Physiol Rev Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Physiol. Rev. 82: 291-329, 2002;
0031-9333/02 $15.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (228)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Blake, D. J.
Right arrow Articles by Davies, K. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Blake, D. J.
Right arrow Articles by Davies, K. E.

Physiological Reviews, Vol. 82, No. 2, April 2002, pp. 291-329; 10.1152/physrev.00028.2001.
Copyright ©2002 by the American Physiological Society

Function and Genetics of Dystrophin and Dystrophin-Related Proteins in Muscle

Derek J. Blake, Andrew Weir, Sarah E. Newey, and Kay E. Davies

Medical Research Council, Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, Oxford, United Kingdom

Blake, Derek J., Andrew Weir, Sarah E. Newey, and Kay E. Davies. Function and Genetics of Dystrophin and Dystrophin-Related Proteins in Muscle. Physiol. Rev. 82: 291-329, 2002.The X-linked muscle-wasting disease Duchenne muscular dystrophy is caused by mutations in the gene encoding dystrophin. There is currently no effective treatment for the disease; however, the complex molecular pathology of this disorder is now being unravelled. Dystrophin is located at the muscle sarcolemma in a membrane-spanning protein complex that connects the cytoskeleton to the basal lamina. Mutations in many components of the dystrophin protein complex cause other forms of autosomally inherited muscular dystrophy, indicating the importance of this complex in normal muscle function. Although the precise function of dystrophin is unknown, the lack of protein causes membrane destabilization and the activation of multiple pathophysiological processes, many of which converge on alterations in intracellular calcium handling. Dystrophin is also the prototype of a family of dystrophin-related proteins, many of which are found in muscle. This family includes utrophin and alpha -dystrobrevin, which are involved in the maintenance of the neuromuscular junction architecture and in muscle homeostasis. New insights into the pathophysiology of dystrophic muscle, the identification of compensating proteins, and the discovery of new binding partners are paving the way for novel therapeutic strategies to treat this fatal muscle disease. This review discusses the role of the dystrophin complex and protein family in muscle and describes the physiological processes that are affected in Duchenne muscular dystrophy.




This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
S. Gastaldello, S. D'Angelo, S. Franzoso, M. Fanin, C. Angelini, R. Betto, and D. Sandona
Inhibition of Proteasome Activity Promotes the Correct Localization of Disease-Causing {alpha}-Sarcoglycan Mutants in HEK-293 Cells Constitutively Expressing {beta}-, {gamma}-, and {delta}-Sarcoglycan
Am. J. Pathol., July 1, 2008; 173(1): 170 - 181.
[Abstract] [Full Text] [PDF]

