Physiol Rev AJP: Cell Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Physiol. Rev. 79: 1283-1316, 1999;
0031-9333/99 $15.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Heldin, C.-H.
Right arrow Articles by Westermark, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Heldin, C.-H.
Right arrow Articles by Westermark, B.

Physiological Reviews, Vol. 79, No. 4, October 1999, pp. 1283-1316
Copyright ©1999 by the American Physiological Society

Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor

Carl-Henrik Heldin and Bengt Westermark

Ludwig Institute for Cancer Research, Biomedical Center, and Department of Pathology, University Hospital, Uppsala, Sweden

Heldin, Carl-Henrik and Bengt Westermark. Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor. J. Neurophysiol. 79: 1283-1316, 1999. Platelet-derived growth factor (PDGF) is a major mitogen for connective tissue cells and certain other cell types. It is a dimeric molecule consisting of disulfide-bonded, structurally similar A- and B-polypeptide chains, which combine to homo- and heterodimers. The PDGF isoforms exert their cellular effects by binding to and activating two structurally related protein tyrosine kinase receptors, denoted the alpha -receptor and the beta -receptor. Activation of PDGF receptors leads to stimulation of cell growth, but also to changes in cell shape and motility; PDGF induces reorganization of the actin filament system and stimulates chemotaxis, i.e., a directed cell movement toward a gradient of PDGF. In vivo, PDGF has important roles during the embryonic development as well as during wound healing. Moreover, overactivity of PDGF has been implicated in several pathological conditions. The sis oncogene of simian sarcoma virus (SSV) is related to the B-chain of PDGF, and SSV transformation involves autocrine stimulation by a PDGF-like molecule. Similarly, overproduction of PDGF may be involved in autocrine and paracrine growth stimulation of human tumors. Overactivity of PDGF has, in addition, been implicated in nonmalignant conditions characterized by an increased cell proliferation, such as atherosclerosis and fibrotic conditions. This review discusses structural and functional properties of PDGF and PDGF receptors, the mechanism whereby PDGF exerts its cellular effects, and the role of PDGF in normal and diseased tissues.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
S. Ammoun, C. Flaiz, N. Ristic, J. Schuldt, and C. O. Hanemann
Dissecting and Targeting the Growth Factor-Dependent and Growth Factor-Independent Extracellular Signal-Regulated Kinase Pathway in Human Schwannoma
Cancer Res., July 1, 2008; 68(13): 5236 - 5245.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. Perros, D. Montani, P. Dorfmuller, I. Durand-Gasselin, C. Tcherakian, J. Le Pavec, M. Mazmanian, E. Fadel, S. Mussot, O. Mercier, et al.
Platelet-derived Growth Factor Expression and Function in Idiopathic Pulmonary Arterial Hypertension
Am. J. Respir. Crit. Care Med., July 1, 2008; 178(1): 81 - 88.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. Jin, E. M. Hansson, S. Tikka, F. Lanner, C. Sahlgren, F. Farnebo, M. Baumann, H. Kalimo, and U. Lendahl
Notch Signaling Regulates Platelet-Derived Growth Factor Receptor-{beta} Expression in Vascular Smooth Muscle Cells
Circ. Res., June 20, 2008; 102(12): 1483 - 1491.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
Z. Gong and L. E. Niklason
Small-diameter human vessel wall engineered from bone marrow-derived mesenchymal stem cells (hMSCs)
FASEB J, June 1, 2008; 22(6): 1635 - 1648.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J. Andrae, R. Gallini, and C. Betsholtz
Role of platelet-derived growth factors in physiology and medicine
Genes & Dev., May 15, 2008; 22(10): 1276 - 1312.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
L. M. Petti, E. C. Ricciardi, H. J. Page, and K. A. Porter
Transforming signals resulting from sustained activation of the PDGF{beta} receptor in mortal human fibroblasts
J. Cell Sci., April 15, 2008; 121(8): 1172 - 1182.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
H. Pinkas, B. Fisch, G. Rozansky, C. Felz, G. Kessler-Icekson, H. Krissi, S. Nitke, A. Ao, and R. Abir
Platelet-derived growth factors (PDGF-A and -B) and their receptors in human fetal and adult ovaries
Mol. Hum. Reprod., April 1, 2008; 14(4): 199 - 206.
[Abstract] [Full Text] [PDF]

Home page
 J. Dent. Res.Home page
Z.S. AI-Aql, A.S. Alagl, D.T. Graves, L.C. Gerstenfeld, and T.A. Einhorn
Molecular Mechanisms Controlling Bone Formation during Fracture Healing and Distraction Osteogenesis
J. Dent. Res., February 1, 2008; 87(2): 107 - 118.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E. A. Pickett, G. S. Olsen, and M. D. Tallquist
Disruption of PDGFR{alpha}-initiated PI3K activation and migration of somite derivatives leads to spina bifida
Development, February 1, 2008; 135(3): 589 - 598.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
C. Werth, D. Stuhlmann, B. Cat, H. Steinbrenner, L. Alili, H. Sies, and P. Brenneisen
Stromal resistance of fibroblasts against oxidative damage: involvement of tumor cell-secreted platelet-derived growth factor (PDGF) and phosphoinositide 3-kinase (PI3K) activation
Carcinogenesis, February 1, 2008; 29(2): 404 - 410.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
A. Oganesian, L. C. Armstrong, M. M. Migliorini, D. K. Strickland, and P. Bornstein
Thrombospondins Use the VLDL Receptor and a Nonapoptotic Pathway to Inhibit Cell Division in Microvascular Endothelial Cells
Mol. Biol. Cell, February 1, 2008; 19(2): 563 - 571.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
C. M. Croce
Oncogenes and Cancer
N. Engl. J. Med., January 31, 2008; 358(5): 502 - 511.
[Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
A. Siegbahn, M. Johnell, A. Nordin, M. Aberg, and T. Velling
TF/FVIIa Transactivate PDGFR to Regulate PDGF-BB Induced Chemotaxis in Different Cell Types: Involvement of Src And PLC
Arterioscler. Thromb. Vasc. Biol., January 1, 2008; 28(1): 135 - 141.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
J. Floege, F. Eitner, and C. E. Alpers
A New Look at Platelet-Derived Growth Factor in Renal Disease
J. Am. Soc. Nephrol., January 1, 2008; 19(1): 12 - 23.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Nakata, N. Fujita, Y. Kitagawa, R. Okamoto, H. Ogita, and Y. Takai
Regulation of Platelet-derived Growth Factor Receptor Activation by Afadin through SHP-2: IMPLICATIONS FOR CELLULAR MORPHOLOGY
J. Biol. Chem., December 28, 2007; 282(52): 37815 - 37825.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Azuma, Y. Nishioka, Y. Aono, M. Inayama, H. Makino, J. Kishi, M. Shono, K. Kinoshita, H. Uehara, F. Ogushi, et al.
Role of {alpha}1-Acid Glycoprotein in Therapeutic Antifibrotic Effects of Imatinib with Macrolides in Mice
Am. J. Respir. Crit. Care Med., December 15, 2007; 176(12): 1243 - 1250.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
D. Mottet, A. Bellahcene, S. Pirotte, D. Waltregny, C. Deroanne, V. Lamour, R. Lidereau, and V. Castronovo
Histone Deacetylase 7 Silencing Alters Endothelial Cell Migration, a Key Step in Angiogenesis
Circ. Res., December 7, 2007; 101(12): 1237 - 1246.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
Y. Qin, E. M. Rezler, V. Gokhale, D. Sun, and L. H. Hurley
Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4
Nucleic Acids Res., December 3, 2007; 35(22): 7698 - 7713.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. Huang, J. B. DuHadaway, G. C. Prendergast, and L. D. Laury-Kleintop
RhoB Regulates PDGFR- Trafficking and Signaling in Vascular Smooth Muscle Cells
Arterioscler. Thromb. Vasc. Biol., December 1, 2007; 27(12): 2597 - 2605.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. P. Piccaluga, C. Agostinelli, A. Califano, A. Carbone, L. Fantoni, S. Ferrari, A. Gazzola, A. Gloghini, S. Righi, M. Rossi, et al.
Gene Expression Analysis of Angioimmunoblastic Lymphoma Indicates Derivation from T Follicular Helper Cells and Vascular Endothelial Growth Factor Deregulation
Cancer Res., November 15, 2007; 67(22): 10703 - 10710.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Xu, C. M. Kitchen, H.-K. G. Shu, and T. J. Murphy
Platelet-derived Growth Factor-induced Stabilization of Cyclooxygenase 2 mRNA in Rat Smooth Muscle Cells Requires the c-Src Family of Protein-tyrosine Kinases
J. Biol. Chem., November 9, 2007; 282(45): 32699 - 32709.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. Ali, Y. Lin, M. M. Gharibo, M. K. Gounder, M. N. Stein, T. F. Lagattuta, M. J. Egorin, E. H. Rubin, and E. A. Poplin
Phase I and Pharmacokinetic Study of Imatinib Mesylate (Gleevec) and Gemcitabine in Patients with Refractory Solid Tumors
Clin. Cancer Res., October 1, 2007; 13(19): 5876 - 5882.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
P. U. Magnusson, C. Looman, A. Ahgren, Y. Wu, L. Claesson-Welsh, and R. L. Heuchel
Platelet-Derived Growth Factor Receptor-{beta} Constitutive Activity Promotes Angiogenesis In Vivo and In Vitro
Arterioscler. Thromb. Vasc. Biol., October 1, 2007; 27(10): 2142 - 2149.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
E. A. Zemskov, I. Mikhailenko, D. K. Strickland, and A. M. Belkin
Cell-surface transglutaminase undergoes internalization and lysosomal degradation: an essential role for LRP1
J. Cell Sci., September 15, 2007; 120(18): 3188 - 3199.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. K. Dhillon, F. Peng, R. M. Ransohoff, and S. Buch
PDGF Synergistically Enhances IFN-{gamma}-Induced Expression of CXCL10 in Blood-Derived Macrophages: Implications for HIV Dementia
J. Immunol., September 1, 2007; 179(5): 2722 - 2730.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Lu, X. Xu, M. Zhang, R. Cao, E. Brakenhielm, C. Li, H. Lin, G. Yao, H. Sun, L. Qi, et al.
Combinatorial protein therapy of angiogenic and arteriogenic factors remarkably improves collaterogenesis and cardiac function in pigs
PNAS, July 17, 2007; 104(29): 12140 - 12145.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
P. Stock, D. Monga, X. Tan, A. Micsenyi, N. Loizos, and S. P.S. Monga
Platelet-derived growth factor receptor-{alpha}: a novel therapeutic target in human hepatocellular cancer
Mol. Cancer Ther., July 1, 2007; 6(7): 1932 - 1941.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Yang, C. Lin, S. Zhao, H. Wang, and Z.-R. Liu
Phosphorylation of p68 RNA Helicase Plays a Role in Platelet-derived Growth Factor-induced Cell Proliferation by Up-regulating Cyclin D1 and c-Myc Expression
J. Biol. Chem., June 8, 2007; 282(23): 16811 - 16819.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
L. Bezuidenhout, M. Bracher, G. Davison, P. Zilla, and N. Davies
Ang-2 and PDGF-BB cooperatively stimulate human peripheral blood monocyte fibrinolysis
J. Leukoc. Biol., June 1, 2007; 81(6): 1496 - 1503.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. Gredmark, K. Straat, M. Homman-Loudiyi, K. Kannisto, and C. Soderberg-Naucler
Human Cytomegalovirus Downregulates Expression of Receptors for Platelet-Derived Growth Factor by Smooth Muscle Cells
J. Virol., May 15, 2007; 81(10): 5112 - 5120.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
S. G. Ball, C. A. Shuttleworth, and C. M. Kielty
Vascular endothelial growth factor can signal through platelet-derived growth factor receptors
J. Cell Biol., May 7, 2007; 177(3): 489 - 500.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
R. R. Langley and I. J. Fidler
Tumor Cell-Organ Microenvironment Interactions in the Pathogenesis of Cancer Metastasis
Endocr. Rev., May 1, 2007; 28(3): 297 - 321.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
C.-K. Lee, H. M. Lee, H. J. Kim, H.-J. Park, K.-J. Won, H. Y. Roh, W. S. Choi, B. H. Jeon, T.-K. Park, and B. Kim
Syk contributes to PDGF-BB-mediated migration of rat aortic smooth muscle cells via MAPK pathways
Cardiovasc Res, April 1, 2007; 74(1): 159 - 168.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
