| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Physiological Reviews, Vol. 82, No. 3, July 2002, pp. 735-767; 10.1152/physrev.00007.2002.
Copyright ©2002 by the American Physiological Society
Institut de Pharmacologie et de Toxicologie, Université de Lausanne, Lausanne, Switzerland
Kellenberger, Stephan and
Laurent Schild.
Epithelial Sodium Channel/Degenerin Family of Ion Channels: A
Variety of Functions for a Shared Structure. Physiol. Rev. 82: 735-767, 2002.
The recently discovered
epithelial sodium channel (ENaC)/degenerin (DEG) gene family encodes
sodium channels involved in various cell functions in metazoans.
Subfamilies found in invertebrates or mammals are functionally
distinct. The degenerins in Caenorhabditis elegans
participate in mechanotransduction in neuronal cells, FaNaC in snails
is a ligand-gated channel activated by neuropeptides, and the
Drosophila subfamily is expressed in gonads and neurons. In
mammals, ENaC mediates Na+ transport in epithelia and is
essential for sodium homeostasis. The ASIC genes encode
proton-gated cation channels in both the central and peripheral
nervous system that could be involved in pain transduction. This review
summarizes the physiological roles of the different channels belonging
to this family, their biophysical and pharmacological characteristics,
and the emerging knowledge of their molecular structure. Although
functionally different, the ENaC/DEG family members share functional
domains that are involved in the control of channel activity and in the
formation of the pore. The functional heterogeneity among the members
of the ENaC/DEG channel family provides a unique opportunity to address the molecular basis of basic channel functions such as activation by
ligands, mechanotransduction, ionic selectivity, or block by pharmacological ligands.
This article has been cited by other articles:
|
|
 |
|
  G. Frindt, Z. Ergonul, and L. G. Palmer Surface Expression of Epithelial Na Channel Protein in Rat Kidney J. Gen. Physiol., May 26, 2008; 131(6): 617 - 627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Brown, Z. Liao, and M. B. Goodman MEC-2 and MEC-6 in the Caenorhabditis elegans Sensory Mechanotransduction Complex: Auxiliary Subunits that Enable Channel Activity J. Gen. Physiol., May 26, 2008; 131(6): 605 - 616. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lu, F. Echeverri, D. Kalabat, B. Laita, D. S. Dahan, R. D. Smith, H. Xu, L. Staszewski, J. Yamamoto, J. Ling, et al. Small Molecule Activator of the Human Epithelial Sodium Channel J. Biol. Chem., May 2, 2008; 283(18): 11981 - 11994. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Grifoni, S. E. McKey, and H. A. Drummond Hsc70 regulates cell surface ASIC2 expression and vascular smooth muscle cell migration Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2022 - H2030. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. S. Raikwar and C. P. Thomas Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel Am J Physiol Renal Physiol, May 1, 2008; 294(5): F1157 - F1165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. Drummond, N. L. Jernigan, and S. C. Grifoni Sensing Tension: Epithelial Sodium Channel/Acid-Sensing Ion Channel Proteins in Cardiovascular Homeostasis Hypertension, May 1, 2008; 51(5): 1265 - 1271. [Full Text] [PDF]
|
|
|
|
|
|
K. P. Gannon, L. G. VanLandingham, N. L. Jernigan, S. C. Grifoni, G. Hamilton, and H. A. Drummond Impaired pressure-induced constriction in mouse middle cerebral arteries of ASIC2 knockout mice Am J Physiol Heart Circ Physiol, April 1, 2008; 294(4): H1793 - H1803. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Harris, A. Garcia-Caballero, M. J. Stutts, D. Firsov, and B. C. Rossier Preferential Assembly of Epithelial Sodium Channel (ENaC) Subunits in Xenopus Oocytes: ROLE OF FURIN-MEDIATED ENDOGENOUS PROTEOLYSIS J. Biol. Chem., March 21, 2008; 283(12): 7455 - 7463. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. Drummond, S. C. Grifoni, and N. L. Jernigan A New Trick for an Old Dogma: ENaC Proteins as Mechanotransducers in Vascular Smooth Muscle Physiology, February 1, 2008; 23(1): 23 - 31. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Cho and C. C. Askwith Presynaptic Release Probability Is Increased in Hippocampal Neurons From ASIC1 Knockout Mice J Neurophysiol, February 1, 2008; 99(2): 426 - 441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.-P. Charles, M. Guitard, C. Leyvraz, B. Breiden, M. Haftek, Z. Haftek-Terreau, J.