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Physiological Reviews, Vol. 79, No. 4, October 1999, pp. 1193-1226
Copyright ©1999 by the American Physiological Society
Department of Pharmacology, Kyoto University Faculty of Medicine, and Department of Physiological Chemistry, Kyoto University Faculty of Pharmaceutical Sciences, Kyoto, Japan
Narumiya, Shuh,
Yukihiko Sugimoto, and
Fumitaka Ushikubi.
Prostanoid Receptors: Structures, Properties, and
Functions. J. Neurophysiol. 79: 1193-1226, 1999. Prostanoids
are the cyclooxygenase metabolites of arachidonic acid and include
prostaglandin (PG) D2, PGE2,
PGF2
, PGI2, and thromboxne A2.
They are synthesized and released upon cell stimulation and act on
cells in the vicinity of their synthesis to exert their actions.
Receptors mediating the actions of prostanoids were recently identified
and cloned. They are G protein-coupled receptors with seven
transmembrane domains. There are eight types and subtypes of prostanoid
receptors that are encoded by different genes but as a whole constitute
a subfamily in the superfamily of the rhodopsin-type receptors.
Each of the receptors was expressed in cultured cells, and its
ligand-binding properties and signal transduction pathways were
characterized. Moreover, domains and amino acid residues conferring the
specificities of ligand binding and signal transduction are being
clarified. Information also is accumulating as to the distribution of
these receptors in the body. It is also becoming clear for some types
of receptors how expression of their genes is regulated. Furthermore,
the gene for each of the eight types of prostanoid receptor has been
disrupted, and mice deficient in each type of receptor are being
examined to identify and assess the roles played by each receptor under various physiological and pathophysiological conditions. In this article, we summarize these findings and attempt to give an overview of
the current status of research on the prostanoid receptors.
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L Mastalerz, M Sanak, A Gawlewicz-Mroczka, A Gielicz, A Cmiel, and A Szczeklik Prostaglandin E2 systemic production in patients with asthma with and without aspirin hypersensitivity Thorax, January 1, 2008; 63(1): 27 - 34. [Abstract] [Full Text] [PDF]
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C. Paredes, T. Tazzeo, and L. J. Janssen E-Ring Isoprostane Augments Cholinergic Neurotransmission in Bovine Trachealis via FP Prostanoid Receptors Am. J. Respir. Cell Mol. Biol., December 1, 2007; 37(6): 739 - 747. [Abstract] [Full Text] [PDF]
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M. Nagamachi, D. Sakata, K. Kabashima, T. Furuyashiki, T. Murata, E. Segi-Nishida, K. Soontrapa, T. Matsuoka, Y. Miyachi, and S. Narumiya Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1 J. Exp. Med., November 26, 2007; 204(12): 2865 - 2874. [Abstract] [Full Text] [PDF]
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 S. Kitaoka, T. Furuyashiki, A. Nishi, T. Shuto, S. Koyasu, T. Matsuoka, M. Miyasaka, P. Greengard, and S. Narumiya Prostaglandin E2 Acts on EP1 Receptor and Amplifies Both Dopamine D1 and D2 Receptor Signaling in the Striatum J. Neurosci., November 21, 2007; 27(47): 12900 - 12907. [Abstract] [Full Text] [PDF]
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J. H. C. Kengni, I. St-Louis, S. Parent, V. Leblanc, C. Shooner, and E. Asselin Regulation of prostaglandin D synthase and prostacyclin synthase in the endometrium of cyclic, pregnant, and pseudopregnant rats and their regulation by sex steroids J. Endocrinol., November 1, 2007; 195(2): 301 - 311. [Abstract] [Full Text] [PDF]
