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Physiol. Rev. 81: 1791-1826, 2001;
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Physiological Reviews, Vol. 81, No. 4, October 2001, pp. 1791-1826
Copyright ©2001 by the American Physiological Society

Electrophysiology of the Sodium-Potassium-ATPase in Cardiac Cells

Helfried Günther Glitsch

Arbeitsgruppe Muskelphysiologie, Fakultät für Biologie, Ruhr-Universität Bochum, Bochum, Germany

Glitsch, Helfried Günther Electrophysiology of the Sodium-Potassium-ATPase in Cardiac Cells. Physiol. Rev. 81: 1791-1826, 2001.Like several other ion transporters, the Na+-K+ pump of animal cells is electrogenic. The pump generates the pump current Ip. Under physiological conditions, Ip is an outward current. It can be measured by electrophysiological methods. These methods permit the study of characteristics of the Na+-K+ pump in its physiological environment, i.e., in the cell membrane. The cell membrane, across which a potential gradient exists, separates the cytosol and extracellular medium, which have distinctly different ionic compositions. The introduction of the patch-clamp techniques and the enzymatic isolation of cells have facilitated the investigation of Ip in single cardiac myocytes. This review summarizes and discusses the results obtained from Ip measurements in isolated cardiac cells. These results offer new exciting insights into the voltage and ionic dependence of the Na+-K+ pump activity, its effect on membrane potential, and its modulation by hormones, transmitters, and drugs. They are fundamental for our current understanding of Na+-K+ pumping in electrically excitable cells.




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