| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Physiological Reviews, Vol. 80, No. 4, October 2000, pp. 1291-1335
Copyright ©2000 by the American Physiological Society
Departments of Anesthesiology and Physiology and Biophysics, School of Medicine, State University of New York, Stony Brook, New York
Rebecchi, Mario J. and
Srinivas N. Pentyala.
Structure, Function, and Control of
Phosphoinositide-Specific Phospholipase C. Physiol. Rev. 80: 1291-1335, 2000.
Phosphoinositide-specific
phospholipase C (PLC) subtypes 
, 
, and 
comprise a related
group of multidomain phosphodiesterases that cleave the polar head
groups from inositol lipids. Activated by all classes of cell surface
receptor, these enzymes generate the ubiquitous second messengers
inositol 1,4,5-trisphosphate and diacylglycerol. The last 5 years have
seen remarkable advances in our understanding of the molecular and
biological facets of PLCs. New insights into their multidomain
arrangement and catalytic mechanism have been gained from
crystallographic studies of PLC-1 , while new modes of
controlling PLC activity have been uncovered in cellular studies. Most
notable is the realization that PLC-, -, and - isoforms act in
concert, each contributing to a specific aspect of the cellular
response. Clues to their true biological roles were also obtained. Long
assumed to function broadly in calcium-regulated processes, genetic
studies in yeast, slime molds, plants, flies, and mammals point to
specific and conditional roles for each PLC isoform in cell signaling
and development. In this review we consider each subtype of PLC in
organisms ranging from yeast to mammals and discuss their molecular
regulation and biological function.
This article has been cited by other articles:
|
|
 |
|
  U. Golebiewska and S. Scarlata G{alpha}q Binds Two Effectors Separately in Cells: Evidence for Predetermined Signaling Pathways Biophys. J., September 1, 2008; 95(5): 2575 - 2582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Tian and Z.-j. Xie The Na-K-ATPase and Calcium-Signaling Microdomains Physiology, August 1, 2008; 23(4): 205 - 211. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. W. Tawfeek and A. B. Abou-Samra Negative Regulation of Parathyroid Hormone (PTH)-Activated Phospholipase C by PTH/PTH-Related Peptide Receptor Phosphorylation and Protein Kinase A Endocrinology, August 1, 2008; 149(8): 4016 - 4023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Grubb, O. Vasilevski, H. Huynh, and E. A. Woodcock The extreme C-terminal region of phospholipase C{beta}1 determines subcellular localization and function; the "b" splice variant mediates {alpha}1-adrenergic receptor responses in cardiomyocytes FASEB J, August 1, 2008; 22(8): 2768 - 2774. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Clarke, S. Forman, J. Pritchett, V. Ohanian, and J. Ohanian Phospholipase C-{delta}1 modulates sustained contraction of rat mesenteric small arteries in response to noradrenaline, but not endothelin-1 Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H826 - H834. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Nozawa, G. Howell, S. Suzuki, Q. Zhang, Y. Qi, J. Klein-Seetharaman, A. Wells, J. R. Grandis, and S. M. Thomas Combined Inhibition of PLC{gamma}-1 and c-Src Abrogates Epidermal Growth Factor Receptor-Mediated Head and Neck Squamous Cell Carcinoma Invasion Clin. Cancer Res., July 1, 2008; 14(13): 4336 - 4344. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. V. Quinn, P. Behe, and A. Tinker Monitoring changes in membrane phosphatidylinositol 4,5-bisphosphate in living cells using a domain from the transcription factor tubby J. Physiol., June 15, 2008; 586(12): 2855 - 2871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Stallings, Y. X. Zeng, F. Narvaez, and M. J. Rebecchi Phospholipase C-{delta}1 Expression Is Linked to Proliferation, DNA Synthesis, and Cyclin E Levels J. Biol. Chem., May 16, 2008; 283(20): 13992 - 14001. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Sengupta, F. Philip, and S. Scarlata Caveolin-1 alters Ca2+ signal duration through specific interaction with the G{alpha}q family of G proteins J. Cell Sci., May 1, 2008; 121(9): 1363 - 1372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Peng, E Shen, J. Fan, Y. Zhang, J. M. O. Arnold, and Q. Feng Disruption of phospholipase C{gamma}1 signalling attenuates cardiac tumor necrosis factor-{alpha} expression and improves myocardial function during endotoxemia Cardiovasc Res, April 1, 2008; 78(1): 90 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Golebiewska, M. Nyako, W. Woturski, I. Zaitseva, and S. McLaughlin Diffusion Coefficient of Fluorescent Phosphatidylinositol 4,5-bisphosphate in the Plasma Membrane of Cells Mol. Biol. Cell, April 1, 2008; 19(4): 1663 - 1669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-C. Lee, T. Inoue, R. Imae, N. Kono, S. Shirae, S. Matsuda, K. Gengyo-Ando, S. Mitani, and H. Arai Caenorhabditis elegans mboa-7, a Member of the MBOAT Family, Is Required for Selective Incorporation of Polyunsaturated Fatty Acids into Phosphatidylinositol Mol. Biol. Cell, March 1, 2008; 19(3): 1174 - 1184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Lacalle, R. M. Peregil, J. P. Albar, E. Merino, C. Martinez-A, I. Merida, and S. Manes Type I phosphatidylinositol 4-phosphate 5-kinase controls neutrophil polarity and directional movement J. Cell Biol., December 31, 2007; 179(7): 1539 - 1553. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Fu, Y.-R. Qin, D. Xie, L. Hu, D. L. Kwong, G. Srivastava, S. W. Tsao, and X.-Y. Guan Characterization of a Novel Tumor-Suppressor Gene PLC{delta}1 at 3p22 in Esophageal Squamous Cell Carcinoma Cancer Res., November 15, 2007; 67(22): 10720 - 10726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-K. Chen, G. Y.-P. Ko, and S. E. Dryer Somatostatin Peptides Produce Multiple Effects on Gating Properties of Native Cone Photoreceptor cGMP-Gated Channels That Depend on Circadian Phase and Previous Illumination J. Neurosci., November 7, 2007; 27(45): 12168 - 12175. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Chen, C. MacLeod, B. Deng, L. Mason, M. Kasaian, S. Goldman, S. Wolf, C. Williams, and M. R. Bowman CAT-2 amplifies the agonist-evoked force of airway smooth muscle by enhancing spermine-mediated phosphatidylinositol-(4)-phosphate-5-kinase-{gamma} activity Am J Physiol Lung Cell Mol Physiol, October 1, 2007; 293(4): L883 - L891. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. P. Jones and M. Katan Role of Phospholipase C{gamma}1 in Cell Spreading Requires Association with a {beta}-Pix/GIT1-Containing Complex, Leading to Activation of Cdc42 and Rac1 Mol. Cell. Biol., August 15, 2007; 27(16): 5790 - 5805. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Martinez, M. Vermeulen, E. von Euw, J. Sabatte, J. Maggini, A. Ceballos, A. Trevani, K. Nahmod, G. Salamone, M. Barrio, et al. Extracellular Acidosis Triggers the Maturation of Human Dendritic Cells and the Production of IL-12 J. Immunol., August 1, 2007; 179(3): 1950 - 1959. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Bertagnolo, M. Benedusi, F. Brugnoli, P. Lanuti, M. Marchisio, P. Querzoli, and S. Capitani Phospholipase C-{beta}2 promotes mitosis and migration of human breast cancer-derived cells Carcinogenesis, August 1, 2007; 28(8): 1638 - 1645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Philip, P. Sengupta, and S. Scarlata Signaling through a G Protein-coupled Receptor and Its Corresponding G Protein Follows a Stoichiometrically Limited Model J. Biol. Chem., June 29, 2007; 282(26): 19203 - 19216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Lukacs, B. Thyagarajan, P. Varnai, A. Balla, T. Balla, and T. Rohacs Dual Regulation of TRPV1 by Phosphoinositides J. Neurosci., June 27, 2007; 27(26): 7070 - 7080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nomikos, A. Mulgrew-Nesbitt, P. Pallavi, G. Mihalyne, I. Zaitseva, K. Swann, F. A. Lai, D. Murray, and S. McLaughlin Binding of Phosphoinositide-specific Phospholipase C-{zeta} (PLC-{zeta}) to Phospholipid Membranes: POTENTIAL ROLE OF AN UNSTRUCTURED CLUSTER OF BASIC RESIDUES J. Biol. Chem., June 1, 2007; 282(22): 16644 - 16653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhou, S. J. Martinez, M. Haber, E. V. Jones, D. Bouvier, G. Doucet, A. T. Corera, E. A. Fon, A. H. Zisch, and K. K. Murai EphA4 Signaling Regulates Phospholipase C{gamma}1 Activation, Cofilin Membrane Association, and Dendritic Spine Morphology J. Neurosci., May 9, 2007; 27(19): 5127 - 5138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Lefebvre, F. Furt, M.-A. Hartmann, L. V. Michaelson, J.-P. Carde, F. Sargueil-Boiron, M. Rossignol, J. A. Napier, J. Cullimore, J.-J. Bessoule, et al. Characterization of Lipid Rafts from Medicago truncatula Root Plasma Membranes: A Proteomic Study Reveals the Presence of a Raft-Associated Redox System Plant Physiology, May 1, 2007; 144(1): 402 - 418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Shao, X. Shi, H. Wehbi, C. Zambonelli, J. F. Head, B. A. Seaton, and M. F. Roberts Dimer Structure of an Interfacially Impaired Phosphatidylinositol-specific Phospholipase C J. Biol. Chem., March 23, 2007; 282(12): 9228 - 9235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Kunkel, A. Toker, R. Y. Tsien, and A. C. Newton Calcium-dependent Regulation of Protein Kinase D Revealed by a Genetically Encoded Kinase Activity Reporter J. Biol. Chem., March 2, 2007; 282(9): 6733 - 6742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Faenza, G. Ramazzotti, A. Bavelloni, R. Fiume, G. C. Gaboardi, M. Y. Follo, R. S. Gilmour, A. M. Martelli, K. Ravid, and L. Cocco Inositide-Dependent Phospholipase C Signaling Mimics Insulin in Skeletal Muscle Differentiation by Affecting Specific Regions of the Cyclin D3 Promoter Endocrinology, March 1, 2007; 148(3): 1108 - 1117. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Chouayekh, H. Nothaft, S. Delaunay, M. Linder, B. Payrastre, N. Seghezzi, F. Titgemeyer, and M. J. Virolle Phosphoinositides Are Involved in Control of the Glucose-Dependent Growth Resumption That Follows the Transition Phase in Streptomyces lividans J. Bacteriol., February 1, 2007; 189(3): 741 - 749. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Schubert and C. G. Dotti Transmitting on actin: synaptic control of dendritic architecture J. Cell Sci., January 15, 2007; 120(2): 205 - 212. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Hyduk, J. R. Chan,, S. T. Duffy, M. Chen, M. D. Peterson, T. K. Waddell, G. C. Digby, K. Szaszi, A. Kapus, and M. I. Cybulsky Phospholipase C, calcium, and calmodulin are critical for {alpha}4{beta}1 integrin affinity up-regulation and monocyte arrest triggered by chemoattractants Blood, January 1, 2007; 109(1): 176 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Helling, A. Possart, S. Cottier, U. Klahre, and B. Kost Pollen Tube Tip Growth Depends on Plasma Membrane Polarization Mediated by Tobacco PLC3 Activity and Endocytic Membrane Recycling PLANT CELL, December 1, 2006; 18(12): 3519 - 3534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Ross, D. Mateu, A. V. Gomes, C. Arana, T. Tran, and I. Litosch Structural Determinants for Phosphatidic Acid Regulation of Phospholipase C-beta1 J. Biol. Chem., November 3, 2006; 281(44): 33087 - 33094. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Yoneda, M. Kashima, S. Yoshida, K. Terada, S. Nakagawa, A. Sakamoto, K. Hayakawa, K. Suzuki, J. Ueda, and T. Watanabe Molecular cloning, testicular postnatal expression, and oocyte-activating potential of porcine phospholipase C{zeta}. Reproduction, September 1, 2006; 132(3): 393 - 401. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. M. Tyler, S. Tripathy, X. Zhang, P. Dehal, R. H. Y. Jiang, A. Aerts, F. D. Arredondo, L. Baxter, D. Bensasson, J. L. Beynon, et al. Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis. Science, September 1, 2006; 313(5791): 1261 - 1266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Dowal, P. Provitera, and S. Scarlata Stable Association between G{alpha}q and Phospholipase Cbeta1 in Living Cells J. Biol. Chem., August 18, 2006; 281(33): 23999 - 24014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Banerjee, R. Joshi, G. Venkiteswaran, N. Agrawal, S. Srikanth, F. Alam, and G. Hasan Compensation of inositol 1,4,5-trisphosphate receptor function by altering sarco-endoplasmic reticulum calcium ATPase activity in the Drosophila flight circuit. J. Neurosci., August 9, 2006; 26(32): 8278 - 8288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Mangat, T. Singal, N. S. Dhalla, and P. S. Tappia Inhibition of phospholipase C-{gamma}1 augments the decrease in cardiomyocyte viability by H2O2 Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H854 - H860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Matsu-ura, T. Michikawa, T. Inoue, A. Miyawaki, M. Yoshida, and K. Mikoshiba Cytosolic inositol 1,4,5-trisphosphate dynamics during intracellular calcium oscillations in living cells J. Cell Biol., June 5, 2006; 173(5): 755 - 765. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ginnan, B. J. Guikema, H. A. Singer, and D. Jourd'heuil PKC-{delta} mediates activation of ERK1/2 and induction of iNOS by IL-1beta in vascular smooth muscle cells Am J Physiol Cell Physiol, June 1, 2006; 290(6): C1583 - C1591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Dowd, S. Coursol, A. L. Skirpan, T.-h. Kao, and S. Gilroy Petunia Phospholipase C1 Is Involved in Pollen Tube Growth PLANT CELL, June 1, 2006; 18(6): 1438 - 1453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Politi, L. D. Gaspers, A. P. Thomas, and T. Hofer Models of IP3 and Ca2+ Oscillations: Frequency Encoding and Identification of Underlying Feedbacks Biophys. J., May 1, 2006; 90(9): 3120 - 3133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Eltit, A. A. Garcia, J. Hidalgo, J. L. Liberona, M. Chiong, S. Lavandero, E. Maldonado, and E. Jaimovich Membrane Electrical Activity Elicits Inositol 1,4,5-Trisphosphate-dependent Slow Ca2+ Signals through a Gbeta{gamma}/Phosphatidylinositol 3-Kinase {gamma} Pathway in Skeletal Myotubes J. Biol. Chem., April 28, 2006; 281(17): 12143 - 12154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Codazzi, A. Di Cesare, N. Chiulli, A. Albanese, T. Meyer, D. Zacchetti, and F. Grohovaz Synergistic control of protein kinase Cgamma activity by ionotropic and metabotropic glutamate receptor inputs in hippocampal neurons. J. Neurosci., March 29, 2006; 26(13): 3404 - 3411. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Chen, E. M. Talley, N. Patel, A. Gomis, W. E. McIntire, B. Dong, F. Viana, J. C. Garrison, and D. A. Bayliss Inhibition of a background potassium channel by Gq protein {alpha}-subunits PNAS, February 28, 2006; 103(9): 3422 - 3427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Tang, Y. Tu, S. K. Nayak, J. Woodson, M. Jehl, and E. M. Ross Gbeta{gamma} Inhibits G{alpha} GTPase-activating Proteins by Inhibition of G{alpha}-GTP Binding during Stimulation by Receptor J. Biol. Chem., February 24, 2006; 281(8): 4746 - 4753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. G. Kelley, K. A. Kaproth-Joslin, S. E. Reks, A. V. Smrcka, and R. J. H. Wojcikiewicz G-protein-coupled Receptor Agonists Activate Endogenous Phospholipase C{epsilon} and Phospholipase Cbeta3 in a Temporally Distinct Manner J. Biol. Chem., February 3, 2006; 281(5): 2639 - 2648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T Balla Phosphoinositide-derived messengers in endocrine signaling J. Endocrinol., February 1, 2006; 188(2): 135 - 153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Tang, E. M. Edwards, B. B. Holmes, J. R. Falck, and W. B. Campbell Role of phospholipase C and diacylglyceride lipase pathway in arachidonic acid release and acetylcholine-induced vascular relaxation in rabbit aorta Am J Physiol Heart Circ Physiol, January 1, 2006; 290(1): H37 - H45. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Wilkerson, T. J. Heppner, A. D. Bonev, and M. T. Nelson Inositol trisphosphate receptor calcium release is required for cerebral artery smooth muscle cell proliferation Am J Physiol Heart Circ Physiol, January 1, 2006; 290(1): H240 - H247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nakamura, Y. Hamada, T. Fujiwara, H. Enomoto, T. Hiroe, S. Tanaka, M. Nose, M. Nakahara, N. Yoshida, T. Takenawa, et al. Phospholipase C-{delta}1 and -{delta}3 Are Essential in the Trophoblast for Placental Development Mol. Cell. Biol., December 15, 2005; 25(24): 10979 - 10988. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Piechulek, T. Rehlen, C. Walliser, P. Vatter, B. Moepps, and P. Gierschik Isozyme-specific Stimulation of Phospholipase C-{gamma}2 by Rac GTPases J. Biol. Chem., November 25, 2005; 280(47): 38923 - 38931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E Houdeau, A Levy, and S Mhaouty-Kodja Up-regulation of rat myometrial phospholipases C{beta}1 and C{beta}3 correlates with increased term sensitivity to carbachol and oxytocin J. Endocrinol., November 1, 2005; 187(2): 197 - 204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Harayama, T. Murase, and M. Miyake A Cyclic Adenosine 3',5'-Monophosphate Stimulates Phospholipase C{gamma}1-Calcium Signaling via the Activation of Tyrosine Kinase in Boar Spermatozoa J Androl, November 1, 2005; 26(6): 732 - 740. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Frecker, S. Munk, H. Wang, and C. Whiteside Mesangial cell-reduced Ca2+ signaling in high glucose is due to inactivation of phospholipase C-{beta}3 by protein kinase C Am J Physiol Renal Physiol, November 1, 2005; 289(5): F1078 - F1087. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Irino, M. Ichinohe, Y. Nakamura, M. Nakahara, and K. Fukami Phospholipase C{delta}4 Associates with Glutamate Receptor Interacting Protein 1 in Testis J. Biochem., October 1, 2005; 138(4): 451 - 456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rao and S. Sockanathan Transmembrane Protein GDE2 Induces Motor Neuron Differentiation in Vivo Science, September 30, 2005; 309(5744): 2212 - 2215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nakahara, M. Shimozawa, Y. Nakamura, Y. Irino, M. Morita, Y. Kudo, and K. Fukami A Novel Phospholipase C, PLC{eta}2, Is a Neuron-specific Isozyme J. Biol. Chem., August 12, 2005; 280(32): 29128 - 29134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Maejima, S. Oka, Y. Hashimotodani, T. Ohno-Shosaku, A. Aiba, D. Wu, K. Waku, T. Sugiura, and M. Kano Synaptically Driven Endocannabinoid Release Requires Ca2+-Assisted Metabotropic Glutamate Receptor Subtype 1 to Phospholipase C {beta}4 Signaling Cascade in the Cerebellum J. Neurosci., July 20, 2005; 25(29): 6826 - 6835. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Bartlett, K. W. Young, S. R. Nahorski, and R. A. J. Challiss Single Cell Analysis and Temporal Profiling of Agonist-mediated Inositol 1,4,5-Trisphosphate, Ca2+, Diacylglycerol, and Protein Kinase C Signaling using Fluorescent Biosensors J. Biol. Chem., June 10, 2005; 280(23): 21837 - 21846. [Abstract] [Full Text] [PDF]
|
|
|
|
