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Physiol. Rev. 81: 345-418, 2001;
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Physiological Reviews, Vol. 81, No. 1, January 2001, pp. 345-418
Copyright ©2001 by the American Physiological Society

Sodium-Potassium-Adenosinetriphosphatase-Dependent Sodium Transport in the Kidney: Hormonal Control

Eric Féraille and Alain Doucet

Division of Nephrology, Geneva University Hospital, Geneva, Switzerland; and Centre National de la Recherche Scientifique Unité de Recherche Associée 1859, Service de Biologie Cellulaire, Centre d'Etudes de Saclay, Gif sur Yvette, France

Féraille, Eric and Alain Doucet. Sodium-Potassium-Adenosinetriphosphatase-Dependent Sodium Transport in the Kidney: Hormonal Control. Physiol. Rev. 81: 345-418, 2001.Tubular reabsorption of filtered sodium is quantitatively the main contribution of kidneys to salt and water homeostasis. The transcellular reabsorption of sodium proceeds by a two-step mechanism: Na+-K+-ATPase-energized basolateral active extrusion of sodium permits passive apical entry through various sodium transport systems. In the past 15 years, most of the renal sodium transport systems (Na+-K+-ATPase, channels, cotransporters, and exchangers) have been characterized at a molecular level. Coupled to the methods developed during the 1965-1985 decades to circumvent kidney heterogeneity and analyze sodium transport at the level of single nephron segments, cloning of the transporters allowed us to move our understanding of hormone regulation of sodium transport from a cellular to a molecular level. The main purpose of this review is to analyze how molecular events at the transporter level account for the physiological changes in tubular handling of sodium promoted by hormones. In recent years, it also became obvious that intracellular signaling pathways interacted with each other, leading to synergisms or antagonisms. A second aim of this review is therefore to analyze the integrated network of signaling pathways underlying hormone action. Given the central role of Na+-K+-ATPase in sodium reabsorption, the first part of this review focuses on its structural and functional properties, with a special mention of the specificity of Na+-K+-ATPase expressed in renal tubule. In a second part, the general mechanisms of hormone signaling are briefly introduced before a more detailed discussion of the nephron segment-specific expression of hormone receptors and signaling pathways. The three following parts integrate the molecular and physiological aspects of the hormonal regulation of sodium transport processes in three nephron segments: the proximal tubule, the thick ascending limb of Henle's loop, and the collecting duct.




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Na+-K+ Pump Regulation and Skeletal Muscle Contractility
Physiol Rev, October 1, 2003; 83(4): 1269 - 1324.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. Lei, S. Nowbar, C. N. Mariash, and D. H. Ingbar
Thyroid hormone stimulates Na-K-ATPase activity and its plasma membrane insertion in rat alveolar epithelial cells
Am J Physiol Lung Cell Mol Physiol, September 1, 2003; 285(3): L762 - L772.
[Abstract] [Full Text] [PDF]

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 Mol. Biol. CellHome page
E. Lecuona, K. Ridge, L. Pesce, D. Batlle, and J. I. Sznajder
The GTP-binding Protein RhoA Mediates Na,K-ATPase Exocytosis in Alveolar Epithelial Cells
Mol. Biol. Cell, September 1, 2003; 14(9): 3888 - 3897.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
R. Efendiev, C. E. Budu, A. R. Cinelli, A. M. Bertorello, and C. H. Pedemonte
Intracellular Na+ Regulates Dopamine and Angiotensin II Receptors Availability at the Plasma Membrane and Their Cellular Responses in Renal Epithelia
J. Biol. Chem., August 1, 2003; 278(31): 28719 - 28726.
[Abstract] [Full Text] [PDF]

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 J. Am. Soc. Nephrol.Home page
E. D. Lederer, S. J. Khundmiri, and E. J. Weinman
Role of NHERF-1 in Regulation of the Activity of Na-K ATPase and Sodium-Phosphate Co-transport in Epithelial Cells
J. Am. Soc. Nephrol., July 1, 2003; 14(7): 1711 - 1719.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
R. K. Wetzel and K. J. Sweadner
Phospholemman expression in extraglomerular mesangium and afferent arteriole of the juxtaglomerular apparatus
Am J Physiol Renal Physiol, July 1, 2003; 285(1): F121 - F129.
[Abstract] [Full Text] [PDF]

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 Mol. Biol. CellHome page
M. Vinciguerra, G. Deschenes, U. Hasler, D. Mordasini, M. Rousselot, A. Doucet, A. Vandewalle, P.-Y. Martin, and E. Feraille
Intracellular Na+ Controls Cell Surface Expression of Na,K-ATPase via a cAMP-independent PKA Pathway in Mammalian Kidney Collecting Duct Cells
Mol. Biol. Cell, July 1, 2003; 14(7): 2677 - 2688.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
U. Hasler, D. Mordasini, M. Bianchi, A. Vandewalle, E. Feraille, and P.-Y. Martin
Dual Influence of Aldosterone on AQP2 Expression in Cultured Renal Collecting Duct Principal Cells
J. Biol. Chem., June 6, 2003; 278(24): 21639 - 21648.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
G. Laverty, C. McWilliams, A. Sheldon, and S. S. Arnason
PTH stimulates a Cl--dependent and EIPA-sensitive current in chick proximal tubule cells in culture
Am J Physiol Renal Physiol, May 1, 2003; 284(5): F987 - F995.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
L. E. Yang, H. Zhong, P. K. K. Leong, A. Perianayagam, V. M. Campese, and A. A. McDonough
Chronic renal injury-induced hypertension alters renal NHE3 distribution and abundance
Am J Physiol Renal Physiol, May 1, 2003; 284(5): F1056 - F1065.
[Abstract] [Full Text] [PDF]

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 J. Physiol.Home page
M. J McKenna, H. Gissel, and T. Clausen
Effects of Electrical Stimulation and Insulin on Na+-K+-ATPase ([3H]Ouabain Binding) in Rat Skeletal Muscle
J. Physiol., March 1, 2003; 547(2): 567 - 580.
[Abstract] [Full Text] [PDF]

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 Mol. Biol. CellHome page
A. M. Bertorello, Y. Komarova, K. Smith, I. B. Leibiger, R. Efendiev, C. H. Pedemonte, G. Borisy, and J. I. Sznajder
Analysis of Na+,K+-ATPase Motion and Incorporation into the Plasma Membrane in Response to G Protein-coupled Receptor Signals in Living Cells
Mol. Biol. Cell, March 1, 2003; 14(3): 1149 - 1157.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
H. L. Brooks, S. Ageloff, T.-H. Kwon, W. Brandt, J. M. Terris, A. Seth, L. Michea, S. Nielsen, R. Fenton, and M. A. Knepper
cDNA array identification of genes regulated in rat renal medulla in response to vasopressin infusion
Am J Physiol Renal Physiol, January 1, 2003; 284(1): F218 - F228.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
V. A. Narkar, T. Hussain, and M. F. Lokhandwala
Activation of D2-like receptors causes recruitment of tyrosine-phosphorylated NKA alpha 1-subunits in kidney
Am J Physiol Renal Physiol, December 1, 2002; 283(6): F1290 - F1295.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
P. K. K. Leong, L. E. Yang, N.-H. Holstein-Rathlou, and A. A. McDonough
Angiotensin II clamp prevents the second step in renal apical NHE3 internalization during acute hypertension
Am J Physiol Renal Physiol, November 1, 2002; 283(5): F1142 - F1150.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
P.-Y. Martin, M. Bianchi, F. Roger, L. Niksic, and E. Feraille
Arginine vasopressin modulates expression of neuronal NOS in rat renal medulla
Am J Physiol Renal Physiol, September 1, 2002; 283(3): F559 - F568.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
G. Crambert, M. Fuzesi, H. Garty, S. Karlish, and K. Geering
Phospholemman (FXYD1) associates with Na,K-ATPase and regulates its transport properties
PNAS, August 20, 2002; 99(17): 11476 - 11481.
[Abstract] [Full Text] [PDF]

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 Circ. Res.Home page
Y. Li and M. B. Anand-Srivastava
Inactivation of Enhanced Expression of Gi Proteins by Pertussis Toxin Attenuates the Development of High Blood Pressure in Spontaneously Hypertensive Rats
Circ. Res., August 9, 2002; 91(3): 247 - 254.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
J. Reinhardt, M. Kosch, M. Lerner, H. Bertram, D. Lemke, and H. Oberleithner
Stimulation of protein kinase C pathway mediates endocytosis of human nongastric H+-K+-ATPase, ATP1AL1
Am J Physiol Renal Physiol, August 1, 2002; 283(2): F335 - F343.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
P. Gomes and P. Soares-da-Silva
D2-like receptor-mediated inhibition of Na+-K+-ATPase activity is dependent on the opening of K+ channels
Am J Physiol Renal Physiol, July 1, 2002; 283(1): F114 - F123.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
H. X. Pu, R. Scanzano, and R. Blostein
Distinct Regulatory Effects of the Na,K-ATPase gamma Subunit
J. Biol. Chem., May 31, 2002; 277(23): 20270 - 20276.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
J. D. Stockand
New ideas about aldosterone signaling in epithelia
Am J Physiol Renal Physiol, April 1, 2002; 282(4): F559 - F576.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
E. Arystarkhova, C. Donnet, N. K. Asinovski, and K. J. Sweadner
Differential Regulation of Renal Na,K-ATPase by Splice Variants of the gamma Subunit
J. Biol. Chem., March 15, 2002; 277(12): 10162 - 10172.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
N. Yoshikawa, Y. Makino, K. Okamoto, C. Morimoto, I. Makino, and H. Tanaka
Distinct Interaction of Cortivazol with the Ligand Binding Domain Confers Glucocorticoid Receptor Specificity. CORTIVAZOL IS A SPECIFIC LIGAND FOR THE GLUCOCORTICOID RECEPTOR
J. Biol. Chem., February 8, 2002; 277(7): 5529 - 5540.
[Abstract] [Full Text] [PDF]

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 J. Am. Soc. Nephrol.Home page
H. Lehrmann, J. Thomas, S. J. Kim, C. Jacobi, and J. Leipziger
Luminal P2Y2 Receptor-Mediated Inhibition of Na+ Absorption in Isolated Perfused Mouse CCD
J. Am. Soc. Nephrol., January 1, 2002; 13(1): 10 - 18.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
V. Summa, D. Mordasini, F. Roger, M. Bens, P.-Y. Martin, A. Vandewalle, F. Verrey, and E. Feraille
Short Term Effect of Aldosterone on Na,K-ATPase Cell Surface Expression in Kidney Collecting Duct Cells
J. Biol. Chem., December 7, 2001; 276(50): 47087 - 47093.
[Abstract] [Full Text] [PDF]

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 J. Am. Soc. Nephrol.Home page
G. DESCHENES, S. GONIN, E. ZOLTY, L. CHEVAL, M. ROUSSELOT, P.-Y. MARTIN, J.-M. VERBAVATZ, E. FERAILLE, and A. DOUCET
Increased Synthesis and AVP Unresponsiveness of Na,K-ATPase in Collecting Duct from Nephrotic Rats
J. Am. Soc. Nephrol., November 1, 2001; 12(11): 2241 - 2252.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
R. K. Wetzel and K. J. Sweadner
Immunocytochemical localization of Na-K-ATPase alpha - and gamma -subunits in rat kidney
Am J Physiol Renal Physiol, September 1, 2001; 281(3): F531 - F545.
[Abstract] [Full Text] [PDF]

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 EndocrinologyHome page
A. V. Chibalin, M. V. Kovalenko, J. W. Ryder, E. Feraille, H. Wallberg-Henriksson, and J. R. Zierath
Insulin- and Glucose-Induced Phosphorylation of the Na+,K+-Adenosine Triphosphatase {alpha}-Subunits in Rat Skeletal Muscle
Endocrinology, August 1, 2001; 142(8): 3474 - 3482.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
V. Narkar, T. Hussain, and M. Lokhandwala
Role of tyrosine kinase and p44/42 MAPK in D2-like receptor-mediated stimulation of Na+, K+-ATPase in kidney
Am J Physiol Renal Physiol, April 1, 2002; 282(4): F697 - F702.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
E. Arystarkhova, R. K. Wetzel, and K. J. Sweadner
Distribution and oligomeric association of splice forms of Na+-K+-ATPase regulatory gamma -subunit in rat kidney
Am J Physiol Renal Physiol, March 1, 2002; 282(3): F393 - F407.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
N. Li, F.-X. Yi, J. L. Spurrier, C. A. Bobrowitz, and A.-P. Zou
Production of superoxide through NADH oxidase in thick ascending limb of Henle's loop in rat kidney
Am J Physiol Renal Physiol, June 1, 2002; 282(6): F1111 - F1119.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
P. Gomes and P. Soares-da-Silva
Role of cAMP-PKA-PLC signaling cascade on dopamine-induced PKC-mediated inhibition of renal Na+-K+-ATPase activity
Am J Physiol Renal Physiol, June 1, 2002; 282(6): F1084 - F1096.
[Abstract] [Full Text] [PDF]


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