| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York; and Joslin Diabetes Center, Harvard University Medical School, Boston, Massachusetts
Nandi, Anindita, Yukari Kitamura, C. Ronald Kahn, and Domenico Accili. Mouse Models of Insulin Resistance. Physiol Rev 84: 623–647, 2004; 10.1152/physrev.00032.2003.—Insulin resistance plays a key role in the pathogenesis of several human diseases, including diabetes, obesity, hypertension, and cardiovascular diseases. The predisposi-tion to insulin resistance results from genetic and environmental factors. The search for gene variants that predispose to insulin resistance has been thwarted by its genetically heterogeneous pathogenesis. However, using techniques of targeted mutagenesis and transgenesis in rodents, investigators have developed mouse models to test critical hypotheses on the pathogenesis of insulin resistance. Moreover, experimental crosses among mutant mice have shed light onto the polygenic nature of the interactions underlying this complex metabolic condition.
This article has been cited by other articles:
|
|
 |
|
  H. Zhang, J. Liu, C. R. Li, B. Momen, R. A. Kohanski, and L. Pick Deletion of Drosophila insulin-like peptides causes growth defects and metabolic abnormalities PNAS, November 17, 2009; 106(46): 19617 - 19622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Muniyappa, H. Chen, R. H. Muzumdar, F. H. Einstein, X. Yan, L. Q. Yue, N. Barzilai, and M. J. Quon Comparison between surrogate indexes of insulin sensitivity/resistance and hyperinsulinemic euglycemic clamp estimates in rats Am J Physiol Endocrinol Metab, November 1, 2009; 297(5): E1023 - E1029. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Potthoff, T. Inagaki, S. Satapati, X. Ding, T. He, R. Goetz, M. Mohammadi, B. N. Finck, D. J. Mangelsdorf, S. A. Kliewer, et al. FGF21 induces PGC-1{alpha} and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response PNAS, June 30, 2009; 106(26): 10853 - 10858. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Escribano, C. Guillen, C. Nevado, A. Gomez-Hernandez, C. R. Kahn, and M. Benito {beta}-Cell Hyperplasia Induced by Hepatic Insulin Resistance: Role of a Liver-Pancreas Endocrine Axis Through Insulin Receptor A Isoform Diabetes, April 1, 2009; 58(4): 820 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. CHATZIGEORGIOU, A. HALAPAS, K. KALAFATAKIS, and E. KAMPER The Use of Animal Models in the Study of Diabetes Mellitus In Vivo, March 1, 2009; 23(2): 245 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Bashan, J. Kovsan, I. Kachko, H. Ovadia, and A. Rudich Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species Physiol Rev, January 1, 2009; 89(1): 27 - 71. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Gonzalez-Navarro, A. Vinue, M. Vila-Caballer, A. Fortuno, O. Beloqui, G. Zalba, D. Burks, J. Diez, and V. Andres Molecular Mechanisms of Atherosclerosis in Metabolic Syndrome: Role of Reduced IRS2-Dependent Signaling Arterioscler Thromb Vasc Biol, December 1, 2008; 28(12): 2187 - 2194. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Lu, Y. Yang, E. M. Allister, N. Wijesekara, and M. B. Wheeler The Identification of Potential Factors Associated with the Development of Type 2 Diabetes: A Quantitative Proteomics Approach Mol. Cell. Proteomics, August 1, 2008; 7(8): 1434 - 1451. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. S. Singhal, R. T. Patel, Y. Qi, Y.-S. Lee, and R. S. Ahima Loss of resistin ameliorates hyperlipidemia and hepatic steatosis in leptin-deficient mice Am J Physiol Endocrinol Metab, August 1, 2008; 295(2): E331 - E338. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Lastres-Becker, S. Brodesser, D. Lutjohann, M. Azizov, J. Buchmann, E. Hintermann, K. Sandhoff, A. Schurmann, J. Nowock, and G. Auburger Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice Hum. Mol. Genet., May 15, 2008; 17(10): 1465 - 1481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kruger, I. Kratchmarova, B. Blagoev, Y.-H. Tseng, C. R. Kahn, and M. Mann Dissection of the insulin signaling pathway via quantitative phosphoproteomics PNAS, February 19, 2008; 105(7): 2451 - 2456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E.-G. Hong, D. Y. Jung, H. J. Ko, Z. Zhang, Z. Ma, J. Y. Jun, J. H. Kim, A. D. Sumner, T. C. Vary, T. W. Gardner, et al. Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling Am J Physiol Endocrinol Metab, December 1, 2007; 293(6): E1687 - E1696. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Delibegovic, K. K. Bence, N. Mody, E.-G. Hong, H. J. Ko, J. K. Kim, B. B. Kahn, and B. G. Neel Improved Glucose Homeostasis in Mice with Muscle-Specific Deletion of Protein-Tyrosine Phosphatase 1B Mol. Cell. Biol., November 1, 2007; 27(21): 7727 - 7734. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Xue, Y.-B. Kim, A. Lee, E. Toschi, S. Bonner-Weir, C. R. Kahn, B. G. Neel, and B. B. Kahn Protein-tyrosine Phosphatase 1B Deficiency Reduces Insulin Resistance and the Diabetic Phenotype in Mice with Polygenic Insulin Resistance J. Biol. Chem., August 17, 2007; 282(33): 23829 - 23840. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Seibler, A. Kleinridders, B. Kuter-Luks, S. Niehaves, J. C. Bruning, and F. Schwenk Reversible gene knockdown in mice using a tight, inducible shRNA expression system Nucleic Acids Res., April 1, 2007; 35(7): e54 - e54. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Savage, K. F. Petersen, and G. I. Shulman Disordered Lipid Metabolism and the Pathogenesis of Insulin Resistance Physiol Rev, April 1, 2007; 87(2): 507 - 520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. T. De Souza, E. P. Araujo, L. F. Stoppiglia, J. R. Pauli, E. Ropelle, S. A. Rocco, R. M. Marin, K. G. Franchini, J. B. Carvalheira, M. J. Saad, et al. Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action FASEB J, April 1, 2007; 21(4): 1153 - 1163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Clee and A. D. Attie The Genetic Landscape of Type 2 Diabetes in Mice Endocr. Rev., February 1, 2007; 28(1): 48 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J Ogino, K Sakurai, K Yoshiwara, Y. Suzuki, N Ishizuka, N Seki, Y. Suzuki, H Koseki, T Shirasawa, N Hashimoto, et al. Insulin resistance and increased pancreatic {beta}-cell proliferation in mice expressing a mutant insulin receptor (P1195L). J. Endocrinol., September 1, 2006; 190(3): 739 - 747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Qi, J. E. Heredia, J. Y. Altarejos, R. Screaton, N. Goebel, S. Niessen, I. X. MacLeod, C. W. Liew, R. N. Kulkarni, J. Bain, et al. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science, June 23, 2006; 312(5781): 1763 - 1766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Veldhuis, J. N. Roemmich, E. J. Richmond, and C. Y. Bowers Somatotropic and Gonadotropic Axes Linkages in Infancy, Childhood, and the Puberty-Adult Transition Endocr. Rev., April 1, 2006; 27(2): 101 - 140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Thrailkill, C. K. Lumpkin Jr., R. C. Bunn, S. F. Kemp, and J. L. Fowlkes Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues Am J Physiol Endocrinol Metab, November 1, 2005; 289(5): E735 - E745. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Shearer, P. T. Fueger, D. P. Bracy, D. H. Wasserman, and J. N. Rottman Partial Gene Deletion of Heart-Type Fatty Acid-Binding Protein Limits the Severity of Dietary-Induced Insulin Resistance Diabetes, November 1, 2005; 54(11): 3133 - 3139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Carvalho, K. Kotani, O. D. Peroni, and B. B. Kahn Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle Am J Physiol Endocrinol Metab, October 1, 2005; 289(4): E551 - E561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Diao, Z. Asghar, C. B. Chan, and M. B. Wheeler Glucose-regulated Glucagon Secretion Requires Insulin Receptor Expression in Pancreatic {alpha}-Cells J. Biol. Chem., September 30, 2005; 280(39): 33487 - 33496. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zheng, H. Yamada, K. Sakamoto, S. Horita, M. Kunimi, Y. Endo, Y. Li, K. Tobe, Y. Terauchi, T. Kadowaki, et al. Roles of Insulin Receptor Substrates in Insulin-Induced Stimulation of Renal Proximal Bicarbonate Absorption J. Am. Soc. Nephrol., August 1, 2005; 16(8): 2288 - 2295. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Capozza, T. P. Combs, A. W. Cohen, Y.-R. Cho, S.-Y. Park, W. Schubert, T. M. Williams, D. L. Brasaemle, L. A. Jelicks, P. E. Scherer, et al. Caveolin-3 knockout mice show increased adiposity and whole body insulin resistance, with ligand-induced insulin receptor instability in skeletal muscle Am J Physiol Cell Physiol, June 1, 2005; 288(6): C1317 - C1331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bardoux, P. Zhang, D. Flamez, A. Perilhou, T. A. Lavin, J.-F. Tanti, K. Hellemans, E. Gomas, C. Godard, F. Andreelli, et al. Essential Role of Chicken Ovalbumin Upstream Promoter-Transcription Factor II in Insulin Secretion and Insulin Sensitivity Revealed by Conditional Gene Knockout Diabetes, May 1, 2005; 54(5): 1357 - 1363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sadagurski, G. Weingarten, C. J. Rhodes, M. F. White, and E. Wertheimer Insulin Receptor Substrate 2 Plays Diverse Cell-specific Roles in the Regulation of Glucose Transport J. Biol. Chem., April 15, 2005; 280(15): 14536 - 14544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. G. Haj, J. M. Zabolotny, Y.-B. Kim, B. B. Kahn, and B. G. Neel Liver-specific Protein-tyrosine Phosphatase 1B (PTP1B) Re-expression Alters Glucose Homeostasis of PTP1B-/-Mice J. Biol. Chem., April 15, 2005; 280(15): 15038 - 15046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kurlawalla-Martinez, B. Stiles, Y. Wang, S. U. Devaskar, B. B. Kahn, and H. Wu Insulin Hypersensitivity and Resistance to Streptozotocin-Induced Diabetes in Mice Lacking PTEN in Adipose Tissue Mol. Cell. Biol., March 15, 2005; 25(6): 2498 - 2510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Dong, B. A. Maddux, J. Altomonte, M. Meseck, D. Accili, R. Terkeltaub, K. Johnson, J. F. Youngren, and I. D. Goldfine Increased Hepatic Levels of the Insulin Receptor Inhibitor, PC-1/NPP1, Induce Insulin Resistance and Glucose Intolerance Diabetes, February 1, 2005; 54(2): 367 - 372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Florez, M. Sjogren, N. Burtt, M. Orho-Melander, S. Schayer, M. Sun, P. Almgren, U. Lindblad, T. Tuomi, D. Gaudet, et al. Association Testing in 9,000 People Fails to Confirm the Association of the Insulin Receptor Substrate-1 G972R Polymorphism With Type 2 Diabetes Diabetes, December 1, 2004; 53(12): 3313 - 3318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Wheatcroft, A. M. Shah, J.-M. Li, E. Duncan, B. T. Noronha, P. A. Crossey, and M. T. Kearney Preserved Glucoregulation but Attenuation of the Vascular Actions of Insulin in Mice Heterozygous for Knockout of the Insulin Receptor Diabetes, October 1, 2004; 53(10): 2645 - 2652. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
