| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Institute of Clinical Pharmacology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
Lösel, Ralf M., Elisabeth Falkenstein, Martin Feuring, Armin Schultz, Hanns-Christian Tillmann, Karin Rossol-Haseroth, and Martin Wehling. Nongenomic Steroid Action: Controversies, Questions, and Answers. Physiol Rev 83: 965–1016, 2003; 10.1152/physrev.00003.2003.—Steroids may exert their action in living cells by several ways: 1) the well-known genomic pathway, involving hormone binding to cytosolic (classic) receptors and subsequent modulation of gene expression followed by protein synthesis. 2) Alternatively, pathways are operating that do not act on the genome, therefore indicating nongenomic action. Although it is comparatively easy to confirm the nongenomic nature of a particular phenomenon observed, e.g., by using inhibitors of transcription or translation, considerable controversy exists about the identity of receptors that mediate these responses. Many different approaches have been employed to answer this question, including pharmacology, knock-out animals, and numerous biochemical studies. Evidence is presented for and against both the participation of classic receptors, or proteins closely related to them, as well as for the involvement of yet poorly understood, novel membrane steroid receptors. In addition, clinical implications for a wide array of nongenomic steroid actions are outlined.
This article has been cited by other articles:
|
|
 |
|
  R. Alzamora, L. R. Brown, and B. J. Harvey Direct Binding and Activation of Protein Kinase C Isoforms by Aldosterone and 17{beta}-Estradiol Mol. Endocrinol., November 1, 2007; 21(11): 2637 - 2650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Newton and N. S. Holden Separating Transrepression and Transactivation: A Distressing Divorce for the Glucocorticoid Receptor? Mol. Pharmacol., October 1, 2007; 72(4): 799 - 809. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Nonclercq, F. Journe, I. Laios, C. Chaboteaux, R.-A. Toillon, G. Leclercq, and G. Laurent Effect of nuclear export inhibition on estrogen receptor regulation in breast cancer cells J. Mol. Endocrinol., August 1, 2007; 39(2): 105 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Schumacher, R. Guennoun, A. Ghoumari, C. Massaad, F. Robert, M. El-Etr, Y. Akwa, K. Rajkowski, and E.-E. Baulieu Novel Perspectives for Progesterone in Hormone Replacement Therapy, with Special Reference to the Nervous System Endocr. Rev., June 1, 2007; 28(4): 387 - 439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Cheng, S. C. Watkins, and W. H. Walker Testosterone Activates Mitogen-Activated Protein Kinase via Src Kinase and the Epidermal Growth Factor Receptor in Sertoli Cells Endocrinology, May 1, 2007; 148(5): 2066 - 2074. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Moraes, K. E. Swales, J. A. Wray, A. Damazo, J. M. Gibbins, T. D. Warner, and D. Bishop-Bailey Nongenomic signaling of the retinoid X receptor through binding and inhibiting Gq in human platelets Blood, May 1, 2007; 109(9): 3741 - 3744. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Massarweh and R. Schiff Unraveling the Mechanisms of Endocrine Resistance in Breast Cancer: New Therapeutic Opportunities Clin. Cancer Res., April 1, 2007; 13(7): 1950 - 1954. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. W. Good Nongenomic Actions of Aldosterone on the Renal Tubule Hypertension, April 1, 2007; 49(4): 728 - 739. [Full Text] [PDF]
|
|
|
|
|
|
G. Coiret, A.-S. Borowiec, P. Mariot, H. Ouadid-Ahidouch, and F. Matifat The Antiestrogen Tamoxifen Activates BK Channels and Stimulates Proliferation of MCF-7 Breast Cancer Cells Mol. Pharmacol., March 1, 2007; 71(3): 843 - 851. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kousteni, M. Almeida, L. Han, T. Bellido, R. L. Jilka, and S. C. Manolagas Induction of Osteoblast Differentiation by Selective Activation of Kinase-Mediated Actions of the Estrogen Receptor Mol. Cell. Biol., February 15, 2007; 27(4): 1516 - 1530. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Rayner, Y.-X. Chen, B. Hibbert, D. White, H. Miller, E. H. Postel, and E. R. O'Brien NM23-H2, an estrogen receptor beta-associated protein, shows diminished expression with progression of atherosclerosis Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R743 - R750. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Krietsch, M. S. Fernandes, J. Kero, R. Losel, M. Heyens, E. W.-F. Lam, I. Huhtaniemi, J. J. Brosens, and B. Gellersen Human Homologs of the Putative G Protein-Coupled Membrane Progestin Receptors (mPR{alpha}, {beta}, and {gamma}) Localize to the Endoplasmic Reticulum and Are Not Activated by Progesterone Mol. Endocrinol., December 1, 2006; 20(12): 3146 - 3164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Massarweh and R. Schiff Resistance to endocrine therapy in breast cancer: exploiting estrogen receptor/growth factor signaling crosstalk Endocr. Relat. Cancer, December 1, 2006; 13(Supplement_1): S15 - S24. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. B. Huber, B. Schermer, R. U. Muller, M. Hohne, M. Bartram, A. Calixto, H. Hagmann, C. Reinhardt, F. Koos, K. Kunzelmann, et al. Inaugural Article: Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels PNAS, November 14, 2006; 103(46): 17079 - 17086. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Hanna, Y. Pang, P. Thomas, and Y. Zhu Cell-surface expression, progestin binding, and rapid nongenomic signaling of zebrafish membrane progestin receptors {alpha} and {beta} in transfected cells. J. Endocrinol., August 1, 2006; 190(2): 247 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Keay, J. T. Bridgham, and J. W. Thornton The Octopus vulgaris Estrogen Receptor Is a Constitutive Transcriptional Activator: Evolutionary and Functional Implications Endocrinology, August 1, 2006; 147(8): 3861 - 3869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C M. Luetjens, A. Didolkar, S. Kliesch, W. Paulus, A. Jeibmann, W. Bocker, E. Nieschlag, and M. Simoni Tissue expression of the nuclear progesterone receptor in male non-human primates and men. J. Endocrinol., June 1, 2006; 189(3): 529 - 539. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Boixel, B. Gavillet, J.-S. Rougier, and H. Abriel Aldosterone increases voltage-gated sodium current in ventricular myocytes Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2257 - H2266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Brandes The influence of estrogen on migraine: a systematic review. JAMA, April 19, 2006; 295(15): 1824 - 1830. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gentile, T. Darden, C. Erxleben, C. Romeo, A. Russo, N. Martin, S. Rossie, and D. L. Armstrong Rac GTPase signaling through the PP5 protein phosphatase PNAS, March 28, 2006; 103(13): 5202 - 5206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A Orihuela, A. Parada-Bustamante, L. M Zuniga, and H. B Croxatto Inositol triphosphate participates in an oestradiol nongenomic signalling pathway involved in accelerated oviductal transport in cycling rats. J. Endocrinol., March 1, 2006; 188(3): 579 - 588. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Wiegert, M. Joels, and H. Krugers Timing is essential for rapid effects of corticosterone on synaptic potentiation in the mouse hippocampus Learn. Mem., March 1, 2006; 13(2): 110 - 113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Schiffrin Effects of Aldosterone on the Vasculature Hypertension, March 1, 2006; 47(3): 312 - 318. [Full Text] [PDF]
|
|
|
|
|
|
