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Physiological Reviews, Vol. 81, No. 4, October 2001, pp. 1791-1826
Copyright ©2001 by the American Physiological Society
Arbeitsgruppe Muskelphysiologie, Fakultät für Biologie, Ruhr-Universität Bochum, Bochum, Germany
Glitsch, Helfried Günther
Electrophysiology of the Sodium-Potassium-ATPase in
Cardiac Cells. Physiol. Rev. 81: 1791-1826, 2001.
Like several other ion transporters, the
Na+-K+ pump of animal cells is electrogenic.
The pump generates the pump current Ip. Under
physiological conditions, Ip is an outward
current. It can be measured by electrophysiological methods. These
methods permit the study of characteristics of the
Na+-K+ pump in its physiological environment,
i.e., in the cell membrane. The cell membrane, across which a potential
gradient exists, separates the cytosol and extracellular medium, which
have distinctly different ionic compositions. The introduction of the
patch-clamp techniques and the enzymatic isolation of cells have
facilitated the investigation of Ip in single
cardiac myocytes. This review summarizes and discusses the results
obtained from Ip measurements in isolated
cardiac cells. These results offer new exciting insights into the
voltage and ionic dependence of the Na+-K+ pump
activity, its effect on membrane potential, and its modulation by
hormones, transmitters, and drugs. They are fundamental for our current
understanding of Na+-K+ pumping in electrically
excitable cells.
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