Home page
 JSLHRHome page
L. B. Thomas, G. L. Joseph, T. D. Adkins, F. H. Andrade, and J. C. Stemple
Laryngeal Muscles Are Spared in the Dystrophin Deficient mdx Mouse
J Speech Lang Hear Res, June 1, 2008; 51(3): 586 - 595.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Khairallah, R. J. Khairallah, M. E. Young, B. G. Allen, M. A. Gillis, G. Danialou, C. F. Deschepper, B. J. Petrof, and C. Des Rosiers
Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiency
PNAS, May 13, 2008; 105(19): 7028 - 7033.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. G. Fradkin, R. A. Baines, M. C. van der Plas, and J. N. Noordermeer
The Dystrophin Dp186 Isoform Regulates Neurotransmitter Release at a Central Synapse in Drosophila
J. Neurosci., May 7, 2008; 28(19): 5105 - 5114.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. G. Reynolds, S. A. McCalmon, J. A. Donaghey, and F. J. Naya
Deregulated Protein Kinase A Signaling and Myospryn Expression in Muscular Dystrophy
J. Biol. Chem., March 28, 2008; 283(13): 8070 - 8074.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
D. Zhou, J. Wang, M. A. Zapala, J. Xue, N. J. Schork, and G. G. Haddad
Gene expression in mouse brain following chronic hypoxia: role of sarcospan in glial cell death
Physiol Genomics, February 19, 2008; 32(3): 370 - 379.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
J. V. Chakkalakal, P. Miura, G. Belanger, R. N. Michel, and B. J. Jasmin
Modulation of utrophin A mRNA stability in fast versus slow muscles via an AU-rich element and calcineurin signaling
Nucleic Acids Res., February 11, 2008; 36(3): 826 - 838.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
V. Labarque, K. Freson, C. Thys, C. Wittevrongel, M. F. Hoylaerts, R. De Vos, N. Goemans, and C. Van Geet
Increased Gs signalling in platelets and impaired collagen activation, due to a defect in the dystrophin gene, result in increased blood loss during spinal surgery
Hum. Mol. Genet., February 1, 2008; 17(3): 357 - 366.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
N. Tahallah, A. Brunelle, S. De La Porte, and O. Laprevote
Lipid mapping in human dystrophic muscle by cluster-time-of-flight secondary ion mass spectrometry imaging
J. Lipid Res., February 1, 2008; 49(2): 438 - 454.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
N. Haines, S. Seabrooke, and B. A. Stewart
Dystroglycan and Protein O-Mannosyltransferases 1 and 2 Are Required to Maintain Integrity of Drosophila Larval Muscles
Mol. Biol. Cell, December 1, 2007; 18(12): 4721 - 4730.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. D. Schertzer, S. M. Gehrig, J. G. Ryall, and G. S. Lynch
Modulation of Insulin-like Growth Factor (IGF)-I and IGF-Binding Protein Interactions Enhances Skeletal Muscle Regeneration and Ameliorates the Dystrophic Pathology in mdx Mice
Am. J. Pathol., October 1, 2007; 171(4): 1180 - 1188.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
G. Anastasi, G. Cutroneo, A. Sidoti, C. Rinaldi, D. Bruschetta, G. Rizzo, R. D'Angelo, G. Tarone, A. Amato, and A. Favaloro
Sarcoglycan Subcomplex Expression in Normal Human Smooth Muscle
J. Histochem. Cytochem., August 1, 2007; 55(8): 831 - 843.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. J. McCarthy, K. A. Esser, and F. H. Andrade
MicroRNA-206 is overexpressed in the diaphragm but not the hindlimb muscle of mdx mouse
Am J Physiol Cell Physiol, July 1, 2007; 293(1): C451 - C457.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
R. Xu, K. Chandrasekharan, J. H. Yoon, M. Camboni, and P. T. Martin
Overexpression of the Cytotoxic T Cell (CT) Carbohydrate Inhibits Muscular Dystrophy in the dyW Mouse Model of Congenital Muscular Dystrophy 1A
Am. J. Pathol., July 1, 2007; 171(1): 181 - 199.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
T. M. Suchyna and F. Sachs
Mechanosensitive channel properties and membrane mechanics in mouse dystrophic myotubes
J. Physiol., May 15, 2007; 581(1): 369 - 387.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
C. T. Esapa, A. Waite, M. Locke, M. A. Benson, M. Kraus, R.A. J. McIlhinney, R. V. Sillitoe, P. W. Beesley, and D. J. Blake