H. N. Jabbour, R. W. Kelly, H. M. Fraser, and H. O. D. Critchley Endocrine Regulation of Menstruation Endocr. Rev., February 1, 2006; 27(1): 17 - 46. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Horvath and A. Wanner Inhaled corticosteroids: effects on the airway vasculature in bronchial asthma Eur. Respir. J., January 1, 2006; 27(1): 172 - 187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Ebner, D. I. Corol, H. Havlikova, J. W. Honour, and J. P. Fry Identification of Neuroactive Steroids and Their Precursors and Metabolites in Adult Male Rat Brain Endocrinology, January 1, 2006; 147(1): 179 - 190. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. R. Chapman, M. M. Kennelly, K. A. Harper, G. N. Europe-Finner, and S. C. Robson Examining the spatio-temporal expression of mRNA encoding the membrane-bound progesterone receptor-alpha isoform in human cervix and myometrium during pregnancy and labour Mol. Hum. Reprod., January 1, 2006; 12(1): 19 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Arreguin-Arevalo and Terry. M. Nett A Nongenomic Action of Estradiol as the Mechanism Underlying the Acute Suppression of Secretion of Luteinizing Hormone in Ovariectomized Ewes Biol Reprod, January 1, 2006; 74(1): 202 - 208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Karst, S. Berger, M. Turiault, F. Tronche, G. Schutz, and M. Joels Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone PNAS, December 27, 2005; 102(52): 19204 - 19207. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-C. Liou, S.-Y. Ho, M.-R. Shen, Y.-P. Liao, W.-T. Chiu, and K.-H. Kang A rapid, nongenomic pathway facilitates the synaptic transmission induced by retinoic acid at the developing synapse J. Cell Sci., October 15, 2005; 118(20): 4721 - 4730. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-J. Min, M. Mogi, J.-M. Li, J. Iwanami, M. Iwai, and M. Horiuchi Aldosterone and Angiotensin II Synergistically Induce Mitogenic Response in Vascular Smooth Muscle Cells Circ. Res., September 2, 2005; 97(5): 434 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Xiao, A. Qi, and Y. Chen Cultured Embryonic Hippocampal Neurons Deficient in Glucocorticoid (GC) Receptor: A Novel Model for Studying Nongenomic Effects of GC in the Neural System Endocrinology, September 1, 2005; 146(9): 4036 - 4041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E.V. Younglai, Y.J. Wu, T.K. Kwan, and C.-Y. Kwan Non-genomic action of estradiol and progesterone on cytosolic calcium concentrations in primary cultures of human granulosa-lutein cells Hum. Reprod., September 1, 2005; 20(9): 2383 - 2390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Maier, D. Runzler, J. Schindelar, G. Grabner, W. Waldhausl, G. Kohler, and A. Luger G-protein-coupled glucocorticoid receptors on the pituitary cell membrane J. Cell Sci., August 1, 2005; 118(15): 3353 - 3361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Arreguin-Arevalo and T. M. Nett A Nongenomic Action of 17{beta}-Estradiol as the Mechanism Underlying the Acute Suppression of Secretion of Luteinizing Hormone Biol Reprod, July 1, 2005; 73(1): 115 - 122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wehling Rapid Effects of Aldosterone: Relevant in Cardiac Ischemia? Hypertension, July 1, 2005; 46(1): 27 - 28. [Full Text] [PDF]
|
|
|
|
 |
|
 D. P. Srivastava, E. J. Yu, K. Kennedy, H. Chatwin, V. Reale, M. Hamon, T. Smith, and P. D. Evans Rapid, Nongenomic Responses to Ecdysteroids and Catecholamines Mediated by a Novel Drosophila G-Protein-Coupled Receptor J. Neurosci., June 29, 2005; 25(26): 6145 - 6155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. L. Tan, K. De Gendt, N. Atanassova, M. Walker, R. M. Sharpe, P. T. K. Saunders, E. Denolet, and G. Verhoeven The Role of Androgens in Sertoli Cell Proliferation and Functional Maturation: Studies in Mice with Total or Sertoli Cell-Selective Ablation of the Androgen Receptor Endocrinology, June 1, 2005; 146(6): 2674 - 2683. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Woclawek-Potocka, T. J. Acosta, A. Korzekwa, M. M. Bah, M. Shibaya, K. Okuda, and D. J. Skarzynski Phytoestrogens Modulate Prostaglandin Production in Bovine Endometrium: Cell Type Specificity and Intracellular Mechanisms Experimental Biology and Medicine, May 1, 2005; 230(5): 326 - 333. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Quintanilla, F. J. Munoz, M. J. Metcalfe, M. Hitschfeld, G. Olivares, J. A. Godoy, and N. C. Inestrosa Trolox and 17{beta}-Estradiol Protect against Amyloid {beta}-Peptide Neurotoxicity by a Mechanism That Involves Modulation of the Wnt Signaling Pathway J. Biol. Chem., March 25, 2005; 280(12): 11615 - 11625. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. K. Osborne and R. Schiff Estrogen-Receptor Biology: Continuing Progress and Therapeutic Implications J. Clin. Oncol., March 10, 2005; 23(8): 1616 - 1622. [Full Text] [PDF]
|
|
|
|
|
|
L. Michea, A. M. Delpiano, C. Hitschfeld, L. Lobos, S. Lavandero, and E. T. Marusic Eplerenone Blocks Nongenomic Effects of Aldosterone on the Na+/H+ Exchanger, Intracellular Ca2+ Levels, and Vasoconstriction in Mesenteric Resistance Vessels Endocrinology, March 1, 2005; 146(3): 973 - 980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Shah, D. Modi, G. Sachdeva, S. Gadkar, and C. Puri Coexistence of Intracellular and Membrane-Bound Progesterone Receptors in Human Testis J. Clin. Endocrinol. Metab., January 1, 2005; 90(1): 474 - 483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Fix, C. Jordan, P. Cano, and W. H. Walker Testosterone activates mitogen-activated protein kinase and the cAMP response element binding protein transcription factor in Sertoli cells PNAS, July 27, 2004; 101(30): 10919 - 10924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-P. Liao, S.-Y. Ho, and J.-C. Liou Non-genomic regulation of transmitter release by retinoic acid at developing motoneurons in Xenopus cell culture J. Cell Sci., June 15, 2004; 117(14): 2917 - 2924. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Turgeon, D. P. McDonnell, K. A. Martin, and P. M. Wise Hormone Therapy: Physiological Complexity Belies Therapeutic Simplicity Science, May 28, 2004; 304(5675): 1269 - 1273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Le Moellic, A. Ouvrard-Pascaud, C. Capurro, F. Cluzeaud, M. Fay, F. Jaisser, N. Farman, and M. Blot-Chabaud Early Nongenomic Events in Aldosterone Action in Renal Collecting Duct Cells: PKC{alpha} Activation, Mineralocorticoid Receptor Phosphorylation, and Cross-Talk with the Genomic Response J. Am. Soc. Nephrol., May 1, 2004; 15(5): 1145 - 1160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Winter, N. Schulz, G. Giebisch, J. P. Geibel, and C. A. Wagner Nongenomic stimulation of vacuolar H+-ATPases in intercalated renal tubule cells by aldosterone PNAS, February 24, 2004; 101(8): 2636 - 2641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. P. Zanello and A. W. Norman Rapid modulation of osteoblast ion channel responses by 1{alpha},25(OH)2-vitamin D3 requires the presence of a functional vitamin D nuclear receptor PNAS, February 10, 2004; 101(6): 1589 - 1594. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Dievart and S. E. Clark LRR-containing receptors regulating plant development and defense Development, January 15, 2004; 131(2): 251 - 261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chauhan, S. Kunz, K. Davis, J. Roberts, G. Martin, M. C. Demetriou, T. C. Sroka, A. E. Cress, and R. L. Miesfeld Androgen Control of Cell Proliferation and Cytoskeletal Reorganization in Human Fibrosarcoma Cells: ROLE OF RhoB SIGNALING J. Biol. Chem., January 9, 2004; 279(2): 937 - 944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Schiff, S. A. Massarweh, J. Shou, L. Bharwani, S. K. Mohsin, and C. K. Osborne Cross-Talk between Estrogen Receptor and Growth Factor Pathways as a Molecular Target for Overcoming Endocrine Resistance Clin. Cancer Res., January 1, 2004; 10(1): 331S - 336S. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
