| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Biochemsitry, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Tromsø, Norway
Østerud, Bjarne, and Eirik Bjørklid. Role of Monocytes in Atherogenesis. Physiol Rev 83: 1069-1112, 2003; 10.1152/physrev.00005.2003.—This review focuses on the role of monocytes in the early phase of atherogenesis, before foam cell formation. An emerging consensus underscores the importance of the cellular inflammatory system in atherogenesis. Initiation of the process apparently hinges on accumulating low-density lipoproteins (LDL) undergoing oxidation and glycation, providing stimuli for the release of monocyte attracting chemokines and for the upregulation of endothelial adhesive molecules. These conditions favor monocyte transmigration to the intima, where chemically modified, aggregated, or proteoglycan- or antibody-complexed LDL may be endocytotically internalized via scavenger receptors present on the emergent macrophage surface. The differentiating monocytes in concert with T lymphocytes exert a modulating effect on lipoproteins. These events propagate a series of reactions entailing generation of lipid peroxides and expression of chemokines, adhesion molecules, cytokines, and growth factors, thereby sustaining an ongoing inflammatory process leading ultimately to lesion formation. New data emerging from studies using transgenic animals, notably mice, have provided novel insights into many of the cellular interactions and signaling mechanisms involving monocytes/macrophages in the atherogenic processes. A number of these studies, focusing on mechanisms for monocyte activation and the roles of adhesive molecules, chemokines, cytokines and growth factors, are addressed in this review.
This article has been cited by other articles:
|
|
 |
|
  N. El Khatib, S. Genieys, B. Kazmierczak, and V. Volpert Mathematical modelling of atherosclerosis as an inflammatory disease Phil Trans R Soc A, December 13, 2009; 367(1908): 4877 - 4886. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Amoruso, C. Bardelli, L. G. Fresu, A. Palma, M. Vidali, V. Ferrero, F. Ribichini, C. Vassanelli, and S. Brunelleschi Enhanced Peroxisome Proliferator-Activated Receptor-{gamma} Expression in Monocyte/Macrophages from Coronary Artery Disease Patients and Possible Gender Differences J. Pharmacol. Exp. Ther., November 1, 2009; 331(2): 531 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Tsubakimoto, H. Yamada, H. Yokoi, S. Kishida, H. Takata, H. Kawahito, A. Matsui, N. Urao, Y. Nozawa, H. Hirai, et al. Bone Marrow Angiotensin AT1 Receptor Regulates Differentiation of Monocyte Lineage Progenitors From Hematopoietic Stem Cells Arterioscler Thromb Vasc Biol, October 1, 2009; 29(10): 1529 - 1536. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Kelly, M. E. Griffin, R. A. Fava, S. G. Wood, K. A. Bessette, E. R. Miller, S. A. Huber, C. J. Binder, J. L. Witztum, and P. M. Morganelli Inhibition of arterial lesion progression in CD16-deficient mice: evidence for altered immunity and the role of IL-10 Cardiovasc Res, September 19, 2009; (2009) cvp300v2. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Lee, S.-Y. Park, D. Thapa, A. R. Kim, H.-M. Shin, and J.-A. Kim HMC05, Herbal Formula, Inhibits TNF-{alpha}-induced Inflammatory Response in Human Umbilical Vein Endothelial Cells Evid. Based Complement. Altern. Med., September 7, 2009; (2009) nep126v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Chen, Z. Huang, L. Wang, Y. Wang, F. Wu, S. Meng, and C. Wang MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages Cardiovasc Res, July 1, 2009; 83(1): 131 - 139. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Vyas, S. Chaudhuri, D. W. Leaman, A. A. Komar, A. Musiyenko, S. Barik, and B. Mazumder Genome-Wide Polysome Profiling Reveals an Inflammation-Responsive Posttranscriptional Operon in Gamma Interferon-Activated Monocytes Mol. Cell. Biol., January 15, 2009; 29(2): 458 - 470. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Pacher Cannabinoid CB1 Receptor Antagonists for Atherosclerosis and Cardiometabolic Disorders: New Hopes, Old Concerns? Arterioscler Thromb Vasc Biol, January 1, 2009; 29(1): 7 - 9. [Full Text] [PDF]
