| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Physiology, University of Oxford, Oxford, United Kingdom; and National Institute of Environmental Health Sciences-NIH, Research Triangle Park, North Carolina
In electrically nonexcitable cells, Ca2+ influx is essential for regulating a host of kinetically distinct processes involving exocytosis, enzyme control, gene regulation, cell growth and proliferation, and apoptosis. The major Ca2+ entry pathway in these cells is the store-operated one, in which the emptying of intracellular Ca2+ stores activates Ca2+ influx (store-operated Ca2+ entry, or capacitative Ca2+ entry). Several biophysically distinct store-operated currents have been reported, but the best characterized is the Ca2+ release-activated Ca2+ current, ICRAC. Although it was initially considered to function only in nonexcitable cells, growing evidence now points towards a central role for ICRAC-like currents in excitable cells too. In spite of intense research, the signal that relays the store Ca2+ content to CRAC channels in the plasma membrane, as well as the molecular identity of the Ca2+ sensor within the stores, remains elusive. Resolution of these issues would be greatly helped by the identification of the CRAC channel gene. In some systems, evidence suggests that store-operated channels might be related to TRP homologs, although no consensus has yet been reached. Better understood are mechanisms that inactivate store-operated entry and hence control the overall duration of Ca2+ entry. Recent work has revealed a central role for mitochondria in the regulation of ICRAC, and this is particularly prominent under physiological conditions. ICRAC therefore represents a dynamic interplay between endoplasmic reticulum, mitochondria, and plasma membrane. In this review, we describe the key electrophysiological features of ICRAC and other store-operated Ca2+ currents and how they are regulated, and we consider recent advances that have shed insight into the molecular mechanisms involved in this ubiquitous and vital Ca2+ entry pathway.
This article has been cited by other articles:
|
|
 |
|
  I. Lajdova, V. Spustova, A. Oksa, A. Chorvatova, D. Chorvat Jr, and R. Dzurik Intracellular calcium homeostasis in patients with early stagesof chronic kidney disease: effects of vitamin D3 supplementation Nephrol. Dial. Transplant., November 1, 2009; 24(11): 3376 - 3381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Baryshnikov, M. V. Pulina, A. Zulian, C. I. Linde, and V. A. Golovina Orai1, a critical component of store-operated Ca2+ entry, is functionally associated with Na+/Ca2+ exchanger and plasma membrane Ca2+ pump in proliferating human arterial myocytes Am J Physiol Cell Physiol, November 1, 2009; 297(5): C1103 - C1112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Berna-Erro, A. Braun, R. Kraft, C. Kleinschnitz, M. K. Schuhmann, D. Stegner, T. Wultsch, J. Eilers, S. G. Meuth, G. Stoll, et al. STIM2 Regulates Capacitive Ca2+ Entry in Neurons and Plays a Key Role in Hypoxic Neuronal Cell Death Sci. Signal., October 20, 2009; 2(93): ra67 - ra67. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Yu, L. Sun, and K. Machaca Orai1 internalization and STIM1 clustering inhibition modulate SOCE inactivation during meiosis PNAS, October 13, 2009; 106(41): 17401 - 17406. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Brini and E. Carafoli Calcium Pumps in Health and Disease Physiol Rev, October 1, 2009; 89(4): 1341 - 1378. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-W. Ng, C. Nelson, and A. B. Parekh Coupling of Ca2+ Microdomains to Spatially and Temporally Distinct Cellular Responses by the Tyrosine Kinase Syk J. Biol. Chem., September 11, 2009; 284(37): 24767 - 24772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Derler, M. Fahrner, M. Muik, B. Lackner, R. Schindl, K. Groschner, and C. Romanin A Ca2+ Release-activated Ca2+ (CRAC) Modulatory Domain (CMD) within STIM1 Mediates Fast Ca2+-dependent Inactivation of ORAI1 Channels J. Biol. Chem., September 11, 2009; 284(37): 24933 - 24938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. M. Mullins, C. Y. Park, R. E. Dolmetsch, and R. S. Lewis STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels PNAS, September 8, 2009; 106(36): 15495 - 15500. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Milenkovic, I. Rinke, M. Witte, B. Dietz, and R. Rubsamen P2 Receptor-Mediated Signaling in Spherical Bushy Cells of the Mammalian Cochlear Nucleus J Neurophysiol, September 1, 2009; 102(3): 1821 - 1833. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Rhodes, S. L. Russell, C. D. Illingworth, G. Duncan, and I. M. Wormstone Regional Differences in Store-Operated Ca2+ Entry in the Epithelium of the Intact Human Lens Invest. Ophthalmol. Vis. Sci., September 1, 2009; 50(9): 4330 - 4336. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Costello, F. Michelangeli, K. Nash, L. Lefievre, J. Morris, G. Machado-Oliveira, C. Barratt, J. Kirkman-Brown, and S. Publicover Ca2+-stores in sperm: their identities and functions Reproduction, September 1, 2009; 138(3): 425 - 437. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Di Sabatino, L. Rovedatti, R. Kaur, J. P. Spencer, J. T. Brown, V. D. Morisset, P. Biancheri, N. A. B. Leakey, J. I. Wilde, L. Scott, et al. Targeting Gut T Cell Ca2+ Release-Activated Ca2+ Channels Inhibits T Cell Cytokine Production and T-Box Transcription Factor T-Bet in Inflammatory Bowel Disease J. Immunol., September 1, 2009; 183(5): 3454 - 3462. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Mignen, J. L. Thompson, and T. J. Shuttleworth The molecular architecture of the arachidonate-regulated Ca2+-selective ARC channel is a pentameric assembly of Orai1 and Orai3 subunits J. Physiol., September 1, 2009; 587(17): 4181 - 4197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. P. Lee, J. P. Yuan, W. Zeng, I. So, P. F. Worley, and S. Muallem Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels PNAS, August 25, 2009; 106(34): 14687 - 14692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Deng, Y. Wang, Y. Zhou, J. Soboloff, and D. L. Gill STIM and Orai: Dynamic Intermembrane Coupling to Control Cellular Calcium Signals J. Biol. Chem., August 21, 2009; 284(34): 22501 - 22505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Frischauf, M. Muik, I. Derler, J. Bergsmann, M. Fahrner, R. Schindl, K. Groschner, and C. Romanin Molecular Determinants of the Coupling between STIM1 and Orai Channels: DIFFERENTIAL ACTIVATION OF Orai1-3 CHANNELS BY A STIM1 COILED-COIL MUTANT J. Biol. Chem., August 7, 2009; 284(32): 21696 - 21706. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Potier, J. C. Gonzalez, R. K. Motiani, I. F. Abdullaev, J. M. Bisaillon, H. A. Singer, and M. Trebak Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration FASEB J, August 1, 2009; 23(8): 2425 - 2437. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T.-Y. Chiu, H.-C. Teng, P.-C. Huang, F.-J. Kao, and D.-M. Yang Dominant Role of Orai1 with STIM1 on the Cytosolic Entry and Cytotoxicity of Lead Ions Toxicol. Sci., August 1, 2009; 110(2): 353 - 362. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. L. Jernigan, M. L. Paffett, B. R. Walker, and T. C. Resta ASIC1 contributes to pulmonary vascular smooth muscle store-operated Ca2+ entry Am J Physiol Lung Cell Mol Physiol, August 1, 2009; 297(2): L271 - L285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Korzeniowski, M. A. Popovic, Z. Szentpetery, P. Varnai, S. S. Stojilkovic, and T. Balla Dependence of STIM1/Orai1-mediated Calcium Entry on Plasma Membrane Phosphoinositides J. Biol. Chem., July 31, 2009; 284(31): 21027 - 21035. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Lu, J. Wang, G. Peng, L. A. Shimoda, and J. T. Sylvester Knockdown of stromal interaction molecule 1 attenuates store-operated Ca2+ entry and Ca2+ responses to acute hypoxia in pulmonary arterial smooth muscle Am J Physiol Lung Cell Mol Physiol, July 1, 2009; 297(1): L17 - L25. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Wang, Y. Zhang, W. G. Wier, X. Yu, M. Zhao, H. Hu, L. Sun, X. He, Y. Wang, B. Wang, et al. Role of store-operated Ca2+ entry in adenosine-induced vasodilatation of rat small mesenteric artery Am J Physiol Heart Circ Physiol, July 1, 2009; 297(1): H347 - H354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Derler, M. Fahrner, O. Carugo, M. Muik, J. Bergsmann, R. Schindl, I. Frischauf, S. Eshaghi, and C. Romanin Increased Hydrophobicity at the N Terminus/Membrane Interface Impairs Gating of the Severe Combined Immunodeficiency-related ORAI1 Mutant J. Biol. Chem., June 5, 2009; 284(23): 15903 - 15915. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sours-Brothers, M. Ding, S. Graham, and R. Ma Interaction Between TRPC1/TRPC4 Assembly and STIM1 Contributes to Store-Operated Ca2+ Entry in Mesangial Cells Experimental Biology and Medicine, June 1, 2009; 234(6): 673 - 682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Ng, M. D. McCormack, J. A. Airey, C. A. Singer, P. S. Keller, X.-M. Shen, and J. R. Hume TRPC1 and STIM1 mediate capacitative Ca2+ entry in mouse pulmonary arterial smooth muscle cells J. Physiol., June 1, 2009; 587(11): 2429 - 2442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Maruyama, T. Ogura, K. Mio, K. Kato, T. Kaneko, S. Kiyonaka, Y. Mori, and C. Sato Tetrameric Orai1 Is a Teardrop-shaped Molecule with a Long, Tapered Cytoplasmic Domain J. Biol. Chem., May 15, 2009; 284(20): 13676 - 13685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. I. DeHaven, B. F. Jones, J. G. Petranka, J. T. Smyth, T. Tomita, G. S. Bird, and J. W. Putney Jr TRPC channels function independently of STIM1 and Orai1 J. Physiol., May 15, 2009; 587(10): 2275 - 2298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Trebak STIM1/Orai1, ICRAC, and Endothelial SOC Circ. Res., May 8, 2009; 104(9): e56 - e57. [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, X. Deng, Y. Zhou, E. Hendron, S. Mancarella, M. F. Ritchie, X. D. Tang, Y. Baba, T. Kurosaki, Y. Mori, et al. STIM protein coupling in the activation of Orai channels PNAS, May 5, 2009; 106(18): 7391 - 7396. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Morita, A. Tanimura, Y. Baba, T. Kurosaki, and Y. Tojyo A Stim1-dependent, noncapacitative Ca2+-entry pathway is activated by B-cell-receptor stimulation and depletion of Ca2+ J. Cell Sci., April 15, 2009; 122(8): 1220 - 1228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Kim, W. Zeng, J. P. Yuan, D. M. Shin, P. F. Worley, and S. Muallem Native Store-operated Ca2+ Influx Requires the Channel Function of Orai1 and TRPC1 J. Biol. Chem., April 10, 2009; 284(15): 9733 - 9741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Matsuoka, K. Harada, T. Ikeda, K. Uetsuki, T. Sata, A. Warashina, and M. Inoue Ca2+ pathway involved in the refilling of store sites in rat adrenal medullary cells Am J Physiol Cell Physiol, April 1, 2009; 296(4): C889 - C899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-P. Savineau Is the translocon a crucial player of the calcium homeostasis in vascular smooth muscle cell? Am J Physiol Heart Circ Physiol, April 1, 2009; 296(4): H906 - H907. [Full Text] [PDF]
