Physiol Rev Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Physiol. Rev. 82: 245-289, 2002;
0031-9333/02 $15.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (160)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kunzelmann, K.
Right arrow Articles by Mall, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kunzelmann, K.
Right arrow Articles by Mall, M.

Physiological Reviews, Vol. 82, No. 1, January 2002, pp. 245-289; 10.1152/physrev.00026.2001.
Copyright ©2002 by the American Physiological Society

Electrolyte Transport in the Mammalian Colon: Mechanisms and Implications for Disease

Karl Kunzelmann and Marcus Mall

Department of Physiology and Pharmacology, University of Queensland, St. Lucia, Queensland, Brisbane, Australia; and Universitäts-Kinderklinik, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany

Kunzelmann, Karl and Marcus Mall. Electrolyte Transport in the Mammalian Colon: Mechanisms and Implications for Disease. Physiol. Rev. 82: 245-289, 2002.The colonic epithelium has both absorptive and secretory functions. The transport is characterized by a net absorption of NaCl, short-chain fatty acids (SCFA), and water, allowing extrusion of a feces with very little water and salt content. In addition, the epithelium does secret mucus, bicarbonate, and KCl. Polarized distribution of transport proteins in both luminal and basolateral membranes enables efficient salt transport in both directions, probably even within an individual cell. Meanwhile, most of the participating transport proteins have been identified, and their function has been studied in detail. Absorption of NaCl is a rather steady process that is controlled by steroid hormones regulating the expression of epithelial Na+ channels (ENaC), the Na+-K+-ATPase, and additional modulating factors such as the serum- and glucocorticoid-regulated kinase SGK. Acute regulation of absorption may occur by a Na+ feedback mechanism and the cystic fibrosis transmembrane conductance regulator (CFTR). Cl- secretion in the adult colon relies on luminal CFTR, which is a cAMP-regulated Cl- channel and a regulator of other transport proteins. As a consequence, mutations in CFTR result in both impaired Cl- secretion and enhanced Na+ absorption in the colon of cystic fibrosis (CF) patients. Ca2+- and cAMP-activated basolateral K+ channels support both secretion and absorption of electrolytes and work in concert with additional regulatory proteins, which determine their functional and pharmacological profile. Knowledge of the mechanisms of electrolyte transport in the colon enables the development of new strategies for the treatment of CF and secretory diarrhea. It will also lead to a better understanding of the pathophysiological events during inflammatory bowel disease and development of colonic carcinoma.




This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
D. Wu and Z. Hu
Rutaecarpine Induces Chloride Secretion across Rat Isolated Distal Colon
J. Pharmacol. Exp. Ther., April 1, 2008; 325(1): 256 - 266.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Spitzner, J. R. Martins, R. B. Soria, J. Ousingsawat, K. Scheidt, R. Schreiber, and K. Kunzelmann
Eag1 and Bestrophin 1 Are Up-regulated in Fast-growing Colonic Cancer Cells
J. Biol. Chem., March 21, 2008; 283(12): 7421 - 7428.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
F. A. Wald, A. S. Oriolo, A. Mashukova, N. L. Fregien, A. H. Langshaw, and P. J. I. Salas
Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells
J. Cell Sci., March 1, 2008; 121(5): 644 - 654.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
P. Pariwat, S. Homvisasevongsa, C. Muanprasat, and V. Chatsudthipong
A Natural Plant-Derived Dihydroisosteviol Prevents Cholera Toxin-Induced Intestinal Fluid Secretion
J. Pharmacol. Exp. Ther., February 1, 2008; 324(2): 798 - 805.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
R. T. Worrell, L. Merk, and J. B. Matthews
Ammonium transport in the colonic crypt cell line, T84: role for Rhesus glycoproteins and NKCC1
