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Physiological Reviews, Vol. 82, No. 2, April 2002, pp. 429-472; 10.1152/physrev.00001.2002.
Copyright ©2002 by the American Physiological Society
Department of Physiology and the Kühne Minerva Center for Studies of Visual Transduction, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
Minke, Baruch and
Boaz Cook.
TRP Channel Proteins and Signal
Transduction. Physiol. Rev. 82: 429-472, 2002.
TRP channel proteins constitute a large
and diverse family of proteins that are expressed in many tissues and
cell types. This family was designated TRP because of a spontaneously
occurring Drosophila mutant lacking TRP that responded to a
continuous light with a transient receptor potential (hence TRP). In
addition to responses to light, TRPs mediate responses to nerve growth
factor, pheromones, olfaction, mechanical, chemical, temperature, pH, osmolarity, vasorelaxation of blood vessels, and metabolic stress. Furthermore, mutations in several members of TRP-related channel proteins are responsible for several diseases, such as several tumors
and neurodegenerative disorders. TRP-related channel proteins are
found in a variety of organisms, tissues, and cell types, including
nonexcitable, smooth muscle, and neuronal cells. The large functional
diversity of TRPs is also reflected in their diverse permeability to
ions, although, in general, they are classified as nonselective
cationic channels. The molecular domains that are conserved in all
members of the TRP family constitute parts of the transmembrane
domains and in most members also the ankyrin-like repeats at the
NH2 terminal of the protein and a "TRP domain" at the
COOH terminal, which is a highly conserved 25-amino acid stretch with
still unknown function. All of the above features suggest that members
of the TRP family are "special assignment" channels, which are
recruited to diverse signaling pathways. The channels' roles and
characteristics such as gating mechanism, regulation, and permeability
are determined by evolution according to the specific functional requirements.
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Y. Takai, R. Sugawara, H. Ohinata, and A. Takai Two types of non-selective cation channel opened by muscarinic stimulation with carbachol in bovine ciliary muscle cells J. Physiol., September 15, 2004; 559(3): 899 - 922. [Abstract] [Full Text] [PDF]
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S. Schillo, G. Belusic, K. Hartmann, C. Franz, B. Kuhl, G. Brenner-Weiss, R. Paulsen, and A. Huber Targeted Mutagenesis of the Farnesylation Site of Drosophila G{gamma}e Disrupts Membrane Association of the G Protein {beta}{gamma} Complex and Affects the Light Sensitivity of the Visual System J. Biol. Chem., August 27, 2004; 279(35): 36309 - 36316. [Abstract] [Full Text] [PDF]
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I. S. Ambudkar Cellular Domains That Contribute to Ca2+ Entry Events Sci. Signal., July 27, 2004; 2004(243): pe32 - pe32. [Abstract] [Full Text] [PDF]
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 A. J. Stokes, L. M.N. Shimoda, M. Koblan-Huberson, C. N. Adra, and H. Turner A TRPV2-PKA Signaling Module for Transduction of Physical Stimuli in Mast Cells J. Exp. Med., July 19, 2004; 200(2): 137 - 147. [Abstract] [Full Text] [PDF]
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Q. Li, X. Luo, and S. Muallem Functional Mapping of Ca2+ Signaling Complexes in Plasma Membrane Microdomains of Polarized Cells J. Biol. Chem., July 2, 2004; 279(27): 27837 - 27840. [Abstract] [Full Text] [PDF]
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N. Garcia-Sanz, A. Fernandez-Carvajal, C. Morenilla-Palao, R. Planells-Cases, E. Fajardo-Sanchez, G. Fernandez-Ballester, and A. Ferrer-Montiel Identification of a Tetramerization Domain in the C Terminus of the Vanilloid Receptor J. Neurosci., June 9, 2004; 24(23): 5307 - 5314. [Abstract] [Full Text] [PDF]
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H. F. Cantiello Regulation of calcium signaling by polycystin-2 Am J Physiol Renal Physiol, June 1, 2004; 286(6): F1012 - F1029. [Abstract] [Full Text] [PDF]
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M. Suzuki and A. Mizuno A Novel Human Cl- Channel Family Related to Drosophila flightless Locus J. Biol. Chem., May 21, 2004; 279(21): 22461 - 22468. [Abstract] [Full Text] [PDF]
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B. Martinac Mechanosensitive ion channels: molecules of mechanotransduction J. Cell Sci., May 15, 2004; 117(12): 2449 - 2460. [Abstract] [Full Text] [PDF]
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B. Ay, Y. S. Prakash, C. M. Pabelick, and G. C. Sieck Store-operated Ca2+ entry in porcine airway smooth muscle Am J Physiol Lung Cell Mol Physiol, May 1, 2004; 286(5): L909 - L917. [Abstract] [Full Text] [PDF]
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F. J. Michel, J. M. Robillard, and L.-E. Trudeau Regulation of rat mesencephalic GABAergic neurones through muscarinic receptors J. Physiol., April 15, 2004; 556(2): 429 - 445. [Abstract] [Full Text] [PDF]
