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Physiological Reviews, Vol. 82, No. 4, October 2002, pp. 825-874; 10.1152/physrev.00009.2002.
Copyright ©2002 by the American Physiological Society
Population Council, Center for Biomedical Research, New York, New York
Cheng, C. Yan and
Dolores D. Mruk.
Cell Junction Dynamics in the Testis: Sertoli-Germ
Cell Interactions and Male Contraceptive Development. Physiol. Rev. 82: 825-874, 2002.
Spermatogenesis is an intriguing but
complicated biological process. However, many studies since the 1960s
have focused either on the hormonal events of the
hypothalamus-pituitary-testicular axis or morphological events that
take place in the seminiferous epithelium. Recent advances in
biochemistry, cell biology, and molecular biology have shifted
attention to understanding some of the key events that regulate
spermatogenesis, such as germ cell apoptosis, cell cycle regulation,
Sertoli-germ cell communication, and junction dynamics. In this
review, we discuss the physiology and biology of junction dynamics in
the testis, in particular how these events affect interactions of
Sertoli and germ cells in the seminiferous epithelium behind the
blood-testis barrier. We also discuss how these events regulate the
opening and closing of the blood-testis barrier to permit the
timely passage of preleptotene and leptotene spermatocytes across the
blood-testis barrier. This is physiologically important since
developing germ cells must translocate across the blood-testis
barrier as well as traverse the seminiferous epithelium during their
development. We also discuss several available in vitro and in vivo
models that can be used to study Sertoli-germ cell anchoring
junctions and Sertoli-Sertoli tight junctions. An in-depth
survey in this subject has also identified several potential targets to
be tackled to perturb spermatogenesis, which will likely lead to the
development of novel male contraceptives.
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H. Johnston, P. J. Baker, M. Abel, H. M. Charlton, G. Jackson, L. Fleming, T. R. Kumar, and P. J. O'Shaughnessy Regulation of Sertoli Cell Number and Activity by Follicle-Stimulating Hormone and Androgen during Postnatal Development in the Mouse Endocrinology, January 1, 2004; 145(1): 318 - 329. [Abstract] [Full Text] [PDF]
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Y.-m. Chen, N. P.Y. Lee, D. D. Mruk, W. M. Lee, and C. Y. Cheng Fer Kinase/FerT and Adherens Junction Dynamics in the Testis: An In Vitro and In Vivo Study Biol Reprod, August 1, 2003; 69(2): 656 - 672. [Abstract] [Full Text] [PDF]
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D. D. Mruk, M. K.Y. Siu, A. M. Conway, N. P.Y. Lee, A. S.N. Lau, and C. Y. Cheng Role of Tissue Inhibitor of Metalloproteases-1 in Junction Dynamics in the Testis J Androl, July 1, 2003; 24(4): 510 - 523. [Abstract] [Full Text] [PDF]
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N. P. Y. Lee and C. Yan Cheng Regulation of Sertoli Cell Tight Junction Dynamics in the Rat Testis via the Nitric Oxide Synthase/Soluble Guanylate Cyclase/3',5'-Cyclic Guanosine Monophosphate/Protein Kinase G Signaling Pathway: an in Vitro Study Endocrinology, July 1, 2003; 144(7): 3114 - 3129. [Abstract] [Full Text] [PDF]
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W.-y. Lui, W. M. Lee, and C. Y. Cheng Sertoli-Germ Cell Adherens Junction Dynamics in the Testis Are Regulated by RhoB GTPase via the ROCK/LIMK Signaling Pathway Biol Reprod, June 1, 2003; 68(6): 2189 - 2206. [Abstract] [Full Text] [PDF]
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M. K. Y. Siu, D. D. Mruk, W. M. Lee, and C. Y. Cheng Adhering Junction Dynamics in the Testis Are Regulated by an Interplay of {beta}1-Integrin and Focal Adhesion Complex-Associated Proteins Endocrinology, May 1, 2003; 144(5): 2141 - 2163. [Abstract] [Full Text] [PDF]
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W.-y. Lui, W. M. Lee, and C. Y. Cheng Transforming Growth Factor {beta}3 Regulates the Dynamics of Sertoli Cell Tight Junctions Via the p38 Mitogen-Activated Protein Kinase Pathway Biol Reprod, May 1, 2003; 68(5): 1597 - 1612. [Abstract] [Full Text] [PDF]
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A. S. N. Lau and D. D. Mruk Rab8B GTPase and Junction Dynamics in the Testis Endocrinology, April 1, 2003; 144(4): 1549 - 1563. [Abstract] [Full Text] [PDF]
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W.-Y. Lui, D. Mruk, W. M Lee, and C. Y. Cheng Sertoli Cell Tight Junction Dynamics: Their Regulation During Spermatogenesis Biol Reprod, April 1, 2003; 68(4): 1087 - 1097. [Abstract] [Full Text] [PDF]
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N. P.Y. Lee, D. Mruk, W. M. Lee, and C. Y. Cheng Is the Cadherin/Catenin Complex a Functional Unit of Cell-Cell Actin-Based Adherens Junctions in the Rat Testis? Biol Reprod, February 1, 2003; 68(2): 489 - 508. [Abstract] [Full Text] [PDF]
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M. K. Y. Siu, W. M. Lee, and C. Y. Cheng The Interplay of Collagen IV, Tumor Necrosis Factor-{alpha}, Gelatinase B (Matrix Metalloprotease-9), and Tissue Inhibitor of Metalloproteases-1 in the Basal Lamina Regulates Sertoli Cell-Tight Junction Dynamics in the Rat Testis Endocrinology, January 1, 2003; 144(1): 371 - 387. [Abstract] [Full Text] [PDF]
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W.-Y. Lui, D. D. Mruk, W. M. Lee, and C. Y. Cheng Adherens Junction Dynamics in the Testis and Spermatogenesis J Androl, January 1, 2003; 24(1): 1 - 14. [Full Text] [PDF]
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