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Physiological Reviews, Vol. 79, No. 4, October 1999, pp. 1373-1430
Copyright ©1999 by the American Physiological Society
Department of Molecular Pharmacology, Diabetes and Metabolic Diseases Research Center, University Medical Center, State University of New York/Stony Brook, Stony Brook, New York
Morris, Andrew J. and
Craig C. Malbon.
Physiological Regulation of G Protein-Linked
Signaling. J. Neurophysiol. 79: 1373-1430, 1999. Heterotrimeric G proteins in vertebrates
constitute a family molecular switches that transduce the activation of
a populous group of cell-surface receptors to a group of diverse
effector units. The receptors include the photopigments such as
rhodopsin and prominent families such as the adrenergic, muscarinic
acetylcholine, and chemokine receptors involved in regulating a broad
spectrum of responses in humans. Signals from receptors are sensed by
heterotrimeric G proteins and transduced to effectors such as adenylyl
cyclases, phospholipases, and various ion channels. Physiological
regulation of G protein-linked receptors allows for integration of
signals that directly or indirectly effect the signaling from
receptor
G proteineffector(s). Steroid hormones can regulate
signaling via transcriptional control of the activities of the genes
encoding members of G protein-linked pathways. Posttranscriptional
mechanisms are under physiological control, altering the stability of
preexisting mRNA and affording an additional level for regulation.
Protein phosphorylation, protein prenylation, and proteolysis
constitute major posttranslational mechanisms employed in the
physiological regulation of G protein-linked signaling. Drawing
upon mechanisms at all three levels, physiological regulation permits
integration of demands placed on G protein-linked signaling.
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L. De Vries, T. Fischer, H. Tronchere, G. M. Brothers, B. Strockbine, D. P. Siderovski, and M. G. Farquhar Activator of G protein signaling 3 is a guanine dissociation inhibitor for Galpha i subunits PNAS, December 19, 2000; 97(26): 14364 - 14369. [Abstract] [Full Text] [PDF]
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H. S. Kang, D. Kerstan, L.-J. Dai, G. Ritchie, and G. A. Quamme beta -Adrenergic agonists stimulate Mg2+ uptake in mouse distal convoluted tubule cells Am J Physiol Renal Physiol, December 1, 2000; 279(6): F1116 - F1123. [Abstract] [Full Text] [PDF]
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J. Y. Zhou, D. P. Siderovski, and R. J. Miller Selective Regulation of N-Type Ca Channels by Different Combinations of G-Protein beta /gamma Subunits and RGS Proteins J. Neurosci., October 1, 2000; 20(19): 7143 - 7148. [Abstract] [Full Text] [PDF]
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Q.-K. Tran, K. Ohashi, and H. Watanabe Calcium signalling in endothelial cells Cardiovasc Res, October 1, 2000; 48(1): 13 - 22. [Abstract] [Full Text] [PDF]
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P. Song, M. Milanese, E. Crimi, S. Bruzzone, E. Zocchi, K. Rehder, and V. Brusasco Gs protein dysfunction in allergen-challenged human isolated passively sensitized bronchi Am J Physiol Lung Cell Mol Physiol, August 1, 2000; 279(2): L209 - L215. [Abstract] [Full Text] [PDF]
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J.-P. Hildebrandt and A. Prowald Ca2+ and p38 MAP kinase regulate mAChR-mediated c-Fos expression in avian exocrine cells Am J Physiol Cell Physiol, May 1, 2000; 278(5): C879 - C884. [Abstract] [Full Text] [PDF]
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C. Gu, Y.-C. Ma, J. Benjamin, D. Littman, M. V. Chao, and X.-Y. Huang Apoptotic Signaling through the beta -Adrenergic Receptor. A NEW Gs EFFECTOR PATHWAY J. Biol. Chem., June 30, 2000; 275(27): 20726 - 20733. [Abstract] [Full Text] [PDF]
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H.-y. Wang, S. Doronin, and C. C. Malbon Insulin Activation of Mitogen-activated Protein Kinases Erk1,2 Is Amplified via beta -adrenergic Receptor Expression and Requires the Integrity of the Tyr350 of the Receptor J. Biol. Chem., November 10, 2000; 275(46): 36086 - 36093. [Abstract] [Full Text] [PDF]
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S. M. Appleyard, J. P. McLaughlin, and C. Chavkin Tyrosine Phosphorylation of the kappa -Opioid Receptor Regulates Agonist Efficacy J. Biol. Chem., December 1, 2000; 275(49): 38281 - 38285. [Abstract] [Full Text] [PDF]
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G.-f. Fan, E. Shumay, H.-y. Wang, and C. C. Malbon The Scaffold Protein Gravin (cAMP-dependent Protein Kinase-anchoring Protein 250) Binds the beta 2-Adrenergic Receptor via the Receptor Cytoplasmic Arg-329 to Leu-413 Domain and Provides a Mobile Scaffold during Desensitization J. Biol. Chem., June 22, 2001; 276(26): 24005 - 24014. [Abstract] [Full Text] [PDF]
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G.-f. Fan, E. Shumay, C. C. Malbon, and H.-y. Wang c-Src Tyrosine Kinase Binds the beta 2-Adrenergic Receptor via Phospho-Tyr-350, Phosphorylates G-protein-linked Receptor Kinase 2, and Mediates Agonist-induced Receptor Desensitization J. Biol. Chem., April 13, 2001; 276(16): 13240 - 13247. [Abstract] [Full Text] [PDF]
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M. H. Wyckoff, K. L. Chambliss, C. Mineo, I. S. Yuhanna, M. E. Mendelsohn, S. M. Mumby, and P. W. Shaul Plasma Membrane Estrogen Receptors Are Coupled to Endothelial Nitric-oxide Synthase through Galpha i J. Biol. Chem., July 13, 2001; 276(29): 27071 - 27076. [Abstract] [Full Text] [PDF]
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J. Yang, Y. Kawai, R. W. Hanson, and I. J. Arinze Sodium Butyrate Induces Transcription from the Galpha i2 Gene Promoter through Multiple Sp1 Sites in the Promoter and by Activating the MEK-ERK Signal Transduction Pathway J. Biol. Chem., July 6, 2001; 276(28): 25742 - 25752. [Abstract] [Full Text] [PDF]
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X. Song, X. Zheng, C. C. Malbon, and H.-y. Wang Galpha i2 Enhances in Vivo Activation of and Insulin Signaling to GLUT4 J. Biol. Chem., September 7, 2001; 276(37): 34651 - 34658. [Abstract] [Full Text] [PDF]
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P. Huang, E. R. Lazarowski, R. Tarran, S. L. Milgram, R. C. Boucher, and M. J. Stutts From the Cover: Compartmentalized autocrine signaling to cystic fibrosis transmembrane conductance regulator at the apical membrane of airway epithelial cells PNAS, November 20, 2001; 98(24): 14120 - 14125. [Abstract] [Full Text] [PDF]
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R. Zanner, G. Hapfelmeier, M. Gratzl, and C. Prinz Intracellular signal transduction during gastrin-induced histamine secretion in rat gastric ECL cells Am J Physiol Cell Physiol, February 1, 2002; 282(2): C374 - C382. [Abstract] [Full Text] [PDF]
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