|
|
||||||||
The Wenner-Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden
Cannon, Barbara, and Jan Nedergaard. Brown Adipose Tissue: Function and Physiological Significance. Physiol Rev 84: 277359, 2004; 10.1152/physrev.00015.2003.The function of brown adipose tissue is to transfer energy from food into heat; physiologically, both the heat produced and the resulting decrease in metabolic efficiency can be of significance. Both the acute activity of the tissue, i.e., the heat production, and the recruitment process in the tissue (that results in a higher thermogenic capacity) are under the control of norepinephrine released from sympathetic nerves. In thermoregulatory thermogenesis, brown adipose tissue is essential for classical nonshivering thermogen-esis (this phenomenon does not exist in the absence of functional brown adipose tissue), as well as for the cold acclimation-recruited norepinephrine-induced thermogenesis. Heat production from brown adipose tissue is activated whenever the organism is in need of extra heat, e.g., postnatally, during entry into a febrile state, and during arousal from hibernation, and the rate of thermogenesis is centrally controlled via a pathway initiated in the hypothalamus. Feeding as such also results in activation of brown adipose tissue; a series of diets, apparently all characterized by being low in protein, result in a leptin-dependent recruitment of the tissue; this metaboloregulatory thermogenesis is also under hypothalamic control. When the tissue is active, high amounts of lipids and glucose are combusted in the tissue. The development of brown adipose tissue with its characteristic protein, uncoupling protein-1 (UCP1), was probably determinative for the evolutionary success of mammals, as its thermogenesis enhances neonatal survival and allows for active life even in cold surroundings.
This article has been cited by other articles:
![]() |
J. M. Gimble and Z. E. Floyd Fat circadian biology J Appl Physiol, November 1, 2009; 107(5): 1629 - 1637. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Won Kang, S. Ribich, B. W. Kim, S. J. Hagen, A. C. Bianco, and D. E. Cohen Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue J. Lipid Res., November 1, 2009; 50(11): 2212 - 2221. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. M Savastano, A. M Gorbach, H. S Eden, S. M Brady, J. C Reynolds, and J. A Yanovski Adiposity and human regional body temperature Am. J. Clinical Nutrition, November 1, 2009; 90(5): 1124 - 1131. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Cinti Transdifferentiation properties of adipocytes in the adipose organ Am J Physiol Endocrinol Metab, November 1, 2009; 297(5): E977 - E986. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. T.H. Au-Yong, N. Thorn, R. Ganatra, A. C. Perkins, and M. E. Symonds Brown Adipose Tissue and Seasonal Variation in Humans Diabetes, November 1, 2009; 58(11): 2583 - 2587. [Abstract] [Full Text] [PDF] |
||||
![]() |
G.-B. Tang, J.-G. Cui, and D.-H. Wang Role of hypoleptinemia during cold adaptation in Brandt's voles (Lasiopodomys brandtii) Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2009; 297(5): R1293 - R1301. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Vernochet, S. B. Peres, K. E. Davis, M. E. McDonald, L. Qiang, H. Wang, P. E. Scherer, and S. R. Farmer C/EBP{alpha} and the Corepressors CtBP1 and CtBP2 Regulate Repression of Select Visceral White Adipose Genes during Induction of the Brown Phenotype in White Adipocytes by Peroxisome Proliferator-Activated Receptor {gamma} Agonists Mol. Cell. Biol., September 1, 2009; 29(17): 4714 - 4728. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. S. Sacks, J. N. Fain, B. Holman, P. Cheema, A. Chary, F. Parks, J. Karas, R. Optican, S. W. Bahouth, E. Garrett, et al. Uncoupling Protein-1 and Related Messenger Ribonucleic Acids in Human Epicardial and Other Adipose Tissues: Epicardial Fat Functioning as Brown Fat J. Clin. Endocrinol. Metab., September 1, 2009; 94(9): 3611 - 3615. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. C. Zingaretti, F. Crosta, A. Vitali, M. Guerrieri, A. Frontini, B. Cannon, J. Nedergaard, and S. Cinti The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue FASEB J, September 1, 2009; 23(9): 3113 - 3120. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. A. Romanovsky, M. C. Almeida, A. Garami, A. A. Steiner, M. H. Norman, S. F. Morrison, K. Nakamura, J. J. Burmeister, and T. B. Nucci The Transient Receptor Potential Vanilloid-1 Channel in Thermoregulation: A Thermosensor It Is Not Pharmacol. Rev., September 1, 2009; 61(3): 228 - 261. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. J. Swoap and M. J. Gutilla Cardiovascular changes during daily torpor in the laboratory mouse Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2009; 297(3): R769 - R774. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Vaillancourt, F.ço. Haman, and J.-M. Weber Fuel selection in Wistar rats exposed to cold: shivering thermogenesis diverts fatty acids from re-esterification to oxidation J. Physiol., September 1, 2009; 587(17): 4349 - 4359. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. Walter and F. Seebacher Endothermy in birds: underlying molecular mechanisms J. Exp. Biol., August 1, 2009; 212(15): 2328 - 2336. [Abstract] [Full Text] [PDF] |
||||
![]() |
A AGRAWAL, N NAIR, and N S BAGHEL A novel approach for reduction of brown fat uptake on FDG PET Br. J. Radiol., August 1, 2009; 82(980): 626 - 631. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Karamitri, A. M. Shore, K. Docherty, J. R. Speakman, and M. A. Lomax Combinatorial Transcription Factor Regulation of the Cyclic AMP-response Element on the Pgc-1{alpha} Promoter in White 3T3-L1 and Brown HIB-1B Preadipocytes J. Biol. Chem., July 31, 2009; 284(31): 20738 - 20752. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Seale and M. A. Lazar Brown Fat in Humans: Turning up the Heat on Obesity Diabetes, July 1, 2009; 58(7): 1482 - 1484. [Full Text] [PDF] |
||||
![]() |
M. Saito, Y. Okamatsu-Ogura, M. Matsushita, K. Watanabe, T. Yoneshiro, J. Nio-Kobayashi, T. Iwanaga, M. Miyagawa, T. Kameya, K. Nakada, et al. High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity Diabetes, July 1, 2009; 58(7): 1526 - 1531. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Bourdon, S. Hojna, M. Jordan, J. Berube, V. Kren, M. Pravenec, P. Liu, S. Arab, and Z. Pausova Genetic locus on rat chromosome 20 regulates diet-induced adipocyte hypertrophy: a microarray gene expression study Physiol Genomics, June 10, 2009; 38(1): 63 - 72. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. M. Wojtanik, K. Edgemon, S. Viswanadha, B. Lindsey, M. Haluzik, W. Chen, G. Poy, M. Reitman, and C. Londos The role of LMNA in adipose: a novel mouse model of lipodystrophy based on the Dunnigan-type familial partial lipodystrophy mutation J. Lipid Res., June 1, 2009; 50(6): 1068 - 1079. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Mano-Otagiri, H. Ohata, A. Iwasaki-Sekino, T. Nemoto, and T. Shibasaki Ghrelin suppresses noradrenaline release in the brown adipose tissue of rats J. Endocrinol., June 1, 2009; 201(3): 341 - 349. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. H. Bruner, M. N. Novilla, C. A. Picut, J. B. Kirkpatrick, T. P. O'Neill, K. L. Scully, W. B. Lawrence, D. G. Goodman, B. H. Saladino, D. G. Peters, et al. Spontaneous Hibernomas in Sprague-Dawley Rats Toxicol Pathol, June 1, 2009; 37(4): 547 - 552. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. T. Festuccia, P.