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Physiological Reviews, Vol. 82, No. 2, April 2002, pp. 331-371; 10.1152/physrev.00030.2001.
Copyright ©2002 by the American Physiological Society
Institute for Medical Biochemistry, Center for Molecular Biology of Inflammation, University of Münster, Münster, Germany; and Department of Cell Biology, Institute of Ophthalmology, University College London, London, United Kingdom
Gerke, Volker and
Stephen E. Moss.
Annexins: From Structure to Function. Physiol. Rev. 82: 331-371, 2002.
Annexins are Ca2+ and
phospholipid binding proteins forming an evolutionary conserved
multigene family with members of the family being expressed throughout
animal and plant kingdoms. Structurally, annexins are characterized by
a highly
-helical and tightly packed protein core domain considered
to represent a Ca2+-regulated membrane binding module. Many
of the annexin cores have been crystallized, and their molecular
structures reveal interesting features that include the architecture of
the annexin-type Ca2+ binding sites and a central
hydrophilic pore proposed to function as a Ca2+ channel. In
addition to the conserved core, all annexins contain a second principal
domain. This domain, which NH2-terminally precedes the
core, is unique for a given member of the family and most likely
specifies individual annexin properties in vivo. Cellular and animal
knock-out models as well as dominant-negative mutants have
recently been established for a number of annexins, and the effects of
such manipulations are strikingly different for different members of
the family. At least for some annexins, it appears that they
participate in the regulation of membrane organization and membrane
traffic and the regulation of ion (Ca2+) currents across
membranes or Ca2+ concentrations within cells. Although
annexins lack signal sequences for secretion, some members of the
family have also been identified extracellularly where they can act as
receptors for serum proteases on the endothelium as well as inhibitors
of neutrophil migration and blood coagulation. Finally, deregulations
in annexin expression and activity have been correlated with human
diseases, e.g., in acute promyelocytic leukemia and the
antiphospholipid antibody syndrome, and the term
annexinopathies has been coined.
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H.-H. Chen, C. P. Vicente, L. He, D. M. Tollefsen, and T.-C. Wun Fusion proteins comprising annexin V and Kunitz protease inhibitors are highly potent thrombogenic site-directed anticoagulants Blood, May 15, 2005; 105(10): 3902 - 3909. [Abstract] [Full Text] [PDF] |
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G. Jeschke, A. Bender, T. Schweikardt, G. Panek, H. Decker, and H. Paulsen Localization of the N-terminal Domain in Light-harvesting Chlorophyll a/b Protein by EPR Measurements J. Biol. Chem., May 13, 2005; 280(19): 18623 - 18630. [Abstract] [Full Text] [PDF] |
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E. Camors, V. Monceau, and D. Charlemagne Annexins and Ca2+ handling in the heart Cardiovasc Res, March 1, 2005; 65(4): 793 - 802. [Abstract] [Full Text] [PDF] |
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S. Chasserot-Golaz, N. Vitale, E. Umbrecht-Jenck, D. Knight, V. Gerke, and M.-F. Bader Annexin 2 Promotes the Formation of Lipid Microdomains Required for Calcium-regulated Exocytosis of Dense-Core Vesicles Mol. Biol. Cell, March 1, 2005; 16(3): 1108 - 1119. [Abstract] [Full Text] [PDF] |
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J. Zhang and K. R. McCrae Annexin A2 mediates endothelial cell activation by antiphospholipid/anti-{beta}2 glycoprotein I antibodies Blood, March 1, 2005; 105(5): 1964 - 1969. [Abstract] [Full Text] [PDF] |
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A. Yamada, K. Irie, T. Hirota, T. Ooshio, A. Fukuhara, and Y. Takai Involvement of the Annexin II-S100A10 Complex in the Formation of E-cadherin-based Adherens Junctions in Madin-Darby Canine Kidney Cells J. Biol. Chem., February 18, 2005; 280(7): 6016 - 6027. [Abstract] [Full Text] [PDF] |
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J. Lu, K. I. Izvolsky, J. Qian, and W. V. Cardoso Identification of FGF10 Targets in the Embryonic Lung Epithelium during Bud Morphogenesis J. Biol. Chem., February 11, 2005; 280(6): 4834 - 4841. [Abstract] [Full Text] [PDF] |
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J. G. J. Hoenderop, B. Nilius, and R. J. M. Bindels Calcium Absorption Across Epithelia Physiol Rev, January 1, 2005; 85(1): 373 - 422. [Abstract] [Full Text] [PDF] |
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A. Cederholm, E. Svenungsson, K. Jensen-Urstad, C. Trollmo, A.-K. Ulfgren, J. Swedenborg, G.-Z. Fei, and J. Frostegard Decreased Binding of Annexin V to Endothelial Cells: A Potential Mechanism in Atherothrombosis of Patients With Systemic Lupus Erythematosus Arterioscler. Thromb. Vasc. Biol., January 1, 2005; 25(1): 198 - 203. [Abstract] [Full Text] [PDF] |
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H. Kenis, H. van Genderen, A. Bennaghmouch, H. A. Rinia, P. Frederik, J. Narula, L. Hofstra, and C. P. M. Reutelingsperger Cell Surface-expressed Phosphatidylserine and Annexin A5 Open a Novel Portal of Cell Entry J. Biol. Chem., December 10, 2004; 279(50): 52623 - 52629. [Abstract] [Full Text] [PDF] |
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M. V. Dorovkov and A. G. Ryazanov Phosphorylation of Annexin I by TRPM7 Channel-Kinase J. Biol. Chem., December 3, 2004; 279(49): 50643 - 50646. [Abstract] [Full Text] [PDF] |
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T. Takei, Y. Kuge, S. Zhao, M. Sato, H. W. Strauss, F. G. Blankenberg, J. F. Tait, and N. Tamaki Time Course of Apoptotic Tumor Response After a Single Dose of Chemotherapy: Comparison with 99mTc-Annexin V Uptake and Histologic Findings in an Experimental Model J. Nucl. Med., December 1, 2004; 45(12): 2083 - 2087. [Abstract] [Full Text] [PDF] |
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A. P. Ponnampalam, G. C. Weston, A. C. Trajstman, B. Susil, and P. A.W. Rogers Molecular classification of human endometrial cycle stages by transcriptional profiling Mol. Hum. Reprod., December 1, 2004; 10(12): 879 - 893. [Abstract] [Full Text] [PDF] |
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V. Monceau, Y. Belikova, G. Kratassiouk, D. Charue, E. Camors, C. Communal, P. Trouve, F. Russo-Marie, and D. Charlemagne Externalization of endogenous annexin A5 participates in apoptosis of rat cardiomyocytes Cardiovasc Res, December 1, 2004; 64(3): 496 - 506. [Abstract] [Full Text] [PDF] |
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G. Ma, T. Greenwell-Wild, K. Lei, W. Jin, J. Swisher, N. Hardegen, C. T. Wild, and S. M. Wahl Secretory Leukocyte Protease Inhibitor Binds to Annexin II, a Cofactor for Macrophage HIV-1 Infection J. Exp. Med., November 15, 2004; 200(10): 1337 - 1346. [Abstract] [Full Text] [PDF] |
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A. M. Hinsby, J. V. Olsen, and M. Mann Tyrosine Phosphoproteomics of Fibroblast Growth Factor Signaling: A ROLE FOR INSULIN RECEPTOR SUBSTRATE-4 J. Biol. Chem., November 5, 2004; 279(45): 46438 - 46447. [Abstract] [Full Text] [PDF] |
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W. Xiang, O. Windl, G. Wunsch, M. Dugas, A. Kohlmann, N. Dierkes, I. M. Westner, and H. A. Kretzschmar Identification of Differentially Expressed Genes in Scrapie-Infected Mouse Brains by Using Global Gene Expression Technology J. Virol., October 15, 2004; 78(20): 11051 - 11060. [Abstract] [Full Text] [PDF] |
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A. B. Deora, G. Kreitzer, A. T. Jacovina, and K. A. Hajjar An Annexin 2 Phosphorylation Switch Mediates p11-dependent Translocation of Annexin 2 to the Cell Surface J. Biol. Chem., October 15, 2004; 279(42): 43411 - 43418. [Abstract] [Full Text] [PDF] |
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T. Okamoto, K. Higuchi, T. Shinkawa, T. Isobe, H. Lorz, T. Koshiba, and E. Kranz Identification of Major Proteins in Maize Egg Cells Plant Cell Physiol., October 15, 2004; 45(10): 1406 - 1412. [Abstract] [Full Text] [PDF] |
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T. Nagata, S. Iizumi, K. Satoh, H. Ooka, J. Kawai, P. Carninci, Y. Hayashizaki, Y. Otomo, K. Murakami, K. Matsubara, et al. Comparative Analysis of Plant and Animal Calcium Signal Transduction Element Using Plant Full-Length cDNA Data Mol. Biol. Evol., October 1, 2004; 21(10): 1855 - 1870. [Abstract] [Full Text] [PDF] |
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M. Jin, C. Smith, H.-Y. Hsieh, D. F. Gibson, and J. F. Tait Essential Role of B-helix Calcium Binding Sites in Annexin V-Membrane Binding J. Biol. Chem., September 24, 2004; 279(39): 40351 - 40357. [Abstract] [Full Text] [PDF] |
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T.-Y. Ling, C.-L. Chen, Y.-H. Huang, I-H. Liu, S. S. Huang, and J. S. Huang Identification and Characterization of the Acidic pH Binding Sites for Growth Regulatory Ligands of Low Density Lipoprotein Receptor-related Protein-1 J. Biol. Chem., September 10, 2004; 279(37): 38736 - 38748. [Abstract] [Full Text] [PDF] |
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D. B. N. Lee, N. Jamgotchian, S. G. Allen, F. W. K. Kan, and I. L. Hale Annexin A2 heterotetramer: role in tight junction assembly Am J Physiol Renal Physiol, September 1, 2004; 287(3): F481 - F491. [Abstract] [Full Text] [PDF] |
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P. Turowski, P. Adamson, J. Sathia, J. J. Zhang, S. E. Moss, G. W. Aylward, M. J. Hayes, N. Kanuga, and J. Greenwood Basement Membrane-Dependent Modification of Phenotype and Gene Expression in Human Retinal Pigment Epithelial ARPE-19 Cells Invest. Ophthalmol. Vis. Sci., August 1, 2004; 45(8): 2786 - 2794. [Abstract] [Full Text] [PDF] |
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