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Physiol. Rev. 83: 581-632, 2003; doi:10.1152/physrev.00031.2002
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Physiological Reviews, Vol. 83, No. 2, April 2003, pp. 581-632; 10.1152/physrev.00031.2002.
Copyright ©2003 by the American Physiological Society

Secretory Granule Exocytosis

Robert D. Burgoyne and Alan Morgan

The Physiological Laboratory, University of Liverpool, Liverpool, United Kingdom

Burgoyne, Robert D. and Alan Morgan. Secretory Granule Exocytosis. Physiol. Rev. 83: 581-632, 2003.Regulated exocytosis of secretory granules or dense-core granules has been examined in many well-characterized cell types including neurons, neuroendocrine, endocrine, exocrine, and hemopoietic cells and also in other less well-studied cell types. Secretory granule exocytosis occurs through mechanisms with many aspects in common with synaptic vesicle exocytosis and most likely uses the same basic protein components. Despite the widespread expression and conservation of a core exocytotic machinery, many variations occur in the control of secretory granule exocytosis that are related to the specialized physiological role of particular cell types. In this review we describe the wide range of cell types in which regulated secretory granule exocytosis occurs and assess the evidence for the expression of the conserved fusion machinery in these cells. The signals that trigger and regulate exocytosis are reviewed. Aspects of the control of exocytosis that are specific for secretory granules compared with synaptic vesicles or for particular cell types are described and compared to define the range of accessory control mechanisms that exert their effects on the core exocytotic machinery.




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Syntaxin/Munc18 Interactions in the Late Events during Vesicle Fusion and Release in Exocytosis
J. Biol. Chem., July 30, 2004; 279(31): 32751 - 32760.
[Abstract] [Full Text] [PDF]


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BloodHome page
I. Oynebraten, O. Bakke, P. Brandtzaeg, F.-E. Johansen, and G. Haraldsen
Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments
Blood, July 15, 2004; 104(2): 314 - 320.
[Abstract] [Full Text] [PDF]


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J. Cell Sci.Home page
M. Iezzi, G. Kouri, M. Fukuda, and C. B. Wollheim
Synaptotagmin V and IX isoforms control Ca2+-dependent insulin exocytosis
J. Cell Sci., July 1, 2004; 117(15): 3119 - 3127.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
M. Matsumoto, T. Miki, T. Shibasaki, M. Kawaguchi, H. Shinozaki, J. Nio, A. Saraya, H. Koseki, M. Miyazaki, T. Iwanaga, et al.
Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells
PNAS, June 1, 2004; 101(22): 8313 - 8318.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
T. Nakayama, K. Mikoshiba, T. Yamamori, and K. Akagawa
Activation of Syntaxin 1C, an Alternative Splice Variant of HPC-1/Syntaxin 1A, by Phorbol 12-Myristate 13-Acetate (PMA) Suppresses Glucose Transport into Astroglioma Cells via the Glucose Transporter-1 (GLUT-1)
J. Biol. Chem., May 28, 2004; 279(22): 23728 - 23739.
[Abstract] [Full Text] [PDF]


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Mol. Biol. CellHome page
F. Reggiori, C.-W. Wang, U. Nair, T. Shintani, H. Abeliovich, and D. J. Klionsky
Early Stages of the Secretory Pathway, but Not Endosomes, Are Required for Cvt Vesicle and Autophagosome Assembly in Saccharomyces cerevisiae
Mol. Biol. Cell, May 1, 2004; 15(5): 2189 - 2204.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
C. Rickman, D. A. Archer, F. A. Meunier, M. Craxton, M. Fukuda, R. D. Burgoyne, and B. Davletov
Synaptotagmin Interaction with the Syntaxin/SNAP-25 Dimer Is Mediated by an Evolutionarily Conserved Motif and Is Sensitive to Inositol Hexakisphosphate
J. Biol. Chem., March 26, 2004; 279(13): 12574 - 12579.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
C. Rickman, F. A. Meunier, T. Binz, and B. Davletov
High Affinity Interaction of Syntaxin and SNAP-25 on the Plasma Membrane Is Abolished by Botulinum Toxin E
J. Biol. Chem., January 2, 2004; 279(1): 644 - 651.
[Abstract] [Full Text] [PDF]


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Physiol. Rev.Home page
M. J. DUNNE, K. E. COSGROVE, R. M. SHEPHERD, A. AYNSLEY-GREEN, and K. J. LINDLEY
Hyperinsulinism in Infancy: From Basic Science to Clinical Disease
Physiol Rev, January 1, 2004; 84(1): 239 - 275.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
T. Tsuboi, G. da Silva Xavier, I. Leclerc, and G. A. Rutter
5'-AMP-activated Protein Kinase Controls Insulin-containing Secretory Vesicle Dynamics
J. Biol. Chem., December 26, 2003; 278(52): 52042 - 52051.
[Abstract] [Full Text] [PDF]


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J. Physiol.Home page
D. Bakowski, R. D Burgoyne, and A. B Parekh
Activation of the store-operated calcium current ICRAC can be dissociated from regulated exocytosis in rat basophilic leukaemia (RBL-1) cells
J. Physiol., December 1, 2003; 553(2): 387 - 393.
[Abstract] [Full Text] [PDF]




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