K. Kusaba, H. Kai, M. Koga, N. Takayama, A. Ikeda, H. Yasukawa, Y. Seki, K. Egashira, and T. Imaizumi
Inhibition of Intrinsic Interferon-{gamma} Function Prevents Neointima Formation After Balloon Injury
Hypertension, April 1, 2007; 49(4): 909 - 915.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
Y. Zheng, M. Watanabe, T. Kuraishi, S. Hattori, C. Kai, and M. Shibuya
Chimeric VEGF-ENZ7/PlGF Specifically Binding to VEGFR-2 Accelerates Skin Wound Healing via Enhancement of Neovascularization
Arterioscler. Thromb. Vasc. Biol., March 1, 2007; 27(3): 503 - 511.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
L. S. Sleer and C. C. Taylor
Cell-Type Localization of Platelet-Derived Growth Factors and Receptors in the Postnatal Rat Ovary and Follicle
Biol Reprod, March 1, 2007; 76(3): 379 - 390.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
L. S. Sleer and C. C. Taylor
Platelet-Derived Growth Factors and Receptors in the Rat Corpus Luteum: Localization and Identification of an Effect on Luteogenesis
Biol Reprod, March 1, 2007; 76(3): 391 - 400.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
T. Yoshida, Q. Gan, Y. Shang, and G. K. Owens
Platelet-derived growth factor-BB represses smooth muscle cell marker genes via changes in binding of MKL factors and histone deacetylases to their promoters
Am J Physiol Cell Physiol, February 1, 2007; 292(2): C886 - C895.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. G. Dolloff, M. R. Russell, N. Loizos, and A. Fatatis
Human Bone Marrow Activates the Akt Pathway in Metastatic Prostate Cells through Transactivation of the {alpha}-Platelet-Derived Growth Factor Receptor
Cancer Res., January 15, 2007; 67(2): 555 - 562.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Inzunza, A. Morani, G. Cheng, M. Warner, J. Hreinsson, J.-A. Gustafsson, and O. Hovatta
Ovarian wedge resection restores fertility in estrogen receptor beta knockout (ERbeta-/-) mice
PNAS, January 9, 2007; 104(2): 600 - 605.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
B. A. Pallante, I. Duignan, D. Okin, A. Chin, M. C. Bressan, T. Mikawa, and J. M. Edelberg
Bone Marrow Oct3/4+ Cells Differentiate Into Cardiac Myocytes via Age-Dependent Paracrine Mechanisms
Circ. Res., January 5, 2007; 100(1): e1 - e11.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
Q. Xiao, L. Zeng, Z. Zhang, Y. Hu, and Q. Xu
Stem cell-derived Sca-1+ progenitors differentiate into smooth muscle cells, which is mediated by collagen IV-integrin {alpha}1/beta1/{alpha}v and PDGF receptor pathways
Am J Physiol Cell Physiol, January 1, 2007; 292(1): C342 - C352.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
Y. Kitadai, T. Sasaki, T. Kuwai, T. Nakamura, C. D. Bucana, and I. J. Fidler
Targeting the Expression of Platelet-Derived Growth Factor Receptor by Reactive Stroma Inhibits Growth and Metastasis of Human Colon Carcinoma
Am. J. Pathol., December 1, 2006; 169(6): 2054 - 2065.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
V. S. Rajkumar, X. Shiwen, M. Bostrom, P. Leoni, J. Muddle, M. Ivarsson, B. Gerdin, C. P. Denton, G. Bou-Gharios, C. M. Black, et al.
Platelet-Derived Growth Factor-{beta} Receptor Activation Is Essential for Fibroblast and Pericyte Recruitment during Cutaneous Wound Healing
Am. J. Pathol., December 1, 2006; 169(6): 2254 - 2265.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
W. Lederle, H.-J. Stark, M. Skobe, N. E. Fusenig, and M. M. Mueller
Platelet-Derived Growth Factor-BB Controls Epithelial Tumor Phenotype by Differential Growth Factor Regulation in Stromal Cells
Am. J. Pathol., November 1, 2006; 169(5): 1767 - 1783.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Kanda, Y. Ihara, H. Murata, Y. Urata, T. Kono, J. Yodoi, S. Seto, K. Yano, and T. Kondo
Glutaredoxin Modulates Platelet-derived Growth Factor-dependent Cell Signaling by Regulating the Redox Status of Low Molecular Weight Protein-tyrosine Phosphatase
J. Biol. Chem., September 29, 2006; 281(39): 28518 - 28528.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. Rolny, I. Nilsson, P. Magnusson, A. Armulik, L. Jakobsson, P. Wentzel, P. Lindblom, J. Norlin, C. Betsholtz, R. Heuchel, et al.
Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiation
Blood, September 15, 2006; 108(6): 1877 - 1886.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. H. Bengtson, S. B. Phagoo, A. Norrby-Teglund, L. Pahlman, M. Morgelin, B. L. Zuraw, L. M. F. Leeb-Lundberg, and H. Herwald
Kinin receptor expression during Staphylococcus aureus infection
Blood, September 15, 2006; 108(6): 2055 - 2063.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Li, C.-H. Heldin, and P. Heldin
Inhibition of Platelet-derived Growth Factor-BB-induced Receptor Activation and Fibroblast Migration by Hyaluronan Activation of CD44
J. Biol. Chem., September 8, 2006; 281(36): 26512 - 26519.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. C. Mendonca, S. Q. Doi, S. Glerum, and D. F. Sellitti
Increase of C-Type Natriuretic Peptide Expression by Serum and Platelet-Derived Growth Factor-BB in Human Aortic Smooth Muscle Cells Is Dependent on Protein Kinase C Activation
Endocrinology, September 1, 2006; 147(9): 4169 - 4178.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Amagasaki, H. Kaneto, C.-H. Heldin, and J. Lennartsson
c-Jun N-terminal Kinase Is Necessary for Platelet-derived Growth Factor-mediated Chemotaxis in Primary Fibroblasts
J. Biol. Chem., August 4, 2006; 281(31): 22173 - 22179.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
H. C. Nystrom, P. Lindblom, A. Wickman, I. Andersson, J. Norlin, J. Faldt, P. Lindahl, O. Skott, M. Bjarnegard, S. M. Fitzgerald, et al.
Platelet-derived growth factor B retention is essential for development of normal structure and function of conduit vessels and capillaries
Cardiovasc Res, August 1, 2006; 71(3): 557 - 565.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Riggi, L. Cironi, P. Provero, M.-L. Suva, J.-C. Stehle, K. Baumer, L. Guillou, and I. Stamenkovic
Expression of the FUS-CHOP Fusion Protein in Primary Mesenchymal Progenitor Cells Gives Rise to a Model of Myxoid Liposarcoma.
Cancer Res., July 15, 2006; 66(14): 7016 - 7023.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. J. Michaud and B. K. Yoder
The Primary Cilium in Cell Signaling and Cancer.
Cancer Res., July 1, 2006; 66(13): 6463 - 6467.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. M. Rivera, S. Antoku, S. Gelkop, N. Y. Shin, S. K. Hanks, T. Pawson, and B. J. Mayer
Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B
PNAS, June 20, 2006; 103(25): 9536 - 9541.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
X. Chen, J. Aravindakshan, Y. Yang, R. Tiwari-Pandey, and M.R. Sairam
Aberrant expression of PDGF ligands and receptors in the tumor prone ovary of follitropin receptor knockout (FORKO) mouse
Carcinogenesis, May 1, 2006; 27(5): 903 - 915.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
Z. Chen, F. Y. Lee, K. N. Bhalla, and J. Wu
Potent Inhibition of Platelet-Derived Growth Factor-Induced Responses in Vascular Smooth Muscle Cells by BMS-354825 (Dasatinib)
Mol. Pharmacol., May 1, 2006; 69(5): 1527 - 1533.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
Z. Zhang and K. E. Meier
New Assignments for Multitasking Signal Transduction Inhibitors
Mol. Pharmacol., May 1, 2006; 69(5): 1510 - 1512.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
E. Koellensperger, D. von Heimburg, M. Markowicz, and N. Pallua
Human Serum from Platelet-Poor Plasma for the Culture of Primary Human Preadipocytes
Stem Cells, May 1, 2006; 24(5): 1218 - 1225.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.