| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Physiological Reviews, Vol. 81, No. 1, January 2001, pp. 419-447
Copyright ©2001 by the American Physiological Society
Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
Compston, Juliet E.
Sex Steroids and Bone. Physiol. Rev. 81: 419-447, 2001.
Sex steroids are essential for skeletal
development and the maintenance of bone health throughout adult life,
and estrogen deficiency at menopause is a major pathogenetic factor in
the development of osteoporosis in postmenopausal women. The mechanisms by which the skeletal effects of sex steroids are mediated remain incompletely understood, but in recent years there have been
considerable advances in our knowledge of how estrogens and, to a
lesser extent androgens, influence bone modeling and remodeling in
health and disease. New insights into estrogen receptor structure and
function, recent discoveries about the development and activity of
osteoclasts, and lessons learned from human and animal genetic
mutations have all contributed to increased understanding of the
skeletal effects of estrogen, both in males and females. Studies of
untreated and treated osteoporosis in postmenopausal women have also
contributed to this knowledge and have provided unequivocal evidence
for the potential of high-dose estrogen therapy to have anabolic
skeletal effects. The development of selective estrogen receptor
modulators has provided a new approach to the prevention of
osteoporosis and other major diseases of menopause and has implications
for the therapeutic use of other steroid hormones, including androgens. Further elucidation of the mechanisms by which sex steroids affect bone
thus has the potential to improve the clinical management not only of
osteoporosis, both in men and women, but also of a number of other
diseases related to sex hormone status.
This article has been cited by other articles:
|
|
 |
|
  P. Utriainen, J. Jaaskelainen, A. Saarinen, E. Vanninen, O. Makitie, and R. Voutilainen Body Composition and Bone Mineral Density in Children with Premature Adrenarche and the Association of LRP5 Gene Polymorphisms with Bone Mineral Density J. Clin. Endocrinol. Metab., November 1, 2009; 94(11): 4144 - 4151. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Pollock, A.-E. Klotsas, J. Compston, and E. Gkrania-Klotsas Bone health in HIV infection Br. Med. Bull., October 29, 2009; (2009) ldp037v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Mohamed and J. K Yeh Alfacalcidol prevents aromatase inhibitor (Letrozole)-induced bone mineral loss in young growing female rats J. Endocrinol., August 1, 2009; 202(2): 317 - 325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. E. Lanyon, T. Sugiyama, and J. S. Price Regulation of Bone Mass: Local Control or Systemic Influence or Both? IBMS BoneKEy, June 1, 2009; 6(6): 218 - 226. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Wen, E. E. Bennett, M. M. Hegedus, and S. Rapacchi Fourier X-ray Scattering Radiography Yields Bone Structural Information Radiology, June 1, 2009; 251(3): 910 - 918. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-H. Yang, S. N. Sarkar, R. Liu, E. J. Perez, X. Wang, Y. Wen, L.-J. Yan, and J. W. Simpkins Estrogen Receptor {beta} as a Mitochondrial Vulnerability Factor J. Biol. Chem., April 3, 2009; 284(14): 9540 - 9548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Rivera, P. J. Christian, S. L. Marion, H. L. Brooks, and P. B. Hoyer Steroidogenic Capacity of Residual Ovarian Tissue in 4-Vinylcyclohexene Diepoxide-Treated Mice Biol Reprod, February 1, 2009; 80(2): 328 - 336. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Kim, D. E. Greenberg, M. E. Ehrmantraut, S. V. Guide, L. Ding, Y. Shea, M. R. Brown, M. Chernick, W. K. Steagall, C. G. Glasgow, et al. Pulmonary Nontuberculous Mycobacterial Disease: Prospective Study of a Distinct Preexisting Syndrome Am. J. Respir. Crit. Care Med., November 15, 2008; 178(10): 1066 - 1074. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Yarrow, C. F. Conover, A. V. Purandare, A. M. Bhakta, N. Zheng, B. Conrad, M. K. Altman, S. E. Franz, T. J. Wronski, and S. E. Borst Supraphysiological testosterone enanthate administration prevents bone loss and augments bone strength in gonadectomized male and female rats Am J Physiol Endocrinol Metab, November 1, 2008; 295(5): E1213 - E1222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. L. Jamieson, S. Shimizu, J. A. D'Ambrosio, O. Meucci, and A. Fatatis CX3CR1 Is Expressed by Prostate Epithelial Cells and Androgens Regulate the Levels of CX3CL1/Fractalkine in the Bone Marrow: Potential Role in Prostate Cancer Bone Tropism Cancer Res., March 15, 2008; 68(6): 1715 - 1722. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Merlet, C. Racine, E. Moreau, S. G. Moreno, and R. Habert Male fetal germ cells are targets for androgens that physiologically inhibit their proliferation PNAS, February 27, 2007; 104(9): 3615 - 3620. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. E S Poole and J. E Compston Osteoporosis and its management BMJ, December 16, 2006; 333(7581): 1251 - 1256. [Full Text] [PDF]
|
|
|
|
 |
|
 N. Rasheed, X. Wang, Q.-T. Niu, J. Yeh, and B. Li Atm-deficient mice: an osteoporosis model with defective osteoblast differentiation and increased osteoclastogenesis Hum. Mol. Genet., June 15, 2006; 15(12): 1938 - 1948. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Tamimi, S. E. Hankinson, G. A. Colditz, and C. Byrne Endogenous Sex Hormone Levels and Mammographic Density among Postmenopausal Women Cancer Epidemiol. Biomarkers Prev., November 1, 2005; 14(11): 2641 - 2647. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Gao, P. J. Reiser, C. C. Coss, M. A. Phelps, J. D. Kearbey, D. D. Miller, and J. T. Dalton Selective Androgen Receptor Modulator Treatment Improves Muscle Strength and Body Composition and Prevents Bone Loss in Orchidectomized Rats Endocrinology, November 1, 2005; 146(11): 4887 - 4897. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Massai, L. Makarainen, A. Kuukankorpi, C. Klipping, I. Duijkers, and T. Dieben The combined contraceptive vaginal ring and bone mineral density in healthy pre-menopausal women Hum. Reprod., October 1, 2005; 20(10): 2764 - 2768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Esposito, A. Iacono, G. M. Raso, M. Pacilio, A. Coppola, R. Di Carlo, and R. Meli Raloxifene, a Selective Estrogen Receptor Modulator, Reduces Carrageenan-Induced Acute Inflammation in Normal and Ovariectomized Rats Endocrinology, August 1, 2005; 146(8): 3301 - 3308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Chen, J. Kim, and J. T. Dalton Discovery and Therapeutic Promise of Selective Androgen Receptor Modulators Mol. Interv., June 1, 2005; 5(3): 173 - 188. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Gennari, D. Merlotti, V. De Paola, A. Calabro, L. Becherini, G. Martini, and R. Nuti Estrogen Receptor Gene Polymorphisms and the Genetics of Osteoporosis: A HuGE Review Am. J. Epidemiol., February 15, 2005; 161(4): 307 - 320. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. F Bezerra, L. M. Mendonca, E. C Lobato, K. O O'Brien, and C. M Donangelo Bone mass is recovered from lactation to postweaning in adolescent mothers with low calcium intakes Am. J. Clinical Nutrition, November 1, 2004; 80(5): 1322 - 1326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Muir, G. Romalo, L. Wolf, W. Elger, and H.-U. Schweikert Estrone Sulfate Is a Major Source of Local Estrogen Formation in Human Bone J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4685 - 4692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. P. Mayer, P. J. Devine, C. A. Dyer, and P. B. Hoyer The Follicle-Deplete Mouse Ovary Produces Androgen Biol Reprod, July 1, 2004; 71(1): 130 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Vanderschueren, L. Vandenput, S. Boonen, M. K. Lindberg, R. Bouillon, and C. Ohlsson Androgens and Bone Endocr. Rev., June 1, 2004; 25(3): 389 - 425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Meier, P. Y. Liu, L. P. Ly, J. de Winter-Modzelewski, M. Jimenez, D. J. Handelsman, and M. J. Seibel Recombinant Human Chorionic Gonadotropin But Not Dihydrotestosterone Alone Stimulates Osteoblastic Collagen Synthesis in Older Men with Partial Age-Related Androgen Deficiency J. Clin. Endocrinol. Metab., June 1, 2004; 89(6): 3033 - 3041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. B. Hoyer Can the Clock Be Turned Back on Ovarian Aging? Sci. Aging Knowl. Environ., March 10, 2004; 2004(10): pe11 - pe11. [Abstract] [Full Text]
|
|
|
|
|
|
M. Heim, O. Frank, G. Kampmann, N. Sochocky, T. Pennimpede, P. Fuchs, W. Hunziker, P. Weber, I. Martin, and I. Bendik The Phytoestrogen Genistein Enhances Osteogenesis and Represses Adipogenic Differentiation of Human Primary Bone Marrow Stromal Cells Endocrinology, February 1, 2004; 145(2): 848 - 859. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Moverare, J. Dahllund, N. Andersson, U. Islander, H. Carlsten, J.-A. Gustafsson, S. Nilsson, and C. Ohlsson Estren Is a Selective Estrogen Receptor Modulator with Transcriptional Activity Mol. Pharmacol., December 1, 2003; 64(6): 1428 - 1433. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Thompson, T. D. Shanafelt, and C. L. Loprinzi Andropause: Symptom Management for Prostate Cancer Patients Treated With Hormonal Ablation Oncologist, October 1, 2003; 8(5): 474 - 487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Viereck, C. Grundker, S. Blaschke, B. Niederkleine, H. Siggelkow, K.-H. Frosch, D. Raddatz, G. Emons, and L. C. Hofbauer Raloxifene Concurrently Stimulates Osteoprotegerin and Inhibits Interleukin-6 Production by Human Trabecular Osteoblasts J. Clin. Endocrinol. Metab., September 1, 2003; 88(9): 4206 - 4213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kawano, T. Sato, T. Yamada, T. Matsumoto, K. Sekine, T. Watanabe, T. Nakamura, T. Fukuda, K. Yoshimura, T. Yoshizawa, et al. Suppressive function of androgen receptor in bone resorption PNAS, August 5, 2003; 100(16): 9416 - 9421. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L Frankenfeld, R. E Patterson, N. K Horner, M. L Neuhouser, H. E Skor, T. F Kalhorn, W. N Howald, and J. W Lampe Validation of a soy food-frequency questionnaire and evaluation of correlates of plasma isoflavone concentrations in postmenopausal women Am. J. Clinical Nutrition, March 1, 2003; 77(3): 674 - 680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yeh, M.-Y. Tsai, Q. Xu, X.-M. Mu, H. Lardy, K.-E. Huang, H. Lin, S.-D. Yeh, S. Altuwaijri, X. Zhou, et al. Generation and characterization of androgen receptor knockout (ARKO) mice: An in vivo model for the study of androgen functions in selective tissues PNAS, October 15, 2002; 99(21): 13498 - 13503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. F. Gevers, N. Loveridge, and I. C. A. F. Robinson Bone Marrow Adipocytes: A Neglected Target Tissue for Growth Hormone Endocrinology, October 1, 2002; 143(10): 4065 - 4073. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sato, J. Vahle, A. Schmidt, M. Westmore, S. Smith, E. Rowley, and L. Y. Ma Abnormal Bone Architecture and Biomechanical Properties with Near-Lifetime Treatment of Rats with PTH Endocrinology, September 1, 2002; 143(9): 3230 - 3242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ueyama, N. Shirasawa, M. Numazawa, K. Yamada, M. Shelangouski, T. Ito, and Y. Tsuruo Gastric Parietal Cells: Potent Endocrine Role in Secreting Estrogen as a Possible Regulator of Gastro-Hepatic Axis Endocrinology, August 1, 2002; 143(8): 3162 - 3170. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Vahle, M. Sato, G. G. Long, J. K. Young, P. C. Francis, J. A. Engelhardt, M. S. Westmore, Y. L. Ma, and J. B. Nold Skeletal Changes in Rats Given Daily Subcutaneous Injections of Recombinant Human Parathyroid Hormone (1-34) for 2 Years and Relevance to Human Safety Toxicol Pathol, April 1, 2002; 30(3): 312 - 321. [Abstract] [PDF]
|
|
|
|
 |
|
 P. M. Wise, M. J. Smith, D. B. Dubal, M. E. Wilson, S. W. Rau, A. B. Cashion, M. Bottner, and K. L. Rosewell Neuroendocrine Modulation and Repercussions of Female Reproductive Aging Recent Prog. Horm. Res., January 1, 2002; 57(1): 235 - 256. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
