| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Institute of Cell Biology, Department of Biology, ETH Zurich, Zurich, Switzerland; and Cancer Research UK, London Research Institute, London, United Kingdom
Werner, Sabine, and Richard Grose. Regulation of Wound Healing by Growth Factors and Cytokines. Physiol Rev 83: 835–870, 2003; 10.1152/physrev.00032.2002.—Cutaneous wound healing is a complex process involving blood clotting, inflammation, new tissue formation, and finally tissue remodeling. It is well described at the histological level, but the genes that regulate skin repair have only partially been identified. Many experimental and clinical studies have demonstrated varied, but in most cases beneficial, effects of exogenous growth factors on the healing process. However, the roles played by endogenous growth factors have remained largely unclear. Initial approaches at addressing this question focused on the expression analysis of various growth factors, cytokines, and their receptors in different wound models, with first functional data being obtained by applying neutralizing antibodies to wounds. During the past few years, the availability of genetically modified mice has allowed elucidation of the function of various genes in the healing process, and these studies have shed light onto the role of growth factors, cytokines, and their downstream effectors in wound repair. This review summarizes the results of expression studies that have been performed in rodents, pigs, and humans to localize growth factors and their receptors in skin wounds. Most importantly, we also report on genetic studies addressing the functions of endogenous growth factors in the wound repair process.
This article has been cited by other articles:
|
|
 |
|
  S. H. Tan, M. Pal, M. J. Tan, M. H. L. Wong, F. U. Tam, J. W. T. Teo, H. C. Chong, C. K. Tan, Y. Y. Goh, M. B. Y. Tang, et al. Regulation of Cell Proliferation and Migration by TAK1 via Transcriptional Control of von Hippel-Lindau Tumor Suppressor J. Biol. Chem., July 3, 2009; 284(27): 18047 - 18058. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Goren, N. Allmann, N. Yogev, C. Schurmann, A. Linke, M. Holdener, A. Waisman, J. Pfeilschifter, and S. Frank A Transgenic Mouse Model of Inducible Macrophage Depletion: Effects of Diphtheria Toxin-Driven Lysozyme M-Specific Cell Lineage Ablation on Wound Inflammatory, Angiogenic, and Contractive Processes Am. J. Pathol., July 1, 2009; 175(1): 132 - 147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Blakytny and E. B. Jude Altered Molecular Mechanisms of Diabetic Foot Ulcers International Journal of Lower Extremity Wounds, June 1, 2009; 8(2): 95 - 104. [Abstract] [PDF]
|
|
|
|
 |
|
 J. M. Carvajal-Gonzalez, A. C. Roman, M. I. Cerezo-Guisado, E. M. Rico-Leo, G. Martin-Partido, and P. M. Fernandez-Salguero Loss of dioxin-receptor expression accelerates wound healing in vivo by a mechanism involving TGF{beta} J. Cell Sci., June 1, 2009; 122(11): 1823 - 1833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Buchstein, D. Hoffmann, H. Smola, S. Lang, M. Paulsson, C. Niemann, T. Krieg, and S. A. Eming Alternative Proteolytic Processing of Hepatocyte Growth Factor during Wound Repair Am. J. Pathol., June 1, 2009; 174(6): 2116 - 2128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Liu, M. Kapoor, and A. Leask Rac1 Expression by Fibroblasts Is Required for Tissue Repair in Vivo Am. J. Pathol., May 1, 2009; 174(5): 1847 - 1856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Geng, R. Lan, G. Wang, A. R. Siddiqi, M. C. Naski, A. I. Brooks, J. L. Barnes, P. Saikumar, J. M. Weinberg, and M. A. Venkatachalam Inhibition of Autoregulated TGF{beta} Signaling Simultaneously Enhances Proliferation and Differentiation of Kidney Epithelium and Promotes Repair Following Renal Ischemia Am. J. Pathol., April 1, 2009; 174(4): 1291 - 1308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. I. Tkalcevic, S. Cuzic, M. J. Parnham, I. Pasalic, and K. Brajsa Differential Evaluation of Excisional Non-occluded Wound Healing in db/db Mice Toxicol Pathol, February 1, 2009; 37(2): 183 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Yin and F.-S. X. Yu ERK1/2 Mediate Wounding- and G-protein-Coupled Receptor Ligands-Induced EGFR Activation via Regulating ADAM17 and HB-EGF Shedding Invest. Ophthalmol. Vis. Sci., January 1, 2009; 50(1): 132 - 139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D'Alessio, L. Gerasi, and F. Blasi uPAR-deficient mouse keratinocytes fail to produce EGFR-dependent laminin-5, affecting migration in vivo and in vitro J. Cell Sci., December 1, 2008; 121(23): 3922 - 3932. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Mabuchi, Y. Terai, K. Morishige, A. Tanabe-Kimura, H. Sasaki, M. Kanemura, S. Tsunetoh, Y. Tanaka, M. Sakata, R. A. Burger, et al. Maintenance Treatment with Bevacizumab Prolongs Survival in an In vivo Ovarian Cancer Model Clin. Cancer Res., December 1, 2008; 14(23): 7781 - 7789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Semenova, H. Koegel, S. Hasse, J. E. Klatte, E. Slonimsky, D. Bilbao, R. Paus, S. Werner, and N. Rosenthal Overexpression of mIGF-1 in Keratinocytes Improves Wound Healing and Accelerates Hair Follicle Formation and Cycling in Mice Am. J. Pathol., November 1, 2008; 173(5): 1295 - 1310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-N. Kung, M.-J. Yang, C.-F. Chang, Y.-P. Chau, and K.-S. Lu In vitro and in vivo wound healing-promoting activities of {beta}-lapachone Am J Physiol Cell Physiol, October 1, 2008; 295(4): C931 - C943. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Kuchler, J. Pollheimer, J. Balogh, J. Sponheim, L. Manley, D. R. Sorensen, P. M. De Angelis, H. Scott, and G. Haraldsen Nuclear Interleukin-33 Is Generally Expressed in Resting Endothelium but Rapidly Lost upon Angiogenic or Proinflammatory Activation Am. J. Pathol., October 1, 2008; 173(4): 1229 - 1242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Meng, X. Cheng, L. Yang, N. Hou, X. Yang, and A. Meng Accelerated re-epithelialization in Dpr2-deficient mice is associated with enhanced response to TGF{beta} signaling J. Cell Sci., September 1, 2008; 121(17): 2904 - 2912. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. S. Zheng and L. C. Burkly No end in site: TWEAK/Fn14 activation and autoimmunity associated- end-organ pathologies J. Leukoc. Biol., August 1, 2008; 84(2): 338 - 347. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. E. Banziger-Tobler, C. Halin, K. Kajiya, and M. Detmar Growth Hormone Promotes Lymphangiogenesis Am. J. Pathol., August 1, 2008; 173(2): 586 - 597. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Dumortier, D. N. Streblow, A. V. Moses, J. M. Jacobs, C. N. Kreklywich, D. Camp, R. D. Smith, S. L. Orloff, and J. A. Nelson Human Cytomegalovirus Secretome Contains Factors That Induce Angiogenesis and Wound Healing J. Virol., July 1, 2008; 82(13): 6524 - 6535. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. H. Yoo, G. Subramanian, M. P. Piechocki, J. F. Ensley, O. Kucuk, O. E. Tulunay, F. Lonardo, H. Kim, J. Won, T. Stevens, et al. Effect of Docetaxel on the Surgical Tumor Microenvironment of Head and Neck Cancer in Murine Models Arch Otolaryngol Head Neck Surg, July 1, 2008; 134(7): 735 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Jiang, S. Rhee, C.-H. Ho, and F. Grinnell Distinguishing fibroblast promigratory and procontractile growth factor environments in 3-D collagen matrices FASEB J, July 1, 2008; 22(7): 2151 - 2160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Schiefelbein, I. Goren, B. Fisslthaler, H. Schmidt, G. Geisslinger, J. Pfeilschifter, and S. Frank Biphasic Regulation of HMG-CoA Reductase Expression and Activity during Wound Healing and Its Functional Role in the Control of Keratinocyte Angiogenic and Proliferative Responses J. Biol. Chem., May 30, 2008; 283(22): 15479 - 15490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yin, J. Lu, and F.-S. X. Yu Role of Small GTPase Rho in Regulating Corneal Epithelial Wound Healing Invest. Ophthalmol. Vis. Sci., March 1, 2008; 49(3): 900 - 909. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ishida, J.-L. Gao, and P. M. Murphy Chemokine Receptor CX3CR1 Mediates Skin Wound Healing by Promoting Macrophage and Fibroblast Accumulation and Function J. Immunol., January 1, 2008; 180(1): 569 - 579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. T. Keylock, V. J. Vieira, M. A. Wallig, L. A. DiPietro, M. Schrementi, and J. A. Woods Exercise accelerates cutaneous wound healing and decreases wound inflammation in aged mice Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R179 - R184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Li, A. Maminishkis, F. E. Wang, and S. S. Miller PDGF-C and -D Induced Proliferation/Migration of Human RPE Is Abolished by Inflammatory Cytokines Invest. Ophthalmol. Vis. Sci., December 1, 2007; 48(12): 5722 - 5732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Taboubi, J. Milanini, E. Delamarre, F. Parat, F. Garrouste, G. Pommier, J. Takasaki, J.-C. Hubaud, H. Kovacic, and M. Lehmann G{alpha}(q/11)-coupled P2Y2 nucleotide receptor inhibits human keratinocyte spreading and migration FASEB J, December 1, 2007; 21(14): 4047 - 4058. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Wang, J. Lincoln, J. E. Cook, and D. L. Becker Abnormal Connexin Expression Underlies Delayed Wound Healing in Diabetic Skin Diabetes, November 1, 2007; 56(11): 2809 - 2817. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. S. Tan, G. Icre, A. Montagner, B. B.-t. Heggeler, W. Wahli, and L. Michalik The Nuclear Hormone Receptor Peroxisome Proliferator-Activated Receptor {beta}/{delta} Potentiates Cell Chemotactism, Polarization, and Migration Mol. Cell. Biol., October 15, 2007; 27(20): 7161 - 7175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Braiman-Wiksman, I. Solomonik, R. Spira, and T. Tennenbaum Novel Insights into Wound Healing Sequence of Events Toxicol Pathol, October 1, 2007; 35(6): 767 - 779. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Pachler, D. Ikeoka, J. Plank, H. Weinhandl, M. Suppan, J. K. Mader, M. Bodenlenz, W. Regittnig, H. Mangge, T. R. Pieber, et al. Subcutaneous adipose tissue exerts proinflammatory cytokines after minimal trauma in humans Am J Physiol Endocrinol Metab, September 1, 2007; 293(3): E690 - E696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gutierrez-Fernandez, M. Inada, M. Balbin, A. Fueyo, A. S. Pitiot, A. Astudillo, K. Hirose, M. Hirata, S. D. Shapiro, A. Noel, et al. Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8) FASEB J, August 1, 2007; 21(10): 2580 - 2591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. DiPersio Double Duty for Rac1 in Epidermal Wound Healing Sci. Signal., June 19, 2007; 2007(391): pe33 - pe33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Hinz, S. H. Phan, V. J. Thannickal, A. Galli, M.-L. Bochaton-Piallat, and G. Gabbiani The Myofibroblast: One Function, Multiple Origins Am. J. Pathol., June 1, 2007; 170(6): 1807 - 1816. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Fitsialos, A.-A. Chassot, L. Turchi, M. A. Dayem, K. LeBrigand, C. Moreilhon, G. Meneguzzi, R. Busca, B. Mari, P. Barbry, et al. Transcriptional Signature of Epidermal Keratinocytes Subjected to in Vitro Scratch Wounding Reveals Selective Roles for ERK1/2, p38, and Phosphatidylinositol 3-Kinase Signaling Pathways J. Biol. Chem., May 18, 2007; 282(20): 15090 - 15102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tscharntke, R. Pofahl, A. Chrostek-Grashoff, N. Smyth, C. Niessen, C. Niemann, B. Hartwig, V. Herzog, H. W. Klein, T. Krieg, et al. Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1 J. Cell Sci., April 15, 2007; 120(8): 1480 - 1490. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Chmielowiec, M. Borowiak, M. Morkel, T. Stradal, B. Munz, S. Werner, J. Wehland, C. Birchmeier, and W. Birchmeier c-Met is essential for wound healing in the skin J. Cell Biol., April 9, 2007; 177(1): 151 - 162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yin, K. Xu, J. Zhang, A. Kumar, and F.-S. X. Yu Wound-induced ATP release and EGF receptor activation in epithelial cells J. Cell Sci., March 1, 2007; 120(5): 815 - 825. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Eming, S. Werner, P. Bugnon, C. Wickenhauser, L. Siewe, O. Utermohlen, J. M. Davidson, T. Krieg, and A. Roers Accelerated Wound Closure in Mice Deficient for Interleukin-10 Am. J. Pathol., January 1, 2007; 170(1): 188 - 202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Weller, K. Foitzik, R. Paus, W. Syska, and M. Maurer Mast cells are required for normal healing of skin wounds in mice FASEB J, November 1, 2006; 20(13): 2366 - 2368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Cianfarani, G. Zambruno, L. Brogelli, F. Sera, P. M. Lacal, M. Pesce, M. C. Capogrossi, C. M. Failla, M. Napolitano, and T. Odorisio Placenta Growth Factor in Diabetic Wound Healing: Altered Expression and Therapeutic Potential Am. J. Pathol., October 1, 2006; 169(4): 1167 - 1182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Kamoshita, Y. Ikeda, M. Fujita, H. Amano, A. Oikawa, T. Suzuki, Y. Ogawa, S. Yamashina, S. Azuma, S. Narumiya, et al. Recruitment of a Prostaglandin E Receptor Subtype, EP3-Expressing Bone Marrow Cells Is Crucial in Wound-Induced Angiogenesis Am. J. Pathol., October 1, 2006; 169(4): 1458 - 1472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pankow, C. Bamberger, A. Klippel, and S. Werner Regulation of epidermal homeostasis and repair by phosphoinositide 3-kinase J. Cell Sci., October 1, 2006; 119(19): 4033 - 4046. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Montes, J. Garcia-Valero, and J. Ferrer Evidence of Innervation in Talc-Induced Pleural Adhesions. Chest, September 1, 2006; 130(3): 702 - 709. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. S. Wang, H. R. Ford, and J. S. Upperman Metabolic Response to Stress in the Neonate Who Has Surgery NeoReviews, August 1, 2006; 7(8): e410 - e418. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Deng, W.-L. Chen, A. Takatori, Z. Peng, L. Zhang, M. Mongan, R. Parthasarathy, M. Sartor, M. Miller, J. Yang, et al. A Role for the Mitogen-activated Protein Kinase Kinase Kinase 1 in Epithelial Wound Healing Mol. Biol. Cell, August 1, 2006; 17(8): 3446 - 3455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. W. Finch and J. S. Rubin Keratinocyte growth factor expression and activity in cancer: implications for use in patients with solid tumors. J Natl Cancer Inst, June 21, 2006; 98(12): 812 - 824. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Cochran, Y.-S. Kim, S. M. Lippow, B. Rao, and K.D. Wittrup Improved mutants from directed evolution are biased to orthologous substitutions Protein Eng. Des. Sel., June 1, 2006; 19(6): 245 - 253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Cheon, Q. Wei, A. Gurung, A. Youn, T. Bright, R. Poon, H. Whetstone, A. Guha, and B. A. Alman Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing FASEB J, April 1, 2006; 20(6): 692 - 701. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. T. Resch, C. Oxvig, L. K. Bale, and C. A. Conover Stress-Activated Signaling Pathways Mediate the Stimulation of Pregnancy-Associated Plasma Protein-A Expression in Cultured Human Fibroblasts Endocrinology, February 1, 2006; 147(2): 885 - 890. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-S. Park, J. M. Wells, A. M. Zorn, S. E. Wert, V. E. Laubach, L. G. Fernandez, and J. A. Whitsett Transdifferentiation of Ciliated Cells during Repair of the Respiratory Epithelium Am. J. Respir. Cell Mol. Biol., February 1, 2006; 34(2): 151 - 157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Goffin, P. Pittet, G. Csucs, J. W. Lussi, J.-J. Meister, and B. Hinz Focal adhesion size controls tension-dependent recruitment of {alpha}-smooth muscle actin to stress fibers J. Cell Biol., January 16, 2006; 172(2): 259 - 268. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Raffetto, R. Vasquez, D. G. Goodwin, and J. O. Menzoian Mitogen-Activated Protein Kinase Pathway Regulates Cell Proliferation in Venous Ulcer Fibroblasts Vascular and Endovascular Surgery, January 1, 2006; 40(1): 59 - 66. [Abstract] [PDF]
|
|
|
|
 |
|
 N. I Spielholz Invited Commentary Physical Therapy, January 1, 2006; 86(1): 59 - 62. [Full Text]
|
|
|
|
|
|
Y. Zhao, T. Shimizu, J. Nishihira, Y. Koyama, T. Kushibiki, A. Honda, H. Watanabe, R. Abe, Y. Tabata, and H. Shimizu Tissue Regeneration Using Macrophage Migration Inhibitory Factor-Impregnated Gelatin Microbeads in Cutaneous Wounds Am. J. Pathol., December 1, 2005; 167(6): 1519 - 1529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Hardman, A. Waite, L. Zeef, M. Burow, T. Nakayama, and G. S. Ashcroft Macrophage Migration Inhibitory Factor: A Central Regulator of Wound Healing Am. J. Pathol., December 1, 2005; 167(6): 1561 - 1574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Muenster, C. A. Harrison, C. Donaldson, W. Vale, and W. H. Fischer An Activin-A/C Chimera Exhibits Activin and Myostatin Antagonistic Properties J. Biol. Chem., November 4, 2005; 280(44): 36626 - 36632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P. Ng, B. Hinz, and M. A. Swartz Interstitial fluid flow induces myofibroblast differentiation and collagen alignment in vitro J. Cell Sci., October 15, 2005; 118(20): 4731 - 4739. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Suh, K. L. Kim, J.-M. Kim, I.-S. Shin, Y.-S. Lee, J.-Y. Lee, H.-S. Jang, J.-S. Lee, J. Byun, J.-H. Choi, et al. Transplantation of Endothelial Progenitor Cells Accelerates Dermal Wound Healing with Increased Recruitment of Monocytes/Macrophages and Neovascularization Stem Cells, October 1, 2005; 23(10): 1571 - 1578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Krampert, S. Kuenzle, S. N.-M. Thai, N. Lee, M. L. Iruela-Arispe, and S. Werner ADAMTS1 Proteinase Is Up-regulated in Wounded Skin and Regulates Migration of Fibroblasts and Endothelial Cells J. Biol. Chem., June 24, 2005; 280(25): 23844 - 23852. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bostrom, H. Bharath, A. Saulewicz, and A.S. Narayanan Cyclosporin A Affects Signaling Events Differentially in Human Gingival Fibroblasts Journal of Dental Research, June 1, 2005; 84(6): 532 - 536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shirakata, R. Kimura, D. Nanba, R. Iwamoto, S. Tokumaru, C. Morimoto, K. Yokota, M. Nakamura, K. Sayama, E. Mekada, et al. Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing J. Cell Sci., June 1, 2005; 118(11): 2363 - 2370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-P. Frechette, I. Martineau, and G. Gagnon Platelet-rich Plasmas: Growth Factor Content and Roles in Wound Healing Journal of Dental Research, May 1, 2005; 84(5): 434 - 439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kampfer, R. Schmidt, G. Geisslinger, J. Pfeilschifter, and S. Frank Wound Inflammation in Diabetic ob/ob Mice: Functional Coupling of Prostaglandin Biosynthesis to Cyclooxygenase-1 Activity in Diabetes-Impaired Wound Healing Diabetes, May 1, 2005; 54(5): 1543 - 1551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Florin, N. Maas-Szabowski, S. Werner, A. Szabowski, and P. Angel Increased keratinocyte proliferation by JUN-dependent expression of PTN and SDF-1 in fibroblasts J. Cell Sci., May 1, 2005; 118(9): 1981 - 1989. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Mace, J. C. Pearson, and W. McGinnis An Epidermal Barrier Wound Repair Pathway in Drosophila Is Mediated by grainy head Science, April 15, 2005; 308(5720): 381 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-F. Wang, J. Z. Cui, S. S. Prasad, and J. A. Matsubara Altered Gene Expression of Angiogenic Factors Induced by Calcium-Mediated Dissociation of Retinal Pigment Epithelial Cells Invest. Ophthalmol. Vis. Sci., April 1, 2005; 46(4): 1508 - 1515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Zcharia, R. Zilka, A. Yaar, O. Yacoby-Zeevi, A. Zetser, S. Metzger, R. Sarid, A. Naggi, B. Casu, N. Ilan, et al. Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models FASEB J, February 1, 2005; 19(2): 211 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Park, H. Shin, Y. K. Shin, Y. Lee, E.-C. Choi, B.-J. Park, and S. Kim The Novel Cytokine p43 Stimulates Dermal Fibroblast Proliferation and Wound Repair Am. J. Pathol., February 1, 2005; 166(2): 387 - 398. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. V. M. Rao and U. R. Pendurthi Tissue Factor-Factor VIIa Signaling Arterioscler. Thromb. Vasc. Biol., January 1, 2005; 25(1): 47 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Kurten, P. Chowdhury, R. C. Sanders Jr., L. M. Pittman, L. W. Sessions, T. C. Chambers, C. S. Lyle, B. J. Schnackenberg, and S. M. Jones Coordinating epidermal growth factor-induced motility promotes efficient wound closure Am J Physiol Cell Physiol, January 1, 2005; 288(1): C109 - C121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Chen, D. J. Abraham, X. Shi-wen, J. D. Pearson, C. M. Black, K. M. Lyons, and A. Leask CCN2 (Connective Tissue Growth Factor) Promotes Fibroblast Adhesion to Fibronectin Mol. Biol. Cell, December 1, 2004; 15(12): 5635 - 5646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kahlina, I. Goren, J. Pfeilschifter, and S. Frank p68 DEAD Box RNA Helicase Expression in Keratinocytes: REGULATION, NUCLEOLAR LOCALIZATION, AND FUNCTIONAL CONNECTION TO PROLIFERATION AND VASCULAR ENDOTHELIAL GROWTH FACTOR GENE EXPRESSION J. Biol. Chem., October 22, 2004; 279(43): 44872 - 44882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Elenius, M. Gotte, O. Reizes, K. Elenius, and M. Bernfield Inhibition by the Soluble Syndecan-1 Ectodomains Delays Wound Repair in Mice Overexpressing Syndecan-1 J. Biol. Chem., October 1, 2004; 279(40): 41928 - 41935. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Velardo, C. Burger, P. R. Williams, H. V. Baker, M. C. Lopez, T. H. Mareci, T. E. White, N. Muzyczka, and P. J. Reier Patterns of Gene Expression Reveal a Temporally Orchestrated Wound Healing Response in the Injured Spinal Cord J. Neurosci., September 29, 2004; 24(39): 8562 - 8576. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Martin and S. M. Parkhurst Parallels between tissue repair and embryo morphogenesis Development, July 1, 2004; 131(13): 3021 - 3034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. S. Thorey, B. Hinz, A. Hoeflich, S. Kaesler, P. Bugnon, M. Elmlinger, R. Wanke, E. Wolf, and S. Werner Transgenic Mice Reveal Novel Activities of Growth Hormone in Wound Repair, Angiogenesis, and Myofibroblast Differentiation J. Biol. Chem., June 18, 2004; 279(25): 26674 - 26684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. R. Block, A. R. Matela, N. SundarRaj, E. R. Iszkula, and J. K. Klarlund Wounding Induces Motility in Sheets of Corneal Epithelial Cells through Loss of Spatial Constraints: ROLE OF HEPARIN-BINDING EPIDERMAL GROWTH FACTOR-LIKE GROWTH FACTOR SIGNALING J. Biol. Chem., June 4, 2004; 279(23): 24307 - 24312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. B. Soeters, M. C. G. van de Poll, W. G. van Gemert, and C. H. C. Dejong Amino Acid Adequacy in Pathophysiological States J. Nutr., June 1, 2004; 134(6): 1575S - 1582S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Shi-wen, S. L. Howat, E. A. Renzoni, A. Holmes, J. D. Pearson, M. R. Dashwood, G. Bou-Gharios, C. P. Denton, R. M. du Bois, C. M. Black, et al. Endothelin-1 Induces Expression of Matrix-associated Genes in Lung Fibroblasts through MEK/ERK J. Biol. Chem., May 28, 2004; 279(22): 23098 - 23103. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Ogbourne, A. Suhrbier, B. Jones, S.-J. Cozzi, G. M. Boyle, M. Morris, D. McAlpine, J. Johns, T. M. Scott, K. P. Sutherland, et al. Antitumor Activity of 3-Ingenyl Angelate: Plasma Membrane and Mitochondrial Disruption and Necrotic Cell Death Cancer Res., April 15, 2004; 64(8): 2833 - 2839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Lim, M. Levy, and T. M. Bray Dietary Zinc Alters Early Inflammatory Responses during Cutaneous Wound Healing in Weanling CD-1 Mice J. Nutr., April 1, 2004; 134(4): 811 - 816. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. T. Resch, B.-K. Chen, L. K. Bale, C. Oxvig, M. T. Overgaard, and C. A. Conover Pregnancy-Associated Plasma Protein A Gene Expression as a Target of Inflammatory Cytokines Endocrinology, March 1, 2004; 145(3): 1124 - 1129. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Landi, L. Aloe, A. Russo, M. Cesari, G. Onder, S. Bonini, P. U. Carbonin, and R. Bernabei Topical Treatment of Pressure Ulcers with Nerve Growth Factor: A Randomized Clinical Trial Ann Intern Med, October 21, 2003; 139(8): 635 - 641. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