-C. Stehle, K. Sandhoff, and E. Hummler Postnatal Requirement of the Epithelial Sodium Channel for Maintenance of Epidermal Barrier Function J. Biol. Chem., February 1, 2008; 283(5): 2622 - 2630. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bertog, J. E. Cuffe, S. Pradervand, E. Hummler, A. Hartner, M. Porst, K. F. Hilgers, B. C. Rossier, and C. Korbmacher Aldosterone responsiveness of the epithelial sodium channel (ENaC) in colon is increased in a mouse model for Liddle's syndrome J. Physiol., January 15, 2008; 586(2): 459 - 475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Paukert, X. Chen, G. Polleichtner, H. Schindelin, and S. Grunder Candidate Amino Acids Involved in H+ Gating of Acid-sensing Ion Channel 1a J. Biol. Chem., January 4, 2008; 283(1): 572 - 581. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Bielefeldt and B. M. Davis Differential effects of ASIC3 and TRPV1 deletion on gastroesophageal sensation in mice Am J Physiol Gastrointest Liver Physiol, January 1, 2008; 294(1): G130 - G138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Shigemura, T. Ohkuri, C. Sadamitsu, K. Yasumatsu, R. Yoshida, G. K. Beauchamp, A. A. Bachmanov, and Y. Ninomiya Amiloride-sensitive NaCl taste responses are associated with genetic variation of ENaC {alpha}-subunit in mice Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R66 - R75. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Pochynyuk, V. Bugaj, A. Vandewalle, and J. D. Stockand Purinergic control of apical plasma membrane PI(4,5)P2 levels sets ENaC activity in principal cells Am J Physiol Renal Physiol, January 1, 2008; 294(1): F38 - F46. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Golubovic, A. Kuhn, M. Williamson, H. Kalbacher, T. W. Holstein, C. J. P. Grimmelikhuijzen, and S. Grunder A Peptide-gated Ion Channel from the Freshwater Polyp Hydra J. Biol. Chem., November 30, 2007; 282(48): 35098 - 35103. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z.-Y. Tan, Y. Lu, C. A. Whiteis, C. J. Benson, M. W. Chapleau, and F. M. Abboud Acid-Sensing Ion Channels Contribute to Transduction of Extracellular Acidosis in Rat Carotid Body Glomus Cells Circ. Res., November 9, 2007; 101(10): 1009 - 1019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-N. Takeda, I. Gautschi, M. X. van Bemmelen, and L. Schild Cadmium Trapping in an Epithelial Sodium Channel Pore Mutant J. Biol. Chem., November 2, 2007; 282(44): 31928 - 31936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Chen, G. Polleichtner, I. Kadurin, and S. Grunder Zebrafish Acid-sensing Ion Channel (ASIC) 4, Characterization of Homo- and Heteromeric Channels, and Identification of Regions Important for Activation by H+ J. Biol. Chem., October 19, 2007; 282(42): 30406 - 30413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. H. Kim, V. Pech, K. B. Spencer, W. H. Beierwaltes, L. A. Everett, E. D. Green, W. Shin, J. W. Verlander, R. L. Sutliff, and S. M. Wall Reduced ENaC protein abundance contributes to the lower blood pressure observed in pendrin-null mice Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1314 - F1324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Pochynyuk, Q. Tong, J. Medina, A. Vandewalle, A. Staruschenko, V. Bugaj, and J. D. Stockand Molecular Determinants of PI(4,5)P2 and PI(3,4,5)P3 Regulation of the Epithelial Na+ Channel J. Gen. Physiol., September 24, 2007; 130(4): 399 - 413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. B. Kashlan, G. M. Mueller, M. Z. Qamar, P. A. Poland, A. Ahner, R. C. Rubenstein, R. P. Hughey, J. L. Brodsky, and T. R. Kleyman Small Heat Shock Protein {alpha}A-crystallin Regulates Epithelial Sodium Channel Expression J. Biol. Chem., September 21, 2007; 282(38): 28149 - 28156. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Boda, W. Nonner, M. Valisko, D. Henderson, B. Eisenberg, and D. Gillespie Steric Selectivity in Na Channels Arising from Protein Polarization and Mobile Side Chains Biophys. J., September 15, 2007; 93(6): 1960 - 1980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Yan, L. Spruce, M. M. Rosenblatt, T. R. Kleyman, and R. C. Rubenstein Intracellular trafficking of a polymorphism in the COOH terminus of the {alpha}-subunit of the human epithelial sodium channel is modulated by casein kinase 1 Am J Physiol Renal Physiol, September 1, 2007; 293(3): F868 - F876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Meltzer, N. Kapoor, Y. J. Qadri, S. J. Anderson, C. M. Fuller, and D. J. Benos Heteromeric Assembly of Acid-sensitive Ion Channel and Epithelial Sodium Channel Subunits J. Biol. Chem., August 31, 2007; 282(35): 25548 - 25559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. O. Hernandez-Gonzalez, C. L. Trevino, L. E. Castellano, J. L. de la Vega-Beltran, A. Y. Ocampo, E. Wertheimer, P. E. Visconti, and A. Darszon Involvement of Cystic Fibrosis Transmembrane Conductance Regulator in Mouse Sperm Capacitation J. Biol. Chem., August 17, 2007; 282(33): 24397 - 24406. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Althaus, R. Bogdan, W. G. Clauss, and M. Fronius Mechano-sensitivity of epithelial sodium channels (ENaCs): laminar shear stress increases ion channel open probability FASEB J, August 1, 2007; 21(10): 2389 - 2399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sheng, A. B. Maarouf, J. B. Bruns, R. P. Hughey, and T. R. Kleyman Functional Role of Extracellular Loop Cysteine Residues of the Epithelial Na+ Channel in Na+ Self-inhibition J. Biol. Chem., July 13, 2007; 282(28): 20180 - 20190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Anantharam and L. G. Palmer Determination of Epithelial Na+ Channel Subunit Stoichiometry from Single-Channel Conductances J. Gen. Physiol., July 1, 2007; 130(1): 55 - 70. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Carattino, W. Liu, W. G. Hill, L. M. Satlin, and T. R. Kleyman Lack of a role of membrane-protein interactions in flow-dependent activation of ENaC Am J Physiol Renal Physiol, July 1, 2007; 293(1): F316 - F324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Lingueglia Acid-sensing Ion Channels in Sensory Perception J. Biol. Chem., June 15, 2007; 282(24): 17325 - 17329. [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Gao, J. D. Li, L. I. Sinoway, and J. Li Effect of muscle interstitial pH on P2X and TRPV1 receptor-mediated pressor response J Appl Physiol, June 1, 2007; 102(6): 2288 - 2293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Jonz and S. Barnes Proton modulation of ion channels in isolated horizontal cells of the goldfish retina J. Physiol., June 1, 2007; 581(2): 529 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sobczak, A. Willing, K. Kusche, N. Bangel, and W.-M. Weber Amiloride-sensitive sodium absorption is different in vertebrates and invertebrates Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2007; 292(6): R2318 - R2327. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Cho and C. C. Askwith Potentiation of acid-sensing ion channels by sulfhydryl compounds Am J Physiol Cell Physiol, June 1, 2007; 292(6): C2161 - C2174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Pochynyuk, Q. Tong, A. Staruschenko, and J. D. Stockand Binding and direct activation of the epithelial Na+ channel (ENaC) by phosphatidylinositides J. Physiol., April 15, 2007; 580(2): 365 - 372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Frindt, Z. Ergonul, and L. G. Palmer Na channel expression and activity in the medullary collecting duct of rat kidney Am J Physiol Renal Physiol, April 1, 2007; 292(4): F1190 - F1196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Cushman, J. Marsh-Haffner, J. P. Adelman, and E. W. McCleskey A Conformation Change in the Extracellular Domain that Accompanies Desensitization of Acid-sensing Ion Channel (ASIC) 3 J. Gen. Physiol., March 26, 2007; 129(4): 345 - 350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Chen and S. Grunder Permeating protons contribute to tachyphylaxis of the acid-sensing ion channel (ASIC) 1a J. Physiol., March 15, 2007; 579(3): 657 - 670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Holzer Taste Receptors in the Gastrointestinal Tract. V. Acid sensing in the gastrointestinal tract Am J Physiol Gastrointest Liver Physiol, March 1, 2007; 292(3): G699 - G705. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Bobkov and B. Ache Block by Amiloride Derivatives of Odor-Evoked Discharge in Lobster Olfactory Receptor Neurons through Action on a Presumptive TRP Channel Chem Senses, February 1, 2007; 32(2): 149 - 159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Brown, S. M. Fernandez-Illescas, Z. Liao, and M. B. Goodman Gain-of-Function Mutations in the MEC-4 DEG/ENaC Sensory Mechanotransduction Channel Alter Gating and Drug Blockade J. Gen. Physiol., January 29, 2007; 129(2): 161 - 173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Harris, D. Firsov, G. Vuagniaux, M. J. Stutts, and B. C. Rossier A Novel Neutrophil Elastase Inhibitor Prevents Elastase Activation and Surface Cleavage of the Epithelial Sodium Channel Expressed in Xenopus laevis Oocytes J. Biol. Chem., January 5, 2007; 282(1): 58 - 64. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Grifoni, K. P. Gannon, D. E. Stec, and H. A. Drummond ENaC proteins contribute to VSMC migration Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H3076 - H3086. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Jernigan and H. A. Drummond Myogenic vasoconstriction in mouse renal interlobar arteries: role of endogenous beta and {gamma}ENaC Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1184 - F1191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Corey What is the hair cell transduction channel? J. Physiol., October 1, 2006; 576(1): 23 - 28. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Poirot, T. Berta, I. Decosterd, and S. Kellenberger Distinct ASIC currents are expressed in rat putative nociceptors and are modulated by nerve injury J. Physiol., October 1, 2006; 576(1): 215 - 234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Pochynyuk, J. Medina, N. Gamper, H. Genth, J. D. Stockand, and A. Staruschenko Rapid Translocation and Insertion of the Epithelial Na+ Channel in Response to RhoA Signaling J. Biol. Chem., September 8, 2006; 281(36): 26520 - 26527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Mercado, I. A. Lopez, D. Acuna, R. Vega, and E. Soto Acid-Sensing Ionic Channels in the Rat Vestibular Endorgans and Ganglia J Neurophysiol, September 1, 2006; 96(3): 1615 - 1624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yagi, H. N. Wenk, L. A. Naves, and E. W. McCleskey Sustained Currents Through ASIC3 Ion Channels at the Modest pH Changes That Occur During Myocardial Ischemia Circ. Res., September 1, 2006; 99(5): 501 - 509. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. I. Pidoplichko and J. A. Dani Acid-sensitive ionic channels in midbrain dopamine neurons are sensitive to ammonium, which may contribute to hyperammonemia damage PNAS, July 25, 2006; 103(30): 11376 - 11380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Anantharam, Y. Tian, and L. G. Palmer Open probability of the epithelial sodium channel is regulated by intracellular sodium J. Physiol., July 15, 2006; 574(2): 333 - 347. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Pochynyuk, Q. Tong, A. Staruschenko, H.-P. Ma, and J. D. Stockand Regulation of the epithelial Na+ channel (ENaC) by phosphatidylinositides Am J Physiol Renal Physiol, May 1, 2006; 290(5): F949 - F957. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Loffing-Cueni, S. Y. Flores, D. Sauter, D. Daidie, N. Siegrist, P. Meneton, O. Staub, and J. Loffing Dietary Sodium Intake Regulates the Ubiquitin-Protein Ligase Nedd4-2 in the Renal Collecting System J. Am. Soc. Nephrol., May 1, 2006; 17(5): 1264 - 1274. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Pfister, I. Gautschi, A.-N. Takeda, M. van Bemmelen, S. Kellenberger, and L. Schild A Gating Mutation in the Internal Pore of ASIC1a J. Biol. Chem., April 28, 2006; 281(17): 11787 - 11791. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Olteanu, B. K. Yoder, W. Liu, M. J. Croyle, E. A. Welty, K. Rosborough, J. M. Wyss, P. D. Bell, L. M. Guay-Woodford, M. O. Bevensee, et al. Heightened epithelial Na+ channel-mediated Na+ absorption in a murine polycystic kidney disease model epithelium lacking apical monocilia Am J Physiol Cell Physiol, April 1, 2006; 290(4): C952 - C963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Tong, A. G. Menon, and J. D. Stockand Functional polymorphisms in the {alpha}-subunit of the human epithelial Na+ channel increase activity Am J Physiol Renal Physiol, April 1, 2006; 290(4): F821 - F827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-L. Ji, X.-F. Su, S. Kedar, J. Li, P. Barbry, P. R. Smith, S. Matalon, and D. J. Benos {delta}-Subunit Confers Novel Biophysical Features to {alpha}beta{gamma}-Human Epithelial Sodium Channel (ENaC) via a Physical Interaction J. Biol. Chem., March 24, 2006; 281(12): 8233 - 8241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. O. Hernandez-Gonzalez, J. Sosnik, J. Edwards, J. J. Acevedo, I. Mendoza-Lujambio, I. Lopez-Gonzalez, I. Demarco, E. Wertheimer, A. Darszon, and P. E. Visconti Sodium and Epithelial Sodium Channels Participate in the Regulation of the Capacitation-associated Hyperpolarization in Mouse Sperm J. Biol. Chem., March 3, 2006; 281(9): 5623 - 5633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
