|
|
||||||||
Physiological Reviews, Vol. 81, No. 4, October 2001, pp. 1535-1565
Copyright ©2001 by the American Physiological Society
KaroBio AB and Departments of Biosciences and of Medical Nutrition, Karolinska Institute, NOVUM; Department of Pathology, Huddinge Hospital, Huddinge, Sweden; and Institute of Biomedicin Department of Anatomy, University of Turku, Turku, Finland
Nilsson, Stefan,
Sari Mäkelä,
Eckardt Treuter,
Michel Tujague,
Jane Thomsen,
Göran Andersson,
Eva Enmark,
Katarina Pettersson,
Margaret Warner, and
Jan-Åke Gustafsson.
Mechanisms of Estrogen Action. Physiol. Rev. 81: 1535-1565, 2001.
Our
appreciation of the physiological functions of estrogens and the
mechanisms through which estrogens bring about these functions has
changed during the past decade. Just as transgenic mice were produced
in which estrogen receptors had been inactivated and we thought that we
were about to understand the role of estrogen receptors in physiology
and pathology, it was found that there was not one but two distinct and
functional estrogen receptors, now called ER
and ER
. Transgenic
mice in which each of the receptors or both the receptors are inactive
have revealed a much broader role for estrogens in the body than was
previously thought. This decade also saw the description of a male
patient who had no functional ER
and whose continued bone growth
clearly revealed an important function of estrogen in men. The
importance of estrogen in both males and females was also demonstrated
in the laboratory in transgenic mice in which the aromatase gene was
inactivated. Finally, crystal structures of the estrogen receptors with
agonists and antagonists have revealed much about how ligand binding
influences receptor conformation and how this conformation influences
interaction of the receptor with coactivators or corepressors and hence
determines cellular response to ligands.
This article has been cited by other articles:
![]() |
J Li and R. McMurray Effects of chronic exposure to DDT and TCDD on disease activity in murine systemic lupus erythematosus Lupus, October 1, 2009; 18(11): 941 - 949. [Abstract] [PDF] |
||||
![]() |
J. Chen, B.-S. An, L. Cheng, G. L. Hammond, and P. C. K. Leung Gonadotropin-Releasing Hormone-Mediated Phosphorylation of Estrogen Receptor-{alpha} Contributes to fosB Expression in Mouse Gonadotrophs Endocrinology, October 1, 2009; 150(10): 4583 - 4593. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Ahmed, E. Valen, A. Sandelin, and J. Matthews Dioxin Increases the Interaction Between Aryl Hydrocarbon Receptor and Estrogen Receptor Alpha at Human Promoters Toxicol. Sci., October 1, 2009; 111(2): 254 - 266. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Dadiani, D. Seger, T. Kreizman, D. Badikhi, R. Margalit, R. Eilam, and H. Degani Estrogen regulation of vascular endothelial growth factor in breast cancer in vitro and in vivo: the role of estrogen receptor {alpha} and c-Myc Endocr. Relat. Cancer, September 1, 2009; 16(3): 819 - 834. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Iqbal, O. Latchoumanin, I. P. Sari, R. J. Lang, H. A. Coleman, H. C. Parkington, and I. J. Clarke Estradiol-17{beta} Inhibits Gonadotropin-Releasing Hormone-Induced Ca2+ in Gonadotropes to Regulate Negative Feedback on Luteinizing Hormone Release Endocrinology, September 1, 2009; 150(9): 4213 - 4220. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Saito, A. Ciobotaru, J. C. Bopassa, L. Toro, E. Stefani, and M. Eghbali Estrogen Contributes to Gender Differences in Mouse Ventricular Repolarization Circ. Res., August 14, 2009; 105(4): 343 - 352. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. Mohamed and J. K Yeh Alfacalcidol prevents aromatase inhibitor (Letrozole)-induced bone mineral loss in young growing female rats J. Endocrinol., August 1, 2009; 202(2): 317 - 325. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Comitato, K. Nesaretnam, G. Leoni, R. Ambra, R. Canali, A. Bolli, M. Marino, and F. Virgili A novel mechanism of natural vitamin E tocotrienol activity: involvement of ER{beta} signal transduction Am J Physiol Endocrinol Metab, August 1, 2009; 297(2): E427 - E437. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Wong and C. S. Weickert Transcriptional Interaction of an Estrogen Receptor Splice Variant and ErbB4 Suggests Convergence in Gene Susceptibility Pathways in Schizophrenia J. Biol. Chem., July 10, 2009; 284(28): 18824 - 18832. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. P. A. Barros, C. Gabbi, A. Morani, M. Warner, and J.-A. Gustafsson Participation of ER{alpha} and ER{beta} in glucose homeostasis in skeletal muscle and white adipose tissue Am J Physiol Endocrinol Metab, July 1, 2009; 297(1): E124 - E133. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Gevry, S. Hardy, P.-E. Jacques, L. Laflamme, A. Svotelis, F. Robert, and L. Gaudreau Histone H2A.Z is essential for estrogen receptor signaling Genes & Dev., July 1, 2009; 23(13): 1522 - 1533. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Stanisic, A. Malovannaya, J. Qin, D. M. Lonard, and B. W. O'Malley OTU Domain-containing Ubiquitin Aldehyde-binding Protein 1 (OTUB1) Deubiquitinates Estrogen Receptor (ER) {alpha} and Affects ER{alpha} Transcriptional Activity J. Biol. Chem., June 12, 2009; 284(24): 16135 - 16145. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Wihlen, S. Ahmed, J. Inzunza, and J. Matthews Estrogen Receptor Subtype- and Promoter-Specific Modulation of Aryl Hydrocarbon Receptor-Dependent Transcription Mol. Cancer Res., June 1, 2009; 7(6): 977 - 986. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Nath-Sain and P. A. Marignani LKB1 Catalytic Activity Contributes to Estrogen Receptor {alpha} Signaling Mol. Biol. Cell, June 1, 2009; 20(11): 2785 - 2795. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Karmakar, E. A. Foster, and C. L. Smith Unique Roles of p160 Coactivators for Regulation of Breast Cancer Cell Proliferation and Estrogen Receptor-{alpha} Transcriptional Activity Endocrinology, April 1, 2009; 150(4): 1588 - 1596. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Kininis, G. D. Isaacs, L. J. Core, N. Hah, and W. L. Kraus Postrecruitment Regulation of RNA Polymerase II Directs Rapid Signaling Responses at the Promoters of Estrogen Target Genes Mol. Cell. Biol., March 1, 2009; 29(5): 1123 - 1133. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Wang, H. Zong, Y. Chi, Y. Hong, Y. Yang, W. Zou, X. Yun, and J. Gu Repression of Estrogen Receptor alpha by CDK11p58 Through Promoting its Ubiquitin-Proteasome Degradation J. Biochem., March 1, 2009; 145(3): 331 - 343. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. C. Jordan A Century of Deciphering the Control Mechanisms of Sex Steroid Action in Breast and Prostate Cancer: The Origins of Targeted Therapy and Chemoprevention Cancer Res., February 15, 2009; 69(4): 1243 - 1254. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Pearse, J. Frith, K. J. Randall, and T. Klinowska Urinary Retention and Cystitis Associated with Subcutaneous Estradiol Pellets in Female Nude Mice Toxicol Pathol, February 1, 2009; 37(2): 227 - 234. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Merot, F. Ferriere, L. Gailhouste, G. Huet, F. Percevault, C. Saligaut, and G. Flouriot Different Outcomes of Unliganded and Liganded Estrogen Receptor-{alpha} on Neurite Outgrowth in PC12 Cells Endocrinology, January 1, 2009; 150(1): 200 - 211. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. J Kojetin, T. P Burris, E. V Jensen, and S. A Khan Implications of the binding of tamoxifen to the coactivator recognition site of the estrogen receptor Endocr. Relat. Cancer, December 1, 2008; 15(4): 851 - 870. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Takahashi, F. Otsuka, T. Miyoshi, H. Otani, J. Goto, M. Yamashita, T. Ogura, H. Makino, and H. Doihara Bone morphogenetic protein 6 (BMP6) and BMP7 inhibit estrogen-induced proliferation of breast cancer cells by suppressing p38 mitogen-activated protein kinase activation J. Endocrinol., December 1, 2008; 199(3): 445 - 455. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Kleuser, D. Malek, R. Gust, H. H. Pertz, and H. Potteck 17-{beta}-Estradiol Inhibits Transforming Growth Factor-{beta} Signaling and Function in Breast Cancer Cells via Activation of Extracellular Signal-Regulated Kinase through the G Protein-Coupled Receptor 30 Mol. Pharmacol., December 1, 2008; 74(6): 1533 - 1543. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. F. Pan, K. D. S. A. Wansa, M. H. Liu, B. Zhao, S. Z. Hong, P. Y. Tan, K. S. Lim, G. Bourque, E. T. Liu, and E. Cheung Regulation of Estrogen Receptor-mediated Long Range Transcription via Evolutionarily Conserved Distal Response Elements J. Biol. Chem., November 21, 2008; 283(47): 32977 - 32988. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Xu, Y. Cheng, J. R. Keast, and P. B. Osborne 17{beta}-Estradiol Activates Estrogen Receptor {beta}-Signalling and Inhibits Transient Receptor Potential Vanilloid Receptor 1 Activation by Capsaicin in Adult Rat Nociceptor Neurons Endocrinology, November 1, 2008; 149(11): 5540 - 5548. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. Jin, Y. Chen, G.-h. Di, P. Miron, Y.-f. Hou, H. Gao, and Z.-m. Shao Estrogen Receptor (ER) {beta} or p53 Attenuates ER{alpha}-mediated Transcriptional Activation on the BRCA2 Promoter J. Biol. Chem., October 31, 2008; 283(44): 29671 - 29680. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Toda, T. Okada, Y. Hayashi, and T. Saibara Preserved tissue structure of efferent ductules in aromatase-deficient mice J. Endocrinol., October 1, 2008; 199(1): 137 - 146. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. M. Sotoca Covaleda, H. van den Berg, J. Vervoort, P. van der Saag, A. Strom, J.-A. Gustafsson, I. Rietjens, and A. J. Murk Influence of Cellular ER{alpha}/ER{beta} Ratio on the ER{alpha}-Agonist Induced Proliferation of Human T47D Breast Cancer Cells Toxicol. Sci., October 1, 2008; 105(2): 303 - 311. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Yasuhara, G. R. O. Gomes, E. R. Siu, C. I. Suenaga, E. Marostica, C. S. Porto, and M. F. M. Lazari Effects of the Antiestrogen Fulvestrant (ICI 182,780) on Gene Expression of the Rat Efferent Ductules Biol Reprod, September 1, 2008; 79(3): 432 - 441. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. M. Fox, T. M. Bernaciak, J. Wen, A. M. Weaver, M. A. Shupnik, and C. M. Silva Signal Transducer and Activator of Transcription 5b, c-Src, and Epidermal Growth Factor Receptor Signaling Play Integral Roles in Estrogen-Stimulated Proliferation of Estrogen Receptor-Positive Breast Cancer Cells Mol. Endocrinol., August 1, 2008; 22(8): 1781 - 1796. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Grasselli, S. Nanni, C. Colussi, A. Aiello, V. Benvenuti, G. Ragone, F. Moretti, A. Sacchi, S. Bacchetti, C. Gaetano, et al. Estrogen Receptor-{alpha} and Endothelial Nitric Oxide Synthase Nuclear Complex Regulates Transcription of Human Telomerase Circ. Res., July 3, 2008; 103(1): 34 - 42. [Abstract] [Full Text] [PDF] |
||||
![]() |
J.-Y. Deng, P.-S. Hsieh, J.-P. Huang, L.-S. Lu, and L.-M. Hung Activation of Estrogen Receptor Is Crucial for Resveratrol-Stimulating Muscular Glucose Uptake via Both Insulin-Dependent and -Independent Pathways Diabetes, July 1, 2008; 57(7): 1814 - 1823. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. M. Miller and S. P. Duckles Vascular Actions of Estrogens: Functional Implications Pharmacol. Rev., June 1, 2008; 60(2): 210 - 241. [Abstract] [Full Text] [PDF] |
||||
![]() |
M.-J. Lee, H. Lin, C.-W. Liu, M.-H. Wu, W.-J. Liao, H.-H. Chang, H.-C. Ku, Y.-S. Chien, W.-H. Ding, and Y.-H. Kao Octylphenol stimulates resistin gene expression in 3T3-L1 adipocytes via the estrogen receptor and extracellular signal-regulated kinase pathways Am J Physiol Cell Physiol, June 1, 2008; 294(6): C1542 - C1551. [Abstract] [Full Text] [PDF] |
||||
![]() |
X. Li, S. L Nott, Y. Huang, R. Hilf, R. A Bambara, X. Qiu, A. Yakovlev, S. Welle, and M. Muyan Gene expression profiling reveals that the regulation of estrogen-responsive element-independent genes by 17{beta}-estradiol-estrogen receptor {beta} is uncoupled from the induction of phenotypic changes in cell models J. Mol. Endocrinol., May 1, 2008; 40(5): 211 - 229. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. A. Greenberg, S. Somme, H. E. Russnes, A. D. Durbin, and D. Malkin The Estrogen Receptor Pathway in Rhabdomyosarcoma: A Role for Estrogen Receptor-{beta} in Proliferation and Response to the Antiestrogen 4'OH-Tamoxifen Cancer Res., May 1, 2008; 68(9): 3476 - 3485. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. C. Chang, T. H. Charn, S.-H. Park, W. G. Helferich, B. Komm, J. A. Katzenellenbogen, and B. S. Katzenellenbogen Estrogen Receptors {alpha} and {beta} as Determinants of Gene Expression: Influence of Ligand, Dose, and Chromatin Binding Mol. Endocrinol., May 1, 2008; 22(5): 1032 - 1043. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Montani, M. Penza, M. Jeremic, G. Biasiotto, G. La Sala, M. De Felici, P. Ciana, A. Maggi, and D. Di Lorenzo Genistein is an Efficient Estrogen in the Whole-Body throughout Mouse Development Toxicol. Sci., May 1, 2008; 103(1): 57 - 67. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. M. Dixon, L. Renshaw, O. Young, J. Murray, E. J. Macaskill, M. McHugh, E. Folkerd, D. A. Cameron, R. P. A'Hern, and M. Dowsett Letrozole Suppresses Plasma Estradiol and Estrone Sulphate More Completely Than Anastrozole in Postmenopausal Women With Breast Cancer J. Clin. Oncol., April 1, 2008; 26(10): 1671 - 1676. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Lundholm, M. Putnik, M. Otsuki, S. Andersson, C. Ohlsson, J.-A. Gustafsson, and K. Dahlman-Wright Effects of estrogen on gene expression profiles in mouse hypothalamus and white adipose tissue: target genes include glutathione peroxidase 3 and cell death-inducing DNA fragmentation factor, {alpha}-subunit-like effector A J. Endocrinol., March 1, 2008; 196(3): 547 - 557. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Chen, M. Hewison, and J. S. Adams Control of Estradiol-Directed Gene Transactivation by an Intracellular Estrogen-Binding Protein and an Estrogen Response Element-Binding Protein Mol. Endocrinol., March 1, 2008; 22(3): 559 - 569. [Abstract] [Full Text] [PDF] |
||||
![]() |
O. Bukulmez, D. B. Hardy, B. R. Carr, R. A. Word, and C. R. Mendelson Inflammatory Status Influences Aromatase and Steroid Receptor Expression in Endometriosis Endocrinology, March 1, 2008; 149(3): 1190 - 1204. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Trinkaus, S. Chin, W. Wolfman, C. Simmons, and M. Clemons Should Urogenital Atrophy in Breast Cancer Survivors Be Treated with Topical Estrogens? Oncologist, March 1, 2008; 13(3): 222 - 231. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Ruegg, E. Swedenborg, D. Wahlstrom, A. Escande, P. Balaguer, K. Pettersson, and I. Pongratz The Transcription Factor Aryl Hydrocarbon Receptor Nuclear Translocator Functions as an Estrogen Receptor {beta}-Selective Coactivator, and Its Recruitment to Alternative Pathways Mediates Antiestrogenic Effects of Dioxin Mol. Endocrinol., February 1, 2008; 22(2): 304 - 316. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Swedenborg, J. Ruegg, A. Hillenweck, S. Rehnmark, M. H. Faulds, D. Zalko, I. Pongratz, and K. Pettersson 3-Methylcholanthrene Displays Dual Effects on Estrogen Receptor (ER) {alpha} and ER{beta} Signaling in a Cell-Type Specific Fashion Mol. Pharmacol., February 1, 2008; 73(2): 575 - 586. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Bourdeau, J. Deschenes, D. Laperriere, M. Aid, J. H. White, and S. Mader Mechanisms of primary and secondary estrogen target gene regulation in breast cancer cells Nucleic Acids Res., January 17, 2008; 36(1): 76 - 93. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. Cai, J. Rambaud, M. Teboul, I. Masse, G. Benoit, J.-A. Gustafsson, F. Delaunay, V. Laudet, and I. Pongratz Expression Levels of Estrogen Receptor Are Modulated by Components of the Molecular Clock Mol. Cell. Biol., January 15, 2008; 28(2): 784 - 793. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Carreras, S. Turner, V. Paharkova-Vatchkova, A. Mao, C. Dascher, and S. Kovats Estradiol Acts Directly on Bone Marrow Myeloid Progenitors to Differentially Regulate GM-CSF or Flt3 Ligand-Mediated Dendritic Cell Differentiation J. Immunol., January 15, 2008; 180(2): 727 - 738. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. R. Boverhof, L. D. Burgoon, K. J. Williams, and T. R. Zacharewski Inhibition of Estrogen-Mediated Uterine Gene Expression Responses by Dioxin Mol. Pharmacol., January 1, 2008; 73(1): 82 - 93. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Pattarozzi, M. Gatti, F. Barbieri, R. Wurth, C. Porcile, G. Lunardi, A. Ratto, R. Favoni, A. Bajetto, A. Ferrari, et al. 17 -Estradiol Promotes Breast Cancer Cell Proliferation-Inducing Stromal Cell-Derived Factor-1-Mediated Epidermal Growth Factor Receptor Transactivation: Reversal by Gefitinib Pretreatment Mol. Pharmacol., January 1, 2008; 73(1): 191 - 202. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Germaniuk-Kurowska, A. Nag, X. Zhao, M. Dimri, H. Band, and V. Band Ada3 Requirement for HAT Recruitment to Estrogen Receptors and Estrogen-Dependent Breast Cancer Cell Proliferation Cancer Res., December 15, 2007; 67(24): 11789 - 11797. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Dhasarathy, M. Kajita, and P. A. Wade The Transcription Factor Snail Mediates Epithelial to Mesenchymal Transitions by Repression of Estrogen Receptor-{alpha} Mol. Endocrinol., December 1, 2007; 21(12): 2907 - 2918. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Iqbal, O. Latchoumanin, and I. J. Clarke Rapid in Vivo Effects of Estradiol-17{beta} in Ovine Pituitary Gonadotropes Are Displayed by Phosphorylation of Extracellularly Regulated Kinase, Serine/Threonine Kinase, and 3',5'-Cyclic Adenosine 5'-Monophosphate-Responsive Element-Binding Protein Endocrinology, December 1, 2007; 148(12): 5794 - 5802. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Parada-Bustamante, P. A Orihuela, M. Rios, P. A Navarrete-Gomez, C. A Cuevas, L. A Velasquez, M. J Villalon, and H. B Croxatto Catechol-O-Methyltransferase and Methoxyestradiols Participate in the Intraoviductal Nongenomic Pathway Through Which Estradiol Accelerates Egg Transport in Cycling Rats Biol Reprod, December 1, 2007; 77(6): 934 - 941. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. D. Curtis, V. S. Likhite, I. X. McLeod, J. R. Yates, and A. M. Nardulli Interaction of the Tumor Metastasis Suppressor Nonmetastatic Protein 23 Homologue H1 and Estrogen Receptor {alpha} Alters Estrogen-Responsive Gene Expression Cancer Res., November 1, 2007; 67(21): 10600 - 10607. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Shao, E. Egecioglu, B. Weijdegard, J. J. Kopchick, J. Fernandez-Rodriguez, N. Andersson, and H. Billig Dynamic regulation of estrogen receptor-{alpha} isoform expression in the mouse fallopian tube: mechanistic insight into estrogen-dependent production and secretion of insulin-like growth factors Am J Physiol Endocrinol Metab, November 1, 2007; 293(5): E1430 - E1442. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Cheng, D. V. Yu, J.-H. Zhou, and D. J. Shapiro Tamoxifen Induction of CCAAT Enhancer-binding Protein {alpha} Is Required for Tamoxifen-induced Apoptosis J. Biol. Chem., October 19, 2007; 282(42): 30535 - 30543. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. C. J. P. Gielen, L. A. M. Santegoets, L. C. M. Kuhne, W. F. J. Van IJcken, B. Boers-Sijmons, P. Hanifi-Moghaddam, T. J. M. Helmerhorst, L. J. Blok, and C. W. Burger Genomic and Nongenomic Effects of Estrogen Signaling in Human Endometrial Cells: Involvement of the Growth Factor Receptor Signaling Downstream AKT Pathway Reproductive Sciences, October 1, 2007; 14(7): 646 - 654. [Abstract] [PDF] |
||||
![]() |
Y.-C. Chen, P. Kraft, P. Bretsky, S. Ketkar, D. J. Hunter, D. Albanes, D. Altshuler, G. Andriole, C. D. Berg, H. Boeing, et al. Sequence Variants of Estrogen Receptor {beta} and Risk of Prostate Cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium Cancer Epidemiol. Biomarkers Prev., October 1, 2007; 16(10): 1973 - 1981. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Kressler, M. B. Hock, and A. Kralli Coactivators PGC-1beta and SRC-1 Interact Functionally to Promote the Agonist Activity of the Selective Estrogen Receptor Modulator Tamoxifen J. Biol. Chem., September 14, 2007; 282(37): 26897 - 26907. [Abstract] [Full Text] [PDF] |
||||
![]() |
W-D Han, Y-L Zhao, Y-G Meng, L Zang, Z-Q Wu, Q Li, Y-L Si, K Huang, J-M Ba, H Morinaga, et al. Estrogenically regulated LRP16 interacts with estrogen receptor {alpha} and enhances the receptor's transcriptional activity Endocr. Relat. Cancer, September 1, 2007; 14(3): 741 - 753. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. J. Peterson, S. Karmakar, M. C. Pace, T. Gao, and C. L. Smith The Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor (SMRT) Corepressor Is Required for Full Estrogen Receptor {alpha} Transcriptional Activity Mol. Cell. Biol., September 1, 2007; 27(17): 5933 - 5948. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Heneweer, R. Houtman, J. Poortman, M. Groot, C. Maliepaard, and A. Peijnenburg Estrogenic Effects in the Immature Rat Uterus after Dietary Exposure to Ethinylestradiol and Zearalenone Using a Systems Biology Approach Toxicol. Sci., September 1, 2007; 99(1): 303 - 314. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Sayeed, S. D. Konduri, W. Liu, S. Bansal, F. Li, and G. M. Das Estrogen Receptor {alpha} Inhibits p53-Mediated Transcriptional Repression: Implications for the Regulation of Apoptosis Cancer Res., August 15, 2007; 67(16): 7746 - 7755. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. M. Gowri, S. Sengupta, S. Bertera, and B. S. Katzenellenbogen Lipin1 Regulation by Estrogen in Uterus and Liver: Implications for Diabetes and Fertility Endocrinology, August 1, 2007; 148(8): 3685 - 3693. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Kininis, B. S. Chen, A. G. Diehl, G. D. Isaacs, T. Zhang, A. C. Siepel, A. G. Clark, and W. L. Kraus Genomic Analyses of Transcription Factor Binding, Histone Acetylation, and Gene Expression Reveal Mechanistically Distinct Classes of Estrogen-Regulated Promoters Mol. Cell. Biol., July 15, 2007; 27(14): 5090 - 5104. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Heldring, A. Pike, S. Andersson, J. Matthews, G. Cheng, J. Hartman, M. Tujague, A. Strom, E. Treuter, M. Warner, et al. Estrogen Receptors: How Do They Signal and What Are Their Targets Physiol Rev, July 1, 2007; 87(3): 905 - 931. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. M. Silva and M. A. Shupnik Integration of Steroid and Growth Factor Pathways in Breast Cancer: Focus on Signal Transducers and Activators of Transcription and Their Potential Role in Resistance Mol. Endocrinol., July 1, 2007; 21(7): 1499 - 1512. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. M. Trauernicht, S. J. Kim, N. H. Kim, and T. G. Boyer Modulation of Estrogen Receptor {alpha} Protein Level and Survival Function by DBC-1 Mol. Endocrinol., July 1, 2007; 21(7): 1526 - 1536. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. C. Trainor, S. Lin, M. S. Finy*, M. R. Rowland, and R. J. Nelson Photoperiod reverses the effects of estrogens on male aggression via genomic and nongenomic pathways PNAS, June 5, 2007; 104(23): 9840 - 9845. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. A. Gilad and B. Schwartz Association of estrogen receptor {beta} with plasma-membrane caveola components: implication in control of vitamin D receptor J. Mol. Endocrinol., June 1, 2007; 38(6): 603 - 618. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Duong, N. Boulle, S. Daujat, J. Chauvet, S. Bonnet, H. Neel, and V. Cavailles Differential Regulation of Estrogen Receptor {alpha} Turnover and Transactivation by Mdm2 and Stress-Inducing Agents Cancer Res., June 1, 2007; 67(11): 5513 - 5521. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. O'Lone, K. Knorr, I. Z. Jaffe, M. E. Schaffer, P. G. V. Martini, R. H. Karas, J. Bienkowska, M. E. Mendelsohn, and U. Hansen Estrogen Receptors {alpha} and {beta} Mediate Distinct Pathways of Vascular Gene Expression, Including Genes Involved in Mitochondrial Electron Transport and Generation of Reactive Oxygen Species Mol. Endocrinol., June 1, 2007; 21(6): 1281 - 1296. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. M. Naciff, G. J. Overmann, S. M. Torontali, G. J. Carr, Z. S. Khambatta, J. P. Tiesman, B. D. Richardson, and G. P. Daston Uterine Temporal Response to Acute Exposure to 17{alpha}-Ethinyl Estradiol in the Immature Rat Toxicol. Sci., June 1, 2007; 97(2): 467 - 490. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Penolazzi, M. Zennaro, E. Lambertini, E. Tavanti, E. Torreggiani, R. Gambari, and R. Piva Induction of Estrogen Receptor {alpha} Expression with Decoy Oligonucleotide Targeted to NFATc1 Binding Sites in Osteoblasts Mol. Pharmacol., June 1, 2007; 71(6): 1457 - 1462. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Lupien, M. Jeyakumar, E. Hebert, K. Hilmi, D. Cotnoir-White, C. Loch, A. Auger, G. Dayan, G.-A. Pinard, J.-M. Wurtz, et al. Raloxifene and ICI182,780 Increase Estrogen Receptor-{alpha} Association with a Nuclear Compartment via Overlapping Sets of Hydrophobic Amino Acids in Activation Function 2 Helix 12 Mol. Endocrinol., April 1, 2007; 21(4): 797 - 816. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Yan, Y.-S. Kim, X.-P. Yang, M. Albers, M. Koegl, and A. M. Jetten Ubiquitin-interaction motifs of RAP80 are critical in its regulation of estrogen receptor {alpha} Nucleic Acids Res., March 12, 2007; 35(5): 1673 - 1686. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Lu, A. Amleh, J. Sun, X. Jin, S. D. McCullough, R. Baer, D. Ren, R. Li, and Y. Hu Ubiquitination and Proteasome-Mediated Degradation of BRCA1 and BARD1 during Steroidogenesis in Human Ovarian Granulosa Cells Mol. Endocrinol., March 1, 2007; 21(3): 651 - 663. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Vasudevan and D. W. Pfaff Membrane-Initiated Actions of Estrogens in Neuroendocrinology: Emerging Principles Endocr. Rev., February 1, 2007; 28(1): 1 - 19. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. H. Al-Dhaheri and B. G. Rowan Protein Kinase A Exhibits Selective Modulation of Estradiol-Dependent Transcription in Breast Cancer Cells that Is Associated with Decreased Ligand Binding, Altered Estrogen Receptor {alpha} Promoter Interaction, and Changes in Receptor Phosphorylation Mol. Endocrinol., February 1, 2007; 21(2): 439 - 456. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Grans, M. Nilsson, K. Dahlman-Wright, and B. Evengard Reduced levels of oestrogen receptor {beta} mRNA in Swedish patients with chronic fatigue syndrome J. Clin. Pathol., February 1, 2007; 60(2): 195 - 198. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. A. Harris Estrogen Receptor-{beta}: Recent Lessons from in Vivo Studies Mol. Endocrinol., January 1, 2007; 21(1): 1 - 13. [Abstract] [Full Text] [PDF] |
||||
![]() |
X. Fan, M. Warner, and J.-A. Gustafsson Estrogen receptor beta expression in the embryonic brain regulates development of calretinin-immunoreactive GABAergic interneurons PNAS, December 19, 2006; 103(51): 19338 - 19343. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. M. Jaber, T. Gao, L. Huang, S. Karmakar, and C. L. Smith The Pure Estrogen Receptor Antagonist ICI 182,780 Promotes a Novel Interaction of Estrogen Receptor-{alpha} with the 3',5'-Cyclic Adenosine Monophosphate Response Element-Binding Protein-Binding Protein/p300 Coactivators Mol. Endocrinol., November 1, 2006; 20(11): 2695 - 2710. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Lu, D. Chen, Z. Lin, S. Reierstad, A. M. Trauernicht, T. G. Boyer, and S. E. Bulun BRCA1 Negatively Regulates the Cancer-Associated Aromatase Promoters I.3 and II in Breast Adipose Fibroblasts and Malignant Epithelial Cells J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4514 - 4519. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Ohshiro, S. K. Rayala, M. D. Williams, R. Kumar, and A. K. El-Naggar Biological Role of Estrogen Receptor {beta} in Salivary Gland Adenocarcinoma Cells. Clin. Cancer Res., October 15, 2006; 12(20): 5994 - 5999. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. R. Thomsen, K. Almstrup, J. E. Nielsen, I. K. Sorensen, O. W. Petersen, H. Leffers, and V. M. Breinholt Estrogenic Effect of Soy Isoflavones on Mammary Gland Morphogenesis and Gene Expression Profile Toxicol. Sci., October 1, 2006; 93(2): 357 - 368. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. C. Chang, J. Frasor, B. Komm, and B. S. Katzenellenbogen Impact of Estrogen Receptor {beta} on Gene Networks Regulated by Estrogen Receptor {alpha} in Breast Cancer Cells Endocrinology, October 1, 2006; 147(10): 4831 - 4842. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. A S Reyes, H. Tsukamura, H. I'Anson, M. A. C Estacio, K. Hirunagi, and K.-I. Maeda Temporal expression of estrogen receptor {alpha} in the hypothalamus and medulla oblongata during fasting: a role of noradrenergic neurons. J. Endocrinol., September 1, 2006; 190(3): 593 - 600. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. N. Duong, S. Elliott, D. E. Frigo, L. I. Melnik, L. Vanhoy, S. Tomchuck, H. P. Lebeau, O. David, B. S. Beckman, J. Alam, et al. AKT Regulation of Estrogen Receptor {beta} Transcriptional Activity in Breast Cancer. Cancer Res., September 1, 2006; 66(17): 8373 - 8381. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. R. Schultz-Norton, W. H. McDonald, J. R. Yates, and A. M. Nardulli Protein Disulfide Isomerase Serves as a Molecular Chaperone to Maintain Estrogen Receptor {alpha} Structure and Function Mol. Endocrinol., September 1, 2006; 20(9): 1982 - 1995. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. T. Zhu, G.-Z. Han, J.-Y. Shim, Y. Wen, and X.-R. Jiang Quantitative Structure-Activity Relationship of Various Endogenous Estrogen Metabolites for Human Estrogen Receptor {alpha} and {beta} Subtypes: Insights into the Structural Determinants Favoring a Differential Subtype Binding Endocrinology, September 1, 2006; 147(9): 4132 - 4150. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y.-H. Chen, M.-J. Lee, H.-H. Chang, P.-F. Hung, and Y.-H. Kao 17{beta}-Estradiol Stimulates Resistin Gene Expression in 3T3-L1 Adipocytes via the Estrogen Receptor, Extracellularly Regulated Kinase, and CCAAT/Enhancer Binding Protein-{alpha} Pathways Endocrinology, September 1, 2006; 147(9): 4496 - 4504. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Naessen, K. Carlstrom, R. Glant, H. Jacobsson, and A. L. Hirschberg Bone mineral density in bulimic women - influence of endocrine factors and previous anorexia. Eur. J. Endocrinol., August 1, 2006; 155(2): 245 - 251. [Abstract] [Full Text] [PDF] |
||||
![]() |
Z. Zhang, K. Chen, J. C. Shih, and C. T. Teng Estrogen-Related Receptors-Stimulated Monoamine Oxidase B Promoter Activity Is Down-Regulated by Estrogen Receptors Mol. Endocrinol., July 1, 2006; 20(7): 1547 - 1561. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Y. Kim, E. M. Woo, Y. T. E. Chong, D. R. Homenko, and W. L. Kraus Acetylation of Estrogen Receptor {alpha} by p300 at Lysines 266 and 268 Enhances the Deoxyribonucleic Acid Binding and Transactivation Activities of the Receptor Mol. Endocrinol., July 1, 2006; 20(7): 1479 - 1493. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. A. Babiker, D. Lips, R. Meyer, E. Delvaux, P. Zandberg, B. Janssen, G. van Eys, C. Grohe, and P. A. Doevendans Estrogen Receptor {beta} Protects the Murine Heart Against Left Ventricular Hypertrophy Arterioscler Thromb Vasc Biol, July 1, 2006; 26(7): 1524 - 1530. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |