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Physiological Reviews, Vol. 83, No. 2, April 2003, pp. 581-632; 10.1152/physrev.00031.2002.
Copyright ©2003 by the American Physiological Society
The Physiological Laboratory, University of Liverpool, Liverpool, United Kingdom
Burgoyne, Robert D. and
Alan Morgan.
Secretory Granule Exocytosis. Physiol. Rev. 83: 581-632, 2003.
Regulated exocytosis of secretory granules
or dense-core granules has been examined in many
well-characterized cell types including neurons, neuroendocrine,
endocrine, exocrine, and hemopoietic cells and also in other less
well-studied cell types. Secretory granule exocytosis occurs
through mechanisms with many aspects in common with synaptic vesicle
exocytosis and most likely uses the same basic protein components.
Despite the widespread expression and conservation of a core exocytotic
machinery, many variations occur in the control of secretory granule
exocytosis that are related to the specialized physiological role of
particular cell types. In this review we describe the wide range of
cell types in which regulated secretory granule exocytosis occurs and
assess the evidence for the expression of the conserved fusion
machinery in these cells. The signals that trigger and regulate
exocytosis are reviewed. Aspects of the control of exocytosis that are
specific for secretory granules compared with synaptic vesicles or for particular cell types are described and compared to define the range of
accessory control mechanisms that exert their effects on the core
exocytotic machinery.
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F. Reggiori, C.-W. Wang, U. Nair, T. Shintani, H. Abeliovich, and D. J. Klionsky Early Stages of the Secretory Pathway, but Not Endosomes, Are Required for Cvt Vesicle and Autophagosome Assembly in Saccharomyces cerevisiae Mol. Biol. Cell, May 1, 2004; 15(5): 2189 - 2204. [Abstract] [Full Text] [PDF]
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C. Rickman, D. A. Archer, F. A. Meunier, M. Craxton, M. Fukuda, R. D. Burgoyne, and B. Davletov Synaptotagmin Interaction with the Syntaxin/SNAP-25 Dimer Is Mediated by an Evolutionarily Conserved Motif and Is Sensitive to Inositol Hexakisphosphate J. Biol. Chem., March 26, 2004; 279(13): 12574 - 12579. [Abstract] [Full Text] [PDF]
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C. Rickman, F. A. Meunier, T. Binz, and B. Davletov High Affinity Interaction of Syntaxin and SNAP-25 on the Plasma Membrane Is Abolished by Botulinum Toxin E J. Biol. Chem., January 2, 2004; 279(1): 644 - 651. [Abstract] [Full Text] [PDF]
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M. J. DUNNE, K. E. COSGROVE, R. M. SHEPHERD, A. AYNSLEY-GREEN, and K. J. LINDLEY Hyperinsulinism in Infancy: From Basic Science to Clinical Disease Physiol Rev, January 1, 2004; 84(1): 239 - 275. [Abstract] [Full Text] [PDF]
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T. Tsuboi, G. da Silva Xavier, I. Leclerc, and G. A. Rutter 5'-AMP-activated Protein Kinase Controls Insulin-containing Secretory Vesicle Dynamics J. Biol. Chem., December 26, 2003; 278(52): 52042 - 52051. [Abstract] [Full Text] [PDF]
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D. Bakowski, R. D Burgoyne, and A. B Parekh Activation of the store-operated calcium current ICRAC can be dissociated from regulated exocytosis in rat basophilic leukaemia (RBL-1) cells J. Physiol., December 1, 2003; 553(2): 387 - 393. [Abstract] [Full Text] [PDF]
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