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Department of Physiology, University of Oxford, Oxford, United Kingdom; and National Institute of Environmental Health Sciences-NIH, Research Triangle Park, North Carolina
In electrically nonexcitable cells, Ca2+ influx is essential for regulating a host of kinetically distinct processes involving exocytosis, enzyme control, gene regulation, cell growth and proliferation, and apoptosis. The major Ca2+ entry pathway in these cells is the store-operated one, in which the emptying of intracellular Ca2+ stores activates Ca2+ influx (store-operated Ca2+ entry, or capacitative Ca2+ entry). Several biophysically distinct store-operated currents have been reported, but the best characterized is the Ca2+ release-activated Ca2+ current, ICRAC. Although it was initially considered to function only in nonexcitable cells, growing evidence now points towards a central role for ICRAC-like currents in excitable cells too. In spite of intense research, the signal that relays the store Ca2+ content to CRAC channels in the plasma membrane, as well as the molecular identity of the Ca2+ sensor within the stores, remains elusive. Resolution of these issues would be greatly helped by the identification of the CRAC channel gene. In some systems, evidence suggests that store-operated channels might be related to TRP homologs, although no consensus has yet been reached. Better understood are mechanisms that inactivate store-operated entry and hence control the overall duration of Ca2+ entry. Recent work has revealed a central role for mitochondria in the regulation of ICRAC, and this is particularly prominent under physiological conditions. ICRAC therefore represents a dynamic interplay between endoplasmic reticulum, mitochondria, and plasma membrane. In this review, we describe the key electrophysiological features of ICRAC and other store-operated Ca2+ currents and how they are regulated, and we consider recent advances that have shed insight into the molecular mechanisms involved in this ubiquitous and vital Ca2+ entry pathway.
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||||
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||||
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||||
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||||
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||||
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||||
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||||
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||||
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||||
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||||
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||||
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||||
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||||
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||||
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||||
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||||
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||||
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A. El-Yassimi, A. Hichami, P. Besnard, and N. A. Khan Linoleic Acid Induces Calcium Signaling, Src Kinase Phosphorylation, and Neurotransmitter Release in Mouse CD36-positive Gustatory Cells J. Biol. Chem., May 9, 2008; 283(19): 12949 - 12959. [Abstract] [Full Text] [PDF] |
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K. T. Cheng, X. Liu, H. L. Ong, and I. S. Ambudkar Functional Requirement for Orai1 in Store-operated TRPC1-STIM1 Channels J. Biol. Chem., May 9, 2008; 283(19): 12935 - 12940. [Abstract] [Full Text] [PDF] |
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S. Dadsetan, L. Zakharova, T. F. Molinski, and A. F. Fomina Store-operated Ca2+ Influx Causes Ca2+ Release from the Intracellular Ca2+ Channels That Is Required for T Cell Activation J. Biol. Chem., May 2, 2008; 283(18): 12512 - 12519. [Abstract] [Full Text] [PDF] |
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D. Smrz, P. Lebduska, L. Draberova, J. Korb, and P. Draber Engagement of Phospholipid Scramblase 1 in Activated Cells: IMPLICATION FOR PHOSPHATIDYLSERINE EXTERNALIZATION AND EXOCYTOSIS J. Biol. Chem., April 18, 2008; 283(16): 10904 - 10918. [Abstract] [Full Text] [PDF] |
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C. M Freisinger, I. Schneider, T. A Westfall, and D. C Slusarski Calcium dynamics integrated into signalling pathways that influence vertebrate axial patterning Phil Trans R Soc B, April 12, 2008; 363(1495): 1377 - 1385. [Abstract] [Full Text] [PDF] |
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M. Muik, I. Frischauf, I. Derler, M. Fahrner, J. Bergsmann, P. Eder, R. Schindl, C. Hesch, B. Polzinger, R. Fritsch, et al. Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation J. Biol. Chem., March 21, 2008; 283(12): 8014 - 8022. [Abstract] [Full Text] [PDF] |
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J. T. Smyth, W. I. DeHaven, G. S. Bird, and J. W. Putney Jr Ca2+-store-dependent and -independent reversal of Stim1 localization and function J. Cell Sci., March 15, 2008; 121(6): 762 - 772. [Abstract] [Full Text] [PDF] |