SGCE missense mutations that cause myoclonus-dystonia syndrome impair {varepsilon}-sarcoglycan trafficking to the plasma membrane: modulation by ubiquitination and torsinA
Hum. Mol. Genet., February 1, 2007; 16(3): 327 - 342.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
N. Haines and B. A. Stewart
Functional Roles for {beta}1,4-N-Acetlygalactosaminyltransferase-A in Drosophila Larval Neurons and Muscles
Genetics, February 1, 2007; 175(2): 671 - 679.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
K. M. Rice, D. L. Preston, D. Neff, M. Norton, and E. R. Blough
Age-Related Dystrophin-Glycoprotein Complex Structure and Function in the Rat Extensor Digitorum Longus and Soleus Muscle
J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2006; 61(11): 1119 - 1129.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
K. Talbot, D.-S. Cho, W.-Y. Ong, M. A. Benson, L.-Y. Han, H. A. Kazi, J. Kamins, C.-G. Hahn, D. J. Blake, and S. E. Arnold
Dysbindin-1 is a synaptic and microtubular protein that binds brain snapin
Hum. Mol. Genet., October 15, 2006; 15(20): 3041 - 3054.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
F.-X. Boittin, O. Petermann, C. Hirn, P. Mittaud, O. M. Dorchies, E. Roulet, and U. T. Ruegg
Ca2+-independent phospholipase A2 enhances store-operated Ca2+ entry in dystrophic skeletal muscle fibers
J. Cell Sci., September 15, 2006; 119(18): 3733 - 3742.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
B. Gavillet, J.-S. Rougier, A. A. Domenighetti, R. Behar, C. Boixel, P. Ruchat, H.-A. Lehr, T. Pedrazzini, and H. Abriel
Cardiac Sodium Channel Nav1.5 Is Regulated by a Multiprotein Complex Composed of Syntrophins and Dystrophin
Circ. Res., August 18, 2006; 99(4): 407 - 414.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
M. L. Mercado, A. R. Amenta, H. Hagiwara, M. S. Rafii, B. E. Lechner, R. T. Owens, D. J. McQuillan, S. C. Froehner, and J. R. Fallon
Biglycan regulates the expression and sarcolemmal localization of dystrobrevin, syntrophin, and nNOS
FASEB J, August 1, 2006; 20(10): 1724 - 1726.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
K. Ito, S. Kimura, S. Ozasa, M. Matsukura, M. Ikezawa, K. Yoshioka, H. Ueno, M. Suzuki, K. Araki, K.-i. Yamamura, et al.
Smooth muscle-specific dystrophin expression improves aberrant vasoregulation in mdx mice
Hum. Mol. Genet., July 15, 2006; 15(14): 2266 - 2275.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
J. V. Chakkalakal, S. A. Michel, E. R. Chin, R. N. Michel, and B. J. Jasmin
Targeted inhibition of Ca2+/calmodulin signaling exacerbates the dystrophic phenotype in mdx mouse muscle
Hum. Mol. Genet., May 1, 2006; 15(9): 1423 - 1435.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
L. M. Judge, M. Haraguchiln, and J. S. Chamberlain
Dissecting the signaling and mechanical functions of the dystrophin-glycoprotein complex
J. Cell Sci., April 15, 2006; 119(8): 1537 - 1546.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. M. Hanft, I. N. Rybakova, J. R. Patel, J. A. Rafael-Fortney, and J. M. Ervasti
Cytoplasmic {gamma}-actin contributes to a compensatory remodeling response in dystrophin-deficient muscle
PNAS, April 4, 2006; 103(14): 5385 - 5390.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
D. Yeung, K. Zablocki, C.-F. Lien, T. Jiang, S. Arkle, W. Brutkowski, J. Brown, H. Lochmuller, J. Simon, E. A. Barnard, et al.
Increased susceptibility to ATP via alteration of P2X receptor function in dystrophic mdx mouse muscle cells
FASEB J, April 1, 2006; 20(6): 610 - 620.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. M. Grady, D. F. Wozniak, K. K. Ohlemiller, and J. R. Sanes
Cerebellar synaptic defects and abnormal motor behavior in mice lacking alpha- and beta-dystrobrevin.
J. Neurosci., March 15, 2006; 26(11): 2841 - 2851.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
O. M. Dorchies, S. Wagner, O. Vuadens, K. Waldhauser, T. M. Buetler, P. Kucera, and U. T. Ruegg
Green tea extract and its major polyphenol (-)-epigallocatechin gallate improve muscle function in a mouse model for Duchenne muscular dystrophy
Am J Physiol Cell Physiol, February 1, 2006; 290(2): C616 - C625.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
M. A.F.V. Goncalves, A. A.F. de Vries, M. Holkers, M. J.M. van de Watering, I. van der Velde, G. P. van Nierop, D. Valerio, and S. Knaan-Shanzer
Human mesenchymal stem cells ectopically expressing full-length dystrophin can complement Duchenne muscular dystrophy myotubes by cell fusion
Hum. Mol. Genet., January 15, 2006; 15(2): 213 - 221.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. C. van der Plas, G. S. K. Pilgram, J. J. Plomp, A. de Jong, L. G. Fradkin, and J. N. Noordermeer
Dystrophin Is Required for Appropriate Retrograde Control of Neurotransmitter Release at the Drosophila Neuromuscular Junction
J. Neurosci., January 4, 2006; 26(1): 333 - 344.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. Danieli-Betto, A. Esposito, E. Germinario, D. Sandona, T. Martinello, A. Jakubiec-Puka, D. Biral, and R. Betto
Deficiency of {alpha}-sarcoglycan differently affects fast- and slow-twitch skeletal muscles
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2005; 289(5): R1328 - R1337.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
L. M. Angus, J. V. Chakkalakal, A. Mejat, J. K. Eibl, G. Belanger, L. A. Megeney, E. R. Chin, L. Schaeffer, R. N. Michel, and B. J. Jasmin
Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1{alpha}, drives utrophin gene expression at the neuromuscular junction
Am J Physiol Cell Physiol, October 1, 2005; 289(4): C908 - C917.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
C. M. Consolino, F. Duclos, J. Lee, R. A. Williamson, K. P. Campbell, and S. V. Brooks
Muscles of mice deficient in {alpha}-sarcoglycan maintain large masses and near control force values throughout the life span
Physiol Genomics, July 14, 2005; 22(2): 244 - 256.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
D. Touboul, A. Brunelle, F. Halgand, S. De La Porte, and O. Laprevote
Lipid imaging by gold cluster time-of-flight secondary ion mass spectrometry: application to Duchenne muscular dystrophy
J. Lipid Res., July 1, 2005; 46(7): 1388 - 1395.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. Yamane, S. Akutsu, T. G. H. Diekwisch, and R. Matsuda
Satellite cells and utrophin are not directly correlated with the degree of skeletal muscle damage in mdx mice
Am J Physiol Cell Physiol, July 1, 2005; 289(1): C42 - C48.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
L. J. Harcourt, A. G. Holmes, P. Gregorevic, J. D. Schertzer, N. Stupka, D. R. Plant, and G. S. Lynch
Interleukin-15 Administration Improves Diaphragm Muscle Pathology and Function in Dystrophic mdx Mice
Am. J. Pathol., April 1, 2005; 166(4): 1131 - 1141.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. A. F. V. Goncalves, G. P. van Nierop, M. R. Tijssen, P. Lefesvre, S. Knaan-Shanzer, I. van der Velde, D. W. van Bekkum, D. Valerio, and A. A. F. de Vries
Transfer of the Full-Length Dystrophin-Coding Sequence into Muscle Cells by a Dual High-Capacity Hybrid Viral Vector with Site-Specific Integration Ability
J. Virol., March 1, 2005; 79(5): 3146 - 3162.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
E. W. Yeung, N. P. Whitehead, T. M. Suchyna, P. A. Gottlieb, F. Sachs, and D. G. Allen
Effects of stretch-activated channel blockers on [Ca2+]i and muscle damage in the mdx mouse
J. Physiol., January 15, 2005; 562(2): 367 - 380.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
K. S. Kendler
Schizophrenia Genetics and Dysbindin: A Corner Turned?
Am J Psychiatry, September 1, 2004; 161(9): 1533 - 1536.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. C. Connors, M. E. Adams, S. C. Froehner, and P. Kofuji
The Potassium Channel Kir4.1 Associates with the Dystrophin-Glycoprotein Complex via {alpha}-Syntrophin in Glia
J. Biol. Chem., July 2, 2004; 279(27): 28387 - 28392.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. A. Benson, C. L. Tinsley, and D. J. Blake
Myospryn Is a Novel Binding Partner for Dysbindin in Muscle
J. Biol. Chem., March 12, 2004; 279(11): 10450 - 10458.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
J. V. Chakkalakal, M.-A. Harrison, S. Carbonetto, E. Chin, R. N. Michel, and B. J. Jasmin
Stimulation of calcineurin signaling attenuates the dystrophic pathology in mdx mice
Hum. Mol. Genet., February 15, 2004; 13(4): 379 - 388.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
