| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin; Department of Biology, University of Minnesota Duluth, Duluth, Minnesota; and Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver, Colorado
Carey, Hannah V., Matthew T. Andrews, and Sandra L. Martin. Mammalian Hibernation: Cellular and Molecular Responses to Depressed Metabolism and Low Temperature. Physiol Rev 83: 1153-1181, 2003; 10.1152/physrev. 00008.2003.—Mammalian hibernators undergo a remarkable phenotypic switch that involves profound changes in physiology, morphology, and behavior in response to periods of unfavorable environmental conditions. The ability to hibernate is found throughout the class Mammalia and appears to involve differential expression of genes common to all mammals, rather than the induction of novel gene products unique to the hibernating state. The hibernation season is characterized by extended bouts of torpor, during which minimal body temperature (Tb) can fall as low as -2.9°C and metabolism can be reduced to 1% of euthermic rates. Many global biochemical and physiological processes exploit low temperatures to lower reaction rates but retain the ability to resume full activity upon rewarming. Other critical functions must continue at physiologically relevant levels during torpor and be precisely regulated even at Tb values near 0°C. Research using new tools of molecular and cellular biology is beginning to reveal how hibernators survive repeated cycles of torpor and arousal during the hibernation season. Comprehensive approaches that exploit advances in genomic and proteomic technologies are needed to further define the differentially expressed genes that distinguish the summer euthermic from winter hibernating states. Detailed understanding of hibernation from the molecular to organismal levels should enable the translation of this information to the development of a variety of hypothermic and hypometabolic strategies to improve outcomes for human and animal health.
This article has been cited by other articles:
|
|
 |
|
  C. U. Meteyer, E. L. Buckles, D. S. Blehert, A. C. Hicks, D. E. Green, V. Shearn-Bochsler, N. J. Thomas, A. Gargas, and M. J. Behr Histopathologic criteria to confirm white-nose syndrome in bats J Vet Diagn Invest, July 1, 2009; 21(4): 411 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Levesque and G. J. Tattersall Seasonal changes in thermoregulatory responses to hypoxia in the Eastern chipmunk (Tamias striatus) J. Exp. Biol., June 15, 2009; 212(12): 1801 - 1810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Gaglia and C. Kenyon Stimulation of Movement in a Quiescent, Hibernation-Like Form of Caenorhabditis elegans by Dopamine Signaling J. Neurosci., June 3, 2009; 29(22): 7302 - 7314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Nelson, J. P. Otis, and H. V. Carey A role for nuclear receptors in mammalian hibernation J. Physiol., May 1, 2009; 587(9): 1863 - 1870. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. B. Fedorov, A. V. Goropashnaya, O. Toien, N. C. Stewart, A. Y. Gracey, C. Chang, S. Qin, G. Pertea, J. Quackenbush, L. C. Showe, et al. Elevated expression of protein biosynthesis genes in liver and muscle of hibernating black bears (Ursus americanus) Physiol Genomics, April 10, 2009; 37(2): 108 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Nelson, J. P. Otis, S. L. Martin, and H. V. Carey Analysis of the hibernation cycle using LC-MS-based metabolomics in ground squirrel liver Physiol Genomics, March 3, 2009; 37(1): 43 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. El Kebbaj, P. Andreoletti, D. Mountassif, M. Kabine, H. Schohn, M. Dauca, N. Latruffe, M. S. El Kebbaj, and M. Cherkaoui-Malki Differential Regulation of Peroxisome Proliferator-Activated Receptor (PPAR)-{alpha}1 and Truncated PPAR{alpha}2 as an Adaptive Response to Fasting in the Control of Hepatic Peroxisomal Fatty Acid {beta}-Oxidation in the Hibernating Mammal Endocrinology, March 1, 2009; 150(3): 1192 - 1201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Turbill, G. Kortner, and F. Geiser Timing of the daily temperature cycle affects the critical arousal temperature and energy expenditure of lesser long-eared bats J. Exp. Biol., December 15, 2008; 211(24): 3871 - 3878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. McGee-Lawrence, H. V. Carey, and S. W. Donahue Mammalian hibernation as a model of disuse osteoporosis: the effects of physical inactivity on bone metabolism, structure, and strength Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2008; 295(6): R1999 - R2014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Miyazawa, Y. Shimizu, T. Shiina, H. Hirayama, H. Morita, and T. Takewaki Central A1-receptor activation associated with onset of torpor protects the heart against low temperature in the Syrian hamster Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2008; 295(3): R991 - R996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Martin, L. E. Epperson, J. C. Rose, C. C. Kurtz, C. Ane, and H. V. Carey Proteomic analysis of the winter-protected phenotype of hibernating ground squirrel intestine Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2008; 295(1): R316 - R328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L Martin Mammalian hibernation: a naturally reversible model for insulin resistance in man? Diabetes and Vascular Disease Research, June 1, 2008; 5(2): 76 - 81. [Abstract] [PDF]
|
|
|
|
|
|
