| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The University of Manchester, Faculty of Biological Sciences, Manchester, United Kingdom
The endoplasmic reticulum (ER) is the largest single intracellular organelle, which is present in all types of nerve cells. The ER is an interconnected, internally continuous system of tubules and cisterns, which extends from the nuclear envelope to axons and presynaptic terminals, as well as to dendrites and dendritic spines. Ca2+ release channels and Ca2+ pumps residing in the ER membrane provide for its excitability. Regulated ER Ca2+ release controls many neuronal functions, from plasmalemmal excitability to synaptic plasticity. Enzymatic cascades dependent on the Ca2+ concentration in the ER lumen integrate rapid Ca2+ signaling with long-lasting adaptive responses through modifications in protein synthesis and processing. Disruptions of ER Ca2+ homeostasis are critically involved in various forms of neuropathology.
This article has been cited by other articles:
|
|
 |
|
  R. Homma, B. J. Baker, L. Jin, O. Garaschuk, A. Konnerth, L. B. Cohen, and D. Zecevic Wide-field and two-photon imaging of brain activity with voltage- and calcium-sensitive dyes Phil Trans R Soc B, September 12, 2009; 364(1529): 2453 - 2467. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Patel, P. Witkovsky, M. V. Avshalumov, and M. E. Rice Mobilization of Calcium from Intracellular Stores Facilitates Somatodendritic Dopamine Release J. Neurosci., May 20, 2009; 29(20): 6568 - 6579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Scott, T. Lalic, D. M. Kullmann, M. Capogna, and D. A. Rusakov Target-Cell Specificity of Kainate Autoreceptor and Ca2+-Store-Dependent Short-Term Plasticity at Hippocampal Mossy Fiber Synapses J. Neurosci., December 3, 2008; 28(49): 13139 - 13149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Chen, T.-S. Tang, H. Tu, O. Nelson, M. Pook, R. Hammer, N. Nukina, and I. Bezprozvanny Deranged Calcium Signaling and Neurodegeneration in Spinocerebellar Ataxia Type 3 J. Neurosci., November 26, 2008; 28(48): 12713 - 12724. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bezin, G. Charpentier, H. C. Lee, G. Baux, P. Fossier, and J.-M. Cancela Regulation of Nuclear Ca2+ Signaling by Translocation of the Ca2+ Messenger Synthesizing Enzyme ADP-ribosyl Cyclase during Neuronal Depolarization J. Biol. Chem., October 10, 2008; 283(41): 27859 - 27870. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Guerreiro, D. Toulorge, E. Hirsch, M. Marien, P. Sokoloff, and P. P. Michel Paraxanthine, the Primary Metabolite of Caffeine, Provides Protection against Dopaminergic Cell Death via Stimulation of Ryanodine Receptor Channels Mol. Pharmacol., October 1, 2008; 74(4): 980 - 989. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Bull, J. P. Finkelstein, J. Galvez, G. Sanchez, P. Donoso, M. I. Behrens, and C. Hidalgo Ischemia Enhances Activation by Ca2+ and Redox Modification of Ryanodine Receptor Channels from Rat Brain Cortex J. Neurosci., September 17, 2008; 28(38): 9463 - 9472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Liu, T. Vaithianathan, K. Manivannan, A. Parrill, and A. M. Dopico Ethanol Modulates BKCa Channels by Acting as an Adjuvant of Calcium Mol. Pharmacol., September 1, 2008; 74(3): 628 - 640. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. N. Ng and H. Toresson {gamma}-Secretase and metalloproteinase activity regulate the distribution of endoplasmic reticulum to hippocampal neuron dendritic spines FASEB J, August 1, 2008; 22(8): 2832 - 2842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Dickinson, J. N. C. Kew, and S. Wonnacott Presynaptic {alpha}7- and {beta}2-Containing Nicotinic Acetylcholine Receptors Modulate Excitatory Amino Acid Release from Rat Prefrontal Cortex Nerve Terminals via Distinct Cellular Mechanisms Mol. Pharmacol., August 1, 2008; 74(2): 348 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. E. Gardam, J. E. Geiger, C. M. Hickey, A. Y. Hung, and N. S. Magoski Flufenamic Acid Affects Multiple Currents and Causes Intracellular Ca2+ Release in Aplysia Bag Cell Neurons J Neurophysiol, July 1, 2008; 100(1): 38 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Geiger and N. S. Magoski Ca2+-Induced Ca2+ Release in Aplysia Bag Cell Neurons Requires Interaction Between Mitochondrial and Endoplasmic Reticulum Stores J Neurophysiol, July 1, 2008; 100(1): 24 - 37. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Henrich and K. J. Buckler Effects of Anoxia and Aglycemia on Cytosolic Calcium Regulation in Rat Sensory Neurons J Neurophysiol, July 1, 2008; 100(1): 456 - 473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. V. Medvedeva, M.-S. Kim, and Y. M. Usachev Mechanisms of Prolonged Presynaptic Ca2+ Signaling and Glutamate Release Induced by TRPV1 Activation in Rat Sensory Neurons J. Neurosci., May 14, 2008; 28(20): 5295 - 5311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ueta, R. Yamamoto, S. Sugiura, K. Inokuchi, and N. Kato Homer 1a Suppresses Neocortex Long-Term Depression in a Cortical Layer-Specific Manner J Neurophysiol, February 1, 2008; 99(2): 950 - 957. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Myoung Kyu Park, Yu Mi Choi, Yun Kyung Kang, and O. H. Petersen The Endoplasmic Reticulum as an Integrator of Multiple Dendritic Events Neuroscientist, February 1, 2008; 14(1): 68 - 77. [Abstract] [PDF]
|
|
|
|
 |
|
 J. G. McCarron, S. Chalmers, and T. C. Muir `Quantal' Ca2+ release at the cytoplasmic aspect of the Ins(1,4,5)P3R channel in smooth muscle J. Cell Sci., January 1, 2008; 121(1): 86 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. E. Hartwick, J. R. Bramley, J. Yu, K. T. Stevens, C. N. Allen, W. H. Baldridge, P. J. Sollars, and G. E. Pickard Light-Evoked Calcium Responses of Isolated Melanopsin-Expressing Retinal Ganglion Cells J. Neurosci., December 5, 2007; 27(49): 13468 - 13480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Stutzmann The Pathogenesis of Alzheimers Disease Is It a Lifelong "Calciumopathy"? Neuroscientist, October 1, 2007; 13(5): 546 - 559. [Abstract] [PDF]
|
|
|
|
|
|
G. Ibarretxe, D. Perrais, F. Jaskolski, A. Vimeney, and C. Mulle Fast Regulation of Axonal Growth Cone Motility by Electrical Activity J. Neurosci., July 18, 2007; 27(29): 7684 - 7695. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Bull, J. P. Finkelstein, A. Humeres, M. I. Behrens, and C. Hidalgo Effects of ATP, Mg2+, and redox agents on the Ca2+ dependence of RyR channels from rat brain cortex Am J Physiol Cell Physiol, July 1, 2007; 293(1): C162 - C171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Yang, B. Pawlyk, X.-H. Wen, M. Adamian, M. Soloviev, N. Michaud, Y. Zhao, M. A. Sandberg, C. L. Makino, and T. Li Mpp4 is required for proper localization of plasma membrane calcium ATPases and maintenance of calcium homeostasis at the rod photoreceptor synaptic terminals Hum. Mol. Genet., May 1, 2007; 16(9): 1017 - 1029. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Foskett, C. White, K.-H. Cheung, and D.-O. D. Mak Inositol Trisphosphate Receptor Ca2+ Release Channels Physiol Rev, April 1, 2007; 87(2): 593 - 658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Verkhratsky and F. Kirchhoff NMDA Receptors in Glia Neuroscientist, February 1, 2007; 13(1): 28 - 37. [Abstract] [PDF]
|
|
|
|
|
|
