| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Physiological Reviews, Vol. 82, No. 2, April 2002, pp. 373-428; 10.1152/physrev.00027.2001.
Copyright ©2002 by the American Physiological Society
Faculty of Biology and the Institute for Catalysis Science and Technology, and Department of Biochemistry, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Glickman, Michael H. and
Aaron Ciechanover.
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction
for the Sake of Construction. Physiol. Rev. 82: 373-428, 2002.
Between the 1960s and 1980s, most life
scientists focused their attention on studies of nucleic acids and the
translation of the coded information. Protein degradation was a
neglected area, considered to be a nonspecific, dead-end process.
Although it was known that proteins do turn over, the large extent and high specificity of the process, whereby distinct proteins have half-lives that range from a few minutes to several days, was not
appreciated. The discovery of the lysosome by Christian de Duve did not
significantly change this view, because it became clear that this
organelle is involved mostly in the degradation of extracellular
proteins, and their proteases cannot be substrate specific. The
discovery of the complex cascade of the ubiquitin pathway
revolutionized the field. It is clear now that degradation of cellular
proteins is a highly complex, temporally controlled, and tightly
regulated process that plays major roles in a variety of basic pathways
during cell life and death as well as in health and disease. With the
multitude of substrates targeted and the myriad processes involved, it
is not surprising that aberrations in the pathway are implicated in the
pathogenesis of many diseases, certain malignancies, and
neurodegeneration among them. Degradation of a protein via the
ubiquitin/proteasome pathway involves two successive steps:
1) conjugation of multiple ubiquitin moieties to the
substrate and 2) degradation of the tagged protein by the downstream 26S proteasome complex. Despite intensive research, the
unknown still exceeds what we currently know on intracellular protein
degradation, and major key questions have remained unsolved. Among
these are the modes of specific and timed recognition for the
degradation of the many substrates and the mechanisms that underlie
aberrations in the system that lead to pathogenesis of diseases.
This article has been cited by other articles:
|
|
 |
|
  M. Zhao, N.-Y. Zhang, A. Zurawel, K. C. Hansen, and C.-W. Liu Degradation of Some Polyubiquitinated Proteins Requires an Intrinsic Proteasomal Binding Element in the Substrates J. Biol. Chem., February 12, 2010; 285(7): 4771 - 4780. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. P. Nguyen, V. M. Soukup, and B. B. Gelman Persistent Hijacking of Brain Proteasomes in HIV-Associated Dementia Am. J. Pathol., February 1, 2010; 176(2): 893 - 902. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Luo, J. Wong, and B. Wong Protein degradation systems in viral myocarditis leading to dilated cardiomyopathy Cardiovasc Res, January 15, 2010; 85(2): 347 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Tsukamoto, T. Minamino, and M. Kitakaze Functional alterations of cardiac proteasomes under physiological and pathological conditions Cardiovasc Res, January 15, 2010; 85(2): 339 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Stangl and V. Stangl The ubiquitin-proteasome pathway and endothelial (dys)function Cardiovasc Res, January 15, 2010; 85(2): 281 - 290. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Powell and A. Divald The ubiquitin-proteasome system in myocardial ischaemia and preconditioning Cardiovasc Res, January 15, 2010; 85(2): 303 - 311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Safadi and G. S. Shaw Differential Interaction of the E3 Ligase Parkin with the Proteasomal Subunit S5a and the Endocytic Protein Eps15 J. Biol. Chem., January 8, 2010; 285(2): 1424 - 1434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. N. R. Rao, J. Sharma, R. Maity, and N. R. Jana Co-chaperone CHIP Stabilizes Aggregate-prone Malin, a Ubiquitin Ligase Mutated in Lafora Disease J. Biol. Chem., January 8, 2010; 285(2): 1404 - 1413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Mancuso, P. Kotzbauer, D. F. Wozniak, H. F. Sims, C. M. Jenkins, S. Guan, X. Han, K. Yang, G. Sun, I. Malik, et al. Genetic Ablation of Calcium-independent Phospholipase A2{gamma} Leads to Alterations in Hippocampal Cardiolipin Content and Molecular Species Distribution, Mitochondrial Degeneration, Autophagy, and Cognitive Dysfunction J. Biol. Chem., December 18, 2009; 284(51): 35632 - 35644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Jacobson, N.-Y. Zhang, P. Xu, K.-J. Han, S. Noone, J. Peng, and C.-W. Liu The Lysine 48 and Lysine 63 Ubiquitin Conjugates Are Processed Differently by the 26 S Proteasome J. Biol. Chem., December 18, 2009; 284(51): 35485 - 35494. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Chen, Q. Wang, H. Huang, L. Xia, X. Jiang, L. Kan, Q. Sun, and D. Chen Effete-mediated degradation of Cyclin A is essential for the maintenance of germline stem cells in Drosophila Development, December 15, 2009; 136(24): 4133 - 4142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Strunk and K. Karbstein Powering through ribosome assembly RNA, December 1, 2009; 15(12): 2083 - 2104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. T. Kim, S. E. Oh, Y.-O. Lee, W. Gibson, and J.-H. Ahn Cleavage Specificity of the UL48 Deubiquitinating Protease Activity of Human Cytomegalovirus and the Growth of an Active-Site Mutant Virus in Cultured Cells J. Virol., December 1, 2009; 83(23): 12046 - 12056. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. MORAWIETZ, L. MARTINEZ-GAMBOA, S. SCHEFFLER, G. HAUSDORF, A. DANKOF, U. KUCKELKORN, T. DOERNER, K. EGERER, G.-R. BURMESTER, D. L. FAUSTMAN, et al. Expression of Proteasomal Immunosubunit ss1i Is Dysregulated in Inflammatory Infiltrates of Minor Salivary Glands in Sjogren's Syndrome J Rheumatol, December 1, 2009; 36(12): 2694 - 2703. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Lecker Given the Science on Malnutrition, How Does the Clinician Respond? Practical Lessons for and Application to the Dialysis Patient Clin. J. Am. Soc. Nephrol., December 1, 2009; 4(Supplement_1): S64 - S70. [Full Text] [PDF]
|
|
|
|
 |
|
 X. Wang, R. A. Herr, M. Rabelink, R. C. Hoeben, E. J.H.J. Wiertz, and T. H. Hansen Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates J. Cell Biol., November 30, 2009; 187(5): 655 - 668. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. O. Pena, S. P. Melo, Y.-Y. Xing, K. White, K. W. Barbour, and F. G. Berger The Intrinsically Disordered N-terminal Domain of Thymidylate Synthase Targets the Enzyme to the Ubiquitin-independent Proteasomal Degradation Pathway J. Biol. Chem., November 13, 2009; 284(46): 31597 - 31607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. H. Khoo, S. Mayer, and A. R. Fersht Effects of Stability on the Biological Function of p53 J. Biol. Chem., November 6, 2009; 284(45): 30974 - 30980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Romanenko, A. Kakehashi, K. Morimura, H. Wanibuchi, M. Wei, A. Vozianov, and S. Fukushima Urinary bladder carcinogenesis induced by chronic exposure to persistent low-dose ionizing radiation after Chernobyl accident Carcinogenesis, November 1, 2009; 30(11): 1821 - 1831. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Kiss, B. Olah, P. Kalo, M. Morales, A. B. Heckmann, A. Borbola, A. Lozsa, K. Kontar, P. Middleton, J. A. Downie, et al. LIN, a Novel Type of U-Box/WD40 Protein, Controls Early Infection by Rhizobia in Legumes Plant Physiology, November 1, 2009; 151(3): 1239 - 1249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gredmark-Russ, M. K. Isaacson, L. Kattenhorn, E. J. Cheung, N. Watson, and H. L. Ploegh A Gammaherpesvirus Ubiquitin-Specific Protease Is Involved in the Establishment of Murine Gammaherpesvirus 68 Infection J. Virol., October 15, 2009; 83(20): 10644 - 10652. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Hofmann, R. Saunier, R. Cossard, M. Esposito, T. Rinaldi, and A. Delahodde A nonproteolytic proteasome activity controls organelle fission in yeast J. Cell Sci., October 15, 2009; 122(20): 3673 - 3683. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.-Q. Li, K. Ohshiro, S. D. N. Reddy, S. B. Pakala, M.-H. Lee, Y. Zhang, S. K. Rayala, and R. Kumar E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1 PNAS, October 13, 2009; 106(41): 17493 - 17498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Geiss-Friedlander, N. Parmentier, U. Moller, H. Urlaub, B. J. Van den Eynde, and F. Melchior The Cytoplasmic Peptidase DPP9 Is Rate-limiting for Degradation of Proline-containing Peptides J. Biol. Chem., October 2, 2009; 284(40): 27211 - 27219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Gonzalez, L. Wang, and B. Damania Kaposi's Sarcoma-Associated Herpesvirus Encodes a Viral Deubiquitinase J. Virol., October 1, 2009; 83(19): 10224 - 10233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Jia, T. Song, C. Wei, C. Ni, Z. Zheng, Q. Xu, H. Ma, L. Li, Y. Zhang, X. He, et al. Negative Regulation of MAVS-Mediated Innate Immune Response by PSMA7 J. Immunol., October 1, 2009; 183(7): 4241 - 4248. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhou, Z. W. Carpenter, G. Brennan, and J. R. Nambu The Unique Morgue Ubiquitination Protein Is Conserved in a Diverse but Restricted Set of Invertebrates Mol. Biol. Evol., October 1, 2009; 26(10): 2245 - 2259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-B. Qian, L. Waldron, N. Choudhary, R. E. Klevit, W. J. Chazin, and C. Patterson Engineering a Ubiquitin Ligase Reveals Conformational Flexibility Required for Ubiquitin Transfer J. Biol. Chem., September 25, 2009; 284(39): 26797 - 26802. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.-C. Chen, L.-N. Qin, X.-M. Li, B. J. Walters, J. A. Wilson, L. Mei, and S. M. Wilson The Proteasome-Associated Deubiquitinating Enzyme Usp14 Is Essential for the Maintenance of Synaptic Ubiquitin Levels and the Development of Neuromuscular Junctions J. Neurosci., September 2, 2009; 29(35): 10909 - 10919. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Collins, C. G. Kurland, P. Biggs, and D. Penny The Modern RNP World of Eukaryotes J. Hered., September 1, 2009; 100(5): 597 - 604. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. F. Fernandes, Q. Bian, J.-K. Jiang, C. J. Thomas, A. Taylor, P. Pereira, and F. Shang Proteasome Inactivation Promotes p38 Mitogen-activated Protein Kinase-dependent Phosphatidylinositol 3-kinase Activation and Increases Interleukin-8 Production in Retinal Pigment Epithelial Cells Mol. Biol. Cell, August 15, 2009; 20(16): 3690 - 3699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Koodathingal, N. E. Jaffe, D. A. Kraut, S. Prakash, S. Fishbain, C. Herman, and A. Matouschek ATP-dependent Proteases Differ Substantially in Their Ability to Unfold Globular Proteins J. Biol. Chem., July 10, 2009; 284(28): 18674 - 18684. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Plant, J. R. Bain, J. E. Correa, M. Woo, and J. Batt Absence of caspase-3 protects against denervation-induced skeletal muscle atrophy J Appl Physiol, July 1, 2009; 107(1): 224 - 234. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Laurell, D. Velazquez-Fernandez, K. Lindsten, C. Juhlin, U. Enberg, J. Geli, A. Hoog, M. Kjellman, J. Lundeberg, B. Hamberger, et al. Transcriptional profiling enables molecular classification of adrenocortical tumours Eur. J. Endocrinol., July 1, 2009; 161(1): 141 - 152. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. F. Burande, M. L. Heuze, I. Lamsoul, B. Monsarrat, S. Uttenweiler-Joseph, and P. G. Lutz A Label-free Quantitative Proteomics Strategy to Identify E3 Ubiquitin Ligase Substrates Targeted to Proteasome Degradation Mol. Cell. Proteomics, July 1, 2009; 8(7): 1719 - 1727. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. Salmon, S. Leonard, V. Masamsetti, A. Pierce, A. J. Podlutsky, N. Podlutskaya, A. Richardson, S. N. Austad, and A. R. Chaudhuri The long lifespan of two bat species is correlated with resistance to protein oxidation and enhanced protein homeostasis FASEB J, July 1, 2009; 23(7): 2317 - 2326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Corcoran, X. Wang, and L. Lybarger Adapter-mediated Substrate Selection for Endoplasmic Reticulum-associated Degradation J. Biol. Chem., June 26, 2009; 284(26): 17475 - 17487. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. U. Sixt, M. Adamzik, D. Spyrka, B. Saul, J. Hakenbeck, J. Wohlschlaeger, U. Costabel, A. Kloss, J. Giesebrecht, B. Dahlmann, et al. Alveolar Extracellular 20S Proteasome in Patients with Acute Respiratory Distress Syndrome Am. J. Respir. Crit. Care Med., June 15, 2009; 179(12): 1098 - 1106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. D. Vosper, G. S. McDowell, C. J. Hindley, C. S. Fiore-Heriche, R. Kucerova, I. Horan, and A. Philpott Ubiquitylation on Canonical and Non-canonical Sites Targets the Transcription Factor Neurogenin for Ubiquitin-mediated Proteolysis J. Biol. Chem., June 5, 2009; 284(23): 15458 - 15468. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Masson, D. Lundin, F. Soderbom, and P. Young Characterization of a REG/PA28 Proteasome Activator Homolog in Dictyostelium discoideum Indicates that the Ubiquitin- and ATP-Independent REG{gamma} Proteasome Is an Ancient Nuclear Protease Eukaryot. Cell, June 1, 2009; 8(6): 844 - 851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Andersen, L. Madsen, S. Prag, A. H. Johnsen, C. A. Semple, K. B. Hendil, and R. Hartmann-Petersen Thioredoxin Txnl1/TRP32 Is a Redox-active Cofactor of the 26 S Proteasome J. Biol. Chem., May 29, 2009; 284(22): 15246 - 15254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Uchiki, H. T. Kim, B. Zhai, S. P. Gygi, J. A. Johnston, J. P. O'Bryan, and A. L. Goldberg The Ubiquitin-interacting Motif Protein, S5a, Is Ubiquitinated by All Types of Ubiquitin Ligases by a Mechanism Different from Typical Substrate Recognition J. Biol. Chem., May 8, 2009; 284(19): 12622 - 12632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. E. Choi, M. Butterworth, S. Malladi, C. S. Duckett, G. M. Cohen, and S. B. Bratton The E3 Ubiquitin Ligase cIAP1 Binds and Ubiquitinates Caspase-3 and -7 via Unique Mechanisms at Distinct Steps in Their Processing J. Biol. Chem., May 8, 2009; 284(19): 12772 - 12782. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. A. O'Connor Nimble micromanagement of macromolecules Blood, May 7, 2009; 113(19): 4482 - 4483. [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Lamarre, N. R. Le Francois, W. R. Driedzic, and P. U. Blier Protein synthesis is lowered while 20S proteasome activity is maintained following acclimation to low temperature in juvenile spotted wolffish (Anarhichas minor Olafsen) J. Exp. Biol., May 1, 2009; 212(9): 1294 - 1301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-P. Bousquet-Dubouch, E. Baudelet, F. Guerin, M. Matondo, S. Uttenweiler-Joseph, O. Burlet-Schiltz, and B. Monsarrat Affinity Purification Strategy to Capture Human Endogenous Proteasome Complexes Diversity and to Identify Proteasome-interacting Proteins Mol. Cell. Proteomics, May 1, 2009; 8(5): 1150 - 1164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mishra, S. K. Godavarthi, M. Maheshwari, A. Goswami, and N. R. Jana The Ubiquitin Ligase E6-AP Is Induced and Recruited to Aggresomes in Response to Proteasome Inhibition and May Be Involved in the Ubiquitination of Hsp70-bound Misfolded Proteins J. Biol. Chem., April 17, 2009; 284(16): 10537 - 10545. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Misaghi, S. Ottosen, A. Izrael-Tomasevic, D. Arnott, M. Lamkanfi, J. Lee, J. Liu, K. O'Rourke, V. M. Dixit, and A. C. Wilson Association of C-Terminal Ubiquitin Hydrolase BRCA1-Associated Protein 1 with Cell Cycle Regulator Host Cell Factor 1 Mol. Cell. Biol., April 15, 2009; 29(8): 2181 - 2192. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Tisdale Mechanisms of Cancer Cachexia Physiol Rev, April 1, 2009; 89(2): 381 - 410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Quezada, S. W. Hicks, J. E. Galan, and C. E. Stebbins A family of Salmonella virulence factors functions as a distinct class of autoregulated E3 ubiquitin ligases PNAS, March 24, 2009; 106(12): 4864 - 4869. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Eldin, L. Papon, A. Oteiza, E. Brocchi, T. G. Lawson, and N. Mechti TRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus J. Gen. Virol., March 1, 2009; 90(3): 536 - 545. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Han, J.-E. Gomes, C. L. Birmingham, L. Pintard, A. Sugimoto, and P. E. Mains The Role of Protein Phosphatase 4 in Regulating Microtubule Severing in the Caenorhabditis elegans Embryo Genetics, March 1, 2009; 181(3): 933 - 943. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Dhawan, H. Luo, A. M. Foerster, S. AbuQamar, H.-N. Du, S. D. Briggs, O. M. Scheid, and T. Mengiste HISTONE MONOUBIQUITINATION1 Interacts with a Subunit of the Mediator Complex and Regulates Defense against Necrotrophic Fungal Pathogens in Arabidopsis PLANT CELL, March 1, 2009; 21(3): 1000 - 1019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. M. Noman, N. Koide, F. Hassan, I. I.-E-Khuda, J. Dagvadorj, G. Tumurkhuu, S. Islam, Y. Naiki, T. Yoshida, and T. Yokochi Thalidomide inhibits lipopolysaccharide-induced tumor necrosis factor-{alpha} production via down-regulation of MyD88 expression Innate Immunity, February 1, 2009; 15(1): 33 - 41. [Abstract] [PDF]
|
|
|
|
|
|
A. V. Gomes, G. W. Young, Y. Wang, C. Zong, M. Eghbali, O. Drews, H. Lu, E. Stefani, and P. Ping Contrasting Proteome Biology and Functional Heterogeneity of the 20 S Proteasome Complexes in Mammalian Tissues Mol. Cell. Proteomics, February 1, 2009; 8(2): 302 - 315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yuksek, W.-l. Chen, D. Chien, and J.-h. J. Ou Ubiquitin-Independent Degradation of Hepatitis C Virus F Protein J. Virol., January 15, 2009; 83(2): 612 - 621. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Cheroni, M. Marino, M. Tortarolo, P. Veglianese, S. De Biasi, E. Fontana, L. V. Zuccarello, C. J. Maynard, N. P. Dantuma, and C. Bendotti Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis Hum. Mol. Genet., January 1, 2009; 18(1): 82 - 96. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Wade and G. M. Wahl Targeting Mdm2 and Mdmx in Cancer Therapy: Better Living through Medicinal Chemistry? Mol. Cancer Res., January 1, 2009; 7(1): 1 - 11. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wang, A. Matsuzawa, S. A. Brown, J. Zhou, C. S. Guy, P.-H. Tseng, K. Forbes, T. P. Nicholson, P. W. Sheppard, H. Hacker, et al. Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin PNAS, December 23, 2008; 105(51): 20197 - 20202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Morishima, A. M. Wang, Z. Yu, W. B. Pratt, Y. Osawa, and A. P. Lieberman CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins Hum. Mol. Genet., December 15, 2008; 17(24): 3942 - 3952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Isono, T. Ohshima, Y. Saeki, J. Matsumoto, M. Hijikata, K. Tanaka, and K. Shimotohno Human T-cell Leukemia Virus Type 1 HBZ Protein Bypasses the Targeting Function of Ubiquitination J. Biol. Chem., December 5, 2008; 283(49): 34273 - 34282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shima, T. Shima, T. Chiba, T. Irimura, P. P. Pandolfi, and I. Kitabayashi PML Activates Transcription by Protecting HIPK2 and p300 from SCFFbx3-Mediated Degradation Mol. Cell. Biol., December 1, 2008; 28(23): 7126 - 7138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. P. Cai, Z. Shen, L. Van Kaer, and L. C. Becker Ischemic preconditioning-induced cardioprotection is lost in mice with immunoproteasome subunit low molecular mass polypeptide-2 deficiency FASEB J, December 1, 2008; 22(12): 4248 - 4257. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Boutell, R. Everett, J. Hilliard, P. Schaffer, A. Orr, and D. Davido Herpes Simplex Virus Type 1 ICP0 Phosphorylation Mutants Impair the E3 Ubiquitin Ligase Activity of ICP0 in a Cell Type-Dependent Manner J. Virol., November 1, 2008; 82(21): 10647 - 10656. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-L. Chan, T.-H. Chang, C.-L. Liao, and Y.-L. Lin The Cellular Antiviral Protein Viperin Is Attenuated by Proteasome-Mediated Protein Degradation in Japanese Encephalitis Virus-Infected Cells J. Virol., November 1, 2008; 82(21): 10455 - 10464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Marten, N. Zeiss, S. Serba, S. Mehrle, M. von Lilienfeld-Toal, and J. Schmidt Bortezomib is ineffective in an orthotopic mouse model of pancreatic adenocarcinoma Mol. Cancer Ther., November 1, 2008; 7(11): 3624 - 3631. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Ruffieux-Daidie, O. Poirot, S. Boulkroun, F. Verrey, S. Kellenberger, and O. Staub Deubiquitylation Regulates Activation and Proteolytic Cleavage of ENaC J. Am. Soc. Nephrol., November 1, 2008; 19(11): 2170 - 2180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Daskalogianni, S. Apcher, M. M. Candeias, N. Naski, F. Calvo, and R. Fahraeus Gly-Ala Repeats Induce Position- and Substrate-specific Regulation of 26 S Proteasome-dependent Partial Processing J. Biol. Chem., October 31, 2008; 283(44): 30090 - 30100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Blickwedehl, M. Agarwal, C. Seong, R. K. Pandita, T. Melendy, P. Sung, T. K. Pandita, and N. Bangia Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability PNAS, October 21, 2008; 105(42): 16165 - 16170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ning, A. D. Campos, B. G. Darnay, G. L. Bentz, and J. S. Pagano TRAF6 and the Three C-Terminal Lysine Sites on IRF7 Are Required for Its Ubiquitination-Mediated Activation by the Tumor Necrosis Factor Receptor Family Member Latent Membrane Protein 1 Mol. Cell. Biol., October 15, 2008; 28(20): 6536 - 6546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Fioravante, R.-Y. Liu, and J. H. Byrne The Ubiquitin-Proteasome System Is Necessary for Long-Term Synaptic Depression in Aplysia J. Neurosci., October 8, 2008; 28(41): 10245 - 10256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Doucet, G. S. Butler, D. Rodriguez, A. Prudova, and C. M. Overall Metadegradomics: Toward in Vivo Quantitative Degradomics of Proteolytic Post-translational Modifications of the Cancer Proteome Mol. Cell. Proteomics, October 1, 2008; 7(10): 1925 - 1951. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Boulkroun, D. Ruffieux-Daidie, J.-J. Vitagliano, O. Poirot, R.-P. Charles, D. Lagnaz, D. Firsov, S. Kellenberger, and O. Staub Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3 Am J Physiol Renal Physiol, October 1, 2008; 295(4): F889 - F900. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Friehs Proteasome inhibition in hypertrophied myocardium Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1373 - H1374. [Full Text] [PDF]
|
|
|
|
|
|
R. Oerlemans, N. E. Franke, Y. G. Assaraf, J. Cloos, I. van Zantwijk, C. R. Berkers, G. L. Scheffer, K. Debipersad, K. Vojtekova, C. Lemos, et al. Molecular basis of bortezomib resistance: proteasome subunit {beta}5 (PSMB5) gene mutation and overexpression of PSMB5 protein Blood, September 15, 2008; 112(6): 2489 - 2499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Den Herder, A. De Keyser, R. De Rycke, S. Rombauts, W. Van de Velde, M. R. Clemente, C. Verplancke, P. Mergaert, E. Kondorosi, M. Holsters, et al. Seven in Absentia Proteins Affect Plant Growth and Nodulation in Medicago truncatula Plant Physiology, September 1, 2008; 148(1): 369 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. B. Pratt, Y. Morishima, and Y. Osawa The Hsp90 Chaperone Machinery Regulates Signaling by Modulating Ligand Binding Clefts J. Biol. Chem., August 22, 2008; 283(34): 22885 - 22889. [Full Text] [PDF]
|
|
|
|
|
|
L. Bedford, D. Hay, A. Devoy, S. Paine, D. G. Powe, R. Seth, T. Gray, I. Topham, K. Fone, N. Rezvani, et al. Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies J. Neurosci., August 13, 2008; 28(33): 8189 - 8198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhang, J. Zhou, A. F. Fernandes, J. R. Sparrow, P. Pereira, A. Taylor, and F. Shang The Proteasome: A Target of Oxidative Damage in Cultured Human Retina Pigment Epithelial Cells Invest. Ophthalmol. Vis. Sci., August 1, 2008; 49(8): 3622 - 3630. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. T. Lei and M. Martinez-Moczygemba Separate endocytic pathways regulate IL-5 receptor internalization and signaling J. Leukoc. Biol., August 1, 2008; 84(2): 499 - 509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Birks, N. Latif, K. Enesa, T. Folkvang, L. A. Luong, P. Sarathchandra, M. Khan, H. Ovaa, C. M. Terracciano, P. J.R. Barton, et al. Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy Cardiovasc Res, August 1, 2008; 79(3): 472 - 480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Fernandes, J. Zhou, X. Zhang, Q. Bian, J. Sparrow, A. Taylor, P. Pereira, and F. Shang Oxidative Inactivation of the Proteasome in Retinal Pigment Epithelial Cells: A POTENTIAL LINK BETWEEN OXIDATIVE STRESS AND UP-REGULATION OF INTERLEUKIN-8 J. Biol. Chem., July 25, 2008; 283(30): 20745 - 20753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N.-Y. Zhang, Z. Tang, and C.-W. Liu {alpha}-Synuclein Protofibrils Inhibit 26 S Proteasome-mediated Protein Degradation: UNDERSTANDING THE CYTOTOXICITY OF PROTEIN PROTOFIBRILS IN NEURODEGENERATIVE DISEASE PATHOGENESIS J. Biol. Chem., July 18, 2008; 283(29): 20288 - 20298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Sehat, S. Andersson, L. Girnita, and O. Larsson Identification of c-Cbl as a New Ligase for Insulin-like Growth Factor-I Receptor with Distinct Roles from Mdm2 in Receptor Ubiquitination and Endocytosis Cancer Res., July 15, 2008; 68(14): 5669 - 5677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Saliba, M. Pangalos, and S. J. Moss The Ubiquitin-like Protein Plic-1 Enhances the Membrane Insertion of GABAA Receptors by Increasing Their Stability within the Endoplasmic Reticulum J. Biol. Chem., July 4, 2008; 283(27): 18538 - 18544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Enesa, K. Ito, L. A. Luong, I. Thorbjornsen, C. Phua, Y. To, J. Dean, D. O. Haskard, J. Boyle, I. Adcock, et al. Hydrogen Peroxide Prolongs Nuclear Localization of NF-{kappa}B in Activated Cells by Suppressing Negative Regulatory Mechanisms J. Biol. Chem., July 4, 2008; 283(27): 18582 - 18590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kraus, E. Malenke, J. Gogel, H. Muller, T. Ruckrich, H. Overkleeft, H. Ovaa, E. Koscielniak, J. T. Hartmann, and C. Driessen Ritonavir induces endoplasmic reticulum stress and sensitizes sarcoma cells toward bortezomib-induced apoptosis Mol. Cancer Ther., July 1, 2008; 7(7): 1940 - 1948. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Gonzalez-Fernandez, E. Martinez-Galisteo, F. Gaytan, J. A. Barcena, and J. E. Sanchez-Criado Changes in the Proteome of Functional and Regressing Corpus Luteum During Pregnancy and Lactation in the Rat Biol Reprod, July 1, 2008; 79(1): 100 - 114. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