-G. Blanchard, V. Turcotte, M. Laplante, M. Sariahmetoglu, D. N. Brindley, D. Richard, and Y. Deshaies The PPAR{gamma} agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2009; 296(5): R1327 - R1335. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. L. Grobe, M. Venegas-Pont, C. D. Sigmund, and M. J. Ryan PPAR{gamma} differentially regulates energy substrate handling in brown vs. white adipose: focus on "The PPAR{gamma} agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake" Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2009; 296(5): R1325 - R1326. [Full Text] [PDF] |
||||
![]() |
A. M. Cypess, S. Lehman, G. Williams, I. Tal, D. Rodman, A. B. Goldfine, F. C. Kuo, E. L. Palmer, Y.-H. Tseng, A. Doria, et al. Identification and Importance of Brown Adipose Tissue in Adult Humans N. Engl. J. Med., April 9, 2009; 360(15): 1509 - 1517. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. A. Virtanen, M. E. Lidell, J. Orava, M. Heglind, R. Westergren, T. Niemi, M. Taittonen, J. Laine, N.-J. Savisto, S. Enerback, et al. Functional Brown Adipose Tissue in Healthy Adults N. Engl. J. Med., April 9, 2009; 360(15): 1518 - 1525. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. S. Celi Brown Adipose Tissue -- When It Pays to Be Inefficient N. Engl. J. Med., April 9, 2009; 360(15): 1553 - 1556. [Full Text] [PDF] |
||||
![]() |
P. Seale, S. Kajimura, and B. M. Spiegelman Transcriptional control of brown adipocyte development and physiological function--of mice and men Genes & Dev., April 1, 2009; 23(7): 788 - 797. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Bousquet-Moore, X. M. Ma, E. A. Nillni, T. A. Czyzyk, J. E. Pintar, B. A. Eipper, and R. E. Mains Reversal of Physiological Deficits Caused by Diminished Levels of Peptidylglycine {alpha}-Amidating Monooxygenase by Dietary Copper Endocrinology, April 1, 2009; 150(4): 1739 - 1747. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Marks, D. M. L. Vianna, and P. Carrive Nonshivering thermogenesis without interscapular brown adipose tissue involvement during conditioned fear in the rat Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2009; 296(4): R1239 - R1247. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. J. Madden and S. F. Morrison Neurons in the paraventricular nucleus of the hypothalamus inhibit sympathetic outflow to brown adipose tissue Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2009; 296(3): R831 - R843. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. Canals, M. C. Carmona, M. Amigo, A. Barbera, A. Bortolozzi, F. Artigas, and R. Gomis A Functional Leptin System Is Essential for Sodium Tungstate Antiobesity Action Endocrinology, February 1, 2009; 150(2): 642 - 650. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Schroeder, L. Shbiro, O. Zagoory-Sharon, T. H. Moran, and A. Weller Toward an animal model of childhood-onset obesity: follow-up of OLETF rats during pregnancy and lactation Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2009; 296(2): R224 - R232. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. Jobgen, C. J. Meininger, S. C. Jobgen, P. Li, M.-J. Lee, S. B. Smith, T. E. Spencer, S. K. Fried, and G. Wu Dietary L-Arginine Supplementation Reduces White Fat Gain and Enhances Skeletal Muscle and Brown Fat Masses in Diet-Induced Obese Rats J. Nutr., February 1, 2009; 139(2): 230 - 237. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. A. Lutaif, E. M. Rocha, L. A.Veloso, L. M. Bento, and J. A. R. Gontijo Renal contribution to thermolability in rats: role of renal nerves Nephrol. Dial. Transplant., December 1, 2008; 23(12): 3798 - 3805. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. W. Gelling, W. Yan, S. Al-Noori, A. Pardini, G. J. Morton, K. Ogimoto, M. W. Schwartz, and P. J. Dempsey Deficiency of TNF{alpha} Converting Enzyme (TACE/ADAM17) Causes a Lean, Hypermetabolic Phenotype in Mice Endocrinology, December 1, 2008; 149(12): 6053 - 6064. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. P. Arruda, L. A. Ketzer, M. Nigro, A. Galina, D. P. Carvalho, and L. de Meis Cold Tolerance in Hypothyroid Rabbits: Role of Skeletal Muscle Mitochondria and Sarcoplasmic Reticulum Ca2+ ATPase Isoform 1 Heat Production Endocrinology, December 1, 2008; 149(12): 6262 - 6271. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Pelletier, K. Gauthier, O. Sideleva, J. Samarut, and J. E. Silva Mice Lacking the Thyroid Hormone Receptor-{alpha} Gene Spend More Energy in Thermogenesis, Burn More Fat, and Are Less Sensitive to High-Fat Diet-Induced Obesity Endocrinology, December 1, 2008; 149(12): 6471 - 6486. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. F. Zizola, G. J. Schwartz, and S. Vogel Cellular retinol-binding protein type III is a PPAR{gamma} target gene and plays a role in lipid metabolism Am J Physiol Endocrinol Metab, December 1, 2008; 295(6): E1358 - E1368. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. P. Cooper, M. Uldry, S. Kajimura, Z. Arany, and B. M. Spiegelman Modulation of PGC-1 Coactivator Pathways in Brown Fat Differentiation through LRP130 J. Biol. Chem., November 14, 2008; 283(46): 31960 - 31967. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Aydin, I. G. Shabalina, N. Place, S. Reiken, S.-J. Zhang, A. M. Bellinger, J. Nedergaard, B. Cannon, A. R. Marks, J. D. Bruton, et al. Nonshivering thermogenesis protects against defective calcium handling in muscle FASEB J, November 1, 2008; 22(11): 3919 - 3924. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Giguere Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors Endocr. Rev., October 1, 2008; 29(6): 677 - 696. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. L. Seifert, V. Bezaire, C. Estey, and M.-E. Harper Essential Role for Uncoupling Protein-3 in Mitochondrial Adaptation to Fasting but Not in Fatty Acid Oxidation or Fatty Acid Anion Export J. Biol. Chem., September 12, 2008; 283(37): 25124 - 25131. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. M. Nautiyal, M. Dailey, N. Brito, M. N. d. A. Brito, R. B. Harris, T. J. Bartness, and H. J. Grill Energetic responses to cold temperatures in rats lacking forebrain-caudal brain stem connections Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2008; 295(3): R789 - R798. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Torres-Farfan, F. J. Valenzuela, M. Mondaca, G. J. Valenzuela, B. Krause, E. A. Herrera, R. Riquelme, A. J. Llanos, and M. Seron-Ferre Evidence of a role for melatonin in fetal sheep physiology: direct actions of melatonin on fetal cerebral artery, brown adipose tissue and adrenal gland J. Physiol., August 15, 2008; 586(16): 4017 - 4027. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Petrovic, I. G. Shabalina, J. A. Timmons, B. Cannon, and J. Nedergaard Thermogenically competent nonadrenergic recruitment in brown preadipocytes by a PPAR{gamma} agonist Am J Physiol Endocrinol Metab, August 1, 2008; 295(2): E287 - E296. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Kus, T. Prazak, P. Brauner, M. Hensler, O. Kuda, P. Flachs, P. Janovska, D. Medrikova, M. Rossmeisl, Z. Jilkova, et al. Induction of muscle thermogenesis by high-fat diet in mice: association with obesity-resistance Am J Physiol Endocrinol Metab, August 1, 2008; 295(2): E356 - E367. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Rey, L. G. Halsey, V. Dolmazon, J.-L. Rouanet, D. Roussel, Y. Handrich, P. J. Butler, and C. Duchamp Long-term fasting decreases mitochondrial avian UCP-mediated oxygen consumption in hypometabolic king penguins Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2008; 295(1): R92 - R100. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. F. Morrison, K. Nakamura, and C. J. Madden Central control of thermogenesis in mammals Exp Physiol, July 1, 2008; 93(7): 773 - 797. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. J. Brees, M. R. Elwell, F. D. Tingley III, S. B. Sands, A. B. Jakowski, A. C. Shen, J. H. Cai, and M. B. Finkelstein Pharmacological Effects of Nicotine on Norepinephrine Metabolism in Rat Brown Adipose Tissue: Relevance to Nicotinic Therapies for Smoking Cessation Toxicol Pathol, June 1, 2008; 36(4): 568 - 575. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Roy, S. Paglialunga, A. Fisette, P. Schrauwen, E. Moonen-Kornips, J. St-Onge, M. K. Hesselink, D. Richard, D. R. Joanisse, and K. Cianflone Shift in metabolic fuel in acylation-stimulating protein-deficient mice following a high-fat diet Am J Physiol Endocrinol Metab, June 1, 2008; 294(6): E1051 - E1059. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. R. Farmer Molecular determinants of brown adipocyte formation and function Genes & Dev., May 15, 2008; 22(10): 1269 - 1275. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Kajimura, P. Seale, T. Tomaru, H. Erdjument-Bromage, M. P. Cooper, J. L. Ruas, S. Chin, P. Tempst, M. A. Lazar, and B. M. Spiegelman Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex Genes & Dev., May 15, 2008; 22(10): 1397 - 1409. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Nakamura and S. F. Morrison Preoptic mechanism for cold-defensive responses to skin cooling J. Physiol., May 15, 2008; 586(10): 2611 - 2620. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Vercauteren, N. Gleyzer, and R. C. Scarpulla PGC-1-related Coactivator Complexes with HCF-1 and NRF-2{beta} in Mediating NRF-2(GABP)-dependent Respiratory Gene Expression J. Biol. Chem., May 2, 2008; 283(18): 12102 - 12111. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Rey, B. Sibille, C. Romestaing, M. Belouze, D. Letexier, S. Servais, H. Barre, C. Duchamp, and Y. Voituron Reptilian uncoupling protein: functionality and expression in sub-zero temperatures J. Exp. Biol., May 1, 2008; 211(9): 1456 - 1462. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Kumar, D. Liu, H. Wang, J. Robidoux, and S. Collins Orphan Nuclear Receptor NOR-1 Enhances 3',5'-Cyclic Adenosine 5'-Monophosphate-Dependent Uncoupling Protein-1 Gene Transcription Mol. Endocrinol., May 1, 2008; 22(5): 1057 - 1064. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. T. Festuccia, S. Oztezcan, M. Laplante, M. Berthiaume, C. Michel, S. Dohgu, R. G. Denis, M. N. Brito, N. A. Brito, D. S. Miller, et al. Peroxisome Proliferator-Activated Receptor-{gamma}-Mediated Positive Energy Balance in the Rat Is Associated with Reduced Sympathetic Drive to Adipose Tissues and Thyroid Status Endocrinology, May 1, 2008; 149(5): 2121 - 2130. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Hemmeryckx, R. van Bree, B. Van Hoef, L. Vercruysse, H. R. Lijnen, and J. Verhaeghe Adverse Adipose Phenotype and Hyperinsulinemia in Gravid Mice Deficient in Placental Growth Factor Endocrinology, May 1, 2008; 149(5): 2176 - 2183. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Williams and G. M. Kolodny Method for Decreasing Uptake of 18F-FDG by Hypermetabolic Brown Adipose Tissue on PET Am. J. Roentgenol., May 1, 2008; 190(5): 1406 - 1409. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. A. Brito, M. N. Brito, and T. J. Bartness Differential sympathetic drive to adipose tissues after food deprivation, cold exposure or glucoprivation Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1445 - R1452. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Neschen, Y. Katterle, J. Richter, R. Augustin, S. Scherneck, F. Mirhashemi, A. Schurmann, H.