C. L. Jasoni, M. G. Todman, M. M. Strumia, and A. E. Herbison Cell Type-Specific Expression of a Genetically Encoded Calcium Indicator Reveals Intrinsic Calcium Oscillations in Adult Gonadotropin-Releasing Hormone Neurons J. Neurosci., January 24, 2007; 27(4): 860 - 867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-L. Sokka, N. Putkonen, G. Mudo, E. Pryazhnikov, S. Reijonen, L. Khiroug, N. Belluardo, D. Lindholm, and L. Korhonen Endoplasmic Reticulum Stress Inhibition Protects against Excitotoxic Neuronal Injury in the Rat Brain J. Neurosci., January 24, 2007; 27(4): 901 - 908. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Rashid, C. H. So, M. M. C. Kong, T. Furtak, M. El-Ghundi, R. Cheng, B. F. O'Dowd, and S. R. George D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum PNAS, January 9, 2007; 104(2): 654 - 659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. M. Choi, S. H. Kim, S. Chung, D. Y. Uhm, and M. K. Park Regional Interaction of Endoplasmic Reticulum Ca2+ Signals between Soma and Dendrites through Rapid Luminal Ca2+ Diffusion. J. Neurosci., November 22, 2006; 26(47): 12127 - 12136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Kachoei, R. J. Knox, D. Uthuza, S. Levy, L. K. Kaczmarek, and N. S. Magoski A Store-Operated Ca2+ Influx Pathway in the Bag Cell Neurons of Aplysia J Neurophysiol, November 1, 2006; 96(5): 2688 - 2698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Stork and Y. V. Li Intracellular Zinc Elevation Measured with a "Calcium-Specific" Indicator during Ischemia and Reperfusion in Rat Hippocampus: A Question on Calcium Overload J. Neurosci., October 11, 2006; 26(41): 10430 - 10437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Billups, B. Billups, R. A. J. Challiss, and S. R. Nahorski Modulation of Gq-Protein-Coupled Inositol Trisphosphate and Ca2+ Signaling by the Membrane Potential J. Neurosci., September 27, 2006; 26(39): 9983 - 9995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Singaravelu, C. Lohr, and J. W. Deitmer Regulation of store-operated calcium entry by calcium-independent phospholipase A2 in rat cerebellar astrocytes. J. Neurosci., September 13, 2006; 26(37): 9579 - 9592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Rusakov Ca2+-Dependent Mechanisms of Presynaptic Control at Central Synapses Neuroscientist, August 1, 2006; 12(4): 317 - 326. [Abstract] [PDF]
|
|
|
|
|
|
S. Wang, A. G. Teschemacher, J. F. R. Paton, and S. Kasparov Mechanism of nitric oxide action on inhibitory GABAergic signaling within the nucleus tractus solitarii FASEB J, July 1, 2006; 20(9): 1537 - 1539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Scott and D. A. Rusakov Main determinants of presynaptic Ca2+ dynamics at individual mossy fiber-CA3 pyramidal cell synapses. J. Neurosci., June 28, 2006; 26(26): 7071 - 7081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Zissimopoulos, D. J. West, A. J. Williams, and F. A. Lai Ryanodine receptor interaction with the SNARE-associated protein snapin J. Cell Sci., June 1, 2006; 119(11): 2386 - 2397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Gant, M. M. Sama, P. W. Landfield, and O. Thibault Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release. J. Neurosci., March 29, 2006; 26(13): 3482 - 3490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Ghatpande, K. Sivaraaman, and S. Vijayaraghavan Store Calcium Mediates Cholinergic Effects on mIPSCs in the Rat Main Olfactory Bulb J Neurophysiol, March 1, 2006; 95(3): 1345 - 1355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Ta, W. Feng, T. F. Molinski, and I. N. Pessah Hydroxylated Xestospongins Block Inositol-1,4,5-trisphosphate-Induced Ca2+ Release and Sensitize Ca2+-Induced Ca2+ Release Mediated by Ryanodine Receptors Mol. Pharmacol., February 1, 2006; 69(2): 532 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. M. Usachev, A. J. Marsh, T. M. Johanns, M. M. Lemke, and S. A. Thayer Activation of Protein Kinase C in Sensory Neurons Accelerates Ca2+ Uptake into the Endoplasmic Reticulum J. Neurosci., January 4, 2006; 26(1): 311 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Rizzuto and T. Pozzan Microdomains of Intracellular Ca2+: Molecular Determinants and Functional Consequences Physiol Rev, January 1, 2006; 86(1): 369 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. H Petersen, A. Spat, and A. Verkhratsky Introduction: reactive oxygen species in health and disease Phil Trans R Soc B, December 29, 2005; 360(1464): 2197 - 2199. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
