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Physiological Reviews, Vol. 80, No. 4, October 2000, pp. 1291-1335
Copyright ©2000 by the American Physiological Society
Departments of Anesthesiology and Physiology and Biophysics, School of Medicine, State University of New York, Stony Brook, New York
Rebecchi, Mario J. and
Srinivas N. Pentyala.
Structure, Function, and Control of
Phosphoinositide-Specific Phospholipase C. Physiol. Rev. 80: 1291-1335, 2000.
Phosphoinositide-specific
phospholipase C (PLC) subtypes 
, 
, and 
comprise a related
group of multidomain phosphodiesterases that cleave the polar head
groups from inositol lipids. Activated by all classes of cell surface
receptor, these enzymes generate the ubiquitous second messengers
inositol 1,4,5-trisphosphate and diacylglycerol. The last 5 years have
seen remarkable advances in our understanding of the molecular and
biological facets of PLCs. New insights into their multidomain
arrangement and catalytic mechanism have been gained from
crystallographic studies of PLC-1 , while new modes of
controlling PLC activity have been uncovered in cellular studies. Most
notable is the realization that PLC-, -, and - isoforms act in
concert, each contributing to a specific aspect of the cellular
response. Clues to their true biological roles were also obtained. Long
assumed to function broadly in calcium-regulated processes, genetic
studies in yeast, slime molds, plants, flies, and mammals point to
specific and conditional roles for each PLC isoform in cell signaling
and development. In this review we consider each subtype of PLC in
organisms ranging from yeast to mammals and discuss their molecular
regulation and biological function.
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H. Frecker, S. Munk, H. Wang, and C. Whiteside Mesangial cell-reduced Ca2+ signaling in high glucose is due to inactivation of phospholipase C-{beta}3 by protein kinase C Am J Physiol Renal Physiol, November 1, 2005; 289(5): F1078 - F1087. [Abstract] [Full Text] [PDF]
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 Y. Irino, M. Ichinohe, Y. Nakamura, M. Nakahara, and K. Fukami Phospholipase C{delta}4 Associates with Glutamate Receptor Interacting Protein 1 in Testis J. Biochem., October 1, 2005; 138(4): 451 - 456. [Abstract] [Full Text] [PDF]
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M. Rao and S. Sockanathan Transmembrane Protein GDE2 Induces Motor Neuron Differentiation in Vivo Science, September 30, 2005; 309(5744): 2212 - 2215. [Abstract] [Full Text] [PDF]
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M. Nakahara, M. Shimozawa, Y. Nakamura, Y. Irino, M. Morita, Y. Kudo, and K. Fukami A Novel Phospholipase C, PLC{eta}2, Is a Neuron-specific Isozyme J. Biol. Chem., August 12, 2005; 280(32): 29128 - 29134. [Abstract] [Full Text] [PDF]
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T. Maejima, S. Oka, Y. Hashimotodani, T. Ohno-Shosaku, A. Aiba, D. Wu, K. Waku, T. Sugiura, and M. Kano Synaptically Driven Endocannabinoid Release Requires Ca2+-Assisted Metabotropic Glutamate Receptor Subtype 1 to Phospholipase C {beta}4 Signaling Cascade in the Cerebellum J. Neurosci., July 20, 2005; 25(29): 6826 - 6835. [Abstract] [Full Text] [PDF]
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P. J. Bartlett, K. W. Young, S. R. Nahorski, and R. A. J. Challiss Single Cell Analysis and Temporal Profiling of Agonist-mediated Inositol 1,4,5-Trisphosphate, Ca2+, Diacylglycerol, and Protein Kinase C Signaling using Fluorescent Biosensors J. Biol. Chem., June 10, 2005; 280(23): 21837 - 21846. [Abstract] [Full Text] [PDF]
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R. S. Sidhu, R. R. Clough, and R. P. Bhullar Regulation of Phospholipase C-{delta}1 through Direct Interactions with the Small GTPase Ral and Calmodulin J. Biol. Chem., June 10, 2005; 280(23): 21933 - 21941. [Abstract] [Full Text] [PDF]
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Z. Kouchi, T. Shikano, Y. Nakamura, H. Shirakawa, K. Fukami, and S. Miyazaki The Role of EF-hand Domains and C2 Domain in Regulation of Enzymatic Activity of Phospholipase C{zeta} J. Biol. Chem., June 3, 2005; 280(22): 21015 - 21021. [Abstract] [Full Text] [PDF]
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C. J. Serrano, L. Graham, K. DeBell, R. Rawat, M. C. Veri, E. Bonvini, B. L. Rellahan, and I. G. Reischl A New Tyrosine Phosphorylation Site in PLC{gamma}1: The Role of Tyrosine 775 in Immune Receptor Signaling J. Immunol., May 15, 2005; 174(10): 6233 - 6237. [Abstract] [Full Text] [PDF]
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 R. Goggel and S. Uhlig The inositol trisphosphate pathway mediates platelet-activating-factor-induced pulmonary oedema Eur. Respir. J., May 1, 2005; 25(5): 849 - 857. [Abstract] [Full Text] [PDF]
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C. Hisatsune, K. Nakamura, Y. Kuroda, T. Nakamura, and K. Mikoshiba Amplification of Ca2+ Signaling by Diacylglycerol-mediated Inositol 1,4,5-Trisphosphate Production J. Biol. Chem., March 25, 2005; 280(12): 11723 - 11730. [Abstract] [Full Text] [PDF]
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 J. Sasaki, T. Sasaki, M. Yamazaki, K. Matsuoka, C. Taya, H. Shitara, S. Takasuga, M. Nishio, K. Mizuno, T. Wada, et al. Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha} J. Exp. Med., March 21, 2005; 201(6): 859 - 870. [Abstract] [Full Text] [PDF]
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M. Iwai, Y. Tateishi, M. Hattori, A. Mizutani, T. Nakamura, A. Futatsugi, T. Inoue, T. Furuichi, T. Michikawa, and K. Mikoshiba Molecular Cloning of Mouse Type 2 and Type 3 Inositol 1,4,5-Trisphosphate Receptors and Identification of a Novel Type 2 Receptor Splice Variant J. Biol. Chem., March 18, 2005; 280(11): 10305 - 10317. [Abstract] [Full Text] [PDF]
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Y. Guo, M. Rebecchi, and S. Scarlata Phospholipase C{beta}2 Binds to and Inhibits Phospholipase C{delta}1 J. Biol. Chem., January 14, 2005; 280(2): 1438 - 1447. [Abstract] [Full Text] [PDF]
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 R. Laporte, A. Hui, and I. Laher Pharmacological Modulation of Sarcoplasmic Reticulum Function in Smooth Muscle Pharmacol. Rev., December 1, 2004; 56(4): 439 - 513. [Abstract] [Full Text] [PDF]
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K. S. Murthy, H. Zhou, J. Huang, and S. N. Pentyala Activation of PLC-{delta}1 by Gi/o-coupled receptor agonists Am J Physiol Cell Physiol, December 1, 2004; 287(6): C1679 - C1687. [Abstract] [Full Text] [PDF]
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G. Asemu, N. S. Dhalla, and P. S. Tappia Inhibition of PLC improves postischemic recovery in isolated rat heart Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2598 - H2605. [Abstract] [Full Text] [PDF]
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 S. Landreville, S. Coulombe, P. Carrier, M. H. Gelb, S. L. Guerin, and C. Salesse Expression of Phospholipases A2 and C in Human Corneal Epithelial Cells Invest. Ophthalmol. Vis. Sci., November 1, 2004; 45(11): 3997 - 4003. [Abstract] [Full Text] [PDF]
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Y. Okubo, S. Kakizawa, K. Hirose, and M. Iino Cross Talk between Metabotropic and Ionotropic Glutamate Receptor-Mediated Signaling in Parallel Fiber-Induced Inositol 1,4,5-Trisphosphate Production in Cerebellar Purkinje Cells J. Neurosci., October 27, 2004; 24(43): 9513 - 9520. [Abstract] [Full Text] [PDF]
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Y. Uezono, M. Kaibara, O. Murasaki, and K. Taniyama Involvement of G protein {beta}{gamma}-subunits in diverse signaling induced by Gi/o-coupled receptors: study using the Xenopus oocyte expression system Am J Physiol Cell Physiol, October 1, 2004; 287(4): C885 - C894. [Abstract] [Full Text] [PDF]
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 T. Nagata, S. Iizumi, K. Satoh, H. Ooka, J. Kawai, P. Carninci, Y. Hayashizaki, Y. Otomo, K. Murakami, K. Matsubara, et al. Comparative Analysis of Plant and Animal Calcium Signal Transduction Element Using Plant Full-Length cDNA Data Mol. Biol. Evol., October 1, 2004; 21(10): 1855 - 1870. [Abstract] [Full Text] [PDF]
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G. Chen, P. Raman, P. Bhonagiri, A. B. Strawbridge, G. R. Pattar, and J. S. Elmendorf Protective Effect of Phosphatidylinositol 4,5-Bisphosphate against Cortical Filamentous Actin Loss and Insulin Resistance Induced by Sustained Exposure of 3T3-L1 Adipocytes to Insulin J. Biol. Chem., September 17, 2004; 279(38): 39705 - 39709. [Abstract] [Full Text] [PDF]
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G. Mouneimne, L. Soon, V. DesMarais, M. Sidani, X. Song, S.-C. Yip, M. Ghosh, R. Eddy, J. M. Backer, and J. Condeelis Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation J. Cell Biol., August 30, 2004; 166(5): 697 - 708. [Abstract] [Full Text] [PDF]
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 M. Isshiki, A. Mutoh, and T. Fujita Subcortical Ca2+ Waves Sneaking Under the Plasma Membrane in Endothelial Cells Circ. Res., August 6, 2004; 95(3): e11 - e21. [Abstract] [Full Text] [PDF]
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M. Hirose, J. Kitano, Y. Nakajima, K. Moriyoshi, S. Yanagi, H. Yamamura, T. Muto, H. Jingami, and S. Nakanishi Phosphorylation and Recruitment of Syk by Immunoreceptor Tyrosine-based Activation Motif-based Phosphorylation of Tamalin J. Biol. Chem., July 30, 2004; 279(31): 32308 - 32315. [Abstract] [Full Text] [PDF]
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 N. P.Y. Lee and C. Y. Cheng Ectoplasmic specialization, a testis-specific cell-cell actin-based adherens junction type: is this a potential target for male contraceptive development? Hum. Reprod. Update, July 1, 2004; 10(4): 349 - 369. [Abstract] [Full Text] [PDF]
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J. L. Leaney, A. Benians, S. Brown, M. Nobles, D. Kelly, and A. Tinker Rapid desensitization of G protein-gated inwardly rectifying K+ currents is determined by G protein cycle Am J Physiol Cell Physiol, July 1, 2004; 287(1): C182 - C191. [Abstract] [Full Text] [PDF]
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C. Martin, R. Goggel, A.-R. Ressmeyer, and S. Uhlig Pressor responses to platelet-activating factor and thromboxane are mediated by Rho-kinase Am J Physiol Lung Cell Mol Physiol, July 1, 2004; 287(1): L250 - L257. [Abstract] [Full Text] [PDF]
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S. B. Lee, P. Varnai, A. Balla, K. Jalink, S.-G. Rhee, and T. Balla The Pleckstrin Homology Domain of Phosphoinositide-specific Phospholipase C{delta}4 Is Not a Critical Determinant of the Membrane Localization of the Enzyme J. Biol. Chem., June 4, 2004; 279(23): 24362 - 24371. [Abstract] [Full Text] [PDF]
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M. B. Stope, F. vom Dorp, D. Szatkowski, A. Bohm, M. Keiper, J. Nolte, P. A. Oude Weernink, D. Rosskopf, S. Evellin, K. H. Jakobs, et al. Rap2B-Dependent Stimulation of Phospholipase C-{varepsilon} by Epidermal Growth Factor Receptor Mediated by c-Src Phosphorylation of RasGRP3 Mol. Cell. Biol., June 1, 2004; 24(11): 4664 - 4676. [Abstract] [Full Text] [PDF]
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