| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Physiology and Laboratory of Cellular and Molecular Physiology, Semmelweis University and Hungarian Academy of Sciences, Budapest, Hungary
Spät, András, and László Hunyady. Control of Aldosterone Secretion: A Model for Convergence in Cellular Signaling Pathways. Physiol Rev 84: 489–539, 2004; 10.1152/physrev.00030.2003.—Aldosterone secretion by glomerulosa cells is stimulated by angiotensin II (ANG II), extracellular K+, corticotrophin, and several paracrine factors. Electrophysiological, fluorimetric, and molecular biological techniques have significantly clarified the molecular action of these stimuli. The steroidogenic effect of corticotrophin is mediated by adenylyl cyclase, whereas potassium activates voltage-operated Ca2+ channels. ANG II, bound to AT1 receptors, acts through the inositol 1,4,5-trisphosphate (IP3)-Ca2+/calmodulin system. All three types of IP3 receptors are coexpressed, rendering a complex control of Ca2+ release possible. Ca2+ release is followed by both capacitative and voltage-activated Ca2+ influx. ANG II inhibits the background K+ channel TASK and Na+-K+-ATPase, and the ensuing depolarization activates T-type (Cav3.2) Ca2+ channels. Activation of protein kinase C by diacylglcerol (DAG) inhibits aldosterone production, whereas the arachidonate released from DAG in ANG II-stimulated cells is converted by lipoxygenase to 12-hydroxyeicosatetraenoic acid, which may also induce Ca2+ signaling. Feedback effects and cross-talk of signal-transducing pathways sensitize glomerulosa cells to low-intensity stimuli, such as physiological elevations of [K+] (
1 mM), ANG II, and ACTH. Ca2+ signaling is also modified by cell swelling, as well as receptor desensitization, resensitization, and downregulation. Long-term regulation of glomerulosa cells involves cell growth and proliferation and induction of steroidogenic enzymes. Ca2+, receptor, and nonreceptor tyrosine kinases and mitogen-activated kinases participate in these processes. Ca2+- and cAMP-dependent phosphorylation induce the transfer of the steroid precursor cholesterol from the cytoplasm to the inner mitochondrial membrane. Ca2+ signaling, transferred into the mitochondria, stimulates the reduction of pyridine nucleotides.
This article has been cited by other articles:
|
|
 |
|
  H. Qin, P. Kent, C. M Isales, P. M Parker, M. V Wilson, and W. B Bollag The role of calcium influx pathways in phospholipase D activation in bovine adrenal glomerulosa cells J. Endocrinol., July 1, 2009; 202(1): 77 - 86. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Benigni and G. Remuzzi Treatment of Chronic Proteinuric Kidney Disease: What Next? Hypertension, July 1, 2009; 54(1): 29 - 31. [Full Text] [PDF]
|
|
|
|
 |
|
 G. Turu, P. Varnai, P. Gyombolai, L. Szidonya, L. Offertaler, G. Bagdy, G. Kunos, and L. Hunyady Paracrine Transactivation of the CB1 Cannabinoid Receptor by AT1 Angiotensin and Other Gq/11 Protein-coupled Receptors J. Biol. Chem., June 19, 2009; 284(25): 16914 - 16921. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Spyroglou, J. Manolopoulou, S. Wagner, M. Bidlingmaier, M. Reincke, and F. Beuschlein Short term regulation of aldosterone secretion after stimulation and suppression experiments in mice J. Mol. Endocrinol., May 1, 2009; 42(5): 407 - 413. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Hu, J. D. Dietz, C. Xia, D. R. Knight, W. T. Loging, A. H. Smith, H. Yuan, D. A. Perry, and J. Keiser Torcetrapib Induces Aldosterone and Cortisol Production by an Intracellular Calcium-Mediated Mechanism Independently of Cholesteryl Ester Transfer Protein Inhibition Endocrinology, May 1, 2009; 150(5): 2211 - 2219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. F Nogueira, Y. Xing, C. A V Morris, and W. E Rainey Role of angiotensin II-induced rapid response genes in the regulation of enzymes needed for aldosterone synthesis J. Mol. Endocrinol., April 1, 2009; 42(4): 319 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Matsuoka, K. Harada, T. Ikeda, K. Uetsuki, T. Sata, A. Warashina, and M. Inoue Ca2+ pathway involved in the refilling of store sites in rat adrenal medullary cells Am J Physiol Cell Physiol, April 1, 2009; 296(4): C889 - C899. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Estilo, W. Liu, N. Pastor-Soler, P. Mitchell, M. D. Carattino, T. R. Kleyman, and L. M. Satlin Effect of aldosterone on BK channel expression in mammalian cortical collecting duct Am J Physiol Renal Physiol, September 1, 2008; 295(3): F780 - F788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Otis, S. Campbell, M. D. Payet, and N. Gallo-Payet In Adrenal Glomerulosa Cells, Angiotensin II Inhibits Proliferation by Interfering with Fibronectin-Integrin Signaling Endocrinology, July 1, 2008; 149(7): 3435 - 3445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Aoyagi, Y. Izumi, M. Hiroyama, T. Matsuzaki, Y. Yasuoka, A. Sanbe, H. Miyazaki, Y. Fujiwara, Y. Nakayama, Y. Kohda, et al. Vasopressin regulates the renin-angiotensin-aldosterone system via V1a receptors in macula densa cells Am J Physiol Renal Physiol, July 1, 2008; 295(1): F100 - F107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Otani, F. Otsuka, K. Inagaki, J. Suzuki, T. Miyoshi, Y. Kano, J. Goto, T. Ogura, and H. Makino Aldosterone Breakthrough Caused by Chronic Blockage of Angiotensin II Type 1 Receptors in Human Adrenocortical Cells: Possible Involvement of Bone Morphogenetic Protein-6 Actions Endocrinology, June 1, 2008; 149(6): 2816 - 2825. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. C. Connell, S. M. MacKenzie, E. M. Freel, R. Fraser, and E. Davies A Lifetime of Aldosterone Excess: Long-Term Consequences of Altered Regulation of Aldosterone Production for Cardiovascular Function Endocr. Rev., April 1, 2008; 29(2): 133 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-W. Chang, V.-C. Wu, C.-Y. Huang, H.-Y. Huang, Y.-M. Chen, T.-S. Chu, K.-D. Wu, and B.-S. Hsieh D4 dopamine receptor enhances angiotensin II-stimulated aldosterone secretion through PKC-{varepsilon} and calcium signaling Am J Physiol Endocrinol Metab, March 1, 2008; 294(3): E622 - E629. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Davies, C. Hu, N. A. Guagliardo, N. Sen, X. Chen, E. M. Talley, R. M. Carey, D. A. Bayliss, and P. Q. Barrett TASK channel deletion in mice causes primary hyperaldosteronism PNAS, February 12, 2008; 105(6): 2203 - 2208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Choi, T. L. Leto, L. Hunyady, K. J. Catt, Y. S. Bae, and S. G. Rhee Mechanism of Angiotensin II-induced Superoxide Production in Cells Reconstituted with Angiotensin Type 1 Receptor and the Components of NADPH Oxidase J. Biol. Chem., January 4, 2008; 283(1): 255 - 267. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Romero, M. W. Plonczynski, B. L. Welsh, C. E. Gomez-Sanchez, M. Y. Zhou, and E. P. Gomez-Sanchez Gene expression profile in rat adrenal zona glomerulosa cells stimulated with aldosterone secretagogues Physiol Genomics, December 19, 2007; 32(1): 117 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. F Nogueira, C. A Vargas, M. Otis, N. Gallo-Payet, W. B Bollag, and W. E Rainey Angiotensin-II acute regulation of rapid response genes in human, bovine, and rat adrenocortical cells J. Mol. Endocrinol., December 1, 2007; 39(6): 365 - 374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J Vittorio, K. Ahuja, M. Kasper, H. Turalic, C.-H. Tseng, U. P Jorde, and C. Gor Comparison of high- versus low-tissue affinity ACE-inhibitor treatment on circulating aldosterone levels in patients with chronic heart failure Journal of Renin-Angiotensin-Aldosterone System, December 1, 2007; 8(4): 200 - 204. [Abstract] [PDF]
