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Physiol. Rev. 79: 1317-1372, 1999;
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Physiological Reviews, Vol. 79, No. 4, October 1999, pp. 1317-1372
Copyright ©1999 by the American Physiological Society

Voltage-Gated Ion Channels and Hereditary Disease

Frank Lehmann-Horn and Karin Jurkat-Rott

Department of Applied Physiology, University of Ulm, Ulm, Germany

Lehmann-Horn, Frank and Karin Jurkat-Rott. Voltage-Gated Ion Channels and Hereditary Disease. J. Neurophysiol. 79: 1317-1372, 1999. By the introduction of technological advancement in methods of structural analysis, electronics, and recombinant DNA techniques, research in physiology has become molecular. Additionally, focus of interest has been moving away from classical physiology to become increasingly centered on mechanisms of disease. A wonderful example for this development, as evident by this review, is the field of ion channel research which would not be nearly as advanced had it not been for human diseases to clarify. It is for this reason that structure-function relationships and ion channel electrophysiology cannot be separated from the genetic and clinical description of ion channelopathies. Unique among reviews of this topic is that all known human hereditary diseases of voltage-gated ion channels are described covering various fields of medicine such as neurology (nocturnal frontal lobe epilepsy, benign neonatal convulsions, episodic ataxia, hemiplegic migraine, deafness, stationary night blindness), nephrology (X-linked recessive nephrolithiasis, Bartter), myology (hypokalemic and hyperkalemic periodic paralysis, myotonia congenita, paramyotonia, malignant hyperthermia), cardiology (LQT syndrome), and interesting parallels in mechanisms of disease emphasized. Likewise, all types of voltage-gated ion channels for cations (sodium, calcium, and potassium channels) and anions (chloride channels) are described together with all knowledge about pharmacology, structure, expression, isoforms, and encoding genes.




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