|
|
|
|
 |
|
 E. Perrier, M.-P. Fournet-Bourguignon, E. Royere, S. Molez, H. Reure, L. Lesage, W. Gosgnach, Y. Frapart, J.-L. Boucher, N. Villeneuve, et al. Effect of uncoupling endothelial nitric oxide synthase on calcium homeostasis in aged porcine endothelial cells Cardiovasc Res, April 1, 2009; 82(1): 133 - 142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Muik, M. Fahrner, I. Derler, R. Schindl, J. Bergsmann, I. Frischauf, K. Groschner, and C. Romanin A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels J. Biol. Chem., March 27, 2009; 284(13): 8421 - 8426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Allen, Z. M. Jaffer, S.-J. Park, S. Burgin, C. Hofmann, M. A. Sells, S. Chen, E. Derr-Yellin, E. G. Michels, A. McDaniel, et al. p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics Blood, March 19, 2009; 113(12): 2695 - 2705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Beyersdorf, A. Braun, T. Vogtle, D. Varga-Szabo, R. R. Galdos, S. Kissler, T. Kerkau, and B. Nieswandt STIM1-Independent T Cell Development and Effector Function In Vivo J. Immunol., March 15, 2009; 182(6): 3390 - 3397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-Y. Kwan, B. Shen, X. Ma, Y.-C. Kwok, Y. Huang, Y.-B. Man, S. Yu, and X. Yao TRPC1 Associates With BKCa Channel to Form a Signal Complex in Vascular Smooth Muscle Cells Circ. Res., March 13, 2009; 104(5): 670 - 678. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Di Capite, A. Shirley, C. Nelson, G. Bates, and A. B. Parekh Intercellular Ca2+ wave propagation involving positive feedback between CRAC channels and cysteinyl leukotrienes FASEB J, March 1, 2009; 23(3): 894 - 905. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Agrotis and C. Koulis STIM1: a new therapeutic target in occlusive vascular disease? Cardiovasc Res, March 1, 2009; 81(4): 627 - 628. [Full Text] [PDF]
|
|
|
|
|
|
C. Rosker, G. Meur, E. J. A. Taylor, and C. W. Taylor Functional Ryanodine Receptors in the Plasma Membrane of RINm5F Pancreatic {beta}-Cells J. Biol. Chem., February 20, 2009; 284(8): 5186 - 5194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Masada, A. Ciruela, D. A. MacDougall, and D. M. F. Cooper Distinct Mechanisms of Regulation by Ca2+/Calmodulin of Type 1 and 8 Adenylyl Cyclases Support Their Different Physiological Roles J. Biol. Chem., February 13, 2009; 284(7): 4451 - 4463. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Dong, E. J. Smoll, K. H. Ko, J. Lee, J. Y. Chow, H. D. Kim, P. A. Insel, and H. Dong P2Y receptors mediate Ca2+ signaling in duodenocytes and contribute to duodenal mucosal bicarbonate secretion Am J Physiol Gastrointest Liver Physiol, February 1, 2009; 296(2): G424 - G432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. R.C. Giachini, C.-W. Chiao, F. S. Carneiro, V. V. Lima, Z. N. Carneiro, A. M. Dorrance, R. C. Tostes, and R. C. Webb Increased Activation of Stromal Interaction Molecule-1/Orai-1 in Aorta From Hypertensive Rats: A Novel Insight Into Vascular Dysfunction Hypertension, February 1, 2009; 53(2): 409 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Bair, P. B. Thippegowda, M. Freichel, N. Cheng, R. D. Ye, S. M. Vogel, Y. Yu, V. Flockerzi, A. B. Malik, and C. Tiruppathi Ca2+ Entry via TRPC Channels Is Necessary for Thrombin-induced NF-{kappa}B Activation in Endothelial Cells through AMP-activated Protein Kinase and Protein Kinase C{delta} J. Biol. Chem., January 2, 2009; 284(1): 563 - 574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. Rao, S. V. Liu, T. Zou, L. Liu, L. Xiao, X. Zhang, E. Bellavance, J. X.