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A. SPAT and L. HUNYADY Control of Aldosterone Secretion: A Model for Convergence in Cellular Signaling Pathways Physiol Rev, April 1, 2004; 84(2): 489 - 539. [Abstract] [Full Text] [PDF]
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 S. Zhang, I. Sokolchik, G. Blanco, and J. Y. Sze Caenorhabditis elegans TRPV ion channel regulates 5HT biosynthesis in chemosensory neurons Development, April 1, 2004; 131(7): 1629 - 1638. [Abstract] [Full Text] [PDF]
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J. Wang, L. A. Shimoda, and J. T. Sylvester Capacitative calcium entry and TRPC channel proteins are expressed in rat distal pulmonary arterial smooth muscle Am J Physiol Lung Cell Mol Physiol, April 1, 2004; 286(4): L848 - L858. [Abstract] [Full Text] [PDF]
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 L. G. Babich, C.-Y. Ku, H. W.J. Young, H. Huang, M. R. Blackburn, and B. M. Sanborn Expression of Capacitative Calcium TrpC Proteins in Rat MyometriumDuring Pregnancy Biol Reprod, April 1, 2004; 70(4): 919 - 924. [Abstract] [Full Text] [PDF]
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Y. Dohke, Y. S. Oh, I. S. Ambudkar, and R. J. Turner Biogenesis and Topology of the Transient Receptor Potential Ca2+ Channel TRPC1 J. Biol. Chem., March 26, 2004; 279(13): 12242 - 12248. [Abstract] [Full Text] [PDF]
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A. Gore, A. Moran, M. Hershfinkel, and I. Sekler Inhibitory Mechanism of Store-operated Ca2+ Channels by Zinc J. Biol. Chem., March 19, 2004; 279(12): 11106 - 11111. [Abstract] [Full Text] [PDF]
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 A. Dalrymple, D. M. Slater, L. Poston, and R. M. Tribe Physiological Induction of Transient Receptor Potential Canonical Proteins, Calcium Entry Channels, in Human Myometrium: Influence of Pregnancy, Labor, and Interleukin-1{beta} J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1291 - 1300. [Abstract] [Full Text] [PDF]
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C. S. Facemire, P. J. Mohler, and W. J. Arendshorst Expression and relative abundance of short transient receptor potential channels in the rat renal microcirculation Am J Physiol Renal Physiol, March 1, 2004; 286(3): F546 - F551. [Abstract] [Full Text]
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H.-Y. Kwan, Y. Huang, and X. Yao Regulation of canonical transient receptor potential isoform 3 (TRPC3) channel by protein kinase G PNAS, February 24, 2004; 101(8): 2625 - 2630. [Abstract] [Full Text] [PDF]
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Y. Dodier, U. Banderali, H. Klein, O. Topalak, O. Dafi, M. Simoes, G. Bernatchez, R. Sauve, and L. Parent Outer Pore Topology of the ECaC-TRPV5 Channel by Cysteine Scan Mutagenesis J. Biol. Chem., February 20, 2004; 279(8): 6853 - 6862. [Abstract] [Full Text] [PDF]
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S. Cayouette, M. P. Lussier, E.-L. Mathieu, S. M. Bousquet, and G. Boulay Exocytotic Insertion of TRPC6 Channel into the Plasma Membrane upon Gq Protein-coupled Receptor Activation J. Biol. Chem., February 20, 2004; 279(8): 7241 - 7246. [Abstract] [Full Text] [PDF]
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W.-P. Li, L. Tsiokas, S. C. Sansom, and R. Ma Epidermal Growth Factor Activates Store-operated Ca2+ Channels through an Inositol 1,4,5-Trisphosphate-independent Pathway in Human Glomerular Mesangial Cells J. Biol. Chem., February 6, 2004; 279(6): 4570 - 4577. [Abstract] [Full Text] [PDF]
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A. V. Yeromin, J. Roos, K. A. Stauderman, and M. D. Cahalan A Store-operated Calcium Channel in Drosophila S2 Cells J. Gen. Physiol., January 26, 2004; 123(2): 167 - 182. [Abstract] [Full Text] [PDF]
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K. Tsuzuki, H. Xing, J. Ling, and J. G. Gu Menthol-Induced Ca2+ Release from Presynaptic Ca2+ Stores Potentiates Sensory Synaptic Transmission J. Neurosci., January 21, 2004; 24(3): 762 - 771. [Abstract] [Full Text] [PDF]
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D. Prawitt, M. K. Monteilh-Zoller, L. Brixel, C. Spangenberg, B. Zabel, A. Fleig, and R. Penner TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i PNAS, December 9, 2003; 100(25): 15166 - 15171. [Abstract] [Full Text] [PDF]
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 R. G. O'Neil and R. C. Brown The Vanilloid Receptor Family of Calcium-Permeable Channels: Molecular Integrators of Microenvironmental Stimuli Physiology, December 1, 2003; 18(6): 226 - 231. [Abstract] [Full Text] [PDF]
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I. Fantozzi, S. Zhang, O. Platoshyn, C. V. Remillard, R. T. Cowling, and J. X.-J. Yuan Hypoxia increases AP-1 binding activity by enhancing capacitative Ca2+ entry in human pulmonary artery endothelial cells Am J Physiol Lung Cell Mol Physiol, December 1, 2003; 285(6): L1233 - L1245. [Abstract] [Full Text] [PDF]
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