| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Physiological Reviews, Vol. 81, No. 2, April 2001, pp. 741-766
Copyright ©2001 by the American Physiological Society
Department of Neurology and Program in Neuroscience, Harvard Medical School, and Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts
Selkoe, Dennis J.
Alzheimer's Disease: Genes, Proteins, and Therapy. Physiol. Rev. 81: 741-766, 2001.
Rapid progress in
deciphering the biological mechanism of Alzheimer's disease (AD) has
arisen from the application of molecular and cell biology to this
complex disorder of the limbic and association cortices. In turn, new
insights into fundamental aspects of protein biology have resulted from
research on the disease. This beneficial interplay between basic and
applied cell biology is well illustrated by advances in understanding
the genotype-to-phenotype relationships of familial Alzheimer's
disease. All four genes definitively linked to inherited forms of the
disease to date have been shown to increase the production and/or
deposition of amyloid 
-protein in the brain. In particular, evidence
that the presenilin proteins, mutations in which cause the most
aggressive form of inherited AD, lead to altered intramembranous
cleavage of the -amyloid precursor protein by the protease called
-secretase has spurred progress toward novel therapeutics. The
finding that presenilin itself may be the long-sought
-secretase, coupled with the recent identification of -secretase,
has provided discrete biochemical targets for drug screening and
development. Alternate and novel strategies for inhibiting the early
mechanism of the disease are also emerging. The progress reviewed here,
coupled with better ability to diagnose the disease early, bode well
for the successful development of therapeutic and preventative drugs
for this major public health problem.
This article has been cited by other articles:
|
|
 |
|
  H. Onozuka, A. Nakajima, K. Matsuzaki, R.-W. Shin, K. Ogino, D. Saigusa, N. Tetsu, A. Yokosuka, Y. Sashida, Y. Mimaki, et al. Nobiletin, a Citrus Flavonoid, Improves Memory Impairment and A{beta} Pathology in a Transgenic Mouse Model of Alzheimer's Disease J. Pharmacol. Exp. Ther., September 1, 2008; 326(3): 739 - 744. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Osenkowski, W. Ye, R. Wang, M. S. Wolfe, and D. J. Selkoe Direct and Potent Regulation of {gamma}-Secretase by Its Lipid Microenvironment J. Biol. Chem., August 15, 2008; 283(33): 22529 - 22540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Meredith Jr., L. A. Thompson, J. H. Toyn, L. Marcin, D. M. Barten, J. Marcinkeviciene, L. Kopcho, Y. Kim, A. Lin, V. Guss, et al. P-Glycoprotein Efflux and Other Factors Limit Brain Amyloid {beta} Reduction by {beta}-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitors in Mice J. Pharmacol. Exp. Ther., August 1, 2008; 326(2): 502 - 513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Osawa, S. Funamoto, M. Nobuhara, S. Wada-Kakuda, M. Shimojo, S. Yagishita, and Y. Ihara Phosphoinositides Suppress {gamma}-Secretase in Both the Detergent-soluble and -insoluble States J. Biol. Chem., July 11, 2008; 283(28): 19283 - 19292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bacher, R. Dodel, B. Aljabari, K. Keyvani, P. Marambaud, R. Kayed, C. Glabe, N. Goertz, A. Hoppmann, N. Sachser, et al. CNI-1493 inhibits A{beta} production, plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease J. Exp. Med., July 7, 2008; 205(7): 1593 - 1599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Iijima-Ando, S. A. Hearn, L. Granger, C. Shenton, A. Gatt, H.-C. Chiang, I. Hakker, Y. Zhong, and K. Iijima Overexpression of Neprilysin Reduces Alzheimer Amyloid-{beta}42 (A{beta}42)-induced Neuron Loss and Intraneuronal A{beta}42 Deposits but Causes a Reduction in cAMP-responsive Element-binding Protein-mediated Transcription, Age-dependent Axon Pathology, and Premature Death in Drosophila J. Biol. Chem., July 4, 2008; 283(27): 19066 - 19076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Mowrer and M. S. Wolfe Promotion of BACE1 mRNA Alternative Splicing Reduces Amyloid {beta}-Peptide Production J. Biol. Chem., July 4, 2008; 283(27): 18694 - 18701. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Jacobsen, T. A. Comery, R. L. Martone, H. Elokdah, D. L. Crandall, A. Oganesian, S. Aschmies, Y. Kirksey, C. Gonzales, J. Xu, et al. Enhanced clearance of A{beta} in brain by sustaining the plasmin proteolysis cascade PNAS, June 24, 2008; 105(25): 8754 - 8759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Shimojo, N. Sahara, T. Mizoroki, S. Funamoto, M. Morishima-Kawashima, T. Kudo, M. Takeda, Y. Ihara, H. Ichinose, and A. Takashima Enzymatic Characteristics of I213T Mutant Presenilin-1/{gamma}-Secretase in Cell Models and Knock-in Mouse Brains: FAMILIAL ALZHEIMER DISEASE-LINKED MUTATION IMPAIRS {gamma}-SITE CLEAVAGE OF AMYLOID PRECURSOR PROTEIN C-TERMINAL FRAGMENT {beta} J. Biol. Chem., June 13, 2008; 283(24): 16488 - 16496. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Koyama, S. Matsuzaki, F. Gomi, K. Yamada, T. Katayama, K. Sato, T. Kumada, A. Fukuda, S. Matsuda, Y. Tano, et al. Induction of Amyloid {beta} Accumulation by ER Calcium Disruption and Resultant Upregulation of Angiogenic Factors in ARPE19 Cells Invest. Ophthalmol. Vis. Sci., June 1, 2008; 49(6): 2376 - 2383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Shimizu, A. Tosaki, K. Kaneko, T. Hisano, T. Sakurai, and N. Nukina Crystal Structure of an Active Form of BACE1, an Enzyme Responsible for Amyloid {beta} Protein Production Mol. Cell. Biol., June 1, 2008; 28(11): 3663 - 3671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Zhang, Y. Dong, G. Zhang, R. D. Moir, W. Xia, Y. Yue, M. Tian, D. J. Culley, G. Crosby, R. E. Tanzi, et al. The Inhalation Anesthetic Desflurane Induces Caspase Activation and Increases Amyloid {beta}-Protein Levels under Hypoxic Conditions J. Biol. Chem., May 2, 2008; 283(18): 11866 - 11875. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Benvenuti, P Luciani, I Cellai, C Deledda, S Baglioni, R Saccardi, S Urbani, F Francini, R Squecco, C Giuliani, et al. Thyroid hormones promote cell differentiation and up-regulate the expression of the seladin-1 gene in in vitro models of human neuronal precursors J. Endocrinol., May 1, 2008; 197(2): 437 - 446. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. El-Amouri, H. Zhu, J. Yu, R. Marr, I. M. Verma, and M. S. Kindy Neprilysin: An Enzyme Candidate to Slow the Progression of Alzheimer's Disease Am. J. Pathol., May 1, 2008; 172(5): 1342 - 1354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lee, C. Retamal, L. Cuitino, A. Caruano-Yzermans, J.-E. Shin, P. van Kerkhof, M.-P. Marzolo, and G. Bu Adaptor Protein Sorting Nexin 17 Regulates Amyloid Precursor Protein Trafficking and Processing in the Early Endosomes J. Biol. Chem., April 25, 2008; 283(17): 11501 - 11508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Zhang, Y. Dong, B. Zhang, F. Ichinose, X. Wu, D. J. Culley, G. Crosby, R. E. Tanzi, and Z. Xie Isoflurane-Induced Caspase-3 Activation Is Dependent on Cytosolic Calcium and Can Be Attenuated by Memantine J. Neurosci., April 23, 2008; 28(17): 4551 - 4560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Y. H. Hook, M. Kindy, and G. Hook Inhibitors of Cathepsin B Improve Memory and Reduce {beta}-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, {beta}-Secretase Site of the Amyloid Precursor Protein J. Biol. Chem., March 21, 2008; 283(12): 7745 - 7753. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Calderon-Garciduenas, A. C. Solt, C. Henriquez-Roldan, R. Torres-Jardon, B. Nuse, L. Herritt, R. Villarreal-Calderon, N. Osnaya, I. Stone, R. Garcia, et al. Long-term Air Pollution Exposure Is Associated with Neuroinflammation, an Altered Innate Immune Response, Disruption of the Blood-Brain Barrier, Ultrafine Particulate Deposition, and Accumulation of Amyloid {beta}-42 and {alpha}-Synuclein in Children and Young Adults Toxicol Pathol, February 1, 2008; 36(2): 289 - 310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ganguly, R.M. R. Feldman, and M. Guo ubiquilin antagonizes presenilin and promotes neurodegeneration in Drosophila Hum. Mol. Genet., January 15, 2008; 17(2): 293 - 302. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yagishita, M. Morishima-Kawashima, S. Ishiura, and Y. Ihara A 46 Is Processed to A 40 and A 43, but Not to A 42, in the Low Density Membrane Domains J. Biol. Chem., January 11, 2008; 283(2): 733 - 738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tagami, M. Okochi, K. Yanagida, A. Ikuta, A. Fukumori, N. Matsumoto, Y. Ishizuka-Katsura, T. Nakayama, N. Itoh, J. Jiang, et al. Regulation of Notch Signaling by Dynamic Changes in the Precision of S3 Cleavage of Notch-1 Mol. Cell. Biol., January 1, 2008; 28(1): 165 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Bai, K. Markham, F. Chen, R. Weerasekera, J. Watts, P. Horne, Y. Wakutani, R. Bagshaw, P. M. Mathews, P. E. Fraser, et al. The in Vivo Brain Interactome of the Amyloid Precursor Protein Mol. Cell. Proteomics, January 1, 2008; 7(1): 15 - 34. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. G. Iben, R. E. Olson, L. A. Balanda, S. Jayachandra, B. J. Robertson, V. Hay, J. Corradi, C. V. C. Prasad, R. Zaczek, C. F. Albright, et al. Signal Peptide Peptidase and {gamma}-Secretase Share Equivalent Inhibitor Binding Pharmacology J. Biol. Chem., December 21, 2007; 282(51): 36829 - 36836. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S L PIMLOTT and K P EBMEIER SPECT imaging in dementia Br. J. Radiol., December 1, 2007; 80(Special_Issue_2): S153 - S159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Ren, D. Schenk, G. S. Basi, and I. P. Shapiro Amyloid -Protein Precursor Juxtamembrane Domain Regulates Specificity of {gamma}-Secretase-dependent Cleavages J. Biol. Chem., November 30, 2007; 282(48): 35350 - 35360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Goldblum, A. Kipfer-Kauer, G.-M. Sarra, S. Wolf, and B. E. Frueh Distribution of Amyloid Precursor Protein and Amyloid-{beta} Immunoreactivity in DBA/2J Glaucomatous Mouse Retinas Invest. Ophthalmol. Vis. Sci., November 1, 2007; 48(11): 5085 - 5090. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. E. Sundermann, P. E. Gilbert, and C. Murphy Apolipoprotein E {varepsilon}4 Genotype and Gender: Effects on Memory Am J Geriatr Psychiatry, October 1, 2007; 15(10): 869 - 878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Goldstein, Y. Cao, T. Fiedler, J. Toyn, L. Iben, D. M. Barten, M. Pierdomenico, J. Corsa, C. V. C. Prasad, R. E. Olson, et al. Ex Vivo Occupancy of {gamma}-Secretase Inhibitors Correlates with Brain beta-Amyloid Peptide Reduction in Tg2576 Mice J. Pharmacol. Exp. Ther., October 1, 2007; 323(1): 102 - 108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Lamarca, A. Sanz-Clemente, R. Perez-Pe, M. J. Martinez-Lorenzo, N. Halaihel, P. Muniesa, and J. A. Carrodeguas Two isoforms of PSAP/MTCH1 share two proapoptotic domains and multiple internal signals for import into the mitochondrial outer membrane Am J Physiol Cell Physiol, October 1, 2007; 293(4): C1347 - C1361. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Muresan and V. Muresan The Amyloid-beta Precursor Protein Is Phosphorylated via Distinct Pathways during Differentiation, Mitosis, Stress, and Degeneration Mol. Biol. Cell, October 1, 2007; 18(10): 3835 - 3844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Huttunen, S. Y. Guenette, C. Peach, C. Greco, W. Xia, D. Y. Kim, C. Barren, R. E. Tanzi, and D. M. Kovacs HtrA2 Regulates beta-Amyloid Precursor Protein (APP) Metabolism through Endoplasmic Reticulum-associated Degradation J. Biol. Chem., September 21, 2007; 282(38): 28285 - 28295. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. McConlogue, M. Buttini, J. P. Anderson, E. F. Brigham, K. S. Chen, S. B. Freedman, D. Games, K. Johnson-Wood, M. Lee, M. Zeller, et al. Partial Reduction of BACE1 Has Dramatic Effects on Alzheimer Plaque and Synaptic Pathology in APP Transgenic Mice J. Biol. Chem., September 7, 2007; 282(36): 26326 - 26334. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Zhang, H. Chen, and L. Lai Identification of amyloid fibril-forming segments based on structure and residue-based statistical potential Bioinformatics, September 1, 2007; 23(17): 2218 - 2225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. S. Eisele, M. Baumann, B. Klebl, C. Nordhammer, M. Jucker, and E. Kilger Gleevec Increases Levels of the Amyloid Precursor Protein Intracellular Domain and of the Amyloid-beta degrading Enzyme Neprilysin Mol. Biol. Cell, September 1, 2007; 18(9): 3591 - 3600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. I. Yin, B. Bassit, L. Zhu, X. Yang, C. Wang, and Y.-M. Li {gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE J. Biol. Chem., August 10, 2007; 282(32): 23639 - 23644. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Yamamoto, K. Schoonjans, and J. Auwerx Sirtuin Functions in Health and Disease Mol. Endocrinol., August 1, 2007; 21(8): 1745 - 1755. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Lu, Y. Lv, Y. Ye, Y. Wang, Y. Hong, M. E. Fortini, Y. Zhong, and Z. Xie A role for presenilin in post-stress regulation: effects of presenilin mutations on Ca2+ currents in Drosophila FASEB J, August 1, 2007; 21(10): 2368 - 2378. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Gomez-Brouchet, D. Pchejetski, L. Brizuela, V. Garcia, M.-F. Altie, M.-L. Maddelein, M.-B. Delisle, and O. Cuvillier Critical Role for Sphingosine Kinase-1 in Regulating Survival of Neuroblastoma Cells Exposed to Amyloid-beta Peptide Mol. Pharmacol., August 1, 2007; 72(2): 341 - 349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. T. Parkin, N. T. Watt, I. Hussain, E. A. Eckman, C. B. Eckman, J. C. Manson, H. N. Baybutt, A. J. Turner, and N. M. Hooper Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein PNAS, June 26, 2007; 104(26): 11062 - 11067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. G. Farias, A. S. Valles, M. Colombres, J. A. Godoy, E. M. Toledo, R. J. Lukas, F. J. Barrantes, and N. C. Inestrosa Wnt-7a Induces Presynaptic Colocalization of {alpha}7-Nicotinic Acetylcholine Receptors and Adenomatous Polyposis Coli in Hippocampal Neurons J. Neurosci., May 16, 2007; 27(20): 5313 - 5325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Prager, L. Wang-Eckhardt, R. Fluhrer, R. Killick, E. Barth, H. Hampel, C. Haass, and J. Walter A Structural Switch of Presenilin 1 by Glycogen Synthase Kinase 3beta-mediated Phosphorylation Regulates the Interaction with beta-Catenin and Its Nuclear Signaling J. Biol. Chem., May 11, 2007; 282(19): 14083 - 14093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Caccamo, S. Oddo, L. X. Tran, and F. M. LaFerla Lithium Reduces Tau Phosphorylation but Not A{beta} or Working Memory Deficits in a Transgenic Model with Both Plaques and Tangles Am. J. Pathol., May 1, 2007; 170(5): 1669 - 1678. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-Y. Lin, T. Gurlo, R. Kayed, A. E. Butler, L. Haataja, C. G. Glabe, and P. C. Butler Toxic Human Islet Amyloid Polypeptide (h-IAPP) Oligomers Are Intracellular, and Vaccination to Induce Anti-Toxic Oligomer Antibodies Does Not Prevent h-IAPP-Induced {beta}-Cell Apoptosis in h-IAPP Transgenic Mice Diabetes, May 1, 2007; 56(5): 1324 - 1332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Moretto, A. Bolchi, C. Rivetti, B. P. Imbimbo, G. Villetti, V. Pietrini, L. Polonelli, S. Del Signore, K. M. Smith, R. J. Ferrante, et al. Conformation-sensitive Antibodies against Alzheimer Amyloid-beta by Immunization with a Thioredoxin-constrained B-cell Epitope Peptide J. Biol. Chem., April 13, 2007; 282(15): 11436 - 11445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. He, K. Cooley, C. H. Y. Chung, N. Dashti, and J. Tang Apolipoprotein Receptor 2 and X11{alpha}/{beta} Mediate Apolipoprotein E-Induced Endocytosis of Amyloid-{beta} Precursor Protein and {beta}-Secretase, Leading to Amyloid-{beta} Production J. Neurosci., April 11, 2007; 27(15): 4052 - 4060. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kanekiyo, T. Ban, K. Aritake, Z.-L. Huang, W.-M. Qu, I. Okazaki, I. Mohri, S. Murayama, K. Ozono, M. Taniike, et al. Lipocalin-type prostaglandin D synthase/beta-trace is a major amyloid beta-chaperone in human cerebrospinal fluid PNAS, April 10, 2007; 104(15): 6412 - 6417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Majumdar, D. Cruz, N. Asamoah, A. Buxbaum, I. Sohar, P. Lobel, and F. R. Maxfield Activation of Microglia Acidifies Lysosomes and Leads to Degradation of Alzheimer Amyloid Fibrils Mol. Biol. Cell, April 1, 2007; 18(4): 1490 - 1496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-R. Hwang, C. Garza, C. Mosier, T. Toneff, E. Wunderlich, P. Goldsmith, and V. Hook Cathepsin L Expression Is Directed to Secretory Vesicles for Enkephalin Neuropeptide Biosynthesis and Secretion J. Biol. Chem., March 30, 2007; 282(13): 9556 - 9563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Planel, K. E. G. Richter, C. E. Nolan, J. E. Finley, L. Liu, Y. Wen, P. Krishnamurthy, M. Herman, L. Wang, J. B. Schachter, et al. Anesthesia Leads to Tau Hyperphosphorylation through Inhibition of Phosphatase Activity by Hypothermia J. Neurosci., March 21, 2007; 27(12): 3090 - 3097. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Shankar, B. L. Bloodgood, M. Townsend, D. M. Walsh, D. J. Selkoe, and B. L. Sabatini Natural Oligomers of the Alzheimer Amyloid-{beta} Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway J. Neurosci., March 14, 2007; 27(11): 2866 - 2875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Boddaert, K. Kinugawa, J.-C. Lambert, F. Boukhtouche, J. Zoll, R. Merval, O. Blanc-Brude, D. Mann, C. Berr, J. Vilar, et al. Evidence of a Role for Lactadherin in Alzheimer's Disease Am. J. Pathol., March 1, 2007; 170(3): 921 - 929. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. V. Nikolic, Y. Bai, D. Obregon, H. Hou, T. Mori, J. Zeng, J. Ehrhart, R. D. Shytle, B. Giunta, D. Morgan, et al. Transcutaneous beta-amyloid immunization reduces cerebral beta-amyloid deposits without T cell infiltration and microhemorrhage PNAS, February 13, 2007; 104(7): 2507 - 2512. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yamamoto, T. Kiyota, M. Horiba, J. L. Buescher, S. M. Walsh, H. E. Gendelman, and T. Ikezu Interferon-{gamma} and Tumor Necrosis Factor-{alpha} Regulate Amyloid-{beta} Plaque Deposition and {beta}-Secretase Expression in Swedish Mutant APP Transgenic Mice Am. J. Pathol., February 1, 2007; 170(2): 680 - 692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Becker, V. Lavie, and B. Solomon Stimulation of endogenous neurogenesis by anti-EFRH immunization in a transgenic mouse model of Alzheimer's disease PNAS, January 30, 2007; 104(5): 1691 - 1696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Calderon-Garciduenas, M. Franco-Lira, R. Torres-Jardon, C. Henriquez-Roldan, G. Barragan-Mejia, G. Valencia-Salazar, A. Gonzalez-Maciel, R. Reynoso-Robles, R. Villarreal-Calderon, and W. Reed Pediatric Respiratory and Systemic Effects of Chronic Air Pollution Exposure: Nose, Lung, Heart, and Brain Pathology Toxicol Pathol, January 1, 2007; 35(1): 154 - 162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Thomas and M. Fenech A review of genome mutation and Alzheimer's disease Mutagenesis, January 1, 2007; 22(1): 15 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S Parihar and G. J. Brewer Mitoenergetic failure in Alzheimer disease Am J Physiol Cell Physiol, January 1, 2007; 292(1): C8 - C23. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Pierrot, S. F. Santos, C. Feyt, M. Morel, J.-P. Brion, and J.-N. Octave Calcium-mediated Transient Phosphorylation of Tau and Amyloid Precursor Protein Followed by Intraneuronal Amyloid-beta Accumulation J. Biol. Chem., December 29, 2006; 281(52): 39907 - 39914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Oddo, V. Vasilevko, A. Caccamo, M. Kitazawa, D. H. Cribbs, and F. M. LaFerla Reduction of Soluble Abeta and Tau, but Not Soluble Abeta Alone, Ameliorates Cognitive Decline in Transgenic Mice with Plaques and Tangles J. Biol. Chem., December 22, 2006; 281(51): 39413 - 39423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
|