|
|
|
|
|
|
L. Lenzini, T. M. Seccia, E. Aldighieri, A. S. Belloni, P. Bernante, L. Giuliani, G. G. Nussdorfer, A. C. Pessina, and G. P. Rossi Heterogeneity of Aldosterone-Producing Adenomas Revealed by a Whole Transcriptome Analysis Hypertension, December 1, 2007; 50(6): 1106 - 1113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G Romero, M. Y. Zhou, L. L Yanes, M. W Plonczynski, T. R Washington, C. E Gomez-Sanchez, and E. P Gomez-Sanchez Regulators of G-protein signaling 4 in adrenal gland: localization, regulation, and role in aldosterone secretion J. Endocrinol., August 1, 2007; 194(2): 429 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Liu, J. A. Enyeart, and J. J. Enyeart Angiotensin II inhibits native bTREK-1 K+ channels through a PLC-, kinase C-, and PIP2-independent pathway requiring ATP hydrolysis Am J Physiol Cell Physiol, August 1, 2007; 293(2): C682 - C695. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Oliveira, C. M. Costa-Neto, C. R. Nakaie, S. Schreier, S. I. Shimuta, and A. C. M. Paiva The Angiotensin II AT1 Receptor Structure-Activity Correlations in the Light of Rhodopsin Structure Physiol Rev, April 1, 2007; 87(2): 565 - 592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Bastida, A. Cremades, M. T. Castells, A. J. Lopez-Contreras, C. Lopez-Garcia, J. Sanchez-Mas, and R. Penafiel Sexual dimorphism of ornithine decarboxylase in the mouse adrenal: influence of polyamine deprivation on catecholamine and corticoid levels Am J Physiol Endocrinol Metab, April 1, 2007; 292(4): E1010 - E1017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Turu, A. Simon, P. Gyombolai, L. Szidonya, G. Bagdy, Z. Lenkei, and L. Hunyady The Role of Diacylglycerol Lipase in Constitutive and Angiotensin AT1 Receptor-stimulated Cannabinoid CB1 Receptor Activity J. Biol. Chem., March 16, 2007; 282(11): 7753 - 7757. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. C. Rump Secondary rise of albuminuria under AT1-receptor blockade--what is the potential role of aldosterone escape? Nephrol. Dial. Transplant., January 1, 2007; 22(1): 5 - 8. [Full Text] [PDF]
|
|
|
|
|
|
B. Peters, P. Teubner, S. Clausmeyer, T. Puschner, C. Maser-Gluth, H.-J. Wrede, B. Kranzlin, and J. Peters StAR expression and the long-term aldosterone response to high-potassium diet in Wistar-Kyoto and spontaneously hypertensive rats Am J Physiol Endocrinol Metab, January 1, 2007; 292(1): E16 - E23. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Hanke and A. C. Bauer-Dantoin Teaching aldosterone regulation and basic scientific principles using a classic paper by Dr. James O. Davis and colleagues Advan Physiol Educ, December 1, 2006; 30(4): 141 - 144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Romero, B. L. Welsh, E. P. Gomez-Sanchez, L. L. Yanes, S. Rilli, and C. E. Gomez-Sanchez Angiotensin II-Mediated Protein Kinase D Activation Stimulates Aldosterone and Cortisol Secretion in H295R Human Adrenocortical Cells Endocrinology, December 1, 2006; 147(12): 6046 - 6055. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Payet, T. L. Goodfriend, L. Bilodeau, C. Mackendale, L. Chouinard, and N. Gallo-Payet An oxidized metabolite of linoleic acid increases intracellular calcium in rat adrenal glomerulosa cells Am J Physiol Endocrinol Metab, December 1, 2006; 291(6): E1160 - E1167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Romero, M. W. Plonczynski, E. P. Gomez-Sanchez, L. L. Yanes, and C. E. Gomez-Sanchez RGS2 Is Regulated by Angiotensin II and Functions as a Negative Feedback of Aldosterone Production in H295R Human Adrenocortical Cells Endocrinology, August 1, 2006; 147(8): 3889 - 3897. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Hunyady and K. J. Catt Pleiotropic AT1 Receptor Signaling Pathways Mediating Physiological and Pathogenic Actions of Angiotensin II Mol. Endocrinol., May 1, 2006; 20(5): 953 - 970. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gambaryan, E. Butt, P. Tas, A. Smolenski, B. Allolio, and U. Walter Regulation of aldosterone production from zona glomerulosa cells by ANG II and cAMP: evidence for PKA-independent activation of CaMK by cAMP Am J Physiol Endocrinol Metab, March 1, 2006; 290(3): E423 - E433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-G. LeHoux and A. Lefebvre Novel protein kinase C-epsilon inhibits human CYP11B2 gene expression through ERK1/2 signalling pathway and JunB J. Mol. Endocrinol., February 1, 2006; 36(1): 51 - 64. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H McNeill, E Whitworth, G P Vinson, and J P Hinson Distribution of extracellular signal-regulated protein kinases 1 and 2 in the rat adrenal and their activation by angiotensin II J. Endocrinol., October 1, 2005; 187(1): 149 - 157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Enyeart, S. J. Danthi, H. Liu, and J. A. Enyeart Angiotensin II Inhibits bTREK-1 K+ Channels in Adrenocortical Cells by Separate Ca2+- and ATP Hydrolysis-dependent Mechanisms J. Biol. Chem., September 2, 2005; 280(35): 30814 - 30828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Gauthier, D. X. Zhang, E. M. Edwards, B. Holmes, and W. B. Campbell Angiotensin II Dilates Bovine Adrenal Cortical Arterioles: Role of Endothelial Nitric Oxide Endocrinology, August 1, 2005; 146(8): 3319 - 3324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sausbier, C. Arntz, I. Bucurenciu, H. Zhao, X.-B. Zhou, U. Sausbier, S. Feil, S. Kamm, K. Essin, C. A. Sailer, et al. Elevated Blood Pressure Linked to Primary Hyperaldosteronism and Impaired Vasodilation in BK Channel-Deficient Mice Circulation, July 5, 2005; 112(1): 60 - 68. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M C Connell and E. Davies The new biology of aldosterone J. Endocrinol., July 1, 2005; 186(1): 1 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Pitt, J. Martinez-Pinna, E. A. Barnard, and M. P. Mahaut-Smith Potentiation of P2Y Receptors by Physiological Elevations of Extracellular K+ via a Mechanism Independent of Ca2+ Influx Mol. Pharmacol., May 1, 2005; 67(5): 1705 - 1713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Raj, I. Biaggioni, P. C. Yamhure, B. K. Black, S. Y. Paranjape, D. W. Byrne, and D. Robertson Renin-Aldosterone Paradox and Perturbed Blood Volume Regulation Underlying Postural Tachycardia Syndrome Circulation, April 5, 2005; 111(13): 1574 - 1582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Otis, S. Campbell, M. D. Payet, and N. Gallo-Payet Angiotensin II Stimulates Protein Synthesis and Inhibits Proliferation in Primary Cultures of Rat Adrenal Glomerulosa Cells Endocrinology, February 1, 2005; 146(2): 633 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. O. Nikolaev, S. Gambaryan, S. Engelhardt, U. Walter, and M. J. Lohse Real-time Monitoring of the PDE2 Activity of Live Cells: HORMONE-STIMULATED cAMP HYDROLYSIS IS FASTER THAN HORMONE-STIMULATED cAMP SYNTHESIS J. Biol. Chem., January 21, 2005; 280(3): 1716 - 1719. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