|
|
|
|
 |
|
 E. Osto, A. Kouroedov, P. Mocharla, A. Akhmedov, C. Besler, L. Rohrer, A. von Eckardstein, S. Iliceto, M. Volpe, T. F. Luscher, et al. Inhibition of Protein Kinase C{beta} Prevents Foam Cell Formation by Reducing Scavenger Receptor A Expression in Human Macrophages Circulation, November 18, 2008; 118(21): 2174 - 2182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Pacher, P. Mukhopadhyay, R. Mohanraj, G. Godlewski, S. Batkai, and G. Kunos Modulation of the Endocannabinoid System in Cardiovascular Disease: Therapeutic Potential and Limitations Hypertension, October 1, 2008; 52(4): 601 - 607. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Pirillo, P. Uboldi, C. Bolego, H. Kuhn, and A. L. Catapano The 15-Lipoxygenase-Modified High Density Lipoproteins 3 Fail to Inhibit the TNF-{alpha}-Induced Inflammatory Response in Human Endothelial Cells J. Immunol., August 15, 2008; 181(4): 2821 - 2830. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Catellier, N. Aleksic, A. R. Folsom, and E. Boerwinkle Atherosclerosis Risk in Communities (ARIC) Carotid MRI Flow Cytometry Study of Monocyte and Platelet Markers: Intraindividual Variability and Reliability Clin. Chem., August 1, 2008; 54(8): 1363 - 1371. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Zaza, P. Pontrelli, G. Pertosa, S. Granata, M. Rossini, S. Porreca, F. J. T. Staal, L. Gesualdo, G. Grandaliano, and F. P. Schena Dialysis-related systemic microinflammation is associated with specific genomic patterns Nephrol. Dial. Transplant., May 1, 2008; 23(5): 1673 - 1681. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Navarro, C. Mora, M. Gomez, M. Muros, C. Lopez-Aguilar, and J. Garcia Influence of renal involvement on peripheral blood mononuclear cell expression behaviour of tumour necrosis factor-{alpha} and interleukin-6 in type 2 diabetic patients Nephrol. Dial. Transplant., March 1, 2008; 23(3): 919 - 926. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Crawford, A. S. Nord, M. D. Badzioch, J. Ranchalis, L. A. McKinstry, M. Ahearn, C. Bertucci, C. Shephard, M. Wong, M. J. Rieder, et al. A common VLDLR polymorphism interacts with APOE genotype in the prediction of carotid artery disease risk J. Lipid Res., March 1, 2008; 49(3): 588 - 596. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Badiou, J.-P. Cristol, I. Jaussent, N. Terrier, M. Morena, F. Maurice, H. Leray-Moragues, J.-P. Rivory, L. Chalabi, C. Delcourt, et al. Fine-Tuning of the Prediction of Mortality in Hemodialysis Patients by Use of Cytokine Proteomic Determination Clin. J. Am. Soc. Nephrol., March 1, 2008; 3(2): 423 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Mishra, K. A. Carnevale, and M. K. Cathcart iPLA2{beta}: front and center in human monocyte chemotaxis to MCP-1 J. Exp. Med., February 18, 2008; 205(2): 347 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Yatera, J. Hsieh, J. C. Hogg, E. Tranfield, H. Suzuki, C.-H. Shih, A. R. Behzad, R. Vincent, and S. F. van Eeden Particulate matter air pollution exposure promotes recruitment of monocytes into atherosclerotic plaques Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H944 - H953. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-J. Zhang, K. E. Bird, T. S. McMillen, R. C. LeBoeuf, T. M. Hagen, and B. Frei Dietary {alpha}-Lipoic Acid Supplementation Inhibits Atherosclerotic Lesion Development in Apolipoprotein E Deficient and Apolipoprotein E/Low-Density Lipoprotein Receptor Deficient Mice Circulation, January 22, 2008; 117(3): 421 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Y. Schubert, A. Benarroch, J. Ostvang, and E. R. Edelman Regulation of Endothelial Cell Proliferation by Primary Monocytes Arterioscler Thromb Vasc Biol, January 1, 2008; 28(1): 97 - 104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nachtigal, A. Ghaffar, and E. P. Mayer Galectin-3 Gene Inactivation Reduces Atherosclerotic Lesions and Adventitial Inflammation in ApoE-Deficient Mice Am. J. Pathol., January 1, 2008; 172(1): 247 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rajesh, P. Mukhopadhyay, S. Batkai, G. Hasko, L. Liaudet, J. W. Huffman, A. Csiszar, Z. Ungvari, K. Mackie, S. Chatterjee, et al. CB2-receptor stimulation attenuates TNF-{alpha}-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2210 - H2218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Gleissner, N. Leitinger, and K. Ley Effects of Native and Modified Low-Density Lipoproteins on Monocyte Recruitment in Atherosclerosis Hypertension, August 1, 2007; 50(2): 276 - 283. [Full Text] [PDF]
|
|
|
|
|
|
T. Nagao, C. Qin, I. Grosheva, F. R. Maxfield, and L. M. Pierini Elevated Cholesterol Levels in the Plasma Membranes of Macrophages Inhibit Migration by Disrupting RhoA Regulation Arterioscler Thromb Vasc Biol, July 1, 2007; 27(7): 1596 - 1602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Villacorta, J. Zhang, M. T. Garcia-Barrio, X.-l. Chen, B. A. Freeman, Y. E. Chen, and T. Cui Nitro-linoleic acid inhibits vascular smooth muscle cell proliferation via the Keap1/Nrf2 signaling pathway Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H770 - H776. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Figarola, N. Shanmugam, R. Natarajan, and S. Rahbar Anti-Inflammatory Effects of the Advanced Glycation End Product Inhibitor LR-90 in Human Monocytes Diabetes, March 1, 2007; 56(3): 647 - 655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Marcil, E. Delvin, A. T. Sane, A. Tremblay, and E. Levy Oxidative stress influences cholesterol efflux in THP-1 macrophages: Role of ATP-binding cassette A1 and nuclear factors Cardiovasc Res, December 1, 2006; 72(3): 473 - 482. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Cui, F. J. Schopfer, J. Zhang, K. Chen, T. Ichikawa, P. R. S. Baker, C. Batthyany, B. K. Chacko, X. Feng, R. P. Patel, et al. Nitrated Fatty Acids: Endogenous Anti-inflammatory Signaling Mediators J. Biol. Chem., November 24, 2006; 281(47): 35686 - 35698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Oram and A. M. Vaughan ATP-Binding Cassette Cholesterol Transporters and Cardiovascular Disease Circ. Res., November 10, 2006; 99(10): 1031 - 1043. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Galkina, A. Kadl, J. Sanders, D. Varughese, I. J. Sarembock, and K. Ley Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent J. Exp. Med., May 15, 2006; 203(5): 1273 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Mateo, Y. Naim Abu Nabah, M. Abu Taha, M. Mata, M. Cerda-Nicolas, A. E. I. Proudfoot, R. A. K. Stahl, A. C. Issekutz, J. Cortijo, E. J. Morcillo, et al. Angiotensin II-Induced Mononuclear Leukocyte Interactions with Arteriolar and Venular Endothelium Are Mediated by the Release of Different CC Chemokines J. Immunol., May 1, 2006; 176(9): 5577 - 5586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Chon, M. C. Verhaar, H. A. Koomans, J. A. Joles, and B. Braam Role of Circulating Karyocytes in the Initiation and Progression of Atherosclerosis Hypertension, May 1, 2006; 47(5): 803 - 810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tedgui and Z. Mallat Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways Physiol Rev, April 1, 2006; 86(2): 515 - 581. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-N. Chen, S.-F. Chang, P.-L. Lee, K. Chang, L.-J. Chen, S. Usami, S. Chien, and J.