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Physiological Reviews, Vol. 82, No. 4, October 2002, pp. 893-922; 10.1152/physrev.00013.2002.
Copyright ©2002 by the American Physiological Society
Department of Physiology, Loyola University Chicago, Maywood, Illinois
Fill, Michael and
Julio A. Copello.
Ryanodine Receptor Calcium Release Channels. Physiol. Rev. 82: 893-922, 2002.
The ryanodine receptors (RyRs) are a
family of Ca2+ release channels found on intracellular
Ca2+ storage/release organelles. The RyR channels are
ubiquitously expressed in many types of cells and participate in a
variety of important Ca2+ signaling phenomena
(neurotransmission, secretion, etc.). In striated muscle, the RyR
channels represent the primary pathway for Ca2+ release
during the excitation-contraction coupling process. In general, the
signals that activate the RyR channels are known (e.g., sarcolemmal
Ca2+ influx or depolarization), but the specific mechanisms
involved are still being debated. The signals that modulate and/or turn off the RyR channels remain ambiguous and the mechanisms involved unclear. Over the last decade, studies of RyR-mediated
Ca2+ release have taken many forms and have steadily
advanced our knowledge. This robust field, however, is not without
controversial ideas and contradictory results. Controversies
surrounding the complex Ca2+ regulation of single RyR
channels receive particular attention here. In addition, a large body
of information is synthesized into a focused perspective of single RyR
channel function. The present status of the single RyR channel field
and its likely future directions are also discussed.
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J. Zhou, G. Brum, A. Gonzalez, B. S. Launikonis, M. D. Stern, and E. Rios Concerted vs. Sequential. Two Activation Patterns of Vast Arrays of Intracellular Ca2+ Channels in Muscle J. Gen. Physiol., September 26, 2005; 126(4): 301 - 309. [Abstract] [Full Text] [PDF]
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M. Isokawa and B. E Alger Retrograde endocannabinoid regulation of GABAergic inhibition in the rat dentate gyrus granule cell J. Physiol., September 15, 2005; 567(3): 1001 - 1010. [Abstract] [Full Text] [PDF]
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B. S. Launikonis, J. Zhou, L. Royer, T. R. Shannon, G. Brum, and E. Rios Confocal imaging of [Ca2+] in cellular organelles by SEER, shifted excitation and emission ratioing of fluorescence J. Physiol., September 1, 2005; 567(2): 523 - 543. [Abstract] [Full Text] [PDF]
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Y. G Wang, E. N Dedkova, X Ji, L. A Blatter, and S. L Lipsius Phenylephrine acts via IP3-dependent intracellular NO release to stimulate L-type Ca2+ current in cat atrial myocytes J. Physiol., August 15, 2005; 567(1): 143 - 157. [Abstract] [Full Text] [PDF]
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 N. C. Featherstone, E. C. Jesudason, M. G. Connell, D. G. Fernig, S. Wray, P. D. Losty, and T. V. Burdyga Spontaneous Propagating Calcium Waves Underpin Airway Peristalsis in Embryonic Rat Lung Am. J. Respir. Cell Mol. Biol., August 1, 2005; 33(2): 153 - 160. [Abstract] [Full Text] [PDF]
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X.-R. Yang, M.-J. Lin, K.-P. Yip, L. H. Jeyakumar, S. Fleischer, G. P. H. Leung, and J. S. K. Sham Multiple ryanodine receptor subtypes and heterogeneous ryanodine receptor-gated Ca2+ stores in pulmonary arterial smooth muscle cells Am J Physiol Lung Cell Mol Physiol, August 1, 2005; 289(2): L338 - L348. [Abstract] [Full Text] [PDF]
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W. Du, J. A. Stiber, P. B. Rosenberg, G. Meissner, and J. P. Eu Ryanodine Receptors in Muscarinic Receptor-mediated Bronchoconstriction J. Biol. Chem., July 15, 2005; 280(28): 26287 - 26294. [Abstract] [Full Text] [PDF]
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X. H. T. Wehrens, S. E. Lehnart, S. Reiken, R. van der Nagel, R. Morales, J. Sun, Z. Cheng, S.-X. Deng, L. J. de Windt, D. W. Landry, et al. Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure PNAS, July 5, 2005; 102(27): 9607 - 9612. [Abstract] [Full Text] [PDF]
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E. A. Sobie, L.-S. Song, and W. J. Lederer Local recovery of Ca2+ release in rat ventricular myocytes J. Physiol., June 1, 2005; 565(2): 441 - 447. [Abstract] [Full Text] [PDF]
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N. Fritz, N. Macrez, J. Mironneau, L. H. Jeyakumar, S. Fleischer, and J.-L. Morel Ryanodine receptor subtype 2 encodes Ca2+ oscillations activated by acetylcholine via the M2 muscarinic receptor/cADP-ribose signalling pathway in duodenum myocytes J. Cell Sci., May 15, 2005; 118(10): 2261 - 2270. [Abstract] [Full Text] [PDF]
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D. A. Deshpande, T. A. White, S. Dogan, T. F. Walseth, R. A. Panettieri, and M. S. Kannan CD38/cyclic ADP-ribose signaling: role in the regulation of calcium homeostasis in airway smooth muscle Am J Physiol Lung Cell Mol Physiol, May 1, 2005; 288(5): L773 - L788. [Abstract] [Full Text] [PDF]
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J. Kockskamper, A. V. Zima, and L. A. Blatter Modulation of sarcoplasmic reticulum Ca2+ release by glycolysis in cat atrial myocytes J. Physiol., May 1, 2005; 564(3): 697 - 714. [Abstract] [Full Text] [PDF]
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M. Klee and F. X. Pimentel-Muinos Bcl-XL specifically activates Bak to induce swelling and restructuring of the endoplasmic reticulum J. Cell Biol., February 28, 2005; 168(5): 723 - 734. [Abstract] [Full Text] [PDF]
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E. Brailoiu, J. L. Hoard, C. M. Filipeanu, G. C. Brailoiu, S. L. Dun, S. Patel, and N. J. Dun Nicotinic Acid Adenine Dinucleotide Phosphate Potentiates Neurite Outgrowth J. Biol. Chem., February 18, 2005; 280(7): 5646 - 5650. [Abstract] [Full Text] [PDF]
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A. Verkhratsky Physiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons Physiol Rev, January 1, 2005; 85(1): 201 - 279. [Abstract] [Full Text] [PDF]
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 T. M. Curtis, J. Tumelty, J. Dawicki, C. N. Scholfield, and J. G. McGeown Identification and Spatiotemporal Characterization of Spontaneous Ca2+ Sparks and Global Ca2+ Oscillations in Retinal Arteriolar Smooth Muscle Cells Invest. Ophthalmol. Vis. Sci., December 1, 2004; 45(12): 4409 - 4414. [Abstract] [Full Text] [PDF]
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H. Hirata, L. Saint-Amant, J. Waterbury, W. Cui, W. Zhou, Q. Li, D. Goldman, M. Granato, and J. Y. Kuwada accordion, a zebrafish behavioral mutant, has a muscle relaxation defect due to a mutation in the ATPase Ca2+ pump SERCA1 Development, November 1, 2004; 131(21): 5457 - 5468. [Abstract] [Full Text] [PDF]
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N. Lowri Thomas, C. H. George, and F. Anthony Lai Functional heterogeneity of ryanodine receptor mutations associated with sudden cardiac death Cardiovasc Res, October 1, 2004; 64(1): 52 - 60. [Abstract] [Full Text] [PDF]
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D. J. Beech, K. Muraki, and R. Flemming Non-selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP J. Physiol., September 15, 2004; 559(3): 685 - 706. [Abstract] [Full Text] [PDF]
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N. Yamaguchi, L. Xu, K. E. Evans, D. A. Pasek, and G. Meissner Different Regions in Skeletal and Cardiac Muscle Ryanodine Receptors Are Involved in Transducing the Functional Effects of Calmodulin J. Biol. Chem., August 27, 2004; 279(35): 36433 - 36439. [Abstract] [Full Text] [PDF]
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K. Tully and S. N. Treistman Distinct Intracellular Calcium Profiles Following Influx Through N- Versus L-Type Calcium Channels: Role of Ca2+-Induced Ca2+ Release J Neurophysiol, July 1, 2004; 92(1): 135 - 143. [Abstract] [Full Text] [PDF]
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