): 1136 - 1142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. B. Davey, P. B. Garlick, A. Warley, and R. Southworth Immunogold labeling study of the distribution of GLUT-1 and GLUT-4 in cardiac tissue following stimulation by insulin or ischemia Am J Physiol Heart Circ Physiol, April 1, 2007; 292(4): H2009 - H2019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ashrafian and H. Watkins Reviews of Translational Medicine and Genomics in Cardiovascular Disease: New Disease Taxonomy and Therapeutic Implications: Cardiomyopathies: Therapeutics Based on Molecular Phenotype J. Am. Coll. Cardiol., March 27, 2007; 49(12): 1251 - 1264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Neubauer The Failing Heart -- An Engine Out of Fuel N. Engl. J. Med., March 15, 2007; 356(11): 1140 - 1151. [Full Text] [PDF]
|
|
|
|
|
|
L. Zhou, M. E. Cabrera, H. Huang, C. L. Yuan, D. K. Monika, N. Sharma, F. Bian, and W. C. Stanley Parallel activation of mitochondrial oxidative metabolism with increased cardiac energy expenditure is not dependent on fatty acid oxidation in pigs J. Physiol., March 15, 2007; 579(3): 811 - 821. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Rennison, T. A. McElfresh, I. C. Okere, E. J. Vazquez, H. V. Patel, A. B. Foster, K. K. Patel, Q. Chen, B. D. Hoit, K.-Y. Tserng, et al. High-fat diet postinfarction enhances mitochondrial function and does not exacerbate left ventricular dysfunction Am J Physiol Heart Circ Physiol, March 1, 2007; 292(3): H1498 - H1506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sharma, I. C. Okere, M. K. Duda, D. J. Chess, K. M. O'Shea, and W. C. Stanley Potential impact of carbohydrate and fat intake on pathological left ventricular hypertrophy Cardiovasc Res, January 15, 2007; 73(2): 257 - 268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D.L. Folmes and G. D. Lopaschuk Role of malonyl-CoA in heart disease and the hypothalamic control of obesity Cardiovasc Res, January 15, 2007; 73(2): 278 - 287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Satrustegui, B. Pardo, and A. del Arco Mitochondrial Transporters as Novel Targets for Intracellular Calcium Signaling Physiol Rev, January 1, 2007; 87(1): 29 - 67. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Southworth, K. A. B. Davey, A. Warley, and P. B. Garlick A reevaluation of the roles of hexokinase I and II in the heart Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H378 - H386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Shiojima and K. Walsh Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway Genes & Dev., December 15, 2006; 20(24): 3347 - 3365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Saks, R. Favier, R. Guzun, U. Schlattner, and T. Wallimann Molecular system bioenergetics: regulation of substrate supply in response to heart energy demands J. Physiol., December 15, 2006; 577(3): 769 - 777. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