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Z. Jaffar, M. E. Ferrini, M. C. Buford, G. A. FitzGerald, and K. Roberts Prostaglandin I2-IP Signaling Blocks Allergic Pulmonary Inflammation by Preventing Recruitment of CD4+ Th2 Cells into the Airways in a Mouse Model of Asthma J. Immunol., November 1, 2007; 179(9): 6193 - 6203. [Abstract] [Full Text] [PDF]
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 H. Oka, M. Miyauchi, K. Sakamoto, S. Moriwaki, S. Niida, K. Noguchi, M.J. Somerman, and T. Takata PGE2 Activates Cementoclastogenesis by Cementoblasts via EP4 Journal of Dental Research, October 1, 2007; 86(10): 974 - 979. [Abstract] [Full Text] [PDF]
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 C. Wang, Y. Gu, G.-W. Li, and L.-Y. M. Huang A critical role of the cAMP sensor Epac in switching protein kinase signalling in prostaglandin E2-induced potentiation of P2X3 receptor currents in inflamed rats J. Physiol., October 1, 2007; 584(1): 191 - 203. [Abstract] [Full Text] [PDF]
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C Chandras, T E Harris, A L. Bernal, D R E Abayasekara, and A E Michael PTGER1 and PTGER2 receptors mediate regulation of progesterone synthesis and type 1 11{beta}-hydroxysteroid dehydrogenase activity by prostaglandin E2 in human granulosa lutein cells J. Endocrinol., September 1, 2007; 194(3): 595 - 602. [Abstract] [Full Text] [PDF]
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K. Kuwano, A. Hashino, T. Asaki, T. Hamamoto, T. Yamada, K. Okubo, and K. Kuwabara 2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), an Orally Available and Long-Acting Prostacyclin Receptor Agonist Prodrug J. Pharmacol. Exp. Ther., September 1, 2007; 322(3): 1181 - 1188. [Abstract] [Full Text] [PDF]
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K. Meisdalen, O. F. Dajani, T. Christoffersen, and D. Sandnes Prostaglandins Enhance Epidermal Growth Factor-Induced DNA Synthesis in Hepatocytes by Stimulation of E Prostanoid 3 and F Prostanoid Receptors J. Pharmacol. Exp. Ther., September 1, 2007; 322(3): 1044 - 1050. [Abstract] [Full Text] [PDF]
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A.-M. Hristovska, L. E. Rasmussen, P. B.L. Hansen, S. S. Nielsen, R. M. Nusing, S. Narumiya, P. Vanhoutte, O. Skott, and B. L. Jensen Prostaglandin E2 Induces Vascular Relaxation by E-Prostanoid 4 Receptor-Mediated Activation of Endothelial Nitric Oxide Synthase Hypertension, September 1, 2007; 50(3): 525 - 530. [Abstract] [Full Text] [PDF]
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V. Bachteeva, E. Fock, E. Lavrova, S. Nikolaeva, S. Gambaryan, and R. Parnova Prostaglandin E2 inhibits vasotocin-induced osmotic water permeability in the frog urinary bladder by EP1-receptor-mediated activation of NO/cGMP pathway Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R528 - R537. [Abstract] [Full Text] [PDF]
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G. L. Larsen, J. Loader, C. Fratelli, J.-k. B. Kang, A. Dakhama, and G. N. Colasurdo Modulation of airway responses by prostaglandins in young and fully grown rabbits Am J Physiol Lung Cell Mol Physiol, July 1, 2007; 293(1): L239 - L244. [Abstract] [Full Text] [PDF]
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S. A. Black Jr., A. H. Palamakumbura, M. Stan, and P. C. Trackman Tissue-specific Mechanisms for CCN2/CTGF Persistence in Fibrotic Gingiva: INTERACTIONS BETWEEN cAMP AND MAPK SIGNALING PATHWAYS, AND PROSTAGLANDIN E2-EP3 RECEPTOR MEDIATED ACTIVATION OF THE c-JUN N-TERMINAL KINASE J. Biol. Chem., May 25, 2007; 282(21): 15416 - 15429. [Abstract] [Full Text] [PDF]
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 H. Francois, C. Facemire, A. Kumar, L. Audoly, B. Koller, and T. Coffman Role of Microsomal Prostaglandin E Synthase 1 in the Kidney J. Am. Soc. Nephrol., May 1, 2007; 18(5): 1466 - 1475. [Abstract] [Full Text] [PDF]
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Y. Sugimoto and S. Narumiya Prostaglandin E Receptors J. Biol. Chem., April 20, 2007; 282(16): 11613 - 11617. [Abstract] [Full Text] [PDF]
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N. Kato, K. Kitahara, S. R Rittling, K. Nakashima, D. T Denhardt, H. Kurosawa, Y. Ezura, and M. Noda Osteopontin deficiency enhances anabolic action of EP4 agonist at a sub-optimal dose in bone J. Endocrinol., April 1, 2007; 193(1): 171 - 182. [Abstract] [Full Text] [PDF]
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 V. C. Sandulache, J. B. Chafin, H.-S. Li-Korotky, T. D. Otteson, J. E. Dohar, and P. A. Hebda Elucidating the Role of Interleukin 1beta and Prostaglandin E2 in Upper Airway Mucosal Wound Healing Arch Otolaryngol Head Neck Surg, April 1, 2007; 133(4): 365 - 374. [Abstract] [Full Text] [PDF]
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 K. M. Eyster The membrane and lipids as integral participants in signal transduction: lipid signal transduction for the non-lipid biochemist Advan Physiol Educ, March 1, 2007; 31(1): 5 - 16. [Abstract] [Full Text] [PDF]
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W. F. van Rodijnen, I. J. Korstjens, N. Legerstee, P. M. ter Wee, and G.-J. Tangelder Direct vasoconstrictor effect of prostaglandin E2 on renal interlobular arteries: role of the EP3 receptor Am J Physiol Renal Physiol, March 1, 2007; 292(3): F1094 - F1101. [Abstract] [Full Text] [PDF]
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M. Sanchez-Alavez, I. Klein, S. E. Brownell, I. V. Tabarean, C. N. Davis, B. Conti, and T. Bartfai Night eating and obesity in the EP3R-deficient mouse PNAS, February 20, 2007; 104(8): 3009 - 3014. [Abstract] [Full Text] [PDF]
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S. Gross, P. Tilly, D. Hentsch, J.-L. Vonesch, and J.-E. Fabre Vascular wall-produced prostaglandin E2 exacerbates arterial thrombosis and atherothrombosis through platelet EP3 receptors J. Exp. Med., February 19, 2007; 204(2): 311 - 320. [Abstract] [Full Text] [PDF]
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 Y. Ushida, Y. Shimokawa, T. Toida, H. Matsui, and M. Takase Bovine {alpha}-Lactalbumin Stimulates Mucus Metabolism in Gastric Mucosa J Dairy Sci, February 1, 2007; 90(2): 541 - 546. [Abstract] [Full Text] [PDF]
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S. Battersby, K.J. Sales, A.R. Williams, R.A. Anderson, S. Gardner, and H.N. Jabbour Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase pathway Hum. Reprod., January 1, 2007; 22(1): 36 - 44. [Abstract] [Full Text] [PDF]
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R. Nasrallah, H. Xiong, and R. L. Hebert Renal prostaglandin E2 receptor (EP) expression profile is altered in streptozotocin and B6-Ins2Akita type I diabetic mice Am J Physiol Renal Physiol, January 1, 2007; 292(1): F278 - F284. [Abstract] [Full Text] [PDF]
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M. A. Frias, M. C. Rebsamen, C. Gerber-Wicht, and U. Lang Prostaglandin E2 activates Stat3 in neonatal rat ventricular cardiomyocytes: A role in cardiac hypertrophy Cardiovasc Res, January 1, 2007; 73(1): 57 - 65. [Abstract] [Full Text] [PDF]
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