J. Kirschner and C. G. Bonnemann
The Congenital and Limb-Girdle Muscular Dystrophies: Sharpening the Focus, Blurring the Boundaries
Arch Neurol, February 1, 2004; 61(2): 189 - 199.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
M. A. Griffin, A. J. Engler, T. A. Barber, K. E. Healy, H. L. Sweeney, and D. E. Discher
Patterning, Prestress, and Peeling Dynamics of Myocytes
Biophys. J., February 1, 2004; 86(2): 1209 - 1222.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. Hoyte, V. Jayasinha, B. Xia, and P. T. Martin
Transgenic Overexpression of Dystroglycan Does Not Inhibit Muscular Dystrophy in mdx Mice
Am. J. Pathol., February 1, 2004; 164(2): 711 - 718.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S. C. Brown, S. Torelli, M. Brockington, Y. Yuva, C. Jimenez, L. Feng, L. Anderson, I. Ugo, S. Kroger, K. Bushby, et al.
Abnormalities in {alpha}-Dystroglycan Expression in MDC1C and LGMD2I Muscular Dystrophies
Am. J. Pathol., February 1, 2004; 164(2): 727 - 737.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
S. B. P. CHARGE and M. A. RUDNICKI
Cellular and Molecular Regulation of Muscle Regeneration
Physiol Rev, January 1, 2004; 84(1): 209 - 238.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. I. Bassett, R. J. Bryson-Richardson, D. F. Daggett, P. Gautier, D. G. Keenan, and P. D. Currie
Dystrophin is required for the formation of stable muscle attachments in the zebrafish embryo
Development, December 1, 2003; 130(23): 5851 - 5860.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. L. McDearmon, A. C. Combs, and J. M. Ervasti
Core 1 Glycans on {alpha}-Dystroglycan Mediate Laminin-induced Acetylcholine Receptor Clustering but Not Laminin Binding
J. Biol. Chem., November 7, 2003; 278(45): 44868 - 44873.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
D. I. Bassett and P. D. Currie
The zebrafish as a model for muscular dystrophy and congenital myopathy
Hum. Mol. Genet., October 15, 2003; 12(90002): R265 - 270.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
P. K. Grewal and J. E. Hewitt
Glycosylation defects: a new mechanism for muscular dystrophy?
Hum. Mol. Genet., October 15, 2003; 12(90002): R259 - 264.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
B. Moghadaszadeh, R. Albrechtsen, L. T. Guo, M. Zaik, N. Kawaguchi, R. H. Borup, P. Kronqvist, H. D. Schroder, K. E. Davies, T. Voit, et al.
Compensation for dystrophin-deficiency: ADAM12 overexpression in skeletal muscle results in increased {alpha}7 integrin, utrophin and associated glycoproteins
Hum. Mol. Genet., October 1, 2003; 12(19): 2467 - 2479.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
Y. Yue, Z. Li, S. Q. Harper, R. L. Davisson, J. S. Chamberlain, and D. Duan
Microdystrophin Gene Therapy of Cardiomyopathy Restores Dystrophin-Glycoprotein Complex and Improves Sarcolemma Integrity in the Mdx Mouse Heart
Circulation, September 30, 2003; 108(13): 1626 - 1632.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
W. Burke
Genomics as a Probe for Disease Biology
N. Engl. J. Med., September 4, 2003; 349(10): 969 - 974.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
D. R. Plant and G. S. Lynch
Depolarization-induced contraction and SR function in mechanically skinned muscle fibers from dystrophic mdx mice
Am J Physiol Cell Physiol, September 1, 2003; 285(3): C522 - C528.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
J. D. Porter, A. P. Merriam, P. Leahy, B. Gong, and S. Khanna
Dissection of temporal gene expression signatures of affected and spared muscle groups in dystrophin-deficient (mdx) mice
Hum. Mol. Genet., August 1, 2003; 12(15): 1813 - 1821.
[Abstract] [Full Text] [PDF]

Home page
 GlycobiologyHome page
P. T. Martin
Dystroglycan glycosylation and its role in matrix binding in skeletal muscle
Glycobiology, August 1, 2003; 13(8): 55R - 66R.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. V. Sillitoe, M. A. Benson, D. J. Blake, and R. Hawkes
Abnormal Dysbindin Expression in Cerebellar Mossy Fiber Synapses in the mdx Mouse Model of Duchenne Muscular Dystrophy
J. Neurosci., July 23, 2003; 23(16): 6576 - 6585.
[Abstract] [Full Text] [PDF]

Home page