-J. Chiu Neutrophils, lymphocytes, and monocytes exhibit diverse behaviors in transendothelial and subendothelial migrations under coculture with smooth muscle cells in disturbed flow Blood, March 1, 2006; 107(5): 1933 - 1942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Oram and J. W. Heinecke ATP-Binding Cassette Transporter A1: A Cell Cholesterol Exporter That Protects Against Cardiovascular Disease Physiol Rev, October 1, 2005; 85(4): 1343 - 1372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Lee, F. Forudi, G. M. Saidel, and M. S. Penn Alterations in Internal Elastic Lamina Permeability As a Function of Age and Anatomical Site Precede Lesion Development in Apolipoprotein E-Null Mice Circ. Res., September 2, 2005; 97(5): 450 - 456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. L. Francone, L. Royer, G. Boucher, M. Haghpassand, A. Freeman, D. Brees, and R. J. Aiello Increased Cholesterol Deposition, Expression of Scavenger Receptors, and Response to Chemotactic Factors in Abca1-Deficient Macrophages Arterioscler Thromb Vasc Biol, June 1, 2005; 25(6): 1198 - 1205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Stawowy, H. Meyborg, D. Stibenz, N. B. P. Stawowy, M. Roser, U. Thanabalasingam, J. P. Veinot, M. Chretien, N. G. Seidah, E. Fleck, et al. Furin-Like Proprotein Convertases Are Central Regulators of the Membrane Type Matrix Metalloproteinase-Pro-Matrix Metalloproteinase-2 Proteolytic Cascade in Atherosclerosis Circulation, May 31, 2005; 111(21): 2820 - 2827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Johnsen, E. Fosse, O. Joakimsen, E. B. Mathiesen, E. Stensland-Bugge, I. Njolstad, and E. Arnesen Monocyte Count Is a Predictor of Novel Plaque Formation: A 7-Year Follow-up Study of 2610 Persons Without Carotid Plaque at Baseline The Tromso Study Stroke, April 1, 2005; 36(4): 715 - 719. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Lapointe, J. Goulet, C. Couillard, B. Lamarche, and S. Lemieux A Nutritional Intervention Promoting the Mediterranean Food Pattern Is Associated with a Decrease in Circulating Oxidized LDL Particles in Healthy Women from the Quebec City Metropolitan Area J. Nutr., March 1, 2005; 135(3): 410 - 415. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Rask-Madsen and G. L. King Proatherosclerotic Mechanisms Involving Protein Kinase C in Diabetes and Insulin Resistance Arterioscler Thromb Vasc Biol, March 1, 2005; 25(3): 487 - 496. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Lang, S. Reuter, T. Buzescu, C. August, and S. Heidenreich Heme-induced heme oxygenase-1 (HO-1) in human monocytes inhibits apoptosis despite caspase-3 up-regulation Int. Immunol., February 1, 2005; 17(2): 155 - 165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Campo, M. A. Sardo, A. Bitto, A. Bonaiuto, G. Trimarchi, M. Bonaiuto, M. Castaldo, C. Saitta, S. Cristadoro, and A. Saitta Platelet-Activating Factor Acetylhydrolase Is Not Associated with Carotid Intima-Media Thickness in Hypercholesterolemic Sicilian Individuals Clin. Chem., November 1, 2004; 50(11): 2077 - 2082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Barter, S. Nicholls, K.-A. Rye, G.M. Anantharamaiah, M. Navab, and A. M. Fogelman Antiinflammatory Properties of HDL Circ. Res., October 15, 2004; 95(8): 764 - 772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Stocker and J. F. Keaney Jr. Role of Oxidative Modifications in Atherosclerosis Physiol Rev, October 1, 2004; 84(4): 1381 - 1478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Llodra, V. Angeli, J. Liu, E. Trogan, E. A. Fisher, and G. J. Randolph From the Cover: Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques PNAS, August 10, 2004; 101(32): 11779 - 11784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Smith, G. L. Bentz, P. M. Smith, E. R. Bivins, and A. D. Yurochko HCMV activates PI(3)K in monocytes and promotes monocyte motility and transendothelial migration in a PI(3)K-dependent manner J. Leukoc. Biol., July 1, 2004; 76(1): 65 - 76. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