-J. Yuan, and J.-Y. Wang Rac1 promotes intestinal epithelial restitution by increasing Ca2+ influx through interaction with phospholipase C-{gamma}1 after wounding Am J Physiol Cell Physiol, December 1, 2008; 295(6): C1499 - C1509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F.-X. Boittin, F. Gribi, K. Serir, and J.-L. Beny Ca2+-independent PLA2 controls endothelial store-operated Ca2+ entry and vascular tone in intact aorta Am J Physiol Heart Circ Physiol, December 1, 2008; 295(6): H2466 - H2474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. F. Abdullaev, J. M. Bisaillon, M. Potier, J. C. Gonzalez, R. K. Motiani, and M. Trebak Stim1 and Orai1 Mediate CRAC Currents and Store-Operated Calcium Entry Important for Endothelial Cell Proliferation Circ. Res., November 21, 2008; 103(11): 1289 - 1299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Matzner, I. M. Zemtsova, N. T. Xuan, M. Duszenko, E. Shumilina, and F. Lang Ion Channels Modulating Mouse Dendritic Cell Functions J. Immunol., November 15, 2008; 181(10): 6803 - 6809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Navarro-Borelly, A. Somasundaram, M. Yamashita, D. Ren, R. J. Miller, and M. Prakriya STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy J. Physiol., November 15, 2008; 586(22): 5383 - 5401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. W. Ng, J. di Capite, K. Singaravelu, and A. B. Parekh Sustained Activation of the Tyrosine Kinase Syk by Antigen in Mast Cells Requires Local Ca2+ Influx through Ca2+ Release-activated Ca2+ Channels J. Biol. Chem., November 14, 2008; 283(46): 31348 - 31355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Gwozdz, J. Dutko-Gwozdz, V. Zarayskiy, K. Peter, and V. M. Bolotina How strict is the correlation between STIM1 and Orai1 expression, puncta formation, and ICRAC activation? Am J Physiol Cell Physiol, November 1, 2008; 295(5): C1133 - C1140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nakata, T. Yoshimaru, Y. Suzuki, T. Inoue, C. Ra, H. Yakura, and K. Mizuno Positive and Negative Regulation of High Affinity IgE Receptor Signaling by Src Homology Region 2 Domain-Containing Phosphatase 1 J. Immunol., October 15, 2008; 181(8): 5414 - 5424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Szikra, K. Cusato, W. B. Thoreson, P. Barabas, T. M. Bartoletti, and D. Krizaj Depletion of calcium stores regulates calcium influx and signal transmission in rod photoreceptors J. Physiol., October 15, 2008; 586(20): 4859 - 4875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Lyfenko and R. T. Dirksen Differential dependence of store-operated and excitation-coupled Ca2+ entry in skeletal muscle on STIM1 and Orai1 J. Physiol., October 15, 2008; 586(20): 4815 - 4824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bezin, G. Charpentier, H. C. Lee, G. Baux, P. Fossier, and J.-M. Cancela Regulation of Nuclear Ca2+ Signaling by Translocation of the Ca2+ Messenger Synthesizing Enzyme ADP-ribosyl Cyclase during Neuronal Depolarization J. Biol. Chem., October 10, 2008; 283(41): 27859 - 27870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Malli, S. Naghdi, C. Romanin, and W. F. Graier Cytosolic Ca2+ prevents the subplasmalemmal clustering of STIM1: an intrinsic mechanism to avoid Ca2+ overload J. Cell Sci., October 1, 2008; 121(19): 3133 - 3139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hewavitharana, X. Deng, Y. Wang, M. F. Ritchie, G. V. Girish, J. Soboloff, and D. L. Gill Location and Function of STIM1 in the Activation of Ca2+ Entry Signals J. Biol. Chem., September 19, 2008; 283(38): 26252 - 26262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Jardin, J. J. Lopez, G. M. Salido, and J. A. Rosado Orai1 Mediates the Interaction between STIM1 and hTRPC1 and Regulates the Mode of Activation of hTRPC1-forming Ca2+ Channels J. Biol. Chem., September 12, 2008; 283(37): 25296 - 25304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Berra-Romani, A. Mazzocco-Spezzia, M. V. Pulina, and V. A. Golovina Ca2+ handling is altered when arterial myocytes progress from a contractile to a proliferative phenotype in culture Am J Physiol Cell Physiol, September 1, 2008; 295(3): C779 - C790. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Schroder, S. Friis, M. Sunesen, C. Mathes, and N. J. Willumsen Automated Patch-Clamp Technique: Increased Throughput in Functional Characterization and in Pharmacological Screening of Small-Conductance Ca2+ Release-Activated Ca2+ Channels J Biomol Screen, August 1, 2008; 13(7): 638 - 647. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Fedida-Metula, S. Elhyany, S. Tsory, S. Segal, M. Hershfinkel, I. Sekler, and D. Fishman Targeting lipid rafts inhibits protein kinase B by disrupting calcium homeostasis and attenuates malignant properties of melanoma cells Carcinogenesis, August 1, 2008; 29(8): 1546 - 1554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. I. DeHaven, J. T. Smyth, R. R. Boyles, G. S. Bird, and J. W. Putney Jr. Complex Actions of 2-Aminoethyldiphenyl Borate on Store-operated Calcium Entry J. Biol. Chem., July 11, 2008; 283(28): 19265 - 19273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Parekh Store-operated channels: mechanisms and function J. Physiol., July 1, 2008; 586(13): 3033 - 3033. [Full Text] [PDF]
|
|
|
|
|
|
W. Lu, J. Wang, L. A. Shimoda, and J. T. Sylvester Differences in STIM1 and TRPC expression in proximal and distal pulmonary arterial smooth muscle are associated with differences in Ca2+ responses to hypoxia Am J Physiol Lung Cell Mol Physiol, July 1, 2008; 295(1): L104 - L113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Putney and G. S. Bird Cytoplasmic calcium oscillations and store-operated calcium influx J. Physiol., July 1, 2008; 586(13): 3055 - 3059. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Parekh Ca2+ microdomains near plasma membrane Ca2+ channels: impact on cell function J. Physiol., July 1, 2008; 586(13): 3043 - 3054. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. M. Bolotina Orai, STIM1 and iPLA2{beta}: a view from a different perspective J. Physiol., July 1, 2008; 586(13): 3035 - 3042. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Cai Unicellular Ca2+ Signaling 'Toolkit' at the Origin of Metazoa Mol. Biol. Evol., July 1, 2008; 25(7): 1357 - 1361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Zhang, J. A. Kozak, W. Jiang, A. V. Yeromin, J. Chen, Y. Yu, A. Penna, W. Shen, V. Chi, and M. D. Cahalan Store-dependent and -independent Modes Regulating Ca2+ Release-activated Ca2+ Channel Activity of Human Orai1 and Orai3 J. Biol. Chem., June 20, 2008; 283(25): 17662 - 17671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Pani, H. L. Ong, X. Liu, K. Rauser, I. S. Ambudkar, and B. B. Singh Lipid Rafts Determine Clustering of STIM1 in Endoplasmic Reticulum-Plasma Membrane Junctions and Regulation of Store-operated Ca2+ Entry (SOCE) J. Biol. Chem., June 20, 2008; 283(25): 17333 - 17340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Woodard, G. M. Salido, and J. A. Rosado Enhanced exocytotic-like insertion of Orai1 into the plasma membrane