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Department of Physiology, University of Oxford, Oxford, United Kingdom; and National Institute of Environmental Health Sciences-NIH, Research Triangle Park, North Carolina
In electrically nonexcitable cells, Ca2+ influx is essential for regulating a host of kinetically distinct processes involving exocytosis, enzyme control, gene regulation, cell growth and proliferation, and apoptosis. The major Ca2+ entry pathway in these cells is the store-operated one, in which the emptying of intracellular Ca2+ stores activates Ca2+ influx (store-operated Ca2+ entry, or capacitative Ca2+ entry). Several biophysically distinct store-operated currents have been reported, but the best characterized is the Ca2+ release-activated Ca2+ current, ICRAC. Although it was initially considered to function only in nonexcitable cells, growing evidence now points towards a central role for ICRAC-like currents in excitable cells too. In spite of intense research, the signal that relays the store Ca2+ content to CRAC channels in the plasma membrane, as well as the molecular identity of the Ca2+ sensor within the stores, remains elusive. Resolution of these issues would be greatly helped by the identification of the CRAC channel gene. In some systems, evidence suggests that store-operated channels might be related to TRP homologs, although no consensus has yet been reached. Better understood are mechanisms that inactivate store-operated entry and hence control the overall duration of Ca2+ entry. Recent work has revealed a central role for mitochondria in the regulation of ICRAC, and this is particularly prominent under physiological conditions. ICRAC therefore represents a dynamic interplay between endoplasmic reticulum, mitochondria, and plasma membrane. In this review, we describe the key electrophysiological features of ICRAC and other store-operated Ca2+ currents and how they are regulated, and we consider recent advances that have shed insight into the molecular mechanisms involved in this ubiquitous and vital Ca2+ entry pathway.
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 F. J. Martin-Romero, J. R. Ortiz-de-Galisteo, J. Lara-Laranjeira, J. A. Dominguez-Arroyo, E. Gonzalez-Carrera, and I. S Alvarez Store-Operated Calcium Entry in Human Oocytes and Sensitivity to Oxidative Stress Biol Reprod, February 1, 2008; 78(2): 307 - 315. [Abstract] [Full Text] [PDF]
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S. Borges, S. Lindstrom, C. Walters, A. Warrier, and M. Wilson Discrete influx events refill depleted Ca2+ stores in a chick retinal neuron J. Physiol., January 15, 2008; 586(2): 605 - 626. [Abstract] [Full Text] [PDF]
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 M. J. Sanderson, P. Delmotte, Y. Bai, and J. F. Perez-Zogbhi Regulation of Airway Smooth Muscle Cell Contractility by Ca2+ Signaling and Sensitivity Proceedings of the ATS, January 1, 2008; 5(1): 23 - 31. [Abstract] [Full Text] [PDF]
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L. C. Ng, B. D. Kyle, A. R. Lennox, X.-M. Shen, W. J. Hatton, and J. R. Hume Cell culture alters Ca2+ entry pathways activated by store-depletion or hypoxia in canine pulmonary arterial smooth muscle cells Am J Physiol Cell Physiol, January 1, 2008; 294(1): C313 - C323. [Abstract] [Full Text] [PDF]
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O. Mignen, J. L. Thompson, and T. J. Shuttleworth Both Orai1 and Orai3 are essential components of the arachidonate-regulated Ca2+-selective (ARC) channels J. Physiol., January 1, 2008; 586(1): 185 - 195. [Abstract] [Full Text] [PDF]
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L. Andresen, H. Jensen, M. T. Pedersen, K. A. Hansen, and S. Skov Molecular Regulation of MHC Class I Chain-Related Protein A Expression after HDAC-Inhibitor Treatment of Jurkat T Cells J. Immunol., December 15, 2007; 179(12): 8235 - 8242. [Abstract] [Full Text] [PDF]
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R. A. Nichols, A. F. Dengler, E. M. Nakagawa, M. Bashkin, B. T. Paul, J. Wu, and G. M. Khan A Constitutive, Transient Receptor Potential-like Ca2+ Influx Pathway in Presynaptic Nerve Endings Independent of Voltage-gated Ca2+ Channels and Na+/Ca2+ Exchange J. Biol. Chem., December 7, 2007; 282(49): 36102 - 36111. [Abstract] [Full Text] [PDF]
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S. Wu, H. Chen, M. F. Alexeyev, J. A. C. King, T. M. Moore, T. Stevens, and R. D. Balczon Microtubule Motors Regulate ISOC Activation Necessary to Increase Endothelial Cell Permeability J. Biol. Chem., November 30, 2007; 282(48): 34801 - 34808. [Abstract] [Full Text] [PDF]
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T. Smani, A. Dominguez-Rodriguez, A. Hmadcha, E. Calderon-Sanchez, A. Horrillo-Ledesma, and A. Ordonez Role of Ca2+-Independent Phospholipase A2 and Store-Operated Pathway in Urocortin-Induced Vasodilatation of Rat Coronary Artery Circ. Res., November 26, 2007; 101(11): 1194 - 1203. [Abstract] [Full Text] [PDF]
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M. T. Khan, C. D. Bhanumathy, Z. T. Schug, and S. K. Joseph Role of Inositol 1,4,5-Trisphosphate Receptors in Apoptosis in DT40 Lymphocytes J. Biol. Chem., November 9, 2007; 282(45): 32983 - 32990. [Abstract] [Full Text] [PDF]
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D. Poburko, C.-H. Liao, V. S. Lemos, E. Lin, Y. Maruyama, W. C. Cole, and C. van Breemen Transient Receptor Potential Channel 6 Mediated, Localized Cytosolic [Na+] Transients Drive Na+/Ca2+ Exchanger Mediated Ca2+ Entry in Purinergically Stimulated Aorta Smooth Muscle Cells Circ. Res., November 9, 2007; 101(10): 1030 - 1038. [Abstract] [Full Text] [PDF]
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 B. J. Hawkins, L. A. Solt, I. Chowdhury, A. S. Kazi, M. R. Abid, W. C. Aird, M. J. May, J. K. Foskett, and M. Madesh G Protein-Coupled Receptor Ca2+-Linked Mitochondrial Reactive Oxygen Species Are Essential for Endothelial/Leukocyte Adherence Mol. Cell. Biol., November 1, 2007; 27(21): 7582 - 7593. [Abstract] [Full Text] [PDF]
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 A. J. Sandoval, J. P. Riquelme, M. D. Carretta, J. L. Hancke, M. A. Hidalgo, and R. A. Burgos Store-operated calcium entry mediates intracellular alkalinization, ERK1/2, and Akt/PKB phosphorylation in bovine neutrophils J. Leukoc. Biol., November 1, 2007; 82(5): 1266 - 1277. [Abstract] [Full Text] [PDF]
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S. S. N. Kolar, R. Barhoumi, E. S. Callaway, Y.-Y. Fan, N. Wang, J. R. Lupton, and R. S. Chapkin Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca2+ accumulation in colonocytes Am J Physiol Gastrointest Liver Physiol, November 1, 2007; 293(5): G935 - G943. [Abstract] [Full Text] [PDF]
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Y. S. Prakash, M. A. Thompson, B. Vaa, I. Matabdin, T. E. Peterson, T. He, and C. M. Pabelick Caveolins and intracellular calcium regulation in human airway smooth muscle Am J Physiol Lung Cell Mol Physiol, November 1, 2007; 293(5): L1118 - L1126. [Abstract] [Full Text] [PDF]
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 M. Goel, W. G. Sinkins, C.-D. Zuo, U. Hopfer, and W. P. Schilling Vasopressin-induced membrane trafficking of TRPC3 and AQP2 channels in cells of the rat renal collecting duct Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1476 - F1488. [Abstract] [Full Text] [PDF]
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X. Liu, K. T. Cheng, B. C. Bandyopadhyay, B. Pani, A. Dietrich, B. C. Paria, W. D. Swaim, D. Beech, E. Yildrim, B. B. Singh, et al. Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1( / ) mice PNAS, October 30, 2007; 104(44): 17542 - 17547. [Abstract] [Full Text] [PDF]
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M. Yamashita, L. Navarro-Borelly, B. A. McNally, and M. Prakriya Orai1 Mutations Alter Ion Permeation and Ca2+-dependent Fast Inactivation of CRAC Channels: Evidence for Coupling of Permeation and Gating J. Gen. Physiol., October 29, 2007; 130(5): 525 - 540. [Abstract] [Full Text] [PDF]
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W.-C. Chang, J. Di Capite, C. Nelson, and A. B. Parekh All-or-None Activation of CRAC Channels by Agonist Elicits Graded Responses in Populations of Mast Cells J. Immunol., October 15, 2007; 179(8): 5255 - 5263. [Abstract] [Full Text] [PDF]
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Z. Li, J. Lu, P. Xu, X. Xie, L. Chen, and T. Xu Mapping the Interacting Domains of STIM1 and Orai1 in Ca2+ Release-activated Ca2+ Channel Activation J. Biol. Chem., October 5, 2007; 282(40): 29448 - 29456. [Abstract] [Full Text] [PDF]
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 M. D. Amaral and L. Pozzo-Miller BDNF Induces Calcium Elevations Associated With IBDNF, a Nonselective Cationic Current Mediated by TRPC Channels J Neurophysiol, October 1, 2007; 98(4): 2476 - 2482. [Abstract] [Full Text] [PDF]
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S. Graham, M. Ding, S. Sours-Brothers, T. Yorio, J.-X. Ma, and R. Ma Downregulation of TRPC6 protein expression by high glucose, a possible mechanism for the impaired Ca2+ signaling in glomerular mesangial cells in diabetes Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1381 - F1390. [Abstract] [Full Text] [PDF]
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A. Quintana, C. Schwindling, A. S. Wenning, U. Becherer, J. Rettig, E. C. Schwarz, and M. Hoth T cell activation requires mitochondrial translocation to the immunological synapse PNAS, September 4, 2007; 104(36): 14418 - 14423. [Abstract] [Full Text] [PDF]
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S. Razani-Boroujerdi, R. T. Boyd, M. I. Davila-Garcia, J. S. Nandi, N. C. Mishra, S. P. Singh, J. C. Pena-Philippides, R. Langley, and M. L. Sopori T Cells Express {alpha}7-Nicotinic Acetylcholine Receptor Subunits That Require a Functional TCR and Leukocyte-Specific Protein Tyrosine Kinase for Nicotine-Induced Ca2+ Response J. Immunol., September 1, 2007; 179(5): 2889 - 2898. [Abstract] [Full Text] [PDF]
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J. Wang, L. Weigand, J. Foxson, L. A. Shimoda, and J. T. Sylvester Ca2+ signaling in hypoxic pulmonary vasoconstriction: effects of myosin light chain and Rho kinase antagonists Am J Physiol Lung Cell Mol Physiol, September 1, 2007; 293(3): L674 - L685. [Abstract] [Full Text] [PDF]
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O. Beskina, A. Miller, A. Mazzocco-Spezzia, M. V. Pulina, and V. A. Golovina Mechanisms of interleukin-1beta-induced Ca2+ signals in mouse cortical astrocytes: roles of store- and receptor-operated Ca2+ entry Am J Physiol Cell Physiol, September 1, 2007; 293(3): C1103 - C1111. [Abstract] [Full Text] [PDF]
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B. S. Launikonis and E. Rios Store-operated Ca2+ entry during intracellular Ca2+ release in mammalian skeletal muscle J. Physiol., August 15, 2007; 583(1): 81 - 97. [Abstract] [Full Text] [PDF]
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A. P. Albert, S. N. Saleh, C. M. Peppiatt-Wildman, and W. A. Large Multiple activation mechanisms of store-operated TRPC channels in smooth muscle cells J. Physiol., August 15, 2007; 583(1): 25 - 36. [Abstract] [Full Text] [PDF]
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A. Caplanusi, A. J. Fuller, R. A. Gonzalez-Villalobos, T. G. Hammond, and L. G. Navar Metabolic inhibition-induced transient Ca2+ increase depends on mitochondria in a human proximal renal cell line Am J Physiol Renal Physiol, August 1, 2007; 293(2): F533 - F540. [Abstract] [Full Text] [PDF]
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