Am J Physiol Gastrointest Liver Physiol, February 1, 2008; 294(2): G429 - G440.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Bertog, J. E. Cuffe, S. Pradervand, E. Hummler, A. Hartner, M. Porst, K. F. Hilgers, B. C. Rossier, and C. Korbmacher
Aldosterone responsiveness of the epithelial sodium channel (ENaC) in colon is increased in a mouse model for Liddle's syndrome
J. Physiol., January 15, 2008; 586(2): 459 - 475.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
P. J. Bajwa, A. Alioua, J. W. Lee, D. S. Straus, L. Toro, and C. Lytle
Fenofibrate inhibits intestinal Cl secretion by blocking basolateral KCNQ1 K+ channels
Am J Physiol Gastrointest Liver Physiol, December 1, 2007; 293(6): G1288 - G1299.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. B. Subramanya, V. M. Rajendran, P. Srinivasan, N. S. Nanda Kumar, B. S. Ramakrishna, and H. J. Binder
Differential regulation of cholera toxin-inhibited Na-H exchange isoforms by butyrate in rat ileum
Am J Physiol Gastrointest Liver Physiol, October 1, 2007; 293(4): G857 - G863.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
D. J. Hampel, J. Stoll, L. Nibbe, and M. Gollasch
Hyperammonaemic encephalopathy and severe metabolic acidosis in a patient with chronic renal insufficiency years after ureterosigmoidostomy
Nephrol. Dial. Transplant., September 1, 2007; 22(9): 2713 - 2719.
[Full Text] [PDF]

Home page
 J. Physiol.Home page
C. A. Flores, J. E. Melvin, C. D. Figueroa, and F. V. Sepulveda
Abolition of Ca2+-mediated intestinal anion secretion and increased stool dehydration in mice lacking the intermediate conductance Ca2+-dependent K+ channel Kcnn4
J. Physiol., September 1, 2007; 583(2): 705 - 717.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
B.-S. Feng, S.-H. He, P.-Y. Zheng, L. Wu, and P.-C. Yang
Mast Cells Play a Crucial Role in Staphylococcus aureus Peptidoglycan-Induced Diarrhea
Am. J. Pathol., August 1, 2007; 171(2): 537 - 547.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
P. R. Kiela, N. Kuscuoglu, A. J. Midura, M. T. Midura-Kiela, C. B. Larmonier, M. Lipko, and F. K. Ghishan
Molecular mechanism of rat NHE3 gene promoter regulation by sodium butyrate
Am J Physiol Cell Physiol, July 1, 2007; 293(1): C64 - C74.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
L. M. Klevay, J. D. Bogden, M. Aladjem, H. H. Sandstead, F. W. Kemp, W. Li, J. Skurnick, and A. Aviv
Renal And Gastrointestinal Potassium Excretion In Humans: New Insight Based On New Data And Review And Analysis Of Published Studies
J. Am. Coll. Nutr., April 1, 2007; 26(2): 103 - 110.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. R. Gawenis, E. M. Bradford, V. Prasad, J. N. Lorenz, J. E. Simpson, L. L. Clarke, A. L. Woo, C. Grisham, L. P. Sanford, T. Doetschman, et al.
Colonic Anion Secretory Defects and Metabolic Acidosis in Mice Lacking the NBC1 Formula Cotransporter
J. Biol. Chem., March 23, 2007; 282(12): 9042 - 9052.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. M. Ring, S. X. Cheng, Q. Leng, K. T. Kahle, J. Rinehart, M. D. Lalioti, H. M. Volkman, F. H. Wilson, S. C. Hebert, and R. P. Lifton
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo
PNAS, March 6, 2007; 104(10): 4020 - 4024.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
H. Dong, A. Smith, M. Hovaida, and J. Y. Chow
Role of Ca2+-activated K+ channels in duodenal mucosal ion transport and bicarbonate secretion
Am J Physiol Gastrointest Liver Physiol, December 1, 2006; 291(6): G1120 - G1128.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
G. Lamprecht and U. Seidler
The emerging role of PDZ adapter proteins for regulation of intestinal ion transport
Am J Physiol Gastrointest Liver Physiol, November 1, 2006; 291(5): G766 - G777.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
O. Bachmann, D. Reichelt, B. Tuo, M. P. Manns, and U. Seidler
Carbachol increases Na+-HCO3- cotransport activity in murine colonic crypts in a M3-, Ca2+/calmodulin-, and PKC-dependent manner
Am J Physiol Gastrointest Liver Physiol, October 1, 2006; 291(4): G650 - G657.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
R. G. Deeley, C. Westlake, and S. P. C. Cole
Transmembrane Transport of Endo- and Xenobiotics by Mammalian ATP-Binding Cassette Multidrug Resistance Proteins.