upon intracellular Ca2+ store depletion Am J Physiol Cell Physiol, June 1, 2008; 294(6): C1323 - C1331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Smani, T. Patel, and V. M. Bolotina Complex regulation of store-operated Ca2+ entry pathway by PKC-{varepsilon} in vascular SMCs Am J Physiol Cell Physiol, June 1, 2008; 294(6): C1499 - C1508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Spassova, T. Hewavitharana, R. A. Fandino, A. Kaya, J. Tanaka, and D. L. Gill Voltage Gating at the Selectivity Filter of the Ca2+ Release-activated Ca2+ Channel Induced by Mutation of the Orai1 Protein J. Biol. Chem., May 30, 2008; 283(22): 14938 - 14945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Csutora, K. Peter, H. Kilic, K. M. Park, V. Zarayskiy, T. Gwozdz, and V. M. Bolotina Novel Role for STIM1 as a Trigger for Calcium Influx Factor Production J. Biol. Chem., May 23, 2008; 283(21): 14524 - 14531. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. El-Yassimi, A. Hichami, P. Besnard, and N. A. Khan Linoleic Acid Induces Calcium Signaling, Src Kinase Phosphorylation, and Neurotransmitter Release in Mouse CD36-positive Gustatory Cells J. Biol. Chem., May 9, 2008; 283(19): 12949 - 12959. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. T. Cheng, X. Liu, H. L. Ong, and I. S. Ambudkar Functional Requirement for Orai1 in Store-operated TRPC1-STIM1 Channels J. Biol. Chem., May 9, 2008; 283(19): 12935 - 12940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Dadsetan, L. Zakharova, T. F. Molinski, and A. F. Fomina Store-operated Ca2+ Influx Causes Ca2+ Release from the Intracellular Ca2+ Channels That Is Required for T Cell Activation J. Biol. Chem., May 2, 2008; 283(18): 12512 - 12519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Smrz, P. Lebduska, L. Draberova, J. Korb, and P. Draber Engagement of Phospholipid Scramblase 1 in Activated Cells: IMPLICATION FOR PHOSPHATIDYLSERINE EXTERNALIZATION AND EXOCYTOSIS J. Biol. Chem., April 18, 2008; 283(16): 10904 - 10918. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M Freisinger, I. Schneider, T. A Westfall, and D. C Slusarski Calcium dynamics integrated into signalling pathways that influence vertebrate axial patterning Phil Trans R Soc B, April 12, 2008; 363(1495): 1377 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Muik, I. Frischauf, I. Derler, M. Fahrner, J. Bergsmann, P. Eder, R. Schindl, C. Hesch, B. Polzinger, R. Fritsch, et al. Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation J. Biol. Chem., March 21, 2008; 283(12): 8014 - 8022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Smyth, W. I. DeHaven, G. S. Bird, and J. W. Putney Jr Ca2+-store-dependent and -independent reversal of Stim1 localization and function J. Cell Sci., March 15, 2008; 121(6): 762 - 772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Parvez, A. Beck, C. Peinelt, J. Soboloff, A. Lis, M. Monteilh-Zoller, Donald. L. Gill, A. Fleig, and R. Penner STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation FASEB J, March 1, 2008; 22(3): 752 - 761. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Saliez, C. Bouzin, G. Rath, P. Ghisdal, F. Desjardins, R. Rezzani, L.F. Rodella, J. Vriens, B. Nilius, O. Feron, et al. Role of Caveolar Compartmentation in Endothelium-Derived Hyperpolarizing Factor-Mediated Relaxation: Ca2+ Signals and Gap Junction Function Are Regulated by Caveolin in Endothelial Cells Circulation, February 26, 2008; 117(8): 1065 - 1074. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Xing, X. Yan, A. Estevez, and K. Strange Highly Ca2+-selective TRPM Channels Regulate IP3-dependent Oscillatory Ca2+ Signaling in the C. elegans Intestine J. Gen. Physiol., February 25, 2008; 131(3): 245 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-C. Chang, J. Di Capite, K. Singaravelu, C. Nelson, V. Halse, and A. B. Parekh Local Ca2+ Influx through Ca2+ Release-activated Ca2+ (CRAC) Channels Stimulates Production of an Intracellular Messenger and an Intercellular Pro-inflammatory Signal J. Biol. Chem., February 22, 2008; 283(8): 4622 - 4631. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Abad, G. Lorente, N. Gavara, M. Morales, A. Gual, and X. Gasull Activation of Store-Operated Ca2+ Channels in Trabecular Meshwork Cells Invest. Ophthalmol. Vis. Sci., February 1, 2008; 49(2): 677 - 686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Sieck, T. A. White, M. A. Thompson, C. M. Pabelick, M. E. Wylam, and Y. S. Prakash Regulation of store-operated Ca2+ entry by CD38 in human airway smooth muscle Am J Physiol Lung Cell Mol Physiol, February 1, 2008; 294(2): L378 - L385. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. J. Martin-Romero, J. R. Ortiz-de-Galisteo, J. Lara-Laranjeira, J. A. Dominguez-Arroyo, E. Gonzalez-Carrera, and I. S Alvarez Store-Operated Calcium Entry in Human Oocytes and Sensitivity to Oxidative Stress Biol Reprod, February 1, 2008; 78(2): 307 - 315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Borges, S. Lindstrom, C. Walters, A. Warrier, and M. Wilson Discrete influx events refill depleted Ca2+ stores in a chick retinal neuron J. Physiol., January 15, 2008; 586(2): 605 - 626. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Sanderson, P. Delmotte, Y. Bai, and J. F. Perez-Zogbhi Regulation of Airway Smooth Muscle Cell Contractility by Ca2+ Signaling and Sensitivity Proceedings of the ATS, January 1, 2008; 5(1): 23 - 31. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Ng, B. D. Kyle, A. R. Lennox, X.-M. Shen, W. J. Hatton, and J. R. Hume Cell culture alters Ca2+ entry pathways activated by store-depletion or hypoxia in canine pulmonary arterial smooth muscle cells Am J Physiol Cell Physiol, January 1, 2008; 294(1): C313 - C323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Mignen, J. L. Thompson, and T. J. Shuttleworth Both Orai1 and Orai3 are essential components of the arachidonate-regulated Ca2+-selective (ARC) channels J. Physiol., January 1, 2008; 586(1): 185 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Andresen, H. Jensen, M. T. Pedersen, K. A. Hansen, and S. Skov Molecular Regulation of MHC Class I Chain-Related Protein A Expression after HDAC-Inhibitor Treatment of Jurkat T Cells J. Immunol., December 15, 2007; 179(12): 8235 - 8242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Nichols, A. F. Dengler, E. M. Nakagawa, M. Bashkin, B. T. Paul, J. Wu, and G. M. Khan A Constitutive, Transient Receptor Potential-like Ca2+ Influx Pathway in Presynaptic Nerve Endings Independent of Voltage-gated Ca2+ Channels and Na+/Ca2+ Exchange J. Biol. Chem., December 7, 2007; 282(49): 36102 - 36111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Wu, H. Chen, M. F. Alexeyev, J. A. C. King, T. M. Moore, T. Stevens, and R. D. Balczon Microtubule Motors Regulate ISOC Activation Necessary to Increase Endothelial Cell Permeability J. Biol. Chem., November 30, 2007; 282(48): 34801 - 34808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Smani, A. Dominguez-Rodriguez, A. Hmadcha, E. Calderon-Sanchez, A. Horrillo-Ledesma, and A. Ordonez Role of Ca2+-Independent Phospholipase A2 and Store-Operated Pathway in Urocortin-Induced Vasodilatation of Rat Coronary Artery Circ. Res., November 26, 2007; 101(11): 1194 - 1203. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