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S. Parvez, A. Beck, C. Peinelt, J. Soboloff, A. Lis, M. Monteilh-Zoller, Donald. L. Gill, A. Fleig, and R. Penner STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation FASEB J, March 1, 2008; 22(3): 752 - 761. [Abstract] [Full Text] [PDF] |
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J. Saliez, C. Bouzin, G. Rath, P. Ghisdal, F. Desjardins, R. Rezzani, L.F. Rodella, J. Vriens, B. Nilius, O. Feron, et al. Role of Caveolar Compartmentation in Endothelium-Derived Hyperpolarizing Factor-Mediated Relaxation: Ca2+ Signals and Gap Junction Function Are Regulated by Caveolin in Endothelial Cells Circulation, February 26, 2008; 117(8): 1065 - 1074. [Abstract] [Full Text] [PDF] |
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J. Xing, X. Yan, A. Estevez, and K. Strange Highly Ca2+-selective TRPM Channels Regulate IP3-dependent Oscillatory Ca2+ Signaling in the C. elegans Intestine J. Gen. Physiol., February 25, 2008; 131(3): 245 - 255. [Abstract] [Full Text] [PDF] |
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W.-C. Chang, J. Di Capite, K. Singaravelu, C. Nelson, V. Halse, and A. B. Parekh Local Ca2+ Influx through Ca2+ Release-activated Ca2+ (CRAC) Channels Stimulates Production of an Intracellular Messenger and an Intercellular Pro-inflammatory Signal J. Biol. Chem., February 22, 2008; 283(8): 4622 - 4631. [Abstract] [Full Text] [PDF] |
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E. Abad, G. Lorente, N. Gavara, M. Morales, A. Gual, and X. Gasull Activation of Store-Operated Ca2+ Channels in Trabecular Meshwork Cells Invest. Ophthalmol. Vis. Sci., February 1, 2008; 49(2): 677 - 686. [Abstract] [Full Text] [PDF] |
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G. C. Sieck, T. A. White, M. A. Thompson, C. M. Pabelick, M. E. Wylam, and Y. S. Prakash Regulation of store-operated Ca2+ entry by CD38 in human airway smooth muscle Am J Physiol Lung Cell Mol Physiol, February 1, 2008; 294(2): L378 - L385. [Abstract] [Full Text] [PDF] |
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F. J. Martin-Romero, J. R. Ortiz-de-Galisteo, J. Lara-Laranjeira, J. A. Dominguez-Arroyo, E. Gonzalez-Carrera, and I. S Alvarez Store-Operated Calcium Entry in Human Oocytes and Sensitivity to Oxidative Stress Biol Reprod, February 1, 2008; 78(2): 307 - 315. [Abstract] [Full Text] [PDF] |
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S. Borges, S. Lindstrom, C. Walters, A. Warrier, and M. Wilson Discrete influx events refill depleted Ca2+ stores in a chick retinal neuron J. Physiol., January 15, 2008; 586(2): 605 - 626. [Abstract] [Full Text] [PDF] |
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M. J. Sanderson, P. Delmotte, Y. Bai, and J. F. Perez-Zogbhi Regulation of Airway Smooth Muscle Cell Contractility by Ca2+ Signaling and Sensitivity Proceedings of the ATS, January 1, 2008; 5(1): 23 - 31. [Abstract] [Full Text] [PDF] |
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L. C. Ng, B. D. Kyle, A. R. Lennox, X.-M. Shen, W. J. Hatton, and J. R. Hume Cell culture alters Ca2+ entry pathways activated by store-depletion or hypoxia in canine pulmonary arterial smooth muscle cells Am J Physiol Cell Physiol, January 1, 2008; 294(1): C313 - C323. [Abstract] [Full Text] [PDF] |
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O. Mignen, J. L. Thompson, and T. J. Shuttleworth Both Orai1 and Orai3 are essential components of the arachidonate-regulated Ca2+-selective (ARC) channels J. Physiol., January 1, 2008; 586(1): 185 - 195. [Abstract] [Full Text] [PDF] |
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L. Andresen, H. Jensen, M. T. Pedersen, K. A. Hansen, and S. Skov Molecular Regulation of MHC Class I Chain-Related Protein A Expression after HDAC-Inhibitor Treatment of Jurkat T Cells J. Immunol., December 15, 2007; 179(12): 8235 - 8242. [Abstract] [Full Text] [PDF] |
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R. A. Nichols, A. F. Dengler, E. M. Nakagawa, M. Bashkin, B. T. Paul, J. Wu, and G. M. Khan A Constitutive, Transient Receptor Potential-like Ca2+ Influx Pathway in Presynaptic Nerve Endings Independent of Voltage-gated Ca2+ Channels and Na+/Ca2+ Exchange J. Biol. Chem., December 7, 2007; 282(49): 36102 - 36111. [Abstract] [Full Text] [PDF] |
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S. Wu, H. Chen, M. F. Alexeyev, J. A. C. King, T. M. Moore, T. Stevens, and R. D. Balczon Microtubule Motors Regulate ISOC Activation Necessary to Increase Endothelial Cell Permeability J. Biol. Chem., November 30, 2007; 282(48): 34801 - 34808. [Abstract] [Full Text] [PDF] |
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T. Smani, A. Dominguez-Rodriguez, A. Hmadcha, E. Calderon-Sanchez, A. Horrillo-Ledesma, and A. Ordonez Role of Ca2+-Independent Phospholipase A2 and Store-Operated Pathway in Urocortin-Induced Vasodilatation of Rat Coronary Artery Circ. Res., November 26, 2007; 101(11): 1194 - 1203. [Abstract] [Full Text] [PDF] |
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