Physiol Rev, July 1, 2006; 86(3): 849 - 899.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Geibel, K. Sritharan, R. Geibel, P. Geibel, J. S. Persing, A. Seeger, T. K. Roepke, M. Deichstetter, C. Prinz, S. X. Cheng, et al.
Inaugural Article: Calcium-sensing receptor abrogates secretagogue- induced increases in intestinal net fluid secretion by enhancing cyclic nucleotide destruction
PNAS, June 20, 2006; 103(25): 9390 - 9397.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M. Sausbier, J. E. Matos, U. Sausbier, G. Beranek, C. Arntz, W. Neuhuber, P. Ruth, and J. Leipziger
Distal Colonic K+ Secretion Occurs via BK Channels
J. Am. Soc. Nephrol., May 1, 2006; 17(5): 1275 - 1282.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Physiol.Home page
N. Shcheynikov, Y. Wang, M. Park, S. B.H. Ko, M. Dorwart, S. Naruse, P. J. Thomas, and S. Muallem
Coupling Modes and Stoichiometry of Cl-/HCO3- Exchange by slc26a3 and slc26a6
J. Gen. Physiol., April 24, 2006; 127(5): 511 - 524.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Xu, C. Liu, J. C. Clark, and J. A. Whitsett
Functional Genomic Responses to Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and CFTR{Delta}508 in the Lung
J. Biol. Chem., April 21, 2006; 281(16): 11279 - 11291.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
H J Novaira, D S Ornellas, T M Ortiga-Carvalho, X M Zhang, J Souza-Menezes, S E Guggino, W B Guggino, and M M Morales
Atrial natriuretic peptide modulates cystic fibrosis transmembrane conductance regulator chloride channel expression in rat proximal colon and human intestinal epithelial cells.
J. Endocrinol., April 1, 2006; 189(1): 155 - 165.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
U. Laforenza, E. Cova, G. Gastaldi, S. Tritto, M. Grazioli, N. F. LaRusso, P. L. Splinter, P. D'Adamo, M. Tosco, and U. Ventura
Aquaporin-8 Is Involved in Water Transport in Isolated Superficial Colonocytes from Rat Proximal Colon
J. Nutr., October 1, 2005; 135(10): 2329 - 2336.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
G. Pena-Munzenmayer, M. Catalan, I. Cornejo, C. D. Figueroa, J. E. Melvin, M. I. Niemeyer, L. P. Cid, and F. V. Sepulveda
Basolateral localization of native ClC-2 chloride channels in absorptive intestinal epithelial cells and basolateral sorting encoded by a CBS-2 domain di-leucine motif
J. Cell Sci., September 15, 2005; 118(18): 4243 - 4252.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
K. Abdoun, F. Stumpff, K. Wolf, and H. Martens
Modulation of electroneutral Na transport in sheep rumen epithelium by luminal ammonia
Am J Physiol Gastrointest Liver Physiol, September 1, 2005; 289(3): G508 - G520.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
C. Deachapunya, S. Poonyachoti, W. Thongsaard, and N. Krishnamra
Barakol Extracted from Cassia siamea Stimulates Chloride Secretion in Rat Colon
J. Pharmacol. Exp. Ther., August 1, 2005; 314(2): 732 - 737.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. Vidyasagar, C. Barmeyer, J. Geibel, H. J. Binder, and V. M. Rajendran
Role of short-chain fatty acids in colonic HCO3 secretion
Am J Physiol Gastrointest Liver Physiol, June 1, 2005; 288(6): G1217 - G1226.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. A. Veillette and G. Young
Tissue culture of sockeye salmon intestine: functional response of Na+-K+-ATPase to cortisol
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1598 - R1605.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
L. C. Ajonuma, E. H. Y. Ng, P. H. Chow, C. Y. Hung, L. L. Tsang, A. N. Y. Cheung, C. Brito-Jones, I. H. Lok, C. J.Haines, and H. C. Chan
Increased cystic fibrosis transmembrane conductance regulator (CFTR) expression in the human hydrosalpinx
Hum. Reprod., May 1, 2005; 20(5): 1228 - 1234.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
K. M. Hoque, V. M. Rajendran, and H. J. Binder
Zinc inhibits cAMP-stimulated Cl secretion via basolateral K-channel blockade in rat ileum
Am J Physiol Gastrointest Liver Physiol, May 1, 2005; 288(5): G956 - G963.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
E. Ghanem, C. Lovdahl, E. Dare, C. Ledent, B. B. Fredholm, J.-M. Boeynaems, W. Van Driessche, and R. Beauwens
Luminal adenosine stimulates chloride secretion through A1 receptor in mouse jejunum
Am J Physiol Gastrointest Liver Physiol, May 1, 2005; 288(5): G972 - G977.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. Kolachala, V. Asamoah, L. Wang, S. Srinivasan, D. Merlin, and S. V. Sitaraman
Interferon-{gamma} Down-regulates Adenosine 2b Receptor-mediated Signaling and Short Circuit Current in the Intestinal Epithelia by Inhibiting the Expression of Adenylate Cyclase
J. Biol. Chem., February 11, 2005; 280(6): 4048 - 4057.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
N. Horikawa, T. Suzuki, T. Uchiumi, T. Minamimura, K. Tsukada, N. Takeguchi, and H. Sakai
Cyclic AMP-dependent Cl- secretion induced by thromboxane A2 in isolated human colon
J. Physiol., February 1, 2005; 562(3): 885 - 897.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C.-T. Chang, M. Bens, E. Hummler, S. Boulkroun, L. Schild, J. Teulon, B. C. Rossier, and A. Vandewalle
Vasopressin-stimulated CFTR Cl- currents are increased in the renal collecting duct cells of a mouse model of Liddle's syndrome
J. Physiol., January 1, 2005; 562(1): 271 - 284.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
G. Hajishengallis, H. Nawar, R. I. Tapping, M. W. Russell, and T. D. Connell
The Type II Heat-Labile Enterotoxins LT-IIa and LT-IIb and Their Respective B Pentamers Differentially Induce and Regulate Cytokine Production in Human Monocytic Cells
Infect. Immun., November 1, 2004; 72(11): 6351 - 6358.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
K. Kunzelmann and B. McMorran
First Encounter: How Pathogens Compromise Epithelial Transport
Physiology, October 1, 2004; 19(5): 240 - 244.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G.-X. Wang, C. McCrudden, Y.-P. Dai, B. Horowitz, J. R. Hume, and I. A. Yamboliev
Hypotonic activation of volume-sensitive outwardly rectifying chloride channels in cultured PASMCs is modulated by SGK
Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H533 - H544.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. J. Coady, M.-H. Chang, F. M. Charron, C. Plata, B. Wallendorff, J. F. Sah, S. D. Markowitz, M. F. Romero, and J.-Y. Lapointe
The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter
J. Physiol., June 15, 2004; 557(3): 719 - 731.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. R. Pondugula, J. D. Sanneman, P. Wangemann, P. G. Milhaud, and D. C. Marcus
Glucocorticoids stimulate cation absorption by semicircular canal duct epithelium via epithelial sodium channel
Am J Physiol Renal Physiol, June 1, 2004; 286(6): F1127 - F1135.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. Aviv, N. K. Hollenberg, and A. Weder
Urinary Potassium Excretion and Sodium Sensitivity in Blacks
Hypertension, April 1, 2004; 43(4): 707 - 713.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
D. M. Toivola, S. Krishnan, H. J. Binder, S. K. Singh, and M. B. Omary
Keratins modulate colonocyte electrolyte transport via protein mistargeting
J. Cell Biol., March 15, 2004; 164(6): 911 - 921.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Y. Kim, W. Han, W. Namkung, J. H. Lee, K. H. Kim, H. Shin, E. Kim, and M. G. Lee
Inhibitory Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Anion-transporting Activities by Shank2
J. Biol. Chem., March 12, 2004; 279(11): 10389 - 10396.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. Currid, B. Ortega, and M. A. Valverde
Chloride secretion in a morphologically differentiated human colonic cell line that expresses the epithelial Na+ channel
J. Physiol., February 15, 2004; 555(1): 241 - 250.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
J. Walker, H. B. Jijon, T. Churchill, M. Kulka, and K. L. Madsen
Activation of AMP-activated protein kinase reduces cAMP-mediated epithelial chloride secretion
Am J Physiol Gastrointest Liver Physiol, November 1, 2003; 285(5): G850 - G860.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
R. Norregaard, T. R. Uhrenholt, C. Bistrup, O. Skott, and B. L. Jensen
Stimulation of 11-{beta}-hydroxysteroid dehydrogenase type 2 in rat colon but not in kidney by low dietary NaCl intake
Am J Physiol Renal Physiol, August 1, 2003; 285(2): F348 - F358.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
A S Ramalho, S Beck, D Penque, T Gonska, H H Seydewitz, M Mall, and M D Amaral
Transcript analysis of the cystic fibrosis splicing mutation 1525-1G>A shows use of multiple alternative splicing sites and suggests a putative role of exonic splicing enhancers
J. Med. Genet., July 1, 2003; 40(7): e88 - 88.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
W. J. Joiner, S. Basavappa, S. Vidyasagar, K. Nehrke, S. Krishnan, H. J. Binder, E. L. Boulpaep, and V. M. Rajendran
Active K+ secretion through multiple KCa-type channels and regulation by IKCa channels in rat proximal colon
Am J Physiol Gastrointest Liver Physiol, June 9, 2003; 285(1): G185 - G196.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
H. Hayashi, T. Suzuki, T. Yamamoto, and Y. Suzuki
Cholinergic inhibition of electrogenic sodium absorption in the guinea pig distal colon
Am J Physiol Gastrointest Liver Physiol, April 1, 2003; 284(4): G617 - G628.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. Leipziger
Control of epithelial transport via luminal P2 receptors
Am J Physiol Renal Physiol, March 1, 2003; 284(3): F419 - F432.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. J. Keely and K. E. Barrett
p38 mitogen-activated protein kinase inhibits calcium-dependent chloride secretion in T84 colonic epithelial cells
Am J Physiol Cell Physiol, February 1, 2003; 284(2): C339 - C348.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. A. Choate, K. T. Kahle, F. H. Wilson, C. Nelson-Williams, and R. P. Lifton
WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl--transporting epithelia
PNAS, January 21, 2003; 100(2): 663 - 668.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. R. Hallows, J. E. McCane, B. E. Kemp, L. A. Witters, and J. K. Foskett
Regulation of Channel Gating by AMP-activated Protein Kinase Modulates Cystic Fibrosis Transmembrane Conductance Regulator Activity in Lung Submucosal Cells
J. Biol. Chem., January 3, 2003; 278(2): 998 - 1004.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
J. H. Pratt, W. T. Ambrosius, R. Agarwal, G. J. Eckert, and S. Newman
Racial Difference in the Activity of the Amiloride-Sensitive Epithelial Sodium Channel
Hypertension, December 1, 2002; 40(6): 903 - 908.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. Catalan, I. Cornejo, C. D. Figueroa, M. I. Niemeyer, F. V. Sepulveda, and L. P. Cid
ClC-2 in guinea pig colon: mRNA, immunolabeling, and functional evidence for surface epithelium localization
Am J Physiol Gastrointest Liver Physiol, October 1, 2002; 283(4): G1004 - G1013.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. Gallardo, N. Olea, and F. V. Sepulveda
Distribution of aquaporins in the colon of Octodon degus, a South American desert rodent
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2002; 283(3): R779 - R788.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online