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Physiol. Rev. 82: 569-600, 2002;
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Physiological Reviews, Vol. 82, No. 3, July 2002, pp. 569-600; 10.1152/physrev.00003.2002.
Copyright ©2002 by the American Physiological Society

Lung Epithelial Fluid Transport and the Resolution of Pulmonary Edema

Michael A. Matthay, Hans G. Folkesson, and Christine Clerici

Cardiovascular Research Institute and Departments of Medicine and Anesthesia, University of California, San Francisco, California; Department of Physiology, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio; and Department of Physiology, Faculté de Médecine de Bobigny, Université Paris 13, Paris, France

Matthay, Michael A., Hans G. Folkesson, and Christine Clerici. Lung Epithelial Fluid Transport and the Resolution of Pulmonary Edema. Physiol. Rev. 82: 569-600, 2002.The discovery of mechanisms that regulate salt and water transport by the alveolar and distal airway epithelium of the lung has generated new insights into the regulation of lung fluid balance under both normal and pathological conditions. There is convincing evidence that active sodium and chloride transporters are expressed in the distal lung epithelium and are responsible for the ability of the lung to remove alveolar fluid at the time of birth as well as in the mature lung when pathological conditions lead to the development of pulmonary edema. Currently, the best described molecular transporters are the epithelial sodium channel, the cystic fibrosis transmembrane conductance regulator, Na+-K+-ATPase, and several aquaporin water channels. Both catecholamine-dependent and -independent mechanisms can upregulate isosmolar fluid transport across the distal lung epithelium. Experimental and clinical studies have made it possible to examine the role of these transporters in the resolution of pulmonary edema.




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Home page
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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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J. Biol. Chem., November 24, 2006; 281(47): 36012 - 36020.
[Abstract] [Full Text] [PDF]

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[Full Text] [PDF]

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Home page
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M. B. Maron, H. G. Folkesson, S. M. Stader, and J. M. Walro
PKA delivery to the distal lung air spaces increases alveolar liquid clearance after isoproterenol-induced alveolar epithelial PKA desensitization
Am J Physiol Lung Cell Mol Physiol, August 1, 2005; 289(2): L349 - L354.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. R. Looney, C. Sartori, S. Chakraborty, P. F. James, J. B. Lingrel, and M. A. Matthay
Decreased expression of both the {alpha}1- and {alpha}2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance
Am J Physiol Lung Cell Mol Physiol, July 1, 2005; 289(1): L104 - L110.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. Planes, C. Leyvraz, T. Uchida, M. A. Angelova, G. Vuagniaux, E. Hummler, M. Matthay, C. Clerici, and B. Rossier
In vitro and in vivo regulation of transepithelial lung alveolar sodium transport by serine proteases
Am J Physiol Lung Cell Mol Physiol, June 1, 2005; 288(6): L1099 - L1109.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. R. Flori, D. V. Glidden, G. W. Rutherford, and M. A. Matthay
Pediatric Acute Lung Injury: Prospective Evaluation of Risk Factors Associated with Mortality
Am. J. Respir. Crit. Care Med., May 1, 2005; 171(9): 995 - 1001.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Matalon and H.-L. Ji
Oleic Acid Damages Ion Transport and Promotes Alveolar Edema: The Dark Side of Healthy Living
Am. J. Respir. Crit. Care Med., March 1, 2005; 171(5): 424 - 425.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. Vadasz, R. E. Morty, M. G. Kohstall, A. Olschewski, F. Grimminger, W. Seeger, and H. A. Ghofrani
Oleic Acid Inhibits Alveolar Fluid Reabsorption: A Role in Acute Respiratory Distress Syndrome?
Am. J. Respir. Crit. Care Med., March 1, 2005; 171(5): 469 - 479.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
D. Mehta, J. Bhattacharya, M. A. Matthay, and A. B. Malik
Integrated control of lung fluid balance
Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1081 - L1090.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
N. Mair, M. Frick, C. Bertocchi, T. Haller, A. Amberger, H. Weiss, R. Margreiter, W. Streif, and P. Dietl
Inhibition by cytoplasmic nucleotides of a new cation channel in freshly isolated human and rat type II pneumocytes
Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1284 - L1292.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M.C. McElroy and M. Kasper
The use of alveolar epithelial type I cell-selective markers to investigate lung injury and repair
Eur. Respir. J., October 1, 2004; 24(4): 664 - 673.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. Banasikowska, M. Post, E. Cutz, H. O'Brodovich, and G. Otulakowski
Expression of epithelial sodium channel {alpha}-subunit mRNAs with alternative 5'-untranslated regions in the developing human lung
Am J Physiol Lung Cell Mol Physiol, September 1, 2004; 287(3): L608 - L615.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. T. Robertson, R. Pellegrino, D. Pini, J. Oreglia, S. DeVita, V. Brusasco, and P. Agostoni
Exercise response after rapid intravenous infusion of saline in healthy humans
J Appl Physiol, August 1, 2004; 97(2): 697 - 703.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
X.-J. Chen, S. Seth, G. Yue, P. Kamat, R. W. Compans, D. Guidot, L. A. Brown, D. C. Eaton, and L. Jain
Influenza virus inhibits ENaC and lung fluid clearance
Am J Physiol Lung Cell Mol Physiol, August 1, 2004; 287(2): L366 - L373.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. Brochiero, A. Dagenais, A. Prive, Y. Berthiaume, and R. Grygorczyk
Evidence of a functional CFTR Cl- channel in adult alveolar epithelial cells
Am J Physiol Lung Cell Mol Physiol, August 1, 2004; 287(2): L382 - L392.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
X. Fang, Y. Song, R. Zemans, J. Hirsch, and M. A. Matthay
Fluid transport across cultured rat alveolar epithelial cells: a novel in vitro system
Am J Physiol Lung Cell Mol Physiol, July 1, 2004; 287(1): L104 - L110.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. Sakuma, Y. Zhao, M. Sugita, M. Sagawa, H. Toga, T. Ishibashi, M. Nishio, and M. A. Matthay
Malnutrition impairs alveolar fluid clearance in rat lungs
Am J Physiol Lung Cell Mol Physiol, June 1, 2004; 286(6): L1268 - L1274.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
K. M. Hardiman, C. M. McNicholas-Bevensee, J. Fortenberry, C. T. Myles, B. Malik, D. C. Eaton, and S. Matalon
Regulation of Amiloride-Sensitive Na+ Transport by Basal Nitric Oxide
Am. J. Respir. Cell Mol. Biol., May 1, 2004; 30(5): 720 - 728.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
G. M. Mutlu, V. Dumasius, J. Burhop, P. J. McShane, F. J. Meng, L. Welch, A. Dumasius, N. Mohebahmadi, G. Thakuria, K. Hardiman, et al.
Upregulation of Alveolar Epithelial Active Na+ Transport Is Dependent on {beta}2-Adrenergic Receptor Signaling
Circ. Res., April 30, 2004; 94(8): 1091 - 1100.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. H. Hastings, H. G. Folkesson, and M. A. Matthay
Mechanisms of alveolar protein clearance in the intact lung
Am J Physiol Lung Cell Mol Physiol, April 1, 2004; 286(4): L679 - L689.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
X. Ye, R. Acharya, J. B. Herbert, S. E. Hamilton, and H. G. Folkesson
IL-1{beta} stimulates alveolar fluid absorption in fetal guinea pig lungs via the hypothalamus-pituitary-adrenal gland axis
Am J Physiol Lung Cell Mol Physiol, April 1, 2004; 286(4): L756 - L766.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. B. Ware
Modulation of Alveolar Fluid Clearance by Acute Inflammation: The Plot Thickens
Am. J. Respir. Crit. Care Med., February 1, 2004; 169(3): 332 - 333.
[Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
D. C. Eaton, J. Chen, S. Ramosevac, S. Matalon, and L. Jain
Regulation of Na+ Channels in Lung Alveolar Type II Epithelial Cells
Proceedings of the ATS, January 1, 2004; 1(1): 10 - 16.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Matalon, K. M. Hardiman, L. Jain, D. C. Eaton, M. Kotlikoff, J. P. Eu, J. Sun, G. Meissner, and J. S. Stamler
Regulation of ion channel structure and function by reactive oxygen-nitrogen species
Am J Physiol Lung Cell Mol Physiol, December 1, 2003; 285(6): L1184 - L1189.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
R. Paine III, S. E. Wilcoxen, S. B. Morris, C. Sartori, C. E. O. Baleeiro, M. A. Matthay, and P. J. Christensen
Transgenic Overexpression of Granulocyte Macrophage-Colony Stimulating Factor in the Lung Prevents Hyperoxic Lung Injury
Am. J. Pathol., December 1, 2003; 163(6): 2397 - 2406.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
B. C. Willis, K.-J. Kim, X. Li, J. Liebler, E. D. Crandall, and Z. Borok
Modulation of ion conductance and active transport by TGF-{beta}1 in alveolar epithelial cell monolayers
Am J Physiol Lung Cell Mol Physiol, December 1, 2003; 285(6): L1192 - L1200.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Frank, J. Roux, H. Kawakatsu, G. Su, A. Dagenais, Y. Berthiaume, M. Howard, C. M. Canessa, X. Fang, D. Sheppard, et al.
Transforming Growth Factor-{beta}1 Decreases Expression of the Epithelial Sodium Channel {alpha}ENaC and Alveolar Epithelial Vectorial Sodium and Fluid Transport via an ERK1/2-dependent Mechanism
J. Biol. Chem., November 7, 2003; 278(45): 43939 - 43950.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. E. Morgan, S. M. Stader, C. M. Hodnichak, K. E. Mavrich, H. G. Folkesson, and M. B. Maron
Postreceptor defects in alveolar epithelial {beta}-adrenergic signaling after prolonged isoproterenol infusion
Am J Physiol Lung Cell Mol Physiol, September 1, 2003; 285(3): L578 - L583.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Lazrak and S. Matalon
cAMP-induced changes of apical membrane potentials of confluent H441 monolayers
Am J Physiol Lung Cell Mol Physiol, August 1, 2003; 285(2): L443 - L450.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. M. O'Grady and S. Y. Lee
Chloride and potassium channel function in alveolar epithelial cells
Am J Physiol Lung Cell Mol Physiol, May 1, 2003; 284(5): L689 - L700.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. A. Frank, J.-F. Pittet, H. Lee, M. Godzich, and M. A. Matthay
High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearance
Am J Physiol Lung Cell Mol Physiol, May 1, 2003; 284(5): L791 - L798.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
S. Hoschele and H. Mairbaurl
Alveolar Flooding at High Altitude: Failure of Reabsorption?
Physiology, April 1, 2003; 18(2): 55 - 59.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. Matalon and I. C. Davis
Vectorial Sodium Transport Across the Mammalian Alveolar Epithelium: It Occurs but Through Which Cells?
Circ. Res., March 7, 2003; 92(4): 348 - 349.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
K.M. Ridge, W.G. Olivera, F. Saldias, Z. Azzam, S. Horowitz, D.H. Rutschman, V. Dumasius, P. Factor, and J.I. Sznajder
Alveolar Type 1 Cells Express the {alpha}2 Na,K-ATPase, Which Contributes to Lung Liquid Clearance
Circ. Res., March 7, 2003; 92(4): 453 - 460.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. A. Matthay
Clinical Measurement of Pulmonary Edema
Chest, December 1, 2002; 122(6): 1877 - 1879.
[Full Text] [PDF]

Home page
 ChestHome page
M. A. Matthay
Alveolar Fluid Clearance in Patients With ARDS: Does It Make a Difference?
Chest, December 1, 2002; 122(6_suppl): 340S - 343S.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Planes, M. Blot-Chabaud, M. A. Matthay, S. Couette, T. Uchida, and C. Clerici
Hypoxia and beta 2-Agonists Regulate Cell Surface Expression of the Epithelial Sodium Channel in Native Alveolar Epithelial Cells
J. Biol. Chem., November 27, 2002; 277(49): 47318 - 47324.
[Abstract] [Full Text] [PDF]


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