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Physiological Reviews, Vol. 80, No. 1, January 2000, pp. 315-360
Copyright ©2000 by the American Physiological Society
Department of Pharmacology and Neuroscience, University of Dundee, Dundee, Scotland; and Cerebrovascular and Neuroscience Research Institute, Brigham and Women's Hospital, Boston, Massachusetts
Nicholls, David G. and
Samantha L. Budd.
Mitochondria and Neuronal Survival. Physiol. Rev. 80: 315-360, 2000.
Mitochondria play a central role in the survival and death of
neurons. The detailed bioenergetic mechanisms by which isolated mitochondria generate ATP, sequester Ca2+, generate
reactive oxygen species, and undergo Ca2+-dependent
permeabilization of their inner membrane are currently being applied to
the function of mitochondria in situ within neurons under physiological
and pathophysiological conditions. Here we review the functional
bioenergetics of isolated mitochondria, with emphasis on the
chemiosmotic proton circuit and the application (and occasional
misapplication) of these principles to intact neurons. Mitochondria
play an integral role in both necrotic and apoptotic neuronal cell
death, and the bioenergetic principles underlying current studies are reviewed.
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R. Kovacs, S. Schuchmann, S. Gabriel, O. Kann, J. Kardos, and U. Heinemann Free Radical-Mediated Cell Damage After Experimental Status Epilepticus in Hippocampal Slice Cultures J Neurophysiol, December 1, 2002; 88(6): 2909 - 2918. [Abstract] [Full Text] [PDF]
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A.A. Mongin, H. Bolay, and T. Dalkara Nitric Oxide May Contribute to the Long-Term Impairment of Synaptic Transmission After Transient Ischemia Stroke, October 1, 2002; 33(10): 2348 - 2350. [Full Text] [PDF]
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L. D. Plant, P. J. Kemp, C. Peers, Z. Henderson, and H. A. Pearson Hypoxic Depolarization of Cerebellar Granule Neurons by Specific Inhibition of TASK-1 Stroke, September 1, 2002; 33(9): 2324 - 2328. [Abstract] [Full Text] [PDF]
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 E. Werner and Z. Werb Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases J. Cell Biol., July 22, 2002; 158(2): 357 - 368. [Abstract] [Full Text] [PDF]
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B. Billups and I. D. Forsythe Presynaptic Mitochondrial Calcium Sequestration Influences Transmission at Mammalian Central Synapses J. Neurosci., July 15, 2002; 22(14): 5840 - 5847. [Abstract] [Full Text] [PDF]
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E. J. Weeber, M. Levy, M. J. Sampson, K. Anflous, D. L. Armstrong, S. E. Brown, J. D. Sweatt, and W. J. Craigen The Role of Mitochondrial Porins and the Permeability Transition Pore in Learning and Synaptic Plasticity J. Biol. Chem., May 17, 2002; 277(21): 18891 - 18897. [Abstract] [Full Text] [PDF]
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H. Bolay, Y. Gursoy-Ozdemir, Y. Sara, R. Onur, A. Can, and T. Dalkara Persistent Defect in Transmitter Release and Synapsin Phosphorylation in Cerebral Cortex After Transient Moderate Ischemic Injury Stroke, May 1, 2002; 33(5): 1369 - 1375. [Abstract] [Full Text] [PDF]
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M. F. Lopez and S. Melov Applied Proteomics: Mitochondrial Proteins and Effect on Function Circ. Res., March 8, 2002; 90(4): 380 - 389. [Abstract] [Full Text] [PDF]
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N. J. Solenski, C. G. diPierro, P. A. Trimmer, A.-L. Kwan, and G. A. Helms Ultrastructural Changes of Neuronal Mitochondria After Transient and Permanent Cerebral Ischemia Stroke, March 1, 2002; 33(3): 816 - 824. [Abstract] [Full Text] [PDF]
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M Inoue, N Fujishiro, I Imanaga, and Y Sakamoto Role of ATP decrease in secretion induced by mitochondrial dysfunction in guinea-pig adrenal chromaffin cells J. Physiol., February 15, 2002; 539(1): 145 - 155. [Abstract] [Full Text] [PDF]
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D. Jiang, P. G. Sullivan, S. L. Sensi, O. Steward, and J. H. Weiss Zn2+ Induces Permeability Transition Pore Opening and Release of Pro-apoptotic Peptides from Neuronal Mitochondria J. Biol. Chem., December 7, 2001; 276(50): 47524 - 47529. [Abstract] [Full Text] [PDF]
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 A. J. Woollacott and P. B. Simpson High Throughput Fluorescence Assays for the Measurement of Mitochondrial Activity in Intact Human Neuroblastoma Cells J Biomol Screen, December 1, 2001; 6(6): 413 - 420. [Abstract] [PDF]
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 L. P. Mark, R. W. Prost, J. L. Ulmer, M. M. Smith, D. L. Daniels, J. M. Strottmann, W. D. Brown, and L. Hacein-Bey Pictorial Review of Glutamate Excitotoxicity: Fundamental Concepts for Neuroimaging AJNR Am. J. Neuroradiol., November 1, 2001; 22(10): 1813 - 1824. [Full Text] [PDF]
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 J. K. Andersen, J. Kumar, B. Srinivas, D. Kaur, M. Hsu, and S. Rajagopalan The Hunt for a Cure for Parkinson's Disease Sci. Aging Knowl. Environ., October 3, 2001; 2001(1): re1 - 1. [Abstract] [Full Text] [PDF]
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J. F. Buckman and I. J. Reynolds Spontaneous Changes in Mitochondrial Membrane Potential in Cultured Neurons J. Neurosci., July 15, 2001; 21(14): 5054 - 5065. [Abstract] [Full Text] [PDF]
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J. B Brocard, M. Tassetto, and I. J Reynolds Quantitative evaluation of mitochondrial calcium content in rat cortical neurones following a glutamate stimulus J. Physiol., March 15, 2001; 531(3): 793 - 805. [Abstract] [Full Text] [PDF]
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D. Ricquier and F. Bouillaud Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance J. Physiol., November 15, 2000; 529(1): 3 - 10. [Abstract] [Full Text] [PDF]
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G. Hajnoczky, G. Csordas, M. Madesh, and P. Pacher The machinery of local Ca2+ signalling between sarco-endoplasmic reticulum and mitochondria J. Physiol., November 15, 2000; 529(1): 69 - 81. [Abstract] [Full Text] [PDF]
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M. W. Ward, A. C. Rego, B. G. Frenguelli, and D. G. Nicholls Mitochondrial Membrane Potential and Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells J. Neurosci., October 1, 2000; 20(19): 7208 - 7219. [Abstract] [Full Text] [PDF]
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J. Lotharius and K. L. O'Malley The Parkinsonism-inducing Drug 1-Methyl-4-phenylpyridinium Triggers Intracellular Dopamine Oxidation. A NOVEL MECHANISM OF TOXICITY J. Biol. Chem., December 1, 2000; 275(49): 38581 - 38588. [Abstract] [Full Text] [PDF]
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