T. Ruf and W. Arnold Effects of polyunsaturated fatty acids on hibernation and torpor: a review and hypothesis Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R1044 - R1052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mertens, O. Stiedl, S. Steinlechner, and M. Meyer Cardiac dynamics during daily torpor in the Djungarian hamster (Phodopus sungorus) Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R639 - R650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yan, B. M. Barnes, F. Kohl, and T. G. Marr Modulation of gene expression in hibernating arctic ground squirrels Physiol Genomics, January 17, 2008; 32(2): 170 - 181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Serkova, J. C. Rose, L. E. Epperson, H. V. Carey, and S. L. Martin Quantitative analysis of liver metabolites in three stages of the circannual hibernation cycle in 13-lined ground squirrels by NMR Physiol Genomics, September 11, 2007; 31(1): 15 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. G. Revel, A. Herwig, M.-L. Garidou, H. Dardente, J. S. Menet, M. Masson-Pevet, V. Simonneaux, M. Saboureau, and P. Pevet The circadian clock stops ticking during deep hibernation in the European hamster PNAS, August 21, 2007; 104(34): 13816 - 13820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. B. Storey and J. M. Storey Tribute to P. L. Lutz: putting life on `pause' - molecular regulation of hypometabolism J. Exp. Biol., May 15, 2007; 210(10): 1700 - 1714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L. Symonds, R. S. James, and C. E. Franklin Getting the jump on skeletal muscle disuse atrophy: preservation of contractile performance in aestivating Cyclorana alboguttata (Gunther 1867) J. Exp. Biol., March 1, 2007; 210(5): 825 - 835. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. R. Stone Measuring Impacts of Restoration on Small Mammals in a Mixed-grass Colorado Prairie Ecological Rest., January 1, 2007; 25(3): 183 - 190. [Abstract] [PDF]
|
|
|
|
 |
|
 C. C. Kurtz, S. L. Lindell, M. J. Mangino, and H. V. Carey Hibernation confers resistance to intestinal ischemia-reperfusion injury Am J Physiol Gastrointest Liver Physiol, November 1, 2006; 291(5): G895 - G901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yan, A. Burman, C. Nichols, L. Alila, L. C. Showe, M. K. Showe, B. B. Boyer, B. M. Barnes, and T. G. Marr Detection of differential gene expression in brown adipose tissue of hibernating arctic ground squirrels with mouse microarrays Physiol Genomics, April 13, 2006; 25(2): 346 - 353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Swoap, M. J. Gutilla, L. C. Liles, R. O. Smith, and D. Weinshenker The Full Expression of Fasting-Induced Torpor Requires {beta}3-Adrenergic Receptor Signaling J. Neurosci., January 4, 2006; 26(1): 241 - 245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Williams, L. E. Epperson, W. Li, M. A. Hughes, R. Taylor, J. Rogers, S. L. Martin, A. R. Cossins, and A. Y. Gracey Seasonally hibernating phenotype assessed through transcript screening Physiol Genomics, December 14, 2005; 24(1): 13 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. L. Ma, X. Zhu, P. M. Rivera, O. Toien, B. M. Barnes, J. C. LaManna, M. A. Smith, and K. L. Drew Absence of cellular stress in brain after hypoxia induced by arousal from hibernation in Arctic ground squirrels Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2005; 289(5): R1297 - R1306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Brauch, N. D. Dhruv, E. A. Hanse, and M. T. Andrews Digital transcriptome analysis indicates adaptive mechanisms in the heart of a hibernating mammal Physiol Genomics, October 17, 2005; 23(2): 227 - 234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Fleck and H. V. Carey Modulation of apoptotic pathways in intestinal mucosa during hibernation Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R586 - R595. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yabe, N. Suzuki, T. Furukawa, T. Ishihara, and I. Katsura Multidrug resistance-associated protein MRP-1 regulates dauer diapause by its export activity in Caenorhabditis elegans Development, July 15, 2005; 132(14): 3197 - 3207. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Blackstone, M. Morrison, and M. B. Roth H2S Induces a Suspended Animation-Like State in Mice Science, April 22, 2005; 308(5721): 518 - 518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Lindell, S. L. Klahn, T. M. Piazza, M. J. Mangino, J. R. Torrealba, J. H. Southard, and H. V. Carey Natural resistance to liver cold ischemia-reperfusion injury associated with the hibernation phenotype Am J Physiol Gastrointest Liver Physiol, March 1, 2005; 288(3): G473 - G480. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. E. Epperson, T. A. Dahl, and S. L. Martin Quantitative Analysis of Liver Protein Expression During Hibernation in the Golden-mantled Ground Squirrel Mol. Cell. Proteomics, September 1, 2004; 3(9): 920 - 933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. van Breukelen, N. Sonenberg, and S. L. Martin Seasonal and state-dependent changes of eIF4E and 4E-BP1 during mammalian hibernation: implications for the control of translation during torpor Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2004; 287(2): R349 - R353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Kauffman, M. J. Paul, and I. Zucker Increased heat loss affects hibernation in golden-mantled ground squirrels Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2004; 287(1): R167 - R173. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