-G. Joost, and S. Klaus Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover, and insulin sensitivity in vivo Physiol Genomics, May 1, 2008; 33(3): 333 - 340. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. R. Jensen, L. A. Knaub, J. P. Konhilas, L. A. Leinwand, P. S. MacLean, and R. H. Eckel Increased thermoregulation in cold-exposed transgenic mice overexpressing lipoprotein lipase in skeletal muscle: an avian phenotype? J. Lipid Res., April 1, 2008; 49(4): 870 - 879. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. C. Scarpulla Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function Physiol Rev, April 1, 2008; 88(2): 611 - 638. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Wang, Y. Zhang, E. Yehuda-Shnaidman, A. V. Medvedev, N. Kumar, K. W. Daniel, J. Robidoux, M. P. Czech, D. J. Mangelsdorf, and S. Collins Liver X Receptor {alpha} Is a Transcriptional Repressor of the Uncoupling Protein 1 Gene and the Brown Fat Phenotype Mol. Cell. Biol., April 1, 2008; 28(7): 2187 - 2200. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. A. Myers, K. Hanson, M. Mlynarczyk, K. M. Kaushal, and C. A. Ducsay Long-term hypoxia modulates expression of key genes regulating adipose function in the late-gestation ovine fetus Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2008; 294(4): R1312 - R1318. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Lorenzo, S. Fernandez-Veledo, R. Vila-Bedmar, L. Garcia-Guerra, C. De Alvaro, and I. Nieto-Vazquez Insulin resistance induced by tumor necrosis factor-{alpha} in myocytes and brown adipocytes J Anim Sci, April 1, 2008; 86(14_suppl): E94 - E104. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Madsen, L. M. Pedersen, B. Liaset, T. Ma, R. K. Petersen, S. van den Berg, J. Pan, K. Muller-Decker, E. D. Dulsner, R. Kleemann, et al. cAMP-dependent Signaling Regulates the Adipogenic Effect of n-6 Polyunsaturated Fatty Acids J. Biol. Chem., March 14, 2008; 283(11): 7196 - 7205. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. B. Jakus, A. Sandor, T. Janaky, and V. Farkas Cooperation between BAT and WAT of rats in thermogenesis in response to cold, and the mechanism of glycogen accumulation in BAT during reacclimation J. Lipid Res., February 1, 2008; 49(2): 332 - 339. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Kagawa, Y. Soeda, H. Ishihara, T. Oya, M. Sasahara, S. Yaguchi, R. Oshita, T. Wada, H. Tsuneki, and T. Sasaoka Impact of Transgenic Overexpression of SH2-Containing Inositol 5'-Phosphatase 2 on Glucose Metabolism and Insulin Signaling in Mice Endocrinology, February 1, 2008; 149(2): 642 - 650. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. R Speakman The physiological costs of reproduction in small mammals Phil Trans R Soc B, January 27, 2008; 363(1490): 375 - 398. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Yan, B. M. Barnes, F. Kohl, and T. G. Marr Modulation of gene expression in hibernating arctic ground squirrels Physiol Genomics, January 17, 2008; 32(2): 170 - 181. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Jastroch, K. W. Withers, S. Taudien, P. B. Frappell, M. Helwig, T. Fromme, V. Hirschberg, G. Heldmaier, B. M. McAllan, B. T. Firth, et al. Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis Physiol Genomics, January 17, 2008; 32(2): 161 - 169. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Petrovic, B. Buzadzic, A. Korac, A. Vasilijevic, A. Jankovic, K. Micunovic, and B. Korac Antioxidative defence alterations in skeletal muscle during prolonged acclimation to cold: role of L-arginine/NO-producing pathway J. Exp. Biol., January 1, 2008; 211(1): 114 - 120. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. V. Kramarova, I. G. Shabalina, U. Andersson, R. Westerberg, I. Carlberg, J. Houstek, J. Nedergaard, and B. Cannon Mitochondrial ATP synthase levels in brown adipose tissue are governed by the c-Fo subunit P1 isoform FASEB J, January 1, 2008; 22(1): 55 - 63. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Wiersma, M. A. Chappell, and J. B. Williams Cold- and exercise-induced peak metabolic rates in tropical birds PNAS, December 26, 2007; 104(52): 20866 - 20871. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. N. Brito, N. A. Brito, D. J. Baro, C. K. Song, and T. J. Bartness Differential Activation of the Sympathetic Innervation of Adipose Tissues by Melanocortin Receptor Stimulation Endocrinology, November 1, 2007; 148(11): 5339 - 5347. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Scheele, A. R. Nielsen, T. B. Walden, D. A. Sewell, C. P. Fischer, R. J. Brogan, N. Petrovic, O. Larsson, P. A. Tesch, K. Wennmalm, et al. Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration? FASEB J, November 1, 2007; 21(13): 3653 - 3665. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Mzilikazi, M. Jastroch, C. W. Meyer, and M. Klingenspor The molecular and biochemical basis of nonshivering thermogenesis in an African endemic mammal, Elephantulus myurus Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2007; 293(5): R2120 - R2127. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. D. Fink, J. A. Herlein, K. Almind, S. Cinti, C. R. Kahn, and W. I. Sivitz Mitochondrial proton leak in obesity-resistant and obesity-prone mice Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2007; 293(5): R1773 - R1780. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Baba, J. M. Engles, D. L. Huso, T. Ishimori, and R. L. Wahl Comparison of Uptake of Multiple Clinical Radiotracers into Brown Adipose Tissue Under Cold-Stimulated and Nonstimulated Conditions J. Nucl. Med., October 1, 2007; 48(10): 1715 - 1723. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. B. Goralski, T. C. McCarthy, E. A. Hanniman, B. A. Zabel, E. C. Butcher, S. D. Parlee, S. Muruganandan, and C. J. Sinal Chemerin, a Novel Adipokine That Regulates Adipogenesis and Adipocyte Metabolism J. Biol. Chem., September 21, 2007; 282(38): 28175 - 28188. [Abstract] [Full Text] [PDF] |
||||
![]() |
X. Q. Xiao, S. M. Williams, B. E. Grayson, M. M. Glavas, M. A. Cowley, M. S. Smith, and K. L. Grove Excess Weight Gain during the Early Postnatal Period Is Associated with Permanent Reprogramming of Brown Adipose Tissue Adaptive Thermogenesis Endocrinology, September 1, 2007; 148(9): 4150 - 4159. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Ocloo, I. G. Shabalina, J. Nedergaard, and M. D. Brand Cold-induced alterations of phospholipid fatty acyl composition in brown adipose tissue mitochondria are independent of uncoupling protein-1 Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1086 - R1093. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Karamanlidis, A. Karamitri, K. Docherty, D. G. Hazlerigg, and M. A. Lomax C/EBPbeta Reprograms White 3T3-L1 Preadipocytes to a Brown Adipocyte Pattern of Gene Expression J. Biol. Chem., August 24, 2007; 282(34): 24660 - 24669. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Naiki, E. Saijou, Y. Miyaoka, K. Sekine, and A. Miyajima TRB2, a Mouse Tribbles Ortholog, Suppresses Adipocyte Differentiation by Inhibiting AKT and C/EBPbeta J. Biol. Chem., August 17, 2007; 282(33): 24075 - 24082. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. C Westman, R. D Feinman, J. C Mavropoulos, M. C Vernon, J. S Volek, J. A Wortman, W. S Yancy, and S. D Phinney Low-carbohydrate nutrition and metabolism Am. J. Clinical Nutrition, August 1, 2007; 86(2): 276 - 284. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Nedergaard, T. Bengtsson, and B. Cannon Unexpected evidence for active brown adipose tissue in adult humans Am J Physiol Endocrinol Metab, August 1, 2007; 293(2): E444 - E452. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. M. Huffman, W. E. Grizzle, M. M. Bamman, J.-s. Kim, I. A. Eltoum, A. Elgavish, and T. R. Nagy SIRT1 Is Significantly Elevated in Mouse and Human Prostate Cancer Cancer Res., July 15, 2007; 67(14): 6612 - 6618. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. A. Steiner, V. F. Turek, M. C. Almeida, J. J. Burmeister, D. L. Oliveira, J. L. Roberts, A. W. Bannon, M. H. Norman, J.-C. Louis, J. J. S. Treanor, et al. Nonthermal Activation of Transient Receptor Potential Vanilloid-1 Channels in Abdominal Viscera Tonically Inhibits Autonomic Cold-Defense Effectors J. Neurosci., July 11, 2007; 27(28): 7459 - 7468. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Debevec, M. Christian, D. Morganstein, A. Seth, B. Herzog, M. Parker, and R. White Receptor Interacting Protein 140 Regulates Expression of Uncoupling Protein 1 in Adipocytes through Specific Peroxisome Proliferator Activated Receptor Isoforms and Estrogen-Related Receptor {alpha} Mol. Endocrinol., July 1, 2007; 21(7): 1581 - 1592. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Hadi, C. C. Chen, M. Whatley, K. Pacak, and J. A. Carrasquillo Brown Fat Imaging with 18F-6-Fluorodopamine PET/CT, 18F-FDG PET/CT, and 123I-MIBG SPECT: A Study of Patients Being Evaluated for Pheochromocytoma J. Nucl. Med., July 1, 2007; 48(7): 1077 - 1083. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Li, Y. Zhang, E. Rodrigues, D. Zheng, M. Matheny, K.-Y. Cheng, and P. J. Scarpace Melanocortin activation of nucleus of the solitary tract avoids anorectic tachyphylaxis and induces prolonged weight loss Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E252 - E258. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. C. Souza, M. A. Christoffolete, M. O. Ribeiro, H. Miyoshi, K. J. Strissel, Z. S. Stancheva, N. H. Rogers, T. M. D'Eon, J. W. Perfield II, H. Imachi, et al. Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue J. Lipid Res., June 1, 2007; 48(6): 1273 - 1279. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. D. Mulligan, A. A. Gonzalez, A. M. Stewart, H. V. Carey, and K. W. Saupe Upregulation of AMPK during cold exposure occurs via distinct mechanisms in brown and white adipose tissue of the mouse J. Physiol., April 15, 2007; 580(2): 677 - 684. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Vaillancourt and J.-M. Weber Lipid mobilization of long-distance migrant birds in vivo: the high lipolytic rate of ruff sandpipers is not stimulated during shivering J. Exp. Biol., April 1, 2007; 210(7): 1161 - 1169. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Voss-Andreae, J. G. Murphy, K. L. J. Ellacott, R. C. Stuart, E. A. Nillni, R. D. Cone, and W. Fan Role of the Central Melanocortin Circuitry in Adaptive Thermogenesis of Brown Adipose Tissue Endocrinology, April 1, 2007; 148(4): 1550 - 1560. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. R. Speakman and C. Hambly Starving for Life: What Animal Studies Can and Cannot Tell Us about the Use of Caloric Restriction to Prolong Human Lifespan J. Nutr., April 1, 2007; 137(4): 1078 - 1086. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Okamatsu-Ogura, N. Kitao, K. Kimura, and M. Saito Brown fat UCP1 is not involved in the febrile and thermogenic responses to IL-1beta in mice Am J Physiol Endocrinol Metab, April 1, 2007; 292(4): E1135 - E1139. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Laplante, W. T. Festuccia, G. Soucy, Y. Gelinas, J. Lalonde, and Y. Deshaies Involvement of adipose tissues in the early hypolipidemic action of PPAR{gamma} agonism in the rat Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2007; 292(4): R1408 - R1417. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |