| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Physiology and Neuroscience, Department of Neurosurgery, New York University School of Medicine, New York, New York
Chesler, Mitchell. Regulation and Modulation of pH in the Brain. Physiol Rev 83: 1183-1221, 2003; 10.1152/physrev.00010.2003.—The regulation of pH is a vital homeostatic function shared by all tissues. Mechanisms that govern H+ in the intracellular and extracellular fluid are especially important in the brain, because electrical activity can elicit rapid pH changes in both compartments. These acid-base transients may in turn influence neural activity by affecting a variety of ion channels. The mechanisms responsible for the regulation of intracellular pH in brain are similar to those of other tissues and are comprised principally of forms of Na+/H+ exchange, Na+-driven Cl-/HCO3- exchange, Na+-HCO3- cotransport, and passive Cl-/HCO3- exchange. Differences in the expression or efficacy of these mechanisms have been noted among the functionally and morphologically diverse neurons and glial cells that have been studied. Molecular identification of transporter isoforms has revealed heterogeneity among brain regions and cell types. Neural activity gives rise to an assortment of extracellular and intracellular pH shifts that originate from a variety of mechanisms. Intracellular pH shifts in neurons and glia have been linked to Ca2+ transport, activation of acid extrusion systems, and the accumulation of metabolic products. Extracellular pH shifts can occur within milliseconds of neural activity, arise from an assortment of mechanisms, and are governed by the activity of extracellular carbonic anhydrase. The functional significance of these compartmental, activity-dependent pH shifts is discussed.
This article has been cited by other articles:
|
|
 |
|
  J. R. Casey, W. S. Sly, G. N. Shah, and B. V. Alvarez Bicarbonate homeostasis in excitable tissues: role of AE3 Cl-/HCOFormula exchanger and carbonic anhydrase XIV interaction Am J Physiol Cell Physiol, November 1, 2009; 297(5): 1091 - 1102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Kersh, L. K. Hartzler, K. Havlin, B. B. Hubbell, V. Nanagas, A. Kalra, J. Chua, R. Whitesell, N. A. Ritucci, J. B. Dean, et al. pH regulating transporters in neurons from various chemosensitive brainstem regions in neonatal rats Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2009; 297(5): R1409 - R1420. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Kim and L. O. Trussell Negative Shift in the Glycine Reversal Potential Mediated by a Ca2+- and pH-Dependent Mechanism in Interneurons J. Neurosci., September 16, 2009; 29(37): 11495 - 11510. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. G. Dulla, B. G. Frenguelli, K. J. Staley, and S. A. Masino Intracellular Acidification Causes Adenosine Release During States of Hyperexcitability in the Hippocampus J Neurophysiol, September 1, 2009; 102(3): 1984 - 1993. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sjoblom, A. K. Singh, W. Zheng, J. Wang, B.-g. Tuo, A. Krabbenhoft, B. Riederer, G. Gros, and U. Seidler Duodenal acidity "sensing" but not epithelial HCO3- supply is critically dependent on carbonic anhydrase II expression PNAS, August 4, 2009; 106(31): 13094 - 13099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. I. Lam, P. M. Wise, and M. E. O'Donnell Cerebral microvascular endothelial cell Na/H exchange: evidence for the presence of NHE1 and NHE2 isoforms and regulation by arginine vasopressin Am J Physiol Cell Physiol, August 1, 2009; 297(2): C278 - C289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Palacios-Prado, S. Sonntag, V. A. Skeberdis, K. Willecke, and F. F. Bukauskas Gating, permselectivity and pH-dependent modulation of channels formed by connexin57, a major connexin of horizontal cells in the mouse retina J. Physiol., July 1, 2009; 587(13): 3251 - 3269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. H. Diering, J. Church, and M. Numata Secretory Carrier Membrane Protein 2 Regulates Cell-surface Targeting of Brain-enriched Na+/H+ Exchanger NHE5 J. Biol. Chem., May 15, 2009; 284(20): 13892 - 13903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. N. Ainslie and J. Duffin Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2009; 296(5): R1473 - R1495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-H. Chen, Y.-T. Hsu, C.-C. Chen, and R.-C. Huang Acid-sensing ion channels in neurones of the rat suprachiasmatic nucleus J. Physiol., April 15, 2009; 587(8): 1727 - 1737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Svichar, A. Waheed, W. S. Sly, J. C. Hennings, C. A. Hubner, and M. Chesler Carbonic Anhydrases CA4 and CA14 Both Enhance AE3-Mediated Cl--HCOFormula Exchange in Hippocampal Neurons J. Neurosci., March 11, 2009; 29(10): 3252 - 3258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ogoh, P. N. Ainslie, and T. Miyamoto Onset responses of ventilation and cerebral blood flow to hypercapnia in humans: rest and exercise J Appl Physiol, March 1, 2009; 106(3): 880 - 886. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hou, S. H. Heinemann, and T. Hoshi Modulation of BKCa Channel Gating by Endogenous Signaling Molecules Physiology, February 1, 2009; 24(1): 26 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Thomas The plasma membrane calcium ATPase (PMCA) of neurones is electroneutral and exchanges 2 H+ for each Ca2+ or Ba2+ ion extruded J. Physiol., January 15, 2009; 587(2): 315 - 327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Gonzalez-Nieto, J. M. Gomez-Hernandez, B. Larrosa, C. Gutierrez, M. D. Munoz, I. Fasciani, J. O'Brien, A. Zappala, F. Cicirata, and L. C. Barrio Regulation of neuronal connexin-36 channels by pH PNAS, November 4, 2008; 105(44): 17169 - 17174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ogoh, N. Hayashi, M. Inagaki, P. N. Ainslie, and T. Miyamoto Interaction between the ventilatory and cerebrovascular responses to hypo- and hypercapnia at rest and during exercise J. Physiol., September 1, 2008; 586(17): 4327 - 4338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Cohen, Y. Ben-Abu, S. Hen, and N. Zilberberg A Novel Mechanism for Human K2P2.1 Channel Gating: FACILITATION OF C-TYPE GATING BY PROTONATION OF EXTRACELLULAR HISTIDINE RESIDUES J. Biol. Chem., July 11, 2008; 283(28): 19448 - 19455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mandal, N. A. Delamere, and M. Shahidullah Ouabain-induced stimulation of sodium-hydrogen exchange in rat optic nerve astrocytes Am J Physiol Cell Physiol, July 1, 2008; 295(1): C100 - C110. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Gurnett, R. Veile, J. Zempel, L. Blackburn, M. Lovett, and A. Bowcock Disruption of Sodium Bicarbonate Transporter SLC4A10 in a Patient With Complex Partial Epilepsy and Mental Retardation Arch Neurol, April 1, 2008; 65(4): 550 - 553. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Chen, T. J. Maures, H. Jin, J. S. Huo, S. A. Rabbani, J. Schwartz, and C. Carter-Su SH2B1{beta} (SH2-B{beta}) Enhances Expression of a Subset of Nerve Growth Factor-Regulated Genes Important for Neuronal Differentiation Including Genes Encoding Urokinase Plasminogen Activator Receptor and Matrix Metalloproteinase 3/10 Mol. Endocrinol., February 1, 2008; 22(2): 454 - 476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Erreger and S. F. Traynelis Zinc inhibition of rat NR1/NR2A N-methyl-D-aspartate receptors J. Physiol., February 1, 2008; 586(3): 763 - 778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Miller, D. P. Bulte, H. Devlin, M. D. Robson, R. G. Wise, M. W. Woolrich, P. Jezzard, and T. E. J. Behrens Evidence for a vascular contribution to diffusion FMRI at high b value PNAS, December 26, 2007; 104(52): 20967 - 20972. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-M. Chen, I. Choi, G. G. Haddad, and W. F. Boron Chronic continuous hypoxia decreases the expression of SLC4A7 (NBCn1) and SLC4A10 (NCBE) in mouse brain Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2007; 293(6): R2412 - R2420. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Kreitzer, L. P. Collis, A. J.A. Molina, P. J.S. Smith, and R. P. Malchow Modulation of Extracellular Proton Fluxes from Retinal Horizontal Cells of the Catfish by Depolarization and Glutamate J. Gen. Physiol., July 30, 2007; 130(2): 169 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Makani and M. Chesler Endogenous Alkaline Transients Boost Postsynaptic NMDA Receptor Responses in Hippocampal CA1 Pyramidal Neurons J. Neurosci., July 11, 2007; 27(28): 7438 - 7446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Y. C. Wong, D. M. MacLean, and D. Bowie Na+/Cl- Dipole Couples Agonist Binding to Kainate Receptor Activation J. Neurosci., June 20, 2007; 27(25): 6800 - 6809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Williams, L. T. Jensen, A. Verkhratsky, L. Fugger, and D. Burdakov Control of hypothalamic orexin neurons by acid and CO2 PNAS, June 19, 2007; 104(25): 10685 - 10690. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Jonz and S. Barnes Proton modulation of ion channels in isolated horizontal cells of the goldfish retina J. Physiol., June 1, 2007; 581(2): 529 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Ogilvie, K. K. Ohlemiller, G. N. Shah, B. Ulmasov, T. A. Becker, A. Waheed, A. K. Hennig, P. D. Lukasiewicz, and W. S. Sly Carbonic anhydrase XIV deficiency produces a functional defect in the retinal light response PNAS, May 15, 2007; 104(20): 8514 - 8519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Fedirko, M. Avshalumov, M. E. Rice, and M. Chesler Regulation of Postsynaptic Ca2+ Influx in Hippocampal CA1 Pyramidal Neurons via Extracellular Carbonic Anhydrase J. Neurosci., January 31, 2007; 27(5): 1167 - 1175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kelly and J. Church Relationships Between Calcium and pH in the Regulation of the Slow Afterhyperpolarization in Cultured Rat Hippocampal Neurons J Neurophysiol, November 1, 2006; 96(5): 2342 - 2353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Hill, C. L. Brett, A. Chyou, L. M. Kallay, M. Sakaguchi, R. Rao, and P. G. Gillespie Vestibular Hair Bundles Control pH with (Na+, K+)/H+ Exchangers NHE6 and NHE9 J. Neurosci., September 27, 2006; 26(39): 9944 - 9955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Fedirko, N. Svichar, and M. Chesler Fabrication and Use of High-Speed, Concentric H+- and Ca2+-Selective Microelectrodes Suitable for In Vitro Extracellular Recording J Neurophysiol, August 1, 2006; 96(2): 919 - 924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. F. Pedersen, M. E. O'Donnell, S. E. Anderson, and P. M. Cala Physiology and pathophysiology of Na+/H+ exchange and Na+-K+-2Cl- cotransport in the heart, brain, and blood Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2006; 291(1): R1 - R25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-K. Tong, K. Chen, and M. Chesler Kinetics of Activity-Evoked pH Transients and Extracellular pH Buffering in Rat Hippocampal Slices J Neurophysiol, June 1, 2006; 95(6): 3686 - 3697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. McAlear, X. Liu, J. B. Williams, C. M. McNicholas-Bevensee, and M. O. Bevensee Electrogenic Na/HCO3 Cotransporter (NBCe1) Variants Expressed in Xenopus Oocytes: Functional Comparison and Roles of the Amino and Carboxy Termini J. Gen. Physiol., May 30, 2006; 127(6): 639 - 658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Wang, B. Duan, H. Xu, L. Xu, and T.-L. Xu Calcium-permeable Acid-sensing Ion Channel Is a Molecular Target of the Neurotoxic Metal Ion Lead J. Biol. Chem., February 3, 2006; 281(5): 2497 - 2505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Vukicevic, G. Weder, A. Boillat, A. Boesch, and S. Kellenberger Trypsin Cleaves Acid-sensing Ion Channel 1a in a Domain That Is Critical for Channel Gating J. Biol. Chem., January 13, 2006; 281(2): 714 - 722. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hentschke, M. Wiemann, S. Hentschke, I. Kurth, I. Hermans-Borgmeyer, T. Seidenbecher, T. J. Jentsch, A. Gal, and C. A. Hubner Mice with a Targeted Disruption of the Cl-/HCO3- Exchanger AE3 Display a Reduced Seizure Threshold Mol. Cell. Biol., January 1, 2006; 26(1): 182 - 191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. N. Shah, B. Ulmasov, A. Waheed, T. Becker, S. Makani, N. Svichar, M. Chesler, and W. S. Sly Carbonic anhydrase IV and XIV knockout mice: Roles of the respective carbonic anhydrases in buffering the extracellular space in brain PNAS, November 15, 2005; 102(46): 16771 - 16776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Aubert, R. Costalat, P. J. Magistretti, and L. Pellerin Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation PNAS, November 8, 2005; 102(45): 16448 - 16453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G Ardolino, B Bossi, S Barbieri, and A Priori Non-synaptic mechanisms underlie the after-effects of cathodal transcutaneous direct current stimulation of the human brain J. Physiol., October 15, 2005; 568(2): 653 - 663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Chen, W. Gao, K. C. Reinert, L. S. Popa, C. M. Hendrix, M. E. Ross, and T. J. Ebner Involvement of Kv1 Potassium Channels in Spreading Acidification and Depression in the Cerebellar Cortex J Neurophysiol, August 1, 2005; 94(2): 1287 - 1298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sherman, M. N. Chernova, J. S. Clark, L. Jiang, S. L. Alper, and K. Nehrke The abts and sulp families of anion transporters from Caenorhabditis elegans Am J Physiol Cell Physiol, August 1, 2005; 289(2): C341 - C351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Nagelhus, T. M. Mathiisen, A. C. Bateman, F.-M. Haug, O. P. Ottersen, J. H. Grubb, A. Waheed, and W. S. Sly Carbonic anhydrase XIV is enriched in specific membrane domains of retinal pigment epithelium, Muller cells, and astrocytes PNAS, May 31, 2005; 102(22): 8030 - 8035. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. G. Guyenet, R. L. Stornetta, D. A. Bayliss, and D. K. Mulkey Retrotrapezoid nucleus: a litmus test for the identification of central chemoreceptors Exp Physiol, May 1, 2005; 90(3): 247 - 253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Jin, J. R. Huguenard, and D. A. Prince Impaired Cl- Extrusion in Layer V Pyramidal Neurons of Chronically Injured Epileptogenic Neocortex J Neurophysiol, April 1, 2005; 93(4): 2117 - 2126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Putnam, J. A. Filosa, and N. A. Ritucci Cellular mechanisms involved in CO2 and acid signaling in chemosensitive neurons Am J Physiol Cell Physiol, December 1, 2004; 287(6): C1493 - C1526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. A Molina, M. P Verzi, A. D Birnbaum, E. N Yamoah, K. Hammar, P. J. S Smith, and R. P. Malchow Neurotransmitter modulation of extracellular H+ fluxes from isolated retinal horizontal cells of the skate J. Physiol., November 1, 2004; 560(3): 639 - 657. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Lynch Molecular Structure and Function of the Glycine Receptor Chloride Channel Physiol Rev, October 1, 2004; 84(4): 1051 - 1095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Poirot, M. Vukicevic, A. Boesch, and S. Kellenberger Selective Regulation of Acid-sensing Ion Channel 1 by Serine Proteases J. Biol. Chem., September 10, 2004; 279(37): 38448 - 38457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Vukicevic and S. Kellenberger Modulatory effects of acid-sensing ion channels on action potential generation in hippocampal neurons Am J Physiol Cell Physiol, September 1, 2004; 287(3): C682 - C690. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bouyer, S. R. Bradley, J. Zhao, W. Wang, G. B. Richerson, and W. F. Boron Effect of extracellular acid-base disturbances on the intracellular pH of neurones cultured from rat medullary raphe or hippocampus J. Physiol., August 15, 2004; 559(1): 85 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Abdrakhmanova, L. Cleemann, J. Lindstrom, and M. Morad Differential Modulation of {beta}2 and {beta}4 Subunits of Human Neuronal Nicotinic Acetylcholine Receptors by Acidification Mol. Pharmacol., August 1, 2004; 66(2): 347 - 355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Becker and J. W. Deitmer Voltage Dependence of H+ Buffering Mediated by Sodium Bicarbonate Cotransport Expressed in Xenopus Oocytes J. Biol. Chem., July 2, 2004; 279(27): 28057 - 28062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kelly and J. Church pH modulation of currents that contribute to the medium and slow afterhyperpolarizations in rat CA1 pyramidal neurones J. Physiol., January 15, 2004; 554(2): 449 - 466. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
