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Physiological Reviews, Vol. 81, No. 2, April 2001, pp. 807-869
Copyright ©2001 by the American Physiological Society
Diabetes Research Laboratory, Medical Services, and Department of Molecular Biology, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts
Kyriakis, John M. and
Joseph Avruch.
Mammalian Mitogen-Activated Protein Kinase Signal
Transduction Pathways Activated by Stress and Inflammation. Physiol. Rev. 81: 807-869, 2001.
The molecular details of mammalian
stress-activated signal transduction pathways have only begun to be
dissected. This, despite the fact that the impact of these pathways on
the pathology of chronic inflammation, heart disease, stroke, the
debilitating effects of diabetes mellitus, and the side effects of
cancer therapy, not to mention embryonic development, innate and
acquired immunity, is profound. Cardiovascular disease and diabetes
alone represent the most significant health care problems in the
developed world. Thus it is not surprising that understanding these
pathways has attracted wide interest, and in the past 10 years,
dramatic progress has been made. Accordingly, it is now becoming
possible to envisage the transition of these findings to the
development of novel treatment strategies. This review focuses on the
biochemical components and regulation of mammalian stress-regulated
mitogen-activated protein kinase (MAPK) pathways. The nuclear
factor-
B pathway, a second stress signaling paradigm, has been the
subject of several excellent recent reviews (258, 260).
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G.-X. Zhang, X.-M. Lu, S. Kimura, and A. Nishiyama Role of mitochondria in angiotensin II-induced reactive oxygen species and mitogen-activated protein kinase activation Cardiovasc Res, November 1, 2007; 76(2): 204 - 212. [Abstract] [Full Text] [PDF]
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R. Mishra, M. K. Barthwal, G. Sondarva, B. Rana, L. Wong, M. Chatterjee, J. R. Woodgett, and A. Rana Glycogen Synthase Kinase-3beta Induces Neuronal Cell Death via Direct Phosphorylation of Mixed Lineage Kinase 3 J. Biol. Chem., October 19, 2007; 282(42): 30393 - 30405. [Abstract] [Full Text] [PDF]
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G.-X. Zhang, Y. Nagai, T. Nakagawa, H. Miyanaka, Y. Fujisawa, A. Nishiyama, K. Izuishi, K. Ohmori, and S. Kimura Involvement of endogenous nitric oxide in angiotensin II-induced activation of vascular mitogen-activated protein kinases Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2403 - H2408. [Abstract] [Full Text] [PDF]
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 P. J. Nadeau, S. J. Charette, M. B. Toledano, and J. Landry Disulfide Bond-mediated Multimerization of Ask1 and Its Reduction by Thioredoxin-1 Regulate H2O2-induced c-Jun NH2-terminal Kinase Activation and Apoptosis Mol. Biol. Cell, October 1, 2007; 18(10): 3903 - 3913. [Abstract] [Full Text] [PDF]
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C.-H. Teng, W.-N. Huang, and T.-C. Meng Several Dual Specificity Phosphatases Coordinate to Control the Magnitude and Duration of JNK Activation in Signaling Response to Oxidative Stress J. Biol. Chem., September 28, 2007; 282(39): 28395 - 28407. [Abstract] [Full Text] [PDF]
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Y. Wang Mitogen-Activated Protein Kinases in Heart Development and Diseases Circulation, September 18, 2007; 116(12): 1413 - 1423. [Abstract] [Full Text] [PDF]
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D. Chen, S. Reierstad, Z. Lin, M. Lu, C. Brooks, N. Li, J. Innes, and S. E. Bulun Prostaglandin E2 Induces Breast Cancer Related Aromatase Promoters via Activation of p38 and c-Jun NH2-Terminal Kinase in Adipose Fibroblasts Cancer Res., September 15, 2007; 67(18): 8914 - 8922. [Abstract] [Full Text] [PDF]
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 Y. Kim, P. Zhou, L. Qian, J.-Z. Chuang, J. Lee, C. Li, C. Iadecola, C. Nathan, and A. Ding MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival J. Exp. Med., September 3, 2007; 204(9): 2063 - 2074. [Abstract] [Full Text] [PDF]
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J.F. Schindler, J.B. Monahan, and W.G. Smith p38 Pathway Kinases as Anti-inflammatory Drug Targets Journal of Dental Research, September 1, 2007; 86(9): 800 - 811. [Abstract] [Full Text] [PDF]
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 Wenjing Zhong, Yufen Xie, Yingchun Wang, J. Lewis, A. Trostinskaia, Fangfei Wang, E. E. Puscheck, and D. A. Rappolee Use of Hyperosmolar Stress to Measure Stress-Activated Protein Kinase Activation and Function in Human HTR Cells and Mouse Trophoblast Stem Cells Reproductive Sciences, September 1, 2007; 14(6): 534 - 547. [Abstract] [PDF]
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 G. D. Lu, H.-M. Shen, M. C.M. Chung, and C. N. Ong Critical role of oxidative stress and sustained JNK activation in aloe-emodin-mediated apoptotic cell death in human hepatoma cells Carcinogenesis, September 1, 2007; 28(9): 1937 - 1945. [Abstract] [Full Text] [PDF]
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H. Sumimoto, S. Kamakura, and T. Ito Structure and Function of the PB1 Domain, a Protein Interaction Module Conserved in Animals, Fungi, Amoebas, and Plants Sci. Signal., August 28, 2007; 2007(401): re6 - re6. [Abstract] [Full Text] [PDF]
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J. S. Lee and B. E. Ellis Arabidopsis MAPK Phosphatase 2 (MKP2) Positively Regulates Oxidative Stress Tolerance and Inactivates the MPK3 and MPK6 MAPKs J. Biol. Chem., August 24, 2007; 282(34): 25020 - 25029. [Abstract] [Full Text] [PDF]
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J. Zhong and J. M. Kyriakis Dissection of a Signaling Pathway by Which Pathogen-associated Molecular Patterns Recruit the JNK and p38 MAPKs and Trigger Cytokine Release J. Biol. Chem., August 17, 2007; 282(33): 24246 - 24254. [Abstract] [Full Text] [PDF]
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 S.-i. Tanabe, C. Bodet, and D. Grenier Peptostreptococcus micros cell wall elicits a pro-inflammatory response in human macrophages Innate Immunity, August 1, 2007; 13(4): 219 - 226. [Abstract] [PDF]
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G. K. A. Meyer, A. Neetz, G. Brandes, D. Tsikas, J. H. Butterfield, I. Just, and R. Gerhard Clostridium difficile Toxins A and B Directly Stimulate Human Mast Cells Infect. Immun., August 1, 2007; 75(8): 3868 - 3876. [Abstract] [Full Text] [PDF]
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 M. S. Razzaque Cisplatin nephropathy: is cytotoxicity avoidable? Nephrol. Dial. Transplant., August 1, 2007; 22(8): 2112 - 2116. [Full Text] [PDF]
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S. Kani, E. Nakayama, A. Yoda, N. Onishi, N. Sougawa, Y. Hazaka, T. Umeda, K. Takeda, H. Ichijo, Y. Hamada, et al. Chk2 kinase is required for methylglyoxal-induced G2/M cell-cycle checkpoint arrest: implication of cell-cycle checkpoint regulation in diabetic oxidative stress signaling Genes Cells, August 1, 2007; 12(8): 919 - 928. [Abstract] [Full Text] [PDF]
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 D. Singh, K. L. McCann, and F. Imani MAPK and heat shock protein 27 activation are associated with respiratory syncytial virus induction of human bronchial epithelial monolayer disruption Am J Physiol Lung Cell Mol Physiol, August 1, 2007; 293(2): L436 - L445. [Abstract] [Full Text] [PDF]
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H. F. Kramer and L. J. Goodyear Exercise, MAPK, and NF-{kappa}B signaling in skeletal muscle J Appl Physiol, July 1, 2007; 103(1): 388 - 395. [Abstract] [Full Text] [PDF]
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C. Gaitanaki, T. Kalpachidou, I.-K. S. Aggeli, P. Papazafiri, and I. Beis CoCl2 induces protective events via the p38-MAPK signalling pathway and ANP in the perfused amphibian heart J. Exp. Biol., July 1, 2007; 210(13): 2267 - 2277. [Abstract] [Full Text] [PDF]
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 Y. Xie, W. Zhong, Y. Wang, A. Trostinskaia, F. Wang, E.E. Puscheck, and D.A. Rappolee Using hyperosmolar stress to measure biologic and stress-activated protein kinase responses in preimplantation embryos Mol. Hum. Reprod., July 1, 2007; 13(7): 473 - 481. [Abstract] [Full Text] [PDF]
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J. Peng, L. Peng, F. F. Stevenson, S. R. Doctrow, and J. K. Andersen Iron and Paraquat as Synergistic Environmental Risk Factors in Sporadic Parkinson's Disease Accelerate Age-Related Neurodegeneration J. Neurosci., June 27, 2007; 27(26): 6914 - 6922. [Abstract] [Full Text] [PDF]
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S. N. Fedorov, L. K. Shubina, A. M. Bode, V. A. Stonik, and Z. Dong Dactylone Inhibits Epidermal Growth Factor-Induced Transformation and Phenotype Expression of Human Cancer Cells and Induces G1-S Arrest and Apoptosis Cancer Res., June 15, 2007; 67(12): 5914 - 5920. [Abstract] [Full Text] [PDF]
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M. Zapater, M. Sohrmann, M. Peter, F. Posas, and E. de Nadal Selective Requirement for SAGA in Hog1-Mediated Gene Expression Depending on the Severity of the External Osmostress Conditions Mol. Cell. Biol., June 1, 2007; 27(11): 3900 - 3910. [Abstract] [Full Text] [PDF]
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 C. Li, Z. Huang, R. Kingsley, X. Zhou, F. Li, D. W. Parke II, and W. Cao Biochemical Alterations in the Retinas of Very Low-Density Lipoprotein Receptor Knockout Mice: An Animal Model of Retinal Angiomatous Proliferation Arch Ophthalmol, June 1, 2007; 125(6): 795 - 803. [Abstract] [Full Text] [PDF]
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W. Zhou, B. O. Ibe, and J. U. Raj Platelet-activating factor induces ovine fetal pulmonary venous smooth muscle cell proliferation: role of epidermal growth factor receptor transactivation Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2773 - H2781. [Abstract] [Full Text] [PDF]
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