|
|
||||||||
Physiological Reviews, Vol. 82, No. 4, October 2002, pp. 1013-1067; 10.1152/physrev.00015.2002.
Copyright ©2002 by the American Physiological Society
Institute of Molecular Physiology, University of Sheffield, Western Bank, Sheffield, United Kingdom
North, R. Alan
Molecular Physiology of P2X Receptors. Physiol. Rev. 82: 1013-1067, 2002.
P2X receptors are membrane ion
channels that open in response to the binding of extracellular ATP.
Seven genes in vertebrates encode P2X receptor subunits, which
are 40-50% identical in amino acid sequence. Each subunit has two
transmembrane domains, separated by an extracellular domain (~280
amino acids). Channels form as multimers of several subunits. Homomeric
P2X1, P2X2, P2X3, P2X4, P2X5, and P2X7 channels and heteromeric
P2X2/3 and P2X1/5 channels have been most fully
characterized following heterologous expression. Some agonists (e.g.,

-methylene ATP) and antagonists [e.g., 2',3'-O-(2,4,6-trinitrophenyl)-ATP] are strongly selective
for receptors containing P2X1 and P2X3
subunits. All P2X receptors are permeable to small monovalent cations;
some have significant calcium or anion permeability. In many cells,
activation of homomeric P2X7 receptors induces a
permeability increase to larger organic cations including some
fluorescent dyes and also signals to the cytoskeleton; these changes
probably involve additional interacting proteins. P2X receptors are
abundantly distributed, and functional responses are seen in neurons,
glia, epithelia, endothelia, bone, muscle, and hemopoietic tissues. The
molecular composition of native receptors is becoming understood, and
some cells express more than one type of P2X receptor. On smooth
muscles, P2X receptors respond to ATP released from sympathetic motor
nerves (e.g., in ejaculation). On sensory nerves, they are involved in
the initiation of afferent signals in several viscera (e.g., bladder,
intestine) and play a key role in sensing tissue-damaging and
inflammatory stimuli. Paracrine roles for ATP signaling through P2X
receptors are likely in neurohypophysis, ducted glands, airway
epithelia, kidney, bone, and hemopoietic tissues. In the last case,
P2X7 receptor activation stimulates cytokine release by
engaging intracellular signaling pathways.
This article has been cited by other articles:
![]() |
P. T. Ohara, J.-P. Vit, A. Bhargava, M. Romero, C. Sundberg, A. C. Charles, and L. Jasmin Gliopathic Pain: When Satellite Glial Cells Go Bad Neuroscientist, October 1, 2009; 15(5): 450 - 463. [Abstract] [PDF] |
||||
![]() |
S.-M. Hwang, J. Li, N.-Y. Koo, S.-Y. Choi, S.J. Lee, S.-B. Oh, R. Castro, J.-S. Kim, and K. Park Role of Purinergic Receptor in Alpha Fodrin Degradation in Par C5 Cells Journal of Dental Research, October 1, 2009; 88(10): 927 - 932. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. A. Gomes, Z. Song, W. Stevens, and C. D. Sladek Sustained stimulation of vasopressin and oxytocin release by ATP and phenylephrine requires recruitment of desensitization-resistant P2X purinergic receptors Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2009; 297(4): R940 - R949. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Nicke, Y.-H. Kuan, M. Masin, J. Rettinger, B. Marquez-Klaka, O. Bender, D. C. Gorecki, R. D. Murrell-Lagnado, and F. Soto A Functional P2X7 Splice Variant with an Alternative Transmembrane Domain 1 Escapes Gene Inactivation in P2X7 Knock-out Mice J. Biol. Chem., September 18, 2009; 284(38): 25813 - 25822. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. Milenkovic, I. Rinke, M. Witte, B. Dietz, and R. Rubsamen P2 Receptor-Mediated Signaling in Spherical Bushy Cells of the Mammalian Cochlear Nucleus J Neurophysiol, September 1, 2009; 102(3): 1821 - 1833. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Kauffenstein, A. Drouin, N. Thorin-Trescases, H. Bachelard, B. Robaye, P. D'Orleans-Juste, F. Marceau, E. Thorin, and J. Sevigny NTPDase1 (CD39) controls nucleotide-dependent vasoconstriction in mouse Cardiovasc Res, August 20, 2009; (2009) cvp265v2. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Lecut, K. Frederix, D. M. Johnson, C. Deroanne, M. Thiry, C. Faccinetto, R. Maree, R. J. Evans, P. G. A. Volders, V. Bours, et al. P2X1 Ion Channels Promote Neutrophil Chemotaxis through Rho Kinase Activation J. Immunol., August 15, 2009; 183(4): 2801 - 2809. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Marichal, G. Garcia, M. Radmilovich, O. Trujillo-Cenoz, and R. E. Russo Enigmatic Central Canal Contacting Cells: Immature Neurons in "Standby Mode"? J. Neurosci., August 12, 2009; 29(32): 10010 - 10024. [Abstract] [Full Text] [PDF] |
||||
![]() |
Z. Song, D. A. Gomes, and W. Stevens Role of purinergic P2Y1 receptors in regulation of vasopressin and oxytocin secretion Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2009; 297(2): R478 - R484. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. Peng, M. L. Cotrina, X. Han, H. Yu, L. Bekar, L. Blum, T. Takano, G.-F. Tian, S. A. Goldman, and M. Nedergaard From the Cover: Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury PNAS, July 28, 2009; 106(30): 12489 - 12493. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Hong, N. Schwarz, A. Brass, M. Seman, F. Haag, F. Koch-Nolte, W. P. Schilling, and G. R. Dubyak Differential Regulation of P2X7 Receptor Activation by Extracellular Nicotinamide Adenine Dinucleotide and Ecto-ADP-Ribosyltransferases in Murine Macrophages and T Cells J. Immunol., July 1, 2009; 183(1): 578 - 592. [Abstract] [Full Text] [PDF] |
||||
![]() |
R.X. Faria, R.A.M. Reis, C.M. Casabulho, A.V.P. Alberto, F.P. de Farias, A. Henriques-Pons, and L.A. Alves Pharmacological properties of a pore induced by raising intracellular Ca2+ Am J Physiol Cell Physiol, July 1, 2009; 297(1): C28 - C42. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Casas-Pruneda, J. P. Reyes, G. Pérez-Flores, P. Pérez-Cornejo, and J. Arreola Functional interactions between P2X4 and P2X7 receptors from mouse salivary epithelia J. Physiol., June 15, 2009; 587(12): 2887 - 2901. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. R. J. Taylor, M. Gonzalez-Begne, D. K. Sojka, J. C. Richardson, S. A. Sheardown, S. M. Harrison, C. D. Pusey, F. W. K. Tam, and J. I. Elliott Lymphocytes from P2X7-deficient mice exhibit enhanced P2X7 responses J. Leukoc. Biol., June 1, 2009; 85(6): 978 - 986. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Diaz-Hernandez, M. Diez-Zaera, J. Sanchez-Nogueiro, R. Gomez-Villafuertes, J. M. Canals, J. Alberch, M. T. Miras-Portugal, and J. J. Lucas Altered P2X7-receptor level and function in mouse models of Huntington's disease and therapeutic efficacy of antagonist administration FASEB J, June 1, 2009; 23(6): 1893 - 1906. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Yip, T. Woehrle, R. Corriden, M. Hirsh, Y. Chen, Y. Inoue, V. Ferrari, P. A. Insel, and W. G. Junger Autocrine regulation of T-cell activation by ATP release and P2X7 receptors FASEB J, June 1, 2009; 23(6): 1685 - 1693. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. A. Decker and J. J. Galligan Cross-inhibition between nicotinic acetylcholine receptors and P2X receptors in myenteric neurons and HEK-293 cells Am J Physiol Gastrointest Liver Physiol, June 1, 2009; 296(6): G1267 - G1276. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. C. S. Cross and S. High Dissecting the physiological role of selective transmembrane-segment retention at the ER translocon J. Cell Sci., June 1, 2009; 122(11): 1768 - 1777. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. R.J. Taylor, C. M. Turner, J. I. Elliott, J. McDaid, R. Hewitt, J. Smith, M. C. Pickering, D. L. Whitehouse, H. T. Cook, G. Burnstock, et al. P2X7 Deficiency Attenuates Renal Injury in Experimental Glomerulonephritis J. Am. Soc. Nephrol., June 1, 2009; 20(6): 1275 - 1281. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Boumechache, M. Masin, J. M. Edwardson, D. C. Gorecki, and R. Murrell-Lagnado Analysis of Assembly and Trafficking of Native P2X4 and P2X7 Receptor Complexes in Rodent Immune Cells J. Biol. Chem., May 15, 2009; 284(20): 13446 - 13454. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Bulanova, V. Budagian, Z. Orinska, F. Koch-Nolte, F. Haag, and S. Bulfone-Paus ATP induces P2X7 receptor-independent cytokine and chemokine expression through P2X1 and P2X3 receptors in murine mast cells J. Leukoc. Biol., April 1, 2009; 85(4): 692 - 702. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. A. Prosdocimo, D. C. Douglas, A. M. Romani, W. C. O'Neill, and G. R. Dubyak Autocrine ATP release coupled to extracellular pyrophosphate accumulation in vascular smooth muscle cells Am J Physiol Cell Physiol, April 1, 2009; 296(4): C828 - C839. [Abstract] [Full Text] [PDF] |
||||
![]() |
J.-B. Shen, R. Shutt, M. Agosto, A. Pappano, and B. T. Liang Reversal of cardiac myocyte dysfunction as a unique mechanism of rescue by P2X4 receptors in cardiomyopathy Am J Physiol Heart Circ Physiol, April 1, 2009; 296(4): H1089 - H1095. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Trang, S. Beggs, X. Wan, and M. W. Salter P2X4-Receptor-Mediated Synthesis and Release of Brain-Derived Neurotrophic Factor in Microglia Is Dependent on Calcium and p38-Mitogen-Activated Protein Kinase Activation J. Neurosci., March 18, 2009; 29(11): 3518 - 3528. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Skals, N. R. Jorgensen, J. Leipziger, and H. A. Praetorius {alpha}-Hemolysin from Escherichia coli uses endogenous amplification through P2X receptor activation to induce hemolysis PNAS, March 10, 2009; 106(10): 4030 - 4035. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Gonnord, C. Delarasse, R. Auger, K. Benihoud, M. Prigent, M. H. Cuif, C. Lamaze, and J. M. Kanellopoulos Palmitoylation of the P2X7 receptor, an ATP-gated channel, controls its expression and association with lipid rafts FASEB J, March 1, 2009; 23(3): 795 - 805. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. M. Dopico and D. M. Lovinger Acute Alcohol Action and Desensitization of Ligand-Gated Ion Channels Pharmacol. Rev., March 1, 2009; 61(1): 98 - 114. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Nakamoto, D. A. Brown, M. A. Catalan, M. Gonzalez-Begne, V. G. Romanenko, and J. E. Melvin Purinergic P2X7 Receptors Mediate ATP-induced Saliva Secretion by the Mouse Submandibular Gland J. Biol. Chem., February 20, 2009; 284(8): 4815 - 4822. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. P. Kuehnel, M. Reiss, P. K. Anand, I. Treede, D. Holzer, E. Hoffmann, M. Klapperstueck, T. H. Steinberg, F. Markwardt, and G. Griffiths Sphingosine-1-phosphate receptors stimulate macrophage plasma-membrane actin assembly via ADP release, ATP synthesis and P2X7R activation J. Cell Sci., February 15, 2009; 122(4): 505 - 512. [Abstract] [Full Text] [PDF] |
||||
![]() |
Mark. P. Kuehnel, V. Rybin, P. K. Anand, E. Anes, and G. Griffiths Lipids regulate P2X7-receptor-dependent actin assembly by phagosomes via ADP translocation and ATP synthesis in the phagosome lumen J. Cell Sci., February 15, 2009; 122(4): 499 - 504. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Rieg and V. Vallon ATP and adenosine in the local regulation of water transport and homeostasis by the kidney Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2009; 296(2): R419 - R427. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. W. Inscho Mysteries of Renal Autoregulation Hypertension, February 1, 2009; 53(2): 299 - 306. [Full Text] [PDF] |
||||
![]() |
D. McClenahan, K. Hillenbrand, A. Kapur, D. Carlton, and C. Czuprynski Effects of Extracellular ATP on Bovine Lung Endothelial and Epithelial Cell Monolayer Morphologies, Apoptoses, and Permeabilities Clin. Vaccine Immunol., January 1, 2009; 16(1): 43 - 48. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Fujiwara, B. Keceli, K. Nakajo, and Y. Kubo Voltage- and [ATP]-dependent Gating of the P2X2 ATP Receptor Channel J. Gen. Physiol., January 1, 2009; 133(1): 93 - 109. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Armstrong, A. Pereverzev, S. J. Dixon, and S. M. Sims Activation of P2X7 receptors causes isoform-specific translocation of protein kinase C in osteoclasts J. Cell Sci., January 1, 2009; 122(1): 136 - 144. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Norambuena, M. I. Poblete, M. V. Donoso, C. S. Espinoza, A. Gonzalez, and J. P. Huidobro-Toro P2Y1 Receptor Activation Elicits Its Partition out of Membrane Rafts and Its Rapid Internalization from Human Blood Vessels: Implications for Receptor Signaling Mol. Pharmacol., December 1, 2008; 74(6): 1666 - 1677. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Li and J. E. Olson Purinergic activation of anion conductance and osmolyte efflux in cultured rat hippocampal neurons Am J Physiol Cell Physiol, December 1, 2008; 295(6): C1550 - C1560. [Abstract] [Full Text] [PDF] |
||||
![]() |
L.-P. Bernier, A. R. Ase, S. Chevallier, D. Blais, Q. Zhao, E. Boue-Grabot, D. Logothetis, and P. Seguela Phosphoinositides Regulate P2X4 ATP-Gated Channels through Direct Interactions J. Neurosci., November 26, 2008; 28(48): 12938 - 12945. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Diaz-Hernandez, A. del Puerto, J. I. Diaz-Hernandez, M. Diez-Zaera, J. J. Lucas, J. J. Garrido, and M. T. Miras-Portugal Inhibition of the ATP-gated P2X7 receptor promotes axonal growth and branching in cultured hippocampal neurons J. Cell Sci., November 15, 2008; 121(22): 3717 - 3728. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Tomasinsig, C. Pizzirani, B. Skerlavaj, P. Pellegatti, S. Gulinelli, A. Tossi, F. D. Virgilio, and M. Zanetti The Human Cathelicidin LL-37 Modulates the Activities of the P2X7 Receptor in a Structure-dependent Manner J. Biol. Chem., November 7, 2008; 283(45): 30471 - 30481. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Tolle, V. Jankowski, M. Schuchardt, A. Wiedon, T. Huang, F. Hub, J. Kowalska, J. Jemielity, A. Guranowski, C. Loddenkemper, et al. Adenosine 5'-Tetraphosphate Is a Highly Potent Purinergic Endothelium-Derived Vasoconstrictor Circ. Res., November 7, 2008; 103(10): 1100 - 1108. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Mediero, A. Guzman-Aranguez, A. Crooke, A. Peral, and J. Pintor Corneal Re-epithelialization Stimulated by Diadenosine Polyphosphates Recruits RhoA/ROCK and ERK1/2 Pathways Invest. Ophthalmol. Vis. Sci., November 1, 2008; 49(11): 4982 - 4992. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Palomino-Doza, T. J. Rahman, P. J. Avery, B. M. Mayosi, M. Farrall, H. Watkins, C. R.W. Edwards, and B. Keavney Ambulatory Blood Pressure Is Associated With Polymorphic Variation in P2X Receptor Genes Hypertension, November 1, 2008; 52(5): 980 - 985. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. A. Sim, H. E. Broomhead, and R. A. North Ectodomain Lysines and Suramin Block of P2X1 Receptors J. Biol. Chem., October 31, 2008; 283(44): 29841 - 29846. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. K. Tittle and R. I. Hume Opposite Effects of Zinc on Human and Rat P2X2 Receptors J. Neurosci., October 29, 2008; 28(44): 11131 - 11140. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Chen, X. Zhang, C. Wang, G. Li, Y. Gu, and L.-Y. M. Huang Activation of P2X7 receptors in glial satellite cells reduces pain through downregulation of P2X3 receptors in nociceptive neurons PNAS, October 28, 2008; 105(43): 16773 - 16778. [Abstract] [Full Text] [PDF] |
||||
![]() |
Z. Yan, S. Li, Z. Liang, M. Tomic, and S. S. Stojilkovic The P2X7 Receptor Channel Pore Dilates under Physiological Ion Conditions J. Gen. Physiol., October 27, 2008; 132(5): 563 - 573. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Panupinthu, J. T. Rogers, L. Zhao, L. P. Solano-Flores, F. Possmayer, S. M. Sims, and S. J. Dixon P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis J. Cell Biol., October 20, 2008; 181(5): 859 - 871. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Chaumont, V. Compan, E. Toulme, E. Richler, G. D. Housley, F. Rassendren, and B. S. Khakh Regulation of P2X2 Receptors by the Neuronal Calcium Sensor VILIP1 Sci. Signal., October 14, 2008; 1(41): ra8 - ra8. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Martinac, Y. Saimi, and C. Kung Ion Channels in Microbes Physiol Rev, October 1, 2008; 88(4): 1449 - 1490. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Xiao, C. Zhou, K. Li, D. L. Davies, and J. H. Ye Purinergic Type 2 Receptors at GABAergic Synapses on Ventral Tegmental Area Dopamine Neurons Are Targets for Ethanol Action J. Pharmacol. Exp. Ther., October 1, 2008; 327(1): 196 - 205. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. L. Gavala, Z. A. Pfeiffer, and P. J. Bertics The nucleotide receptor P2RX7 mediates ATP-induced CREB activation in human and murine monocytic cells J. Leukoc. Biol., October 1, 2008; 84(4): 1159 - 1171. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Schachter, A. P. Motta, A. de Souza Zamorano, H. A. da Silva-Souza, M. Z. P. Guimaraes, and P. M. Persechini ATP-induced P2X7-associated uptake of large molecules involves distinct mechanisms for cations and anions in macrophages J. Cell Sci., October 1, 2008; 121(19): 3261 - 3270. [Abstract] [Full Text] [PDF] |
||||
![]() |
U. Schenk, A. M. Westendorf, E. Radaelli, A. Casati, M. Ferro, M. Fumagalli, C. Verderio, J. Buer, E. Scanziani, and F. Grassi Purinergic Control of T Cell Activation by ATP Released Through Pannexin-1 Hemichannels Sci. Signal., September 30, 2008; 1(39): ra6 - ra6. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. T. Young, J. A. Fisher, S. J. Fountain, R. C. Ford, R. A. North, and B. S. Khakh Molecular Shape, Architecture, and Size of P2X4 Receptors Determined Using Fluorescence Resonance Energy Transfer and Electron Microscopy J. Biol. Chem., September 19, 2008; 283(38): 26241 - 26251. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Becker, R. Woltersdorf, W. Boldt, S. Schmitz, U. Braam, G. Schmalzing, and F. Markwardt The P2X7 Carboxyl Tail Is a Regulatory Module of P2X7 Receptor Channel Activity J. Biol. Chem., September 12, 2008; 283(37): 25725 - 25734. [Abstract] [Full Text] [PDF] |
||||
![]() |
C.-W. Chiao, R. C. Tostes, and R. C. Webb P2X7 Receptor Activation Amplifies Lipopolysaccharide-Induced Vascular Hyporeactivity via Interleukin-1{beta} Release J. Pharmacol. Exp. Ther., September 1, 2008; 326(3): 864 - 870. [Abstract] [Full Text] [PDF] |
||||
![]() |
L.-P. Bernier, A. R. Ase, X. Tong, E. Hamel, D. Blais, Q. Zhao, D. E. Logothetis, and P. Seguela Direct Modulation of P2X1 Receptor-Channels by the Lipid Phosphatidylinositol 4,5-Bisphosphate Mol. Pharmacol., September 1, 2008; 74(3): 785 - 792. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Iglesias, S. Locovei, A. Roque, A. P. Alberto, G. Dahl, D. C. Spray, and E. Scemes P2X7 receptor-Pannexin1 complex: pharmacology and signaling Am J Physiol Cell Physiol, September 1, 2008; 295(3): C752 - C760. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Sonin, S.-Y. Zhou, C. Cronin, T. Sonina, J. Wu, K. A. Jacobson, A. Pappano, and B. T. Liang Role of P2X purinergic receptors in the rescue of ischemic heart failure Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H1191 - H1197. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Chaumont and B. S. Khakh Patch-clamp coordinated spectroscopy shows P2X2 receptor permeability dynamics require cytosolic domain rearrangements but not Panx-1 channels PNAS, August 19, 2008; 105(33): 12063 - 12068. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. A. Schalper, N. Palacios-Prado, M. A. Retamal, K. F. Shoji, A. D. Martinez, and J. C. Saez Connexin Hemichannel Composition Determines the FGF-1-induced Membrane Permeability and Free [Ca2+]i Responses Mol. Biol. Cell, August 1, 2008; 19(8): 3501 - 3513. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. A. Roberts, H. R. Digby, M. Kara, S. E. Ajouz, M. J. Sutcliffe, and R. J. Evans Cysteine Substitution Mutagenesis and the Effects of Methanethiosulfonate Reagents at P2X2 and P2X4 Receptors Support a Core Common Mode of ATP Action at P2X Receptors J. Biol. Chem., July 18, 2008; 283(29): 20126 - 20136. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Burnstock Unresolved issues and controversies in purinergic signalling J. Physiol., July 15, 2008; 586(14): 3307 - 3312. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Roger, P. Pelegrin, and A. Surprenant Facilitation of P2X7 Receptor Currents and Membrane Blebbing via Constitutive and Dynamic Calmodulin Binding J. Neurosci., June 18, 2008; 28(25): 6393 - 6401. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. J. Fountain, L. Cao, M. T. Young, and R. A. North Permeation Properties of a P2X Receptor in the Green Algae Ostreococcus tauri J. Biol. Chem., May 30, 2008; 283(22): 15122 - 15126. [Abstract] [Full Text] [PDF] |
||||
![]() |
U. Lalo, Y. Pankratov, S. P. Wichert, M. J. Rossner, R. A. North, F. Kirchhoff, and A. Verkhratsky P2X1 and P2X5 Subunits Form the Functional P2X Receptor in Mouse Cortical Astrocytes J. Neurosci., May 21, 2008; 28(21): 5473 - 5480. [Abstract] [Full Text] [PDF] |
||||
![]() |
C H Knowles and Q Aziz Visceral hypersensitivity in non-erosive reflux disease Gut, May 1, 2008; 57(5): 674 - 683. [Full Text] [PDF] |
||||
![]() |
T. Noguchi, K. Ishii, H. Fukutomi, I. Naguro, A. Matsuzawa, K. Takeda, and H. Ichijo Requirement of Reactive Oxygen Species-dependent Activation of ASK1-p38 MAPK Pathway for Extracellular ATP-induced Apoptosis in Macrophage J. Biol. Chem., March 21, 2008; 283(12): 7657 - 7665. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Adriouch, P. Bannas, N. Schwarz, R. Fliegert, A. H. Guse, M. Seman, F. Haag, and F. Koch-Nolte ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site FASEB J, March 1, 2008; 22(3): 861 - 869. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. R. Lorier, J. Lipski, G. D. Housley, J. J. Greer, and G. D. Funk ATP sensitivity of preBotzinger complex neurones in neonatal rat in vitro: mechanism underlying a P2 receptor-mediated increase in inspiratory frequency J. Physiol., March 1, 2008; 586(5): 1429 - 1446. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. S. K. Samways, K. Migita, Z. Li, and T. M. Egan On the Role of the First Transmembrane Domain in Cation Permeability and Flux of the ATP-gated P2X2 Receptor J. Biol. Chem., February 22, 2008; 283(8): 5110 - 5117. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Donnelly-Roberts, S. McGaraughty, C.-C. Shieh, P. Honore, and M. F. Jarvis Painful Purinergic Receptors J. Pharmacol. Exp. Ther., February 1, 2008; 324(2): 409 - 415. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Dang, K. Lamb, M. Cohen, K. Bielefeldt, and G. F. Gebhart Cyclophosphamide-Induced Bladder Inflammation Sensitizes and Enhances P2X Receptor Function in Rat Bladder Sensory Neurons J Neurophysiol, January 1, 2008; 99(1): 49 - 59. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Christenson, L. Bjorkman, C. Tangemo, and J. Bylund Serum amyloid A inhibits apoptosis of human neutrophils via a P2X7-sensitive pathway independent of formyl peptide receptor-like 1 J. Leukoc. Biol., January 1, 2008; 83(1): 139 - 148. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. R. J. Taylor, M. Gonzalez-Begne, S. Dewhurst, G. Chimini, C. F. Higgins, J. E. Melvin, and J. I. Elliott Sequential Shrinkage and Swelling Underlie P2X7-Stimulated Lymphocyte Phosphatidylserine Exposure and Death J. Immunol., January 1, 2008; 180(1): 300 - 308. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Karoly, A. Mike, P. Illes, and Z. Gerevich The Unusual State-Dependent Affinity of P2X3 Receptors Can Be Explained by an Allosteric Two-Open-State Model Mol. Pharmacol., January 1, 2008; 73(1): 224 - 234. [Abstract] [Full Text] [PDF] |
||||
![]() |
X. Liu, A. Surprenant, H.-J. Mao, S. Roger, R. Xia, H. Bradley, and L.-H. Jiang Identification of Key Residues Coordinating Functional Inhibition of P2X7 Receptors by Zinc and Copper Mol. Pharmacol., January 1, 2008; 73(1): 252 - 259. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. E. Pafundo, O. Chara, M. P. Faillace, G. Krumschnabel, and P. J. Schwarzbaum Kinetics of ATP release and cell volume regulation of hyposmotically challenged goldfish hepatocytes Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R220 - R233. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Vallon P2 receptors in the regulation of renal transport mechanisms Am J Physiol Renal Physiol, January 1, 2008; 294(1): F10 - F27. [Abstract] [Full Text] [PDF] |
||||
![]() |
D.-J. Jun, J. Kim, S.-Y. Jung, R. Song, J.-H. Noh, Y.-S. Park, S.-H. Ryu, J.-H. Kim, Y.-Y. Kong, J.-M. Chung, et al. Extracellular ATP Mediates Necrotic Cell Swelling in SN4741 Dopaminergic Neurons through P2X7 Receptors J. Biol. Chem., December 28, 2007; 282(52): 37350 - 37358. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Coddou, C. Acuna-Castillo, P. Bull, and J. P. Huidobro-Toro Dissecting the Facilitator and Inhibitor Allosteric Metal Sites of the P2X4 Receptor Channel: CRITICAL ROLES OF CYS132 FOR ZINC POTENTIATION AND ASP138 FOR COPPER INHIBITION J. Biol. Chem., December 21, 2007; 282(51): 36879 - 36886. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Guo, M. Masin, O. S. Qureshi, and R. D. Murrell-Lagnado Evidence for Functional P2X4/P2X7 Heteromeric Receptors Mol. Pharmacol., December 1, 2007; 72(6): 1447 - 1456. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. R. Dubyak Go It Alone No More P2X7 Joins the Society of Heteromeric ATP-Gated Receptor Channels Mol. Pharmacol., December 1, 2007; 72(6): 1402 - 1405. [Abstract] [Full Text] [PDF] |
||||
![]() |
Z. Gerevich, Z. S. Zadori, L. Koles, L. Kopp, D. Milius, K. Wirkner, K. Gyires, and P. Illes Dual Effect of Acid pH on Purinergic P2X3 Receptors Depends on the Histidine 206 Residue J. Biol. Chem., November 23, 2007; 282(47): 33949 - 33957. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Cao, M. T. Young, H. E. Broomhead, S. J. Fountain, and R. A. North Thr339-to-Serine Substitution in Rat P2X2 Receptor Second Transmembrane Domain Causes Constitutive Opening and Indicates a Gating Role for Lys308 J. Neurosci., November 21, 2007; 27(47): 12916 - 12923. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. V. Gourine, N. Dale, E. Llaudet, D. M. Poputnikov, K. M. Spyer, and V. N. Gourine Release of ATP in the central nervous system during systemic inflammation: real-time measurement in the hypothalamus of conscious rabbits J. Physiol., November 15, 2007; 585(1): 305 - 316. [Abstract] [Full Text] [PDF] |
||||
![]() |
O. S. Qureshi, A. Paramasivam, J. C. H. Yu, and R. D. Murrell-Lagnado Regulation of P2X4 receptors by lysosomal targeting, glycan protection and exocytosis J. Cell Sci., November 1, 2007; 120(21): 3838 - 3849. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Sluyter, A. N. Shemon, W. E. Hughes, R. O. Stevenson, J. G. Georgiou, G. D. Eslick, R. M. Taylor, and J. S. Wiley Canine erythrocytes express the P2X7 receptor: greatly increased function compared with human erythrocytes Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2007; 293(5): R2090 - R2098. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Li, C. S. Wingo, and S.-L. Xia Downregulation of SGK1 by nucleotides in renal tubular epithelial cells Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1751 - F1757. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Iwata, Y. Katanosaka, T. Hisamitsu, and S. Wakabayashi Enhanced Na+/H+ Exchange Activity Contributes to the Pathogenesis of Muscular Dystrophy via Involvement of P2 Receptors Am. J. Pathol., November 1, 2007; 171(5): 1576 - 1587. [Abstract] [Full Text] [PDF] |
||||
![]() |
J.-B. Shen, R. Shutt, A. Pappano, and B. T. Liang Characterization and mechanism of P2X receptor-mediated increase in cardiac myocyte contractility Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H3056 - H3062. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Hayato, Y. Ohtubo, and K. Yoshii Functional expression of ionotropic purinergic receptors on mouse taste bud cells J. Physiol., October 15, 2007; 584(2): 473 - 488. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Cavaliere, S. Amadio, K. Dinkel, K. G. Reymann, and C. Volonte P2 Receptor Antagonist Trinitrophenyl-Adenosine-Triphosphate Protects Hippocampus from Oxygen and Glucose Deprivation Cell Death J. Pharmacol. Exp. Ther., October 1, 2007; 323(1): 70 - 77. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. M. Kreda, S. F. Okada, C. A. van Heusden, W. O'Neal, S. Gabriel, L. Abdullah, C. W. Davis, R. C. Boucher, and E. R. Lazarowski Coordinated release of nucleotides and mucin from human airway epithelial Calu-3 cells J. Physiol., October 1, 2007; 584(1): 245 - 259. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Wang, Y. Gu, G.-W. Li, and L.-Y. M. Huang A critical role of the cAMP sensor Epac in switching protein kinase signalling in prostaglandin E2-induced potentiation of P2X3 receptor currents in inflamed rats J. Physiol., October 1, 2007; 584(1): 191 - 203. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Pangrsic, M. Potokar, M. Stenovec, M. Kreft, E. Fabbretti, A. Nistri, E. Pryazhnikov, L. Khiroug, R. Giniatullin, and R. Zorec Exocytotic Release of ATP from Cultured Astrocytes J. Biol. Chem., September 28, 2007; 282(39): 